Hylobates moloch (silvery gibbon): 116458727
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Entry
116458727 CDS
T08803
Symbol
ERN1
Name
(RefSeq) serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1
KO
K08852
serine/threonine-protein kinase/endoribonuclease IRE1 [EC:
2.7.11.1
3.1.26.-]
Organism
hmh
Hylobates moloch (silvery gibbon)
Pathway
hmh04140
Autophagy - animal
hmh04141
Protein processing in endoplasmic reticulum
hmh04210
Apoptosis
hmh04932
Non-alcoholic fatty liver disease
hmh05010
Alzheimer disease
hmh05012
Parkinson disease
hmh05014
Amyotrophic lateral sclerosis
hmh05016
Huntington disease
hmh05017
Spinocerebellar ataxia
hmh05022
Pathways of neurodegeneration - multiple diseases
hmh05417
Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
hmh00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04141 Protein processing in endoplasmic reticulum
116458727 (ERN1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
116458727 (ERN1)
09143 Cell growth and death
04210 Apoptosis
116458727 (ERN1)
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
116458727 (ERN1)
05012 Parkinson disease
116458727 (ERN1)
05014 Amyotrophic lateral sclerosis
116458727 (ERN1)
05016 Huntington disease
116458727 (ERN1)
05017 Spinocerebellar ataxia
116458727 (ERN1)
05022 Pathways of neurodegeneration - multiple diseases
116458727 (ERN1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
116458727 (ERN1)
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
116458727 (ERN1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hmh01001
]
116458727 (ERN1)
Enzymes [BR:
hmh01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
116458727 (ERN1)
Protein kinases [BR:
hmh01001
]
Serine/threonine kinases: Other
IRE family
116458727 (ERN1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Pkinase
Ribonuc_2-5A
PK_Tyr_Ser-Thr
PQQ_2
PQQ
Pkinase_fungal
Kdo
APH
Med31
Motif
Other DBs
NCBI-GeneID:
116458727
NCBI-ProteinID:
XP_031994547
LinkDB
All DBs
Position
Unknown
AA seq
980 aa
AA seq
DB search
MPAQRLLLLLTLLLPGLGIFGSTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDP
VLQVPTHVEEPAFLPDPNDGSLYTLGSKNNEGLTKLPFTIPELVQASPCRSSDGILYMGK
KQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYF
DYAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQREGLRKV
MHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMV
HEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDLKFDPGLKSKSKLNYLRNYWL
LIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKKSFEKVINLVDQTSENAPTTVSR
DVEEKPAHAPARPEAPVDSMLKDMATIILSTFLLIGWVAFIITYPLSMHQQQQLQHQQFQ
KELEKIQLLQQQQQQQQQLPFHPPGDTAQDGELLDTSGPYSESSGTSSPSTSPRASNHSL
CSGSSASKAGSSPSLEQDDGDEETSMVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVA
VKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKD
FAHLGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKK
LAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGK
SLQRQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEK
QLQFFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSV
RDLLRAMRNKKHHYRELPAEVQETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLF
QPYYFHEPPEPQPPVTPDAL
NT seq
2943 nt
NT seq
+upstream
nt +downstream
nt
atgccggcccagcggctgctgctgctgctgacgctgctgctgcccggcctcgggattttt
ggaagtaccagcacagtgacgcttcctgaaaccttgttgtttgtgtcaacgctggatgga
agtttgcatgctgtcagcaagaggacaggctcaatcaaatggactttaaaggaagatcca
gtcctgcaggtcccaacacatgtggaagagcctgcctttctcccagatcctaatgatggc
agcctgtatacgcttggaagcaagaataatgaaggcctgacaaaacttccttttaccatc
ccagaattggtgcaggcatccccatgccgaagttcagatggaatcctctacatgggtaaa
aagcaggacatctggtatgttattgacctcctgaccggggagaagcagcagactttgtca
tcggcctttgcagatagtctctgcccatcaacctctcttctgtatcttgggcgaacagaa
tacaccatcaccatgtacgacaccaaaacccgagagctccggtggaatgccacttacttt
gactatgcagcctcgctgcccgaggacgacgtggactacaagatgtcccactttgtgtcc
aatggtgatgggctggtggtgactgtggacagtgaatctggggacgtcctgtggatccaa
aactacgcctcccctgtggtggccttttatgtctggcagcgggagggtctgaggaaggtg
atgcacatcaatgttgctgtggagaccctgcgctatctgaccttcatgtctggggaggtg
gggcgcatcaccaaatggaagtacccgttccccaaggagacagaggccaagagcaagctg
acacccactctgtatgttgggaaatactctaccagcctctatgcctctccctcaatggta
cacgagggggttgctgtcgtgccccgcggcagcacacttcctttgctggaagggccccag
actgatggcgtcaccattggggacaagggggagtgtgtgatcacgcccagcacggacctc
aagtttgaccccggactcaaaagcaagagcaagctcaactacttgaggaattactggctt
ctgataggacaccatgaaaccccactgtctgcatctaccaagatgctggagagatttccc
aacaatctacccaaacatcgggaaaatgtgattcctgctgattcggagaaaaagagcttt
gagaaagttatcaacctggttgaccagacttcagaaaacgcacctaccaccgtgtctcgg
gatgtggaggagaagcccgcccatgcccctgcccggcccgaggcccccgtggactccatg
ctcaaggacatggctaccatcatcctgagcaccttcctgctgattggctgggtggccttc
atcatcacctatcccctgagcatgcatcagcagcagcagctccagcaccagcagttccag
aaggaactagagaagatccagctcctgcagcagcagcagcagcagcagcagcagctgccc
tttcacccacctggagacacggctcaggacggcgagctcctggatacgtccggcccatac
tcagagagctcgggcactagcagccccagcacgtcccccagggcctccaaccactcgctc
tgctccggcagctctgcctccaaggctggcagcagcccctccctggaacaagacgatgga
gatgaggaaaccagcatggtgatagttgggaaaatttccttctgtcccaaggatgtcctg
ggccacggagctgagggcacaattgtgtaccggggcatgtttgacaaccgcgacgtggcc
gtgaagaggatccttcccgagtgttttagcttcgcagaccgtgaggtccagctgttgcga
gaatcggatgagcacccgaatgtgatccgctacttctgcacggagaaggaccggcaattc
cagtacattgccatcgagctgtgtgcagccaccctgcaagagtatgtggagcagaaggac
tttgcgcatctgggcctggagcccatcaccttgctgcagcagaccacctcgggcctggcc
cacctccactccctcaacatcgttcaccgagacctaaagccgcacaacattctcatatcc
atgcccaatgcacacggcaagatcaaggccatgatctccgactttggcctctgcaagaag
ctggcagtgggcagacacagtttcagccgccgatctggggtgcctggcacagaaggctgg
atcgctccggagatgctgagcgaagactgtaaggagaaccctacctacacggtggacata
ttttctgcaggctgcgtcttttactacgtgatctctgagggcagccacccttttggcaag
tccctgcagcggcaggccaacatcctcctgggtgcctgcagcctcgactgcttgcaccca
gagaagcacgaagacgtcattgcacgtgaattgatagagaagatgattgcaatggatcct
cagaaacgcccctcagcgaagcacgtgctcaaacacccattcttctggagcctagagaag
cagctccagttcttccaggacgtgagtgacagaatagaaaaggaatccctggatggcccg
atcgtgaagcagttagagagaggcgggagagctgtggtgaagatggactggcgggagaac
atcaccgtccccctccagacagacctgcgtaaattcaggacctataaaggtggttctgtc
agagatctcctccgagccatgagaaataagaagcaccactaccgggagctgcctgcggag
gtgcaggagacgctggggtccctccccgacgactttgtgtgctacttcacgtctcgcttc
ccccacctcctcgcacacacctaccgggccatggagctgtgcagccacgagagactcttc
cagccctactacttccacgagcccccagagccgcagcccccagtgactccagacgccctc
tga
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