Haliaeetus leucocephalus (bald eagle): 104828936 Help Entry 104828936         CDS       T08630                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism hle  Haliaeetus leucocephalus (bald eagle) Pathway hle04020   Calcium signaling pathway hle04260   Cardiac muscle contraction hle04261   Adrenergic signaling in cardiomyocytes hle04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:hle00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     104828936 (RYR2)    04020 Calcium signaling pathway     104828936 (RYR2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     104828936 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     104828936 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:hle04040]     104828936 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:hle04990]     104828936 (RYR2) Ion channels [BR:hle04040]  Voltage-gated cation channels   Ryanodine receptor    104828936 (RYR2) Domain-containing proteins not elsewhere classified [BR:hle04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    104828936 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  104828936 NCBI-ProteinID:  XP_010561247 LinkDB All DBs Position Unknown AA seq 4951 aa AA seqDB search MHRVDDEVVLQCTATVHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPDLSICTFVLEQS LSVRALQEMLANTEEKAEGLVDVEKWKFMMKSAQGGGHRTLLYGHAILLRHSYSGMYLCC LSTSRSSMDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYL HLSYGNGSLHVDAAFQQTLWSVAPISSGSEVAQGYLIGGDVLRLLHGHMDECLTVPSGEH GEEQRRTVHYEGGAVSIHARSLWRLETLRVAWSGSHIRWGQPFRLRHITTGKYLSLLDDK SLLLTDKEKADVKSTAFCFRSSKEKLDTGTRKEVDGMGAPEIKYGDSICFIQHVDTGLWL TYQSADAKSVRMGSVQRKAIMHHEGHMDDGLTLSRSQNEESRTARVIRSTVFLFNRFIRG LDALSKKAKFSTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQNLFQEE GMINLVLECIDRLNVYSSAAHFADVAGKEAGEAWKSILNSLYELLAALIRGNRKNCAQFS GSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIICLLDKHGRNHKVLD VLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGISEGSAQYRK WYYELMVDHLEPFVTAESTHLRVGWASTEGYSPYPGGGAEWGGNGVGDDLYSYGFDGLHL WSGCVARTVNSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFFPVV SFSAGIKVRFLLGGRHGEFKFLPPPGYAPCFEAVLPKEKLKVEHSREYKQDRSYTRDLLG PTISLSQAAFTPVPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYGPVRDDNK RQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEKVKKMKLPKNYQL LSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRL VPYALLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAMRLDVCSGIMEKFRIFRTEK TYAVKAGKWYFEFEAVTAGDMRVGWTRPGCLPDQELGSDEEAFVFDGFKAQRWHQGNEHF GRSWLAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFEVGDGFLPVCSLGPSQV GRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITIWLSKRLPQFLPVPQNHEHIEVMR IDGTIDSCPCLKVTQKSFGSQNSKTDVMFFRLSMPIECAEVFSRSAAGGLPGSGLFGPKN DLEDYDADSDFEVLMKTAHGHLVPDRTEREKDATKPELNNHKDYVQEKPSRLKQRFMLRR TKPDYSTSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIFPGQEPANVWVGWITSDFHQ YDTSFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGRNNNGLEIGCLVD AASGLLTFTANGKELGTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFK SEHKNPVSQCPPRLHVQFLTHVLWSRVPNHFLKVDVSRISERQGWMIQCLNPLQFMALHI PEENRTIDILELTEQEELLKFHYHTLRLYSAVCALGNNRVAHAMCSHVDESQLLYAIENK YMPGLLRAGYYDLLIDIHLNTYATARLMMNNEFIVPMTDETKSITLFPDENKKHGLPGIG LSTSLRPRMQFSSPSFVSISSECFQFSPEFPLETLKAKTIEMLTEAVQEGSLHVRDPVGG STEFLFVPLIKLFYTLLIMGIFHNGDLKHILQLIEPRVFKEAMSQEDEVDFSEKELSSDE LKSEEGEEENRGEQVPKEGLLQMKLPEPVKLQMCHLLQYLCDCQVRHRIEAIVAFSDDFV AKLQENQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKNDCPCPEEIR DQLLDFHEDLMTHCGIELDEDGTLDGNSDLTIRGRLLYLMEKVTYLKKKQAEKPVDDDAK TSSTLQQLISDTMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTYTINSVSV EDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVME VMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPS MRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCPLLISKGYPDIGWNPV EGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEAIQI SEDPTRDGPSPSNGSSKTLEMEEQEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGK GEAIRIRSILRSLIPLEDLVGVISIPFHMPTIAKDGTVVEPDMSAGFCPDHKAAMVLFLD RVYGIEDQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTRCAP LFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEECLLSICGQLRPSMMQHLLRRLV FDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLFWGIFDALS QKKYEQELFKLALPCLSAVAGALPPDYMESNYVNMMEKQSSMDSDGNFNPQPVDTSNITI PEKLEYFINKYAEHSHDKWSMEKFANGWTYGETYSESAKVQPLMKQYKLLSEKEKEIYRW PIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQISVDTAHGYTPRAIDMSNVTL SRDLHAMAEMMAENYHNIWAKKKKMELEAKGGGNHPLLVPYDTLTAKEKAKDREKAQDIL KFLQINGYVVSRGLKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDGGSRGKGEH FPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLSSGGHASNKEKEMVTSLFCKLGV LVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKMALRAFLDNAAEDLEKTME NLKQGQFTHSRNQPKGVTQIINYTTVALLPVLSSLFEHIGQHQFGEDLILEDVQVSCYRI LASLYALGTSKSIYVERQRSALGECLAAFSGAFPVAFLETHLNKHNIYSIYNTKNARDRA VLNLPTSVEEVCPNIPSLVKLMEEIVELAESGIRYTQMPHIMEVILPMLCSYMSHWWEHG PENNPDKAEMCCTALTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIISKAKPQ LLKTHFLPLMDKLKKKAAVVVSDEEHLRAEGRGDMSEAELLILDEFTTLARDLYAFYPLL IRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFVVQNEINNMSFLIS DTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNICAPGDQELIALAK NRFSMKDTEDEVRDIIRSNLHLQGKLEDPAIRWQMALYKDLPNRTEDSSDPEKTVERVLD IANVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYD KSWIETEEHYFEDKLIEDLAKPGEEPPEEDESLKRVDPLHQLILLFSRTALTEKCKLEED FLYMAYADIMAKSCHDEEDDDGEEEVKSFEVTGSQRSKEKEMEKQKLLYQQARLHDRGAA EMVLQTISASKGEMGPMVAATLKLGIAILNGGNSTVQQKMLDYLKDKKDVGFFQSLAGLM QSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNY LRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVF NTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKD MVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDAFKEYDP DGKGIISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFN VAVLLTNLSEHMPHDTRLQTFLELSESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSR TQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSAN KEENEKDKPEEQDPRMGFFSLVTMKSALVALKYNLMTLMKMLSMKSLKKQMKKVKKMTMK DMVMALFSSYWSILMGLLHFACSVVRGFFRIICSLLLGGSLVEGAKKIKVAELLANMPDP TQDEVRGEGEEGERKPTEAALPAEDLTDLRTLSDESDLLSDIFGLDLKREGGQYKLIPHN PNAGLSDLLSTPSLAPMPEVQEKIQEQVKEDEKEEKEETKSEPEKAEGEDGEKEEKAKED KGKQKLRQLHTHRYGEPEVQESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFI LLFYKVSTSAVTEEKEVPVVSAAESTKLNSLESDNQRVIAVHYVLEESSGYMEPTLRILA ILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVIN TQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSLSA VLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTI LSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDMPDMKCDDMLTCYMFH MYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQ QEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQ ESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14856 nt NT seq  +upstreamnt  +downstreamnt atgcacagggtggatgatgaagtggttctgcagtgcactgcaactgttcacaaggagcaa cagaaattgtgtcttgctgctgaaggatttggcaacaggctttgctttttggaatccaca tcaaattctaagaatgttccacctgatttgtccatctgcacctttgtgctggagcagtct ctgtcagtacgggccctccaggaaatgctggctaacacagaagaaaaggcagaagggcta gttgatgtggaaaaatggaaatttatgatgaagtctgcacaaggtggcggtcatcgaacg ctactctatgggcatgcaatcttgctgcgccattcctacagcggcatgtatctatgctgc ctctctacatctcgatcttcaatggataagctggcatttgatgtaggattgcaagaggac acaacaggtgaggcatgctggtggaccatccatcctgcttccaagcaacgatcagaagga gaaaaagtgcgtgttggagatgatcttattttagtcagtgtttcttcagaaagatatttg catctctcttatggcaatggtagcttacatgttgatgcagccttccagcagacactctgg agcgtagcaccaatcagttcaggaagtgaagttgcccaaggatatctgatcggaggggat gttctgaggttattgcatggtcacatggatgaatgtttgacagtcccttcgggtgaacac ggagaagaacaaagaagaactgtccattatgaaggcggtgctgtgtcaattcatgctcgt tccctttggcgactagagactctaagagttgcgtggagtggcagccacatcagatgggga cagccattcagactaagacatataacaacaggaaaatatttaagtctcctggatgacaag agtcttcttcttacagacaaagagaaagcagatgtaaaatctacggcattctgttttcgg tcctccaaggaaaagttggacacagggacaagaaaagaagtggatggaatgggagcacct gaaataaaatatggggattcaatatgcttcatacaacatgtagatacaggattatggctc acgtaccagtctgctgatgcaaagtctgtacgaatgggttctgtgcagcggaaggcaata atgcaccatgaaggtcacatggatgatggtttaacattgtccagatctcagaatgaagaa tcccgaacagcacgtgtcatccgcagtacggtcttccttttcaacaggtttataaggggc cttgatgctctcagcaagaaagcgaagttttccaccgtcgatttgcctattgagtcagtc agtctgagccttcaggacctgattggatactttcacccccctgatgaacatttggagcat gaagacaaacaaaacaggctccgagcattgaagaatcgccagaacctcttccaggaagag ggtatgatcaaccttgttcttgaatgtattgatcgcttgaatgtatacagcagtgcagct cattttgcagacgtagctgggaaggaagctggagaagcatggaaatctattctgaattct ttgtatgaattgctagcggctctgattcgagggaatcgtaaaaactgtgctcagttttct ggatctcttgattggttgatcagcagattagaaagactggaagcctcttctggaattctg gaggttttacactgtgtgttggtggaaagcccagaagctctaaacattattaaggaagga catattaagtcaatcatctgtcttttggacaaacatggaagaaaccataaggttttggat gttttgtgttctctctgtgtttgtcatggagtagctgttcggtctaatcaacatctaatc tgtgataatctcctgccaggaagagatctgctcttacagacacgccttgtcaaccacgtg agcagcatgcgacccaacatcttcttggggattagtgaaggctctgcccaatacagaaaa tggtactatgaacttatggtggaccatctagagccctttgtgactgcagaatcaactcat ctacgagtgggctgggcttcaacagagggctactcaccgtacccagggggaggagcagaa tggggaggaaatggtgttggtgacgacttgtattcctatggttttgatggtctgcatctg tggtcaggttgtgtagcacgaacagtaaattctcccaaccaacatctgttaagaactgat gatgttattagctgctgtttggacctgagtgcccccagcatctctttccggataaatggt cagccagttcaaggaatgtttgagaatttcaacatagatggcctcttcttcccagttgtc agcttctctgcaggaataaaagtacgtttcttacttggaggtcgccatggagagttcaag ttccttcctccacctggatatgccccttgctttgaagctgtactaccaaaagagaagctg aaagtggagcatagccgagagtacaagcaggatcgtagctatacaagagacctactgggt cccactatctctctgtcacaagcagctttcactccagttcctgtagatactagccagatt gttttgcctccccacctggaaaggattagagaaaaattagcagagaacatccatgaactt tgggttatgaataagattgaacttggctggcagtatggaccagttagagatgacaacaaa agacaacacccatgtttagtggagttctcaaaattgccggagcaggaaagaaattataac ttgcagatgtcacttgaaacactgaaaaccctgctggcattaggctgccatgttggaatt gctgatgaacatgctgaagaaaaagtgaaaaaaatgaaacttccaaagaactaccagttg ttgagtggatataagcctgctcccatggatctgagttttatcaaactgaccccttctcaa gaagctatggtggataaactagcggagaatgctcacaatgtgtgggcaagggaccgtata aggcaaggctggacatacggtatccagcaggatgtgaaaaatcgacgaaatcctcgcctt gtgccttatgctcttttggatgatcggacaaagaagtcaaacaaagacagtcttcgggaa gcagtccgcactcttctaggctatggttacaacctggaagctcctgatcaagatcatgca atgagactggatgtgtgcagtgggataatggaaaaattcaggatcttccgcacagaaaag acttatgcagtgaaggctgggaagtggtactttgaatttgaggcagttactgcaggagac atgagagttggctggaccaggccgggttgtctgccagatcaggaacttggctcagatgaa gaagcttttgtttttgatggctttaaggcacagcggtggcatcaaggtaatgagcatttt ggccgctcttggttagcaggagatgttgttggatgtatggttgacatgaatgagcacact atgatgttcaccttaaatggtgaaatcttgcttgatgactcaggttcagaacttgcattc aaggactttgaggttggtgacggatttctacctgtgtgcagcctgggcccatctcaagtg ggaagaatgaactttggaaaagatgtcagcacgctaaaatatttcactatctgtggctta caggaagggtatgaaccctttgctgttaatacaaacagagacatcaccatttggctgagt aaaaggctccctcagtttctaccagtgccacaaaatcatgaacatattgaggtgatgaga attgatggcaccatagacagctgcccctgcctgaaggtcacacagaagtcctttggttca cagaacagtaaaacagacgtcatgttttttcgattaagcatgcccattgaatgtgctgag gtattctccagatcagctgcaggagggttaccaggctctggtctttttggcccgaagaat gacttggaggattatgatgctgattctgattttgaggttctaatgaaaactgctcatggt catctagttcccgaccggacagaacgagaaaaagatgccacaaaaccagagttaaacaac cataaagattatgttcaagaaaagccttcacgtcttaaacaaagatttatgctcaggagg acaaagccagattatagcactagtcactctgcacggcttactgaggatgtgctagcagat gatagggatgactatgattatttgatgcaaacttccacgtactattattcagtgagaata tttcctggtcaagaacctgccaatgtctgggtgggctggattacatctgactttcaccag tatgacacaagctttgatttggacagagtgcgtactgtcacagttacactgggagatgaa aaagggaaggttcatgagagtataaaacgcagcaactgctatatggtgtgcgcaggagag agcatgagccctggacaaggacgtaataataatggtctggagattggttgcttggttgat gctgccagtggcttgctgactttcacagctaatggcaaggaactaggcacgtactatcag gttgaaccgagtacaaaattatttcctgctgtatttgctcaagctacaagccccaatgtt ttccagtttgaattgggaagaataaagaatgtaatgccattatctgctggcttattcaaa agcgaacacaaaaacccagtctctcagtgtcctccacgactccatgtccaatttctgact catgtgctttggagcagagtgccaaaccacttcttgaaggttgatgtgtctcggatcagt gaacgtcaagggtggatgatacagtgcctgaatcctttgcagttcatggcccttcatatt cctgaagaaaacagaacaattgatatcttagagctgacagaacaagaagaattgctgaaa tttcactaccataccctccgattatattcagcggtttgtgctttaggcaacaaccgagtg gcccatgctatgtgtagccatgtggatgaatctcagctcctgtatgctattgagaataaa tatatgccaggattattacgtgcaggatattatgacttactcattgacatccatctcaat acctatgcaactgccaggttaatgatgaataatgaatttatagttccaatgacagatgag accaagagtattactttgtttcctgatgaaaacaaaaaacatggcctccctggtattgga cttagcacttcattaaggccaagaatgcagttctcctctccgagttttgtaagcattagc agtgaatgctttcagttcagtcctgaattccctctggaaaccttaaaggccaaaaccata gagatgctgactgaagctgttcaggagggcagcctccatgtcagagatccagttggaggt tctacagaatttctgtttgtccctctcatcaagctcttttataccctcctaattatggga atcttccacaacggggatctgaaacacatcttgcagttgattgagcccagggttttcaaa gaagcaatgagccaggaggatgaagttgatttctcagagaaggaactgagttcagatgag ctcaagtcagaagaaggagaggaagaaaacagaggggagcaagtgccaaaggaaggactc cttcagatgaaacttccagaacctgttaaattacagatgtgccatctactccagtacctg tgtgattgccaagtacgacaccgaatagaagccattgtagcattttcagatgattttgtg gccaagcttcaagagaatcaacgcttccgttacaatgaagtgatgcaggccttgaacatg tctgctgccctgactgctagaaaaacaaaagaatttcgatccccacctcaggagcagatt aacatgctgctgaactttaaagatgataaaaatgattgtccttgccctgaagaaattcgg gatcaactcttggatttccatgaagacctaatgacacactgtggaattgaactagatgaa gatggaaccttggatggaaacagtgatttaaccattaggggtcgcctcctatatcttatg gaaaaagttacgtatctgaagaagaagcaagctgagaagccagttgatgatgatgctaag acatcctctactcttcagcagttgatttcagacacaatggtacgctgggcccaggaatca gtgatagaagacccggagttagtaagggccatgtttgtattgctacaccgccaatacgat ggtattggtggcctggttcgagccctaccaaagacgtacaccataaatagtgtatctgtg gaagacacaatcaatcttctggcatccctcggccaaatccgttccttgcttagtgtcaga atggggaaggaggaagagaaacttatgattcgtggattaggagacatcatgaataataaa gtattttaccaacatccaaatctcatgagagctttaggcatgcatgaaactgtcatggaa gtgatggtaaatgtgcttggtggaggagaatccaaggaaatcactttcccaaagatggtg gcaaactgctgtcgttttctatgttatttttgccgcatcagcagacagaatcaaaaagct atgtttgatcatcttagctatttattggaaaacagcagtgttggccttgcctctccttct atgcgaggatcaactcctttagatgttgcagcagcctctgtgatggataacaatgaactt gcattagctttaagagaacctgatctggagaaggtggttcgctacttggctggatgtgga ttgcagagttgtcctttgttgatttctaaaggctacccagacatcggatggaatccagtt gaaggagagcgatatttggattttcttcgttttgctgttttttgcaatggagagagtgtg gaggagaatgctaatgttgtagtcagactgcttatccgtcggcctgaatgttttggtcca gctctaagaggagaaggaggcaatgggttacttgctgccatggaggaagcaatacaaata tcagaagatccaacaagagatggaccttccccaagtaatggatctagtaaaacccttgaa atggaagaacaagaagatgacactattcacatgggaaatgcaatcatgaccttttatgct gctttgattgatctgttaggacgttgtgcccctgaaatgcatctaatccatgctggtaaa ggggaagccattagaatcagatcaattctacggtctttgattccactggaagatttggtg ggagtaattagtattcctttccatatgccaaccatagctaaagatggtactgtggtggaa cctgacatgtctgcggggttttgcccagatcacaaggcagccatggttttgttccttgac agggtctatggaattgaggaccaggattttcttctacaccttcttgaagttggctttctg ccagatctacgtgctgctgcttctttagatacagctgctttaagtgctacggatatggct ttggctctgaatcgctacctttgcacagcagtcttgcctctgttgaccagatgtgctcct ctttttgctggcacagagcaccatgcttccctcatcgattccttattacatactgtgtac agactctcaaagggatgctctcttaccaaagctcagcgagattcaattgaagagtgtttg ctgtctatctgtgggcagttgcggccttccatgatgcagcatttgctgagaagattagta ttcgatgttcctctattaaatgaacatgcgaagatgcctctcaagttgctgacaaatcat tatgaaagatgctggaagtattattgtttgccaggtggatggggtaactttggtgctgcc tcagaagaagaacttcatttatccagaaagttgttctggggtatttttgatgctttgtcg caaaagaagtatgaacaagaactgttcaaattggctttgccttgtttgagcgcagttgca ggggccttacctccagactatatggaatcaaattatgtcaatatgatggaaaaacagtct tcaatggattcagatgggaactttaatcctcaacctgttgatacatcaaacattacaatc cctgaaaagctagaatatttcattaacaaatatgcagaacactctcatgacaaatggtca atggaaaagtttgccaatggatggacatatggtgaaacgtattctgaatctgcaaaagtg caaccattaatgaaacaatataagttgctatctgaaaaggagaaagaaatttatcgatgg ccaatcaaagaatcgctgaaaactatgctggcatggggatggcgaattgaaagaacacgg gagggagattccatggcactgtataatcggacacgtcgcatatctcaaaccagtcaaatc tctgtagatacagcccatggttacactcctcgagcgattgacatgagcaatgtcaccctc tccagagacttacatgctatggccgagatgatggctgaaaactaccataacatatgggca aagaaaaagaaaatggagcttgaagcaaaaggaggaggcaaccatcctcttcttgttcct tatgatacactcacagccaaagaaaaagccaaggacagagaaaaagcacaggatattctg aaatttctacagattaatggatatgttgtctccagaggacttaaggacctggaattggac acgccttccattgagaaacgctttgcctacagtttccttcagcaacttataagatatgtc gatgaagcccatcagtacattctggagtttgatggtggcagcagaggcaaaggagagcac ttcccatatgagcaagaaatcaagttttttgccaaagttgtgctccctttgattgatcag tattttaaaaatcatcgcctgtatttcttatctgcagcaagtaggcctctcagcagtgga ggccatgcctctaataaagagaaagaaatggtgacaagcctgttctgcaaacttggagtt cttgtcaggcataggatttcactgtttggaaatgatgcaacatcaatagtcaactgtctt cacatactgggccagaccttggatgcaaggactgtgatgaaaactggtctggaatctgtt aagatggcattgagagcatttttggacaatgctgctgaggatctggagaaaacaatggaa aatcttaagcaaggccagtttacacacagcagaaaccagccaaagggagttacacaaatc attaattataccacagttgctctcctgccagtgctatcttcattatttgagcatattgga cagcaccagtttggggaagatttgatattggaagatgttcaggtctcctgctacagaata ttggccagtttatatgctctgggaaccagcaagagtatctatgtagagcggcaacgatca gcactaggagaatgcttggctgctttctcaggggcctttccagtggcttttttggaaact catttgaacaaacataacatctactcaatttacaataccaagaatgcaagagacagagca gttctcaatttgcctactagtgtagaagaggtttgcccaaatattccctccttggtgaag ctaatggaagaaattgtggaactggccgagtctggtattcgttacacacaaatgccacat atcatggaagtaatactgcctatgctatgtagttacatgtcacactggtgggagcatggg ccagaaaacaaccctgacaaggctgaaatgtgttgcacagccttgacatcagagcacatg aacactttgttgggtaacatattgaaaatcatctataacaacctcggtattgatgaagga gcctggatgaagagattagcagtgttttcccagcccatcataagcaaagcgaagccacag ctcttaaagacacacttcctgccactgatggataagctaaagaaaaaggcagcagtggtt gtatcggatgaagaacatctaagagcagaaggcagaggtgacatgtcggaggctgaactg ctcatcctagatgagttcaccactttggcacgggacctctatgccttctaccctttgttg attagatttgtggactataacagggcaaaatggctgaaagagcccaaccctgaagcggaa gaattgttccgcatggtggctgaggtcttcatttattggtcaaagtctcataatttcaaa agggaagagcagaactttgtggtacaaaatgaaatcaacaacatgtctttccttattagt gacaccaaatctaagatgtccaaggcagcagtttctgaccaggagaggaagaagatgaag cgaaaaggtgaccggtactctatgcagacctctctcattgtggcagcattgaagagatta cttcctattggcctaaacatttgtgctcctggagaccaagagctaattgcgctggccaaa aatcgattcagtatgaaagatactgaagatgaagtacgagatatcatccgcagtaatctt cacctccagggcaagcttgaggatcctgccattaggtggcagatggcactttacaaagat ttaccaaacaggactgaagattcctcagatccagagaagactgtggaaagggtccttgat atagctaatgtactgtttcacctggaacaggttgagcatcctcagcggtccaaaaaagca gtgtggcataagctgctttctaaacagaggaaaagagcagtagttgcctgctttagaatg gcaccattgtataatctgccaaggcaccgagccgtcaatctctttcttcaaggctatgat aaatcttggattgagacggaagaacactattttgaagacaaactgatagaagacttagca aaacctggggaggaaccaccggaagaagatgaaagccttaaaagagttgatcctttacat caacttattctgctattcagtcgaacagccttgactgaaaaatgcaaattggaagaagat ttcctgtatatggcttatgctgacattatggcaaagagctgccatgatgaagaagatgat gatggtgaagaagaagtgaagagttttgaagtgacaggatcacagcgcagcaaggaaaaa gaaatggaaaagcaaaaacttctgtatcaacaagccagactgcatgaccggggtgctgct gagatggttctgcagacaatcagtgctagtaaaggtgagatggggccaatggttgcagct accctaaagctagggattgccatcttaaatggaggaaattctaccgttcaacagaaaatg cttgactacctcaaggataaaaaggatgtcgggttctttcagagccttgctggtcttatg cagtcctgtagtgttcttgacctaaatgcgtttgaacgtcagaacaaagcagaaggcctt ggcatggtgactgaagagggatcaggagaaaaggtgatgcaggatgatgagttcacctgt gatctcttccgcttccttcaattgctttgtgaaggacataattcagattttcagaattac ctgagaactcagactggtaacaacacaactgttaatattatcatttccactgtggattac ttattaagagttcaggaatccattagtgatttctattggtattattctggtaaggatgtt attgatgagcaaggacaacgaaatttttccaaagccatccaggttgcaaaacaagttttc aatactcttacagagtatatccaggggccatgtaccgggaatcagcaaagcctggcacac agcaggctatgggatgctgtggttggttttcttcatgtgtttgcccacatgcagatgaag ctgtctcaggattccagtcaaattgaattactgaaggaattaatggatcttcagaaggat atggttgtcatgttgctgtctatgctggaaggtaatgttgtgaatggaactattggcaag cagatggttgatatgcttgtggaatcgtccaacaacgtggagatgattctgaagtttttt gatatgttcttaaaattgaaggatttgacttcctctgatgcattcaaagaatatgaccct gatggtaaagggataatttcaaagagggattttcacaaggcaatggaaagccataagcat tacacccagtctgaaactgagtttctactatcgtgtgctgaaacagatgagaatgagact ctggactatgaggagtttgtgaaacgattccacgaacctgccaaagacattggtttcaat gttgctgttctcctgaccaacctgtcagaacacatgccacatgacacccgcttgcaaact tttcttgaactgtcagagagtgtgctgaattactttcagcctttccttgggcgcatagaa atcatgggcagtgcaaagcgcattgaacgagtttattttgaaataagcgagtcaagtcgg actcagtgggagaagcctcaggtaaaagagtcaaagagacaattcatatttgacgttgta aatgaaggcggggagaaagaaaagatggagctttttgttaatttctgtgaggataccatc tttgaaatgcaactggctgcccagatctctgagtccgatctgaatgaaaggtcagcaaat aaagaggagaatgagaaagataagcctgaagaacaggatcctagaatgggtttcttctcc ctcgtgaccatgaagtcagcattagtagcgctcaagtataatttaatgactcttatgaaa atgctcagcatgaaaagcctaaagaaacagatgaaaaaagtgaagaaaatgaccatgaag gacatggtcatggccttgttttcttcctattggagcattttgatgggcttactacatttt gcttgtagtgtcgtccggggcttctttcgcatcatatgcagtttgctgcttggaggaagc ctagtagaaggagcaaagaaaatcaaggtggctgaactgttagctaatatgccagatccc actcaggatgaggtgcgtggggaaggagaagagggggaaaggaaaccaacagaagctgca ttgcctgcagaagacttgacagatctgagaactttgtcagatgagagtgatctactctca gatatatttggtttggatttgaaacgagaaggtgggcagtataaattgatccctcacaat ccaaatgctggattgagtgatttactgagcactccctccttagctccaatgcctgaggtg caggaaaaaatccaggagcaggtgaaagaagatgaaaaggaagagaaggaggaaacaaaa tctgaacctgaaaaagcagaaggagaagatggagaaaaagaagagaaagccaaggaagac aaagggaaacagaaattgagacaactccatactcacagatatggagaaccagaagttcag gaatcagctttctggaagaagatcattgcataccaacagaagcttcttaattattttgcg cgaaacttttataacatgaggatgttggcgttgtttgttgcttttgccatcaacttcatc ctgcttttctataaggtctccacctctgctgtgacagaagaaaaggaagttcctgtggta tctgctgctgaaagtaccaagttaaacagcctggaaagcgacaaccagagggtcattgca gtgcattatgtcctggaagaaagcagtggctacatggagcccacgctgcggattttggcc atcctgcacacagtcatctcattcttctgcatcatagggtattactgtttgaaagttcca ctggttatttttaagagagaaaaggaggtggcaaggaaattggaatttgatgggctgtat ataactgaacagccatcagaagatgatattaagggacagtgggacagactcgtaatcaac acacagtcttttccaaataattactgggacaaatttgtgaaaagaaaggtcatggataaa tatggtgagttctatggccgtgacaggatcagtgagttactaggaatggacaaagctgct ctcgattttagtgatgctcgagaaaagaagaaaccaaagaaggatagctccttatctgct gtgctaaattccattgatgttaagtatcagatgtggaaattaggagttgttttcactgat aattctttcctttacctagcgtggtacatgaccatgtcagtccttggccattacaacaat tttttctttgctgctcatctccttgacattgcaatgggattcaagactttacgaactatc ctgtcatcagtgactcacaatggcaaacagcttgtcctaacagtgggattactggcagta gtagtatacttgtatacagtagtggcattcaattttttccgcaagttctacaacaagagt gaagatggtgatatgccagacatgaaatgtgatgatatgctaacatgctacatgtttcac atgtacgttggagtacgtgcaggtggaggcattggtgacgagatcgaggatccagcagga gatgaatatgaaatctatcggattatctttgacatcactttcttcttctttgtgattgtc atcctgcttgcaattattcaaggtttaattattgatgcttttggtgagttaagagatcag caagagcaagttaaggaagacatggagacaaagtgctttatctgtggaataggaaatgac tactttgatacagtgccccatggctttgagacacacacactacaggagcacaacttggcc aattatttgttttttctgatgtatcttattaacaaagatgaaacagagcatacaggacag gaatcctatgtatggaaaatgtatcaagaacggtgctgggagtttttccctgctggtgat tgcttccgaaaacagtatgaagaccagctcaattaa

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