Hylobates moloch (silvery gibbon): 116458053 Help Entry 116458053         CDS       T08803                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2 isoform X6   KO K04962   ryanodine receptor 2 Organism hmh  Hylobates moloch (silvery gibbon) Pathway hmh04020   Calcium signaling pathway hmh04024   cAMP signaling pathway hmh04260   Cardiac muscle contraction hmh04261   Adrenergic signaling in cardiomyocytes hmh04371   Apelin signaling pathway hmh04713   Circadian entrainment hmh04911   Insulin secretion hmh04921   Oxytocin signaling pathway hmh04972   Pancreatic secretion hmh05020   Prion disease hmh05022   Pathways of neurodegeneration - multiple diseases hmh05410   Hypertrophic cardiomyopathy hmh05412   Arrhythmogenic right ventricular cardiomyopathy hmh05414   Dilated cardiomyopathy hmh05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:hmh00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     116458053 (RYR2)    04020 Calcium signaling pathway     116458053 (RYR2)    04024 cAMP signaling pathway     116458053 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     116458053 (RYR2)    04921 Oxytocin signaling pathway     116458053 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     116458053 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     116458053 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     116458053 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     116458053 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     116458053 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     116458053 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     116458053 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     116458053 (RYR2)    05414 Dilated cardiomyopathy     116458053 (RYR2)    05415 Diabetic cardiomyopathy     116458053 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:hmh04040]     116458053 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:hmh04990]     116458053 (RYR2) Ion channels [BR:hmh04040]  Voltage-gated cation channels   Ryanodine receptor    116458053 (RYR2) Domain-containing proteins not elsewhere classified [BR:hmh04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    116458053 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  116458053 NCBI-ProteinID:  XP_031993538 LinkDB All DBs Position Unknown AA seq 4956 aa AA seqDB search MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTVEKSEGKFMMKTAQGGGHRTLLYGHAILLRHSYSG MYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVS SERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTV PSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLS LMEDKNLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSVCYIQHVD TGLWLTYQSVDVKSVRMGSMQRKAIMHHEGHMDDGISLSRSQHEESRTARVIRSTVFLFN RFIRGLDALSKKAKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQN LFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAALIRGNRKN CAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRN HKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSEGS AQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGF DGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGL FFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREYKQERTYT RDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYGPV RDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEDKVKKMKLP KNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNR RNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSGTGERFRI FRAEKTYAVKAGRWYFEFETVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGFKAQRWHQ GNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPVCSL GVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQVPSNHEH IEVTRIDGTIDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFSKTVAGGLSGAGL FGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPEFNNHKDYAQEKPSRLKQR FLLRRTKPDYSTSHSARLTEDVLADDRDDYDFLMQTSTYYYSVRIFPGQEPANVWVGWIT SDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGRNNNGLEI GCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLS AGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQCLDPLQF MSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHVDEPQLLY AIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEYIVPMTEETKSITLFPDENKKHG LPGIGLSTSLRPRMQFSSPSFVSISNECYQYSPEFPLDILKAKTIQMLTEAVKEGSLHAR DPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAATPEEESDTLEKE LSVDDAKLQGAGEEEAKVGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVA FSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKSECP CPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLSLVEKVTYLKKKQAEKP VESDSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTYT INGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGM HETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSV GLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQMLVSKGYPD IGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAM EEAIKIAEDPSRDGPSPNSGSTKTLDTEEEEDDTIHMGNAIMTFYAALIDLLGRCAPEMH LIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGFCPDHKAA MVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPL LTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLRPSMMQH LLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLFWG IFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGNFNPQPVD TSNIIIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPYKLLSEKE KEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVDAAHGYSPRAID MSNVTLCRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAKEKAKDRE KAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDGGS RGKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKEKEMVTSL FCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAFLDNAAED LEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGEDLILEDVQ VSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNIYSIYNTK SSRERAALSLPTNVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILPMLCSYMS RWWEHGPENNPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPII NKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEAELLILDEFTTLARDLY AFYPLLIRFVDYNRAKWLKEPNPEAEQLFRMVAEVFIYWSKSHNFKREEQNFVVQNEINN MSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNICAPGDQE LIALAKNRFSLKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTDDTSDPEKT VERVLDIANVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNL FLQGYEKSWIETEEHYFEDKLIEDLAKPGAEPPEEDEGTKRVDPLHQLILLFSRTALTEK CKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEVTGSQRSKEKEMEKQKLLYQQARL HDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDYLKEKKDVGFFQ SLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLFRFLQLLCEGHN SDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQ VAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKEL MDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDT FKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPA KDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFE ISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDL NERSANKEESEKERPEEQGPRMAFFSILTVKSALFALRYNILTLMRMLSLKSLKKQMKKV KKMTVKDMVTAFFSSYWSIFMTLLHFVASVFRGFFRIVCSLLLGGSLVEGAKKIKVAELL ANMPDPTQDEVRGDGEEGERKPLEAALPSEDLTDLKELTEESDLLSDIFGLDLKREGGQY KLIPHNPNAGLSDLMSNPVPMPEVQEKFQEQKAKEEEKEEKEESKSEPEKAEGEDGEKEE KAKEDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAF AINFILLFYKVSTSSVVEGKELPTRSSSENAKVTSLDSSSHRIIAVHYVLEESSGYMEPT LRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWD RLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKD SSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFK TLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLT CYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFG ELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDET EHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14871 nt NT seq  +upstreamnt  +downstreamnt atggccgatgggggcgagggcgaagacgagatccagttcctgcgaactgatgatgaagtg gttctgcagtgcaccgcaaccatccacaaagaacaacagaagctatgcttggcagcagaa ggatttggcaacagactttgtttcttggagtccacttccaattccaagaatgtcccccca gacctctccatctgcacctttgtgctggagcagtccctctctgtccgggcgctgcaggag atgctggctaacaccgtggagaaatcagaagggaaattcatgatgaagactgctcaaggt ggtggtcatcgaacactcctctacggacatgccatattgctgcgccattcctatagtggc atgtatctgtgctgcctgtccacctcccggtcttcaactgataagctggcttttgatgtt ggcttgcaagaggacaccacaggtgaggcttgttggtggaccatacaccctgcctctaag cagcgatcagaaggagaaaaagtacgagttggagatgacctcatcttagttagcgtgtcc tctgaaaggtacttgcacttgtcttacggcaatggaagcttacacgtggatgccgctttc cagcagactctctggagcgtggccccaatcagctcgggaagtgaggcagcccaagggtat ctcattggtggtgatgtcctcaggttgctgcatggacacatggacgagtgtctcactgtc ccttcaggagaacatggtgaagagcagcggagaactgttcattatgaaggtggcgctgtg tctgttcatgcacgttccctttggagactagagacgctaagagttgcgtggagtggaagc cacataagatggggacagccattccgactacgccatgtcacaacaggaaaatacttgagt ctcatggaagacaaaaaccttctgctcatggacaaagagaaagctgatgtaaaatcaaca gcatttaccttccggtcttccaaggaaaaattggatgtaggggtgagaaaagaagtcgat ggcatgggaacatctgaaataaaatacggtgactcagtatgctatatacaacatgtagac acaggcctatggcttacttaccagtctgtggacgtgaaatctgtgagaatgggatctatg caacgtaaggctattatgcatcatgaaggccacatggatgatggcataagtttatcgaga tcccagcatgaagaatcacgcacagcacgagttatccgcagcacagtcttccttttcaat agatttataaggggccttgatgctctcagcaagaaagcgaaggcttccacagtcgatttg cctatagagtccgtaagtctaagtctgcaggatctcattggctacttccaccccccagat gagcatttagagcatgaagacaaacagaacagactacgagccctgaagaatcggcaaaat ctcttccaggaagagggaatgatcaacctcgtgctcgagtgcatagaccgtctgcacgtc tacagcagcgcagcacactttgctgatgtggctgggcgagaagccggagagtcttggaaa tccattctgaactctctgtatgagttgctggcggctctaattagaggaaatcgtaaaaac tgtgctcaattttccggctccctcgactggttgatcagcaggttggaaagactggaagct tcttcgggcattctggaagttttacactgtgttttagtagaaagtccagaagctctaaat attattaaagaaggacatattaaatccattatctcacttttagacaaacatggaagaaat cacaaggttctggatgtcttgtgctcactctgtgtttgccatggggttgcagtccgttct aaccagcatctcatctgtgacaacctcttaccaggaagagatttgttattgcagacacgt cttgtgaaccatgtcagcagcatgagacccaatatttttctgggcgtcagtgaaggttct gctcagtataagaaatggtactatgaattgatggtggaccacacagagccatttgtgaca gctgaagcaactcacctgcgagtgggctgggcttccactgaagggtattctccctaccct ggagggggcgaagagtggggtggaaatggtgttggagatgacctcttctcctatggattt gatggccttcatctctggtcaggttgtattgctcgtactgtaagctcaccaaaccaacat ctgttaagaactgatgatgtcatcagttgctgtttagatctgagtgccccaagcatctcg ttccgaattaatggacaacctgttcaaggaatgttcgagaatttcaacatcgacggcctc ttctttccagtcgttagtttctctgcaggaataaaagtacgctttctgcttggggggcga catggagaattcaaatttcttcctccacctggatatgctccttgttacgaagctgttctg ccaaaagaaaagttgaaagtggaacacagccgagagtacaagcaagaaagaacttacaca cgcgacctgctgggccccacggtttccctgacacaagctgccttcacgcccatccccgtg gataccagccagatcgtgttgcctcctcatctagaaagaataagagaaaagctggcagag aatatccatgaactctgggttatgaataaaattgagcttggctggcagtatggtccggtt agagatgacaacaagagacaacatccatgcctggtggagttctccaagctgcctgaacag gagcgcaattacaacttacaaatgtcgcttgagaccctgaagactttgttggcattaggc tgtcatgtgggtatatcagatgaacatgctgaagacaaggtgaaaaaaatgaagctaccc aagaattaccagctgacaagtggatacaagcctgcccctatggacctgagctttatcaaa ctcaccccgtctcaagaagcaatggtggacaagttggcagaaaatgcacacaacgtgtgg gcgcgggatcgaatccgtcagggctggacttacggcatccaacaggatgtaaagaacaga agaaatcctcgccttgttccctacactcttctggatgaccgaaccaagaaatccaacaag gacagcctccgcgaggctgtgcgcacgctgctggggtacggctacaacttggaagcaccg gatcaagatcatgcagccagagccgaagtgtgcagtggcactggggaaaggttccgaatc ttccgtgctgagaagacctatgcagtgaaggccggacggtggtattttgaatttgagacg gtcactgctggagacatgagggttggttggagtcggcctggttgccaaccggatcaggag cttggctcggatgaacgtgcctttgcctttgatggcttcaaggcccagcggtggcatcag ggcaatgaacactatgggcgctcttggcaagcaggcgatgtcgtggggtgtatggttgac atgaacgaacacaccatgatgttcacactgaatggtgaaatccttcttgatgattcaggt tcagaactggctttcaaggactttgatgttggcgatggattcatacctgtgtgtagcctt ggagtggctcaagtgggtaggatgaactttggaaaggatgtcagcaccttgaaatatttc accatctgtggcttacaagagggctatgaaccatttgccgttaatacaaacagggatatt accatgtggctgagcaagaggcttcctcagtttctccaagttccatcaaaccatgaacat atagaggtgaccagaatagacggcaccatagacagttccccatgtttaaaggtcactcag aagtcttttggttctcagaacagcaacactgatatcatgttttatcgcctgagcatgccg atcgagtgtgcggaggtcttctccaagacggtggctggagggctctctggggctggcctt tttgggcccaagaatgatttggaagattatgatgctgattctgactttgaggttctgatg aagacagctcatggccatctagtgcccgatcgtgttgacaaagacaaagaagctactaaa ccagagtttaataaccacaaagattacgcccaggaaaagccctctcgcctgaaacaaaga tttttgcttagaagaacaaagccagattacagcacaagccattcggcaagactcaccgaa gatgtcctggctgatgatcgggatgactatgatttcttgatgcaaacatccacgtactat tactcagtgagaatctttcctggacaagaacctgctaacgtctgggtgggctggatcaca tcagatttccatcagtatgacacaggctttgacttggacagagttcgcacagtaacagtt actctaggagatgaaaaaggaaaagtgcatgaaagcatcaaacgcagcaactgctatatg gtatgtgcgggtgagagcatgagccccgggcaaggacgcaacaataatggactggagatt ggctgtgtggtggatgctgccagcgggctgctcacgttcattgccaatggcaaggaactg agcacatactatcaggtggagccgagtacaaaattatttcctgcagtttttgcacaagct acgagtcccaatgttttccagtttgagttgggaagaataaagaatgtgatgcctctctcg gcgggattgttcaagagtgaacacaagaaccccgtgccgcagtgccccccgcgcctccac gtgcagttcctgtcacacgtcctgtggagcagaatgcccaaccagtttttgaaggtagat gtgtctcgaataagtgaacgccaaggctggttggtgcagtgtttggatcctctgcagttc atgtctcttcatatccctgaggaaaacagatctgttgacatcttagagttgacagagcag gaggaattgctgaaatttcactatcacactctccggctctactcagccgtctgtgctctc gggaaccaccgggtggcccacgccctgtgcagccacgtggatgaacctcagctcctctac gccattgagaacaagtacatgccaggtttgctgcgtgctggctactatgacctgctgatc gacatccacctgagctcctatgccactgccaggctcatgatgaacaacgagtacatcgtc cccatgacggaggagacgaagagcatcaccctattccctgatgagaataaaaagcacggc cttccagggatcggcctcagcacctccctcaggccacggatgcagttttcctcccccagt tttgtaagcattagtaatgaatgttaccagtacagtccagagttcccactggacatcctt aaggccaaaaccatacagatgctgacagaagctgttaaagagggcagtcttcatgcccgg gacccagttggagggactactgagttcctctttgtacctctcatcaagcttttctatacc ctgctgatcatgggcatctttcacaatgaggacttgaagcacatcttgcagttgattgag cccagtgtgtttaaagaagctgccactccagaggaggagagtgacacgctggagaaagag ctcagtgtggacgacgcaaagctgcaaggagctggtgaggaagaagccaaggtgggcaag cggcccaaggaaggcctgctccaaatgaaactgccagagccagttaaattgcagatgtgc ctactgcttcaatacctctgtgactgccaggtccggcatcggatagaagccattgtagcc ttttcagatgattttgtagctaagctccaagacaatcaacgtttccgatacaacgaagtt atgcaagccttaaatatgtcagctgcactcacagccaggaaaacaaaggaatttagatca ccgcctcaagaacagatcaatatgcttctcaattttaaggatgacaaaagtgaatgtcca tgtccagaagaaattcgtgaccaactattggatttccatgaagatttgatgacacattgt ggaattgagctggatgaagatgggtctctggatggaaacagtgatttaacaattagaggg cgtctgctatccctggtagaaaaggtgacatacctgaagaagaagcaagcagaaaaacca gttgagagtgactccaaaaagtcctccactctgcagcagctgatctctgagaccatggtc cgatgggctcaggagtctgtcattgaagaccccgagctggtgagggccatgtttgtgttg ctccatcggcagtatgacggcattgggggtcttgttcgggccctgccaaagacctacacg ataaatggtgtgtccgtggaagacaccatcaacctcctggcatcccttggtcagattcga tccctgctgagtgtgagaatgggcaaagaagaagagaagcttatgattcgtggattaggg gatattatgaataacaaagtgttttaccagcaccctaatctcatgagggcactggggatg cacgagactgtgatggaggtcatggtgaacgtccttggaggtggagagtcgaaggaaatc acctttcccaagatggtggccaactgttgccgttttctctgttacttctgtcgtataagt aggcagaatcaaaaagctatgtttgatcatctcagttatttactggaaaacagcagtgtt ggtcttgcttccccagctatgagaggttcaacaccactggatgtggctgcagcttcggtg atggataataatgaactagcgttagctctccgtgagccggatctagaaaaggtagttcgt tatttggctggttgtggactgcaaagttgccagatgctggtgtctaagggctatccagac attgggtggaacccagttgaaggagagagatatcttgactttctcagatttgctgtcttc tgtaatggggagagtgtggaggaaaatgcaaatgtcgtggtgagattgctcattcggagg cctgagtgttttggtcccgctttgagaggagaaggtgggaatgggcttcttgcagcaatg gaagaagccatcaaaatcgccgaggatccgtcccgagatggtccctcaccaaatagcgga tccactaaaacacttgatacagaggaggaggaagatgacactatccacatggggaacgcg atcatgaccttctatgcagctttgattgacctcttgggacgctgtgctcctgagatgcat ttgattcatgctgggaagggagaagccatcagaattaggtccattttgagatccctaatt cccctgggagatttggtgggcgttatcagcatcgcttttcagatgccaacaatagccaaa gatgggaatgtggtggaacctgacatgtctgcggggttttgcccagatcacaaggcagcc atggttttattccttgacagggtctatggaattgaagttcaagacttcctcctccatctt cttgaggttggctttctgccagatctccgggcggctgcttctttagatacggcagctttg agtgctacagacatggccttggccctcaatcggtacctctgcacagccgtcttgccattg ttaacaagatgtgctcctctctttgctggcacagagcaccatgcttctctcattgactca ttacttcatactgtgtatagactttctaagggctgttcacttaccaaagctcagcgggat tccatagaagtttgtttactctctatttgtggacaactgagaccttctatgatgcagcac ttactcagaagattagtatttgatgttccattattaaatgaacatgcaaagatgcctctt aaactgctgacaaatcattatgaaagatgctggaaatattactgcctgcctggagggtgg ggaaactttggtgctgcctcagaagaagaacttcatttatcaagaaagttgttctggggc atttttgatgccctatctcaaaagaaatatgaacaagaacttttcaaactggcactgcct tgcctgagtgcagttgcgggagctttgcctccagactacatggagtcaaattatgtcagt atgatggaaaaacagtcatcaatggattctgaaggaaactttaacccacaacctgttgat acctcaaatattataattcctgagaagttggaatacttcattaacaaatatgcagaacac tcccatgacaaatggtcaatggacaagttggcaaatggatggatttatggagaaatatat tcagactcttctaaggttcagccattaatgaagccatataagctattgtctgaaaaggaa aaagaaatttatcgctggccaatcaaagaatctttaaaaactatgctggcttggggctgg agaattgaaagaactcgggagggagacagcatggccctttacaaccggactcgtcgtatt tctcagacaagccaggtttctgtagacgctgcccatggttacagtccccgggccattgac atgagcaatgttacactatgtagagacctgcatgctatggcagaaatgatggctgaaaac taccataatatatgggcaaagaaaaagaaaatggagttagagtccaaaggagggggaaac catcctctgctggtgccctatgatacactgacggccaaagagaaagccaaggatagagaa aaagcacaggacatcctcaagttcttgcagatcaatggatatgctgtatccagaggattt aaggacctggaactggacacgccttctattgagaaacggtttgcctatagtttcctccaa caactcattcgctatgtggatgaagcccatcagtatatcctggagtttgatggtggcagc agaggcaaaggagaacatttcccttatgaacaagaaatcaagttctttgcaaaagtcgtt cttcctttaattgatcagtatttcaaaaaccatcgtttatacttcttatctgcagcaagc agacctctctgctctggaggacatgcttccaacaaagagaaagaaatggtgactagccta ttctgcaaacttggagttcttgtcaggcataggatttcactatttggcaatgatgcaaca tcaattgtcaactgtcttcatattttgggtcagactttggatgcgaggacagtgatgaag actggcctggagagtgttaaaagtgcactcagagcttttctggacaatgccgcagaggat ctggagaagaccatggaaaacctcaagcagggccagttcactcacacccgaaaccagccc aaaggcgttactcagattatcaattacaccacagtggccctgctgccaatgctgtcatcg ttatttgaacatattggccagcatcagttcggagaagacctaatattggaagatgtccag gtgtcttgttatagaattctgactagcttatatgctttgggaaccagcaagagtatttat gtggagaggcaacgttctgcattaggagaatgtctagctgcctttgctggtgcctttcct gtagcatttttggaaactcatctggacaaacataatatttactccatctacaatacaaag tcttcacgagaaagagcagctctcagtttgccaactaatgtggaagatgtttgtccaaac ataccatctttggagaaactcatggaagaaatcgtggaattagctgagtccggcattcgc tacactcaaatgccacatgtcatggaagtcatactgcccatgctttgcagctacatgtct cgttggtgggagcatggacctgagaacaatccagaacgggccgagatgtgctgcacagcc ctgaactcagagcacatgaacacacttctagggaacatattgaaaatcatatataataac ttggggattgatgagggagcctggatgaagaggctagcagtgttttcccagcctataata aataaagtgaaacctcagctcttgaaaactcatttcttgccattaatggagaaactcaag aaaaaggcagctatggtggtgtctgaggaagaccacctgaaggccgaggccaggggggac atgtcagaggctgaactcctcatcctagatgagttcaccacactggccagagatctctat gccttctaccctctcttgattagatttgtggactataacagggcaaagtggctaaaggag cctaacccagaagcagagcagctcttccgcatggtggctgaagtgtttatctactggtcg aagtcccataatttcaaaagagaagagcagaacttcgttgtgcagaatgaaatcaacaat atgtctttccttattactgataccaagtcaaagatgtcaaaggcagctgtttctgatcag gaaaggaagaaaatgaagcgcaaaggagatcggtattccatgcagacctctctgattgta gcagctctgaagcggctactgcccattgggttgaacatctgtgcccctggggaccaggag ctcattgctctggccaaaaatcgatttagcctgaaagatactgaggatgaagtacgagat ataatccgcagcaatattcatttacaaggcaagttggaggatcctgctattagatggcaa atggctctttacaaagacttaccaaacaggactgatgatacctcagatccagagaagacg gtagaaagagtattggatatagcaaatgtgctttttcatcttgaacaggtggagcatcct cagagatctaaaaaggctgtatggcataaactactctctaagcagaggaaaagggctgtt gtagcctgcttccggatggcccccttatataatctgccaaggcatcgggctgtcaatctc tttcttcagggatatgaaaagtcttggattgaaacagaagaacattactttgaagataaa ctgatagaagatttagcaaaacctggggctgaacctccagaagaagatgaaggcactaag agagttgatcctctacatcagctgatccttctgtttagtcggacagctttaacagagaaa tgcaaactggaggaagattttttatatatggcctatgcagatattatggcaaagagttgt catgatgaggaagatgacgatggtgaagaggaagtgaagagttttgaagtcacaggatcc caacgcagcaaggaaaaagaaatggaaaagcaaaagcttctataccagcaagcccgactc cacgatcgtggtgcggctgagatggtgctacagacgatcagtgccagcaaaggtgaaact ggaccaatggtagcagctactttgaaacttggaattgctattttaaatggtgggaactcc acagtacagcagaaaatgcttgactacctcaaggagaaaaaggatgtgggcttctttcag agcctggccggcctgatgcagtcatgtagtgtccttgacctaaatgcatttgagcgacaa aacaaagctgaaggtcttgggatggtgacagaggaaggatcaggagaaaaggttctgcag gacgatgagttcacctgtgacctcttccgattcctgcaactactctgtgagggacacaac tcagattttcagaattatctgagaactcagactggcaataatacaactgtcaacataatt atctccactgtggactacctcctgagagttcaggaatcaattagtgacttttattggtat tactctgggaaagatgttattgatgaacaaggacaacggaatttctccaaagctattcaa gtggcaaaacaagtctttaacactcttacagagtatattcagggtccttgcactgggaat caacagagtttggcacacagcaggctgtgggatgctgtggtcggctttcttcatgtgttt gcccatatgcagatgaagctgtcgcaggattccagtcaaatcgagctattaaaagaatta atggatctgcagaaggatatggtggtcatgttgctgtccatgttagaaggtaacgttgtt aatggaacgattggcaaacagatggtggatatgcttgtggaatcttccaacaatgtggag atgattctcaaattttttgacatgttcttaaaactaaaagatttgacgtcgtctgatact tttaaagaatatgaccccgatggcaagggagtcatttccaagagggacttccacaaagcg atggagagtcataagcactacacgcagtcagaaacggaatttcttttgtcttgtgcggag acggatgagaatgaaaccctcgactacgaggagttcgtcaaacgcttccacgaacctgcg aaggacatcggcttcaatgtcgccgtcctcctgacaaacctctctgagcacatgcccaac gatacccgacttcagacttttctagaattagcagagagcgtcctgaattatttccagccc ttcctgggccgcatcgaaatcatgggaagtgccaaacgcatcgagagagtctattttgaa atcagtgagtccagtcgaacccagtgggagaagccccaggtcaaggagtccaaaagacag ttcatatttgacgtggtcaacgaaggaggagaaaaagagaagatggaactctttgtgaac ttctgcgaggacaccatcttcgaaatgcagctggcggctcagatctcagagtcggatctg aacgagaggtcagcgaataaggaagaaagtgagaaggagaggccggaggagcaggggccg agaatggccttcttctccattctcacggtcaagtcggccctgtttgcgctcaggtacaat atcttgacccttatgcgaatgctcagtctgaagagcctgaagaagcagatgaaaaaagta aaaaagatgaccgtgaaggacatggtcacggccttcttttcatcctactggagtattttt atgaccctcttgcacttcgtggccagcgttttcagaggctttttccgcatcgtgtgcagc ctgctgcttgggggaagcctggtcgaaggtgctaaaaagatcaaagttgcagaactgtta gccaacatgccagaccccactcaggatgaggtgagaggagatggggaggagggagagagg aaacccctggaagccgccctgccctccgaggatctgaccgacttaaaggagctgacagaa gaaagtgaccttctttcggatatctttggcctggatctgaagagagaaggagggcagtac aaactaattcctcataatccaaatgctgggctcagtgacctcatgagcaacccagtcccc atgcccgaggtgcaagaaaaatttcaggaacagaaggcaaaagaagaagaaaaggaagaa aaagaagaaagcaaatctgaacctgaaaaagccgagggagaagatggagaaaaagaagag aaagccaaggaagacaagggcaaacaaaagttgaggcagcttcacacacacagatacgga gaaccagaagtgccagagtcagcattctggaagaaaatcatagcatatcaacagaaactt ctaaactattttgctcgcaacttttacaacatgagaatgttagccttatttgtcgcattt gctatcaatttcatcttgctcttttataaggtctccacttcttctgtggttgaaggaaag gagctccccactagaagttcgagtgaaaatgccaaagtgaccagcctggacagcagctcc cacagaatcatcgcagttcactatgtgctagaggagagcagcggctacatggagcccacg ctgcgtatcttagctattctgcacacggtcatttctttcttctgcatcattggatactac tgcttgaaagtcccgttggttatttttaagcgagaaaaggaagtggcacggaaattggaa tttgatgggctttatattacagaacagccttcagaggatgatattaagggccagtgggat agactcgtaatcaacacacagtcatttcccaacaactactgggacaaatttgttaaaaga aaggttatggataagtatggagagttctacggccgagacagaatcagtgaattacttggc atggacaaggcagctctggacttcagtgatgccagagaaaagaagaagccaaagaaggac agctccctatcagctgtactgaactccattgatgtgaagtatcagatgtggaaactagga gtcgttttcactgacaactccttcctctacctcgcctggtatatgactatgtctgttctt ggacactataacaactttttttttgccgctcaccttctcgacattgctatgggattcaag acattaagaaccatcttgtcctcagtaactcacaatggcaaacagctcgtattaaccgtt ggcttattagctgttgttgtatacctatacactgtggtggcattcaattttttccgaaaa ttctacaataaaagtgaagatggtgatacaccagacatgaaatgtgatgatatgctaaca tgctatatgttccacatgtatgttggagttcgtgctggaggagggatcggggatgaaatc gaagacccagcaggagatgaatatgagatctatcgaatcatctttgacatcactttcttc ttctttgttattgtcattctcttggccataatacaaggtctgattatcgatgcttttgga gaactaagagaccaacaggaacaagtcaaagaagatatggaaaccaaatgcttcatctgt gggataggcaatgattacttcgacacagtgccacatggctttgaaacccacactttacag gagcacaacttggctaattacttgttttttctgatgtatcttataaacaaagatgaaaca gaacacacaggacaggaatcttatgtctggaagatgtatcaagaaaggtgttgggaattt ttcccagcaggggattgcttccggaaacagtatgaagaccagctaaattaa

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