Hylobates moloch (silvery gibbon): 116458453 Help Entry 116458453         CDS       T08803                                  Symbol JAK2 Name (RefSeq) tyrosine-protein kinase JAK2   KO K04447   Janus kinase 2 [EC:2.7.10.2] Organism hmh  Hylobates moloch (silvery gibbon) Pathway hmh01521   EGFR tyrosine kinase inhibitor resistance hmh04062   Chemokine signaling pathway hmh04081   Hormone signaling hmh04148   Efferocytosis hmh04151   PI3K-Akt signaling pathway hmh04217   Necroptosis hmh04550   Signaling pathways regulating pluripotency of stem cells hmh04630   JAK-STAT signaling pathway hmh04658   Th1 and Th2 cell differentiation hmh04659   Th17 cell differentiation hmh04725   Cholinergic synapse hmh04917   Prolactin signaling pathway hmh04920   Adipocytokine signaling pathway hmh04933   AGE-RAGE signaling pathway in diabetic complications hmh04935   Growth hormone synthesis, secretion and action hmh05140   Leishmaniasis hmh05145   Toxoplasmosis hmh05152   Tuberculosis hmh05161   Hepatitis B hmh05164   Influenza A hmh05167   Kaposi sarcoma-associated herpesvirus infection hmh05168   Herpes simplex virus 1 infection hmh05200   Pathways in cancer hmh05207   Chemical carcinogenesis - receptor activation hmh05235   PD-L1 expression and PD-1 checkpoint pathway in cancer hmh05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:hmh00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     116458453 (JAK2)    04151 PI3K-Akt signaling pathway     116458453 (JAK2)   09133 Signaling molecules and interaction    04081 Hormone signaling     116458453 (JAK2)  09140 Cellular Processes   09141 Transport and catabolism    04148 Efferocytosis     116458453 (JAK2)   09143 Cell growth and death    04217 Necroptosis     116458453 (JAK2)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     116458453 (JAK2)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     116458453 (JAK2)    04659 Th17 cell differentiation     116458453 (JAK2)    04062 Chemokine signaling pathway     116458453 (JAK2)   09152 Endocrine system    04920 Adipocytokine signaling pathway     116458453 (JAK2)    04917 Prolactin signaling pathway     116458453 (JAK2)    04935 Growth hormone synthesis, secretion and action     116458453 (JAK2)   09156 Nervous system    04725 Cholinergic synapse     116458453 (JAK2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     116458453 (JAK2)    05207 Chemical carcinogenesis - receptor activation     116458453 (JAK2)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     116458453 (JAK2)   09172 Infectious disease: viral    05161 Hepatitis B     116458453 (JAK2)    05164 Influenza A     116458453 (JAK2)    05168 Herpes simplex virus 1 infection     116458453 (JAK2)    05167 Kaposi sarcoma-associated herpesvirus infection     116458453 (JAK2)   09171 Infectious disease: bacterial    05152 Tuberculosis     116458453 (JAK2)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     116458453 (JAK2)    05140 Leishmaniasis     116458453 (JAK2)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     116458453 (JAK2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     116458453 (JAK2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     116458453 (JAK2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hmh01001]     116458453 (JAK2) Enzymes [BR:hmh01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      116458453 (JAK2) Protein kinases [BR:hmh01001]  Non-receptor tyrosine kinases   JAK family [OT]    116458453 (JAK2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 SH2_1 Jak1_Phl C1-set SH2 C2-set_2 ABC1 FERM_C_FAK1 RIO1 Motif Other DBs NCBI-GeneID:  116458453 NCBI-ProteinID:  XP_031993972 LinkDB All DBs Position Unknown AA seq 1867 aa AA seqDB search MGMACLTMTEMEGTSTSSVYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSG EYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYF PRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQF SQCKATARNLKLKYLINLEALQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR EALSFVSLIDGYYRLTADAHHYLCKEVAPPKVLENIQSNCHGPISMDFAISKLKKAGNQT GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNC YQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI RNEDLIFNESLGQGTFTKIFKGTRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYMKKNKNCINILWKLEVAKQLAWA MHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAEL ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQI CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW AGPPPWPGRNSEVQVLRTGPAQAPGAAVTRTAPPLTPAGPSAKALNLLSRTAASLHSHSW DRDSEARAASGACSSFGRDAGVRGLTQAGFLPGELALSSPGPLSPSGMKGASQYYPSYAS SSVGERRTAAWTCSPRRSGRSRLVFHLWRTCPAQIAACTSKPSSGVTRARRASAPCWAGA HPPLSLPHGSGPVGSGGGSSTFGGLHQHERIGYQLHGAEVNGGLRAASTFSLAPGAAYGS VSSHMPVGRANSLPGSRETTASSSGDALGKAWPQSTPRITQAITSGPAPPPPYDGGLYGL ESKIEDHLNEGIHVLCSHAVGTAANVYTLLPGHGALALGFSGPMLLLVRRPPRPLLASRL LQWARASRPLAKSSGRRMRRTCRQLTTQEEEEELKDPRARTSPDEDEEEDDLFSPDKKPQ TKLLILHQAVWVILNSEQEVRERNLNPKTACLKWREEKVSRVFGGPQMVLSAAHLRLSEA HNPAGHVKGITSQLTALGAWAKQTFTCSVAHTLVHRPGQYLQRLLQGLHPAHREDLTVLL RWQQTLPPDHAVPVPHLRVHPGAISITWLEDGQVVDVNWSIPSPMLEGELASTQSKLTLT QKRWLPDHTYTCQVTYQGNTFEDSAKKCADSNLQGVSTYLSQPSPFYLFIRKLPTITRLV VDLAASKGNVKLTWSLGQWEVCGSGNPKAREAVQWHVHHHVHPAGGHQRLDRGGDLPVQG DPPTPAVHDQDQRPVCSPTGLRVCKARRAEEPGQEHLHLPDPDLVAQGHLGAVAEFMRMI GNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQ IRDNMAG NT seq 5604 nt NT seq  +upstreamnt  +downstreamnt atgggaatggcctgccttacgatgacagaaatggagggaacatccacctcttctgtatat cagaatggtgatatttctggaaatgccaattctatgaagcaaatagatccagttcttcag gtgtatctttaccattcccttgggaaatctgaggcagattatctgacctttccgtctggg gagtatgttgcagaagaaatctgtattgctgcttctaaagcttgtggtatcacacctgtg tatcataatatgtttgctttaatgagtgaaacagaaaggatctggtatccacccaaccat gtcttccatatagatgagtcaaccaggcataatgtactctacagaataagattttacttt cctcgttggtattgcagtggcagcaacagagcctatcggcatggaatatctcgaggtgct gaagctcctcttcttgatgactttgtcatgtcttacctctttgctcagtggcggcatgat tttgtgcatggatggataaaagtacctgtgactcatgaaacacaggaagaatgtcttggg atggcagtgttagacatgatgagaatagccaaagaaaacgatcagaccccactggccatc tataactctatcagctacaagacattcttaccaaaatgtattcgagcaaagatccaagac tatcatattttgacaaggaagcgaataaggtacagatttcgcagatttattcagcaattc agccaatgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaagct ctgcagtctgccttctacacagagaaatttgaagtaaaagaacctggaagtggtccttca ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga gggaaacataaagaaagtgagacactgacagaacaggatttacagttatattgcgatttt cctaatattattgatgtcagtattaagcaagcaaaccaagagggttcaaatgaaagccga gttgtaactatccataagcaagatggtaaaaatctggaaattgaacttagctcattaagg gaagctttgtctttcgtgtcattaattgatgggtattatagattaactgcagatgcacat cattacctctgtaaagaagtagcacctccaaaagtgcttgaaaatatacaaagcaactgt catggcccaatttcgatggattttgccatcagtaaactgaagaaagcaggtaatcagact ggactgtatgtacttcgatgcagtcctaaggactttaataaatattttttgacttttgct gtcgagcgagaaaatgtcattgaatataaacactgtttgattacaaaaaatgagaatgaa gagtacaacctcagtgggacaaagaagaacttcagcagtcttaaagatcttttgaattgt taccagatggaaaccgttcgctcagacaatataattttccagtttactaaatgctgtccc ccaaagccaaaagataaatcaaaccttctagtcttcagaacgaatggtgtttctgacgta ccaacctcaccaacattacagaggcctactcatatgaaccaaatggtgtttcacaaaatc agaaatgaagatttgatatttaatgaaagccttggccaaggcacttttacaaagattttt aaaggcacacgaagagaagtaggagactacggtcaactgcatgaaacagaagttctttta aaagttctggataaagcacacagaaactattcagagtctttctttgaagcagcaagcatg atgagcaagctttctcacaagcatttggttttaaattatggagtatgtgtctgtggagac gagaatattctggttcaggagtttgtaaaatttggatcactagatacatatatgaaaaag aataaaaattgtataaatatattatggaaacttgaagttgctaaacagttggcatgggcc atgcattttctagaagaaaacacccttattcatgggaatgtgtgtgccaaaaatattctg cttatcagagaagaagacaggaagacaggaaatcctcctttcatcaaacttagtgatccc ggcattagtattacagttttgccaaaggacattcttcaggagagaataccatgggtacca cctgaatgcattgaaaatcctaaaaatttaaatttggcaacagacaaatggagttttggt accactttgtgggaaatctgcagtggaggagataaacctctaagtgctctggattctcaa agaaagctacaattttatgaagataggcatcagcttcctgcaccaaagtgggcagaatta gcaaaccttataaataattgtatggattatgaaccagatttcaggccttctttcagagcc atcatacgagatcttaacagtttgtttactccagattatgaactattaacagaaaatgac atgttaccaaatatgaggataggtgccctagggttttctggtgcctttgaagaccgggat cctacacagtttgaagagagacatttgaaatttctacagcaacttggcaagggtaatttt gggagtgtggagatgtgccggtatgaccctctacaggacaacactggggaggtggtggct gtaaaaaagcttcagcatagtactgaagagcacctaagagactttgaaagggaaattgaa atcctgaaatccctacaacatgataacattgtgaagtacaagggagtgtgctacagtgct ggtcggcgtaatctaaaattaattatggaatatttaccatatggaagtttacgagactat cttcaaaaacataaagaacggatagatcacaaaaaacttctgcagtacacatctcagata tgcaagggtatggagtatcttggtacaaaaaggtatatccacagggatctggcaacaaga aatatattggtggagaatgagaacagagttaaaattggagattttgggttaaccaaagtc ttgccacaagacaaagaatactataaagtaaaagaacctggtgaaagtcccatattctgg gccggcccgcctccctggccggggcgcaattcagaggttcaggttttgagaactggccca gctcaggctcctggggcagcggtgaccagaacagctcctcctttgaccccagctggacct tcagcgaaggcgctcaacttgctgagtcgcacagcagcctctcttcattcacattcctgg gaccgggactcggaggcaagagcagctagcggggcctgttcctcctttggtagagacgca ggcgtgcgcggcctgactcaggctggcttcctgccgggcgagctggccctcagcagcccc ggacccctgtccccttcgggcatgaagggggcctcccagtactacccctcctacgccagc agctccgtcggagagaggcggacagcggcctggacatgcagcccacgaaggtcgggaagg tcccgtctggtcttccatctttggcgtacctgcccagctcagatagcagcctgcacctct aagccgagctctggagttacccgggccaggcgggcttcggccccatgctgggcaggggct catccccctctgtccctcccgcacggcagcggccctgtgggcagtggcggaggcagcagc acgtttggtggcctgcaccagcacgagcgcataggctaccagttgcacggagcagaagtg aatggtgggcttcgggctgcatccaccttctccttggcccctggagccgcgtatggcagc gtctccagccacatgcctgtcggcagggccaacagcctcccgggctcccgagagaccaca gccagcagctccggggacgcccttgggaaggcctggcctcagtctactccccggatcact caagcaataacttctggtccagctcctccaccgccctacgacgggggtctctacggcctg gagagtaagatagaagaccacctgaacgagggcatccacgtgctctgcagccacgccgtg ggcactgctgccaacgtgtacacgctgctgcctggccacggggcgctggccttgggcttc tccggccccatgctgctgctagtcaggcgccctccccgacctctcttggcctcccgactc ctacagtgggctagggcgagcaggccactggcgaaatcaagcgggaggaggatgaggaga acatgtcggcagctgaccactcaagaggaggaggaggagctgaaggacccccgggcccgg actagcccagacgaggacgaggaggaagatgaccttttctccccagacaagaagccccag accaaactgcttatcctgcaccaggccgtctgggtcatcctgaactcggagcaggaagtg cgagagcggaacctgaatcccaaaacagcctgtttgaaatggcgagaagagaaggtgtcg cgcgtgttcggaggcccccagatggtgctttcagctgctcacctgcgcctgagcgaagcc cacaaccctgccgggcacgtgaaaggcatcaccagccagctgactgccttgggtgcgtgg gccaagcaaacgttcacctgcagcgtggcacacactctggtccatagaccaggtcagtac cttcagcgtctactccagggacttcaccctgcccaccgtgaagatcttacagtcctcctg cgatggcagcagacacttccccccgaccatgcagttcctgtgcctcatctccgggtacac ccaggtgccatcagcatcacctggctggaggatgggcaggtcgtggatgtgaactggtcc atcccctctcccatgctggagggcgagctggcctccacacaaagcaagctcaccctcacc cagaagcgctggctgcccgaccacacctacacctgccaggtcacctatcaaggtaacacc tttgaggacagtgccaagaagtgtgcagattctaacctgcaaggggtgagcacctacttg agccagcccagccccttctacctgttcatccgcaagttgcccacaatcacccgtctggtg gtggacctggcagccagcaaggggaacgtgaagctgacctggtccctgggccagtgggaa gtctgtggctcaggtaatcctaaggcaagagaagcagtgcaatggcacgttcaccatcac gtccaccctgctggtgggcaccagagactggatcgagggggagacctaccagtgcagggt gacccacccacacctgcagtccacgaccaagatcagcgacctgtgtgctcccccacaggt ctacgtgtttgcaaagctagaagagccgaggaaccgggacaagagcatcttcacctgcct gatccagaccttgtagcccagggacatcttggtgcagtggctgaatttatgcgtatgatt ggcaacgacaaacaaggacagatgatcgtgttccatttgatagaacttttgaagaataat ggaagattaccaagaccagatggatgcccagatgagatttatatgatcatgacagaatgc tggaacaataatgtaaatcaacgcccctcctttagggatctagctcttcgagtggatcaa ataagggataacatggccggatga

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