Hylobates moloch (silvery gibbon): 116460769
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Entry
116460769 CDS
T08803
Symbol
MAPK8
Name
(RefSeq) mitogen-activated protein kinase 8 isoform X1
KO
K04440
mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:
2.7.11.24
]
Organism
hmh
Hylobates moloch (silvery gibbon)
Pathway
hmh01522
Endocrine resistance
hmh04010
MAPK signaling pathway
hmh04012
ErbB signaling pathway
hmh04014
Ras signaling pathway
hmh04024
cAMP signaling pathway
hmh04068
FoxO signaling pathway
hmh04071
Sphingolipid signaling pathway
hmh04137
Mitophagy - animal
hmh04140
Autophagy - animal
hmh04141
Protein processing in endoplasmic reticulum
hmh04210
Apoptosis
hmh04215
Apoptosis - multiple species
hmh04217
Necroptosis
hmh04310
Wnt signaling pathway
hmh04380
Osteoclast differentiation
hmh04510
Focal adhesion
hmh04530
Tight junction
hmh04620
Toll-like receptor signaling pathway
hmh04621
NOD-like receptor signaling pathway
hmh04622
RIG-I-like receptor signaling pathway
hmh04625
C-type lectin receptor signaling pathway
hmh04657
IL-17 signaling pathway
hmh04658
Th1 and Th2 cell differentiation
hmh04659
Th17 cell differentiation
hmh04660
T cell receptor signaling pathway
hmh04664
Fc epsilon RI signaling pathway
hmh04668
TNF signaling pathway
hmh04722
Neurotrophin signaling pathway
hmh04723
Retrograde endocannabinoid signaling
hmh04728
Dopaminergic synapse
hmh04750
Inflammatory mediator regulation of TRP channels
hmh04910
Insulin signaling pathway
hmh04912
GnRH signaling pathway
hmh04914
Progesterone-mediated oocyte maturation
hmh04917
Prolactin signaling pathway
hmh04920
Adipocytokine signaling pathway
hmh04926
Relaxin signaling pathway
hmh04930
Type II diabetes mellitus
hmh04931
Insulin resistance
hmh04932
Non-alcoholic fatty liver disease
hmh04933
AGE-RAGE signaling pathway in diabetic complications
hmh04935
Growth hormone synthesis, secretion and action
hmh04936
Alcoholic liver disease
hmh05010
Alzheimer disease
hmh05012
Parkinson disease
hmh05016
Huntington disease
hmh05017
Spinocerebellar ataxia
hmh05020
Prion disease
hmh05022
Pathways of neurodegeneration - multiple diseases
hmh05132
Salmonella infection
hmh05133
Pertussis
hmh05135
Yersinia infection
hmh05142
Chagas disease
hmh05145
Toxoplasmosis
hmh05152
Tuberculosis
hmh05161
Hepatitis B
hmh05162
Measles
hmh05166
Human T-cell leukemia virus 1 infection
hmh05167
Kaposi sarcoma-associated herpesvirus infection
hmh05169
Epstein-Barr virus infection
hmh05170
Human immunodeficiency virus 1 infection
hmh05171
Coronavirus disease - COVID-19
hmh05200
Pathways in cancer
hmh05208
Chemical carcinogenesis - reactive oxygen species
hmh05210
Colorectal cancer
hmh05212
Pancreatic cancer
hmh05231
Choline metabolism in cancer
hmh05415
Diabetic cardiomyopathy
hmh05417
Lipid and atherosclerosis
hmh05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
hmh00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04141 Protein processing in endoplasmic reticulum
116460769 (MAPK8)
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
116460769 (MAPK8)
04012 ErbB signaling pathway
116460769 (MAPK8)
04014 Ras signaling pathway
116460769 (MAPK8)
04310 Wnt signaling pathway
116460769 (MAPK8)
04668 TNF signaling pathway
116460769 (MAPK8)
04068 FoxO signaling pathway
116460769 (MAPK8)
04071 Sphingolipid signaling pathway
116460769 (MAPK8)
04024 cAMP signaling pathway
116460769 (MAPK8)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
116460769 (MAPK8)
04137 Mitophagy - animal
116460769 (MAPK8)
09143 Cell growth and death
04210 Apoptosis
116460769 (MAPK8)
04215 Apoptosis - multiple species
116460769 (MAPK8)
04217 Necroptosis
116460769 (MAPK8)
09144 Cellular community - eukaryotes
04510 Focal adhesion
116460769 (MAPK8)
04530 Tight junction
116460769 (MAPK8)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
116460769 (MAPK8)
04621 NOD-like receptor signaling pathway
116460769 (MAPK8)
04622 RIG-I-like receptor signaling pathway
116460769 (MAPK8)
04625 C-type lectin receptor signaling pathway
116460769 (MAPK8)
04660 T cell receptor signaling pathway
116460769 (MAPK8)
04658 Th1 and Th2 cell differentiation
116460769 (MAPK8)
04659 Th17 cell differentiation
116460769 (MAPK8)
04657 IL-17 signaling pathway
116460769 (MAPK8)
04664 Fc epsilon RI signaling pathway
116460769 (MAPK8)
09152 Endocrine system
04910 Insulin signaling pathway
116460769 (MAPK8)
04920 Adipocytokine signaling pathway
116460769 (MAPK8)
04912 GnRH signaling pathway
116460769 (MAPK8)
04914 Progesterone-mediated oocyte maturation
116460769 (MAPK8)
04917 Prolactin signaling pathway
116460769 (MAPK8)
04926 Relaxin signaling pathway
116460769 (MAPK8)
04935 Growth hormone synthesis, secretion and action
116460769 (MAPK8)
09156 Nervous system
04728 Dopaminergic synapse
116460769 (MAPK8)
04723 Retrograde endocannabinoid signaling
116460769 (MAPK8)
04722 Neurotrophin signaling pathway
116460769 (MAPK8)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
116460769 (MAPK8)
09158 Development and regeneration
04380 Osteoclast differentiation
116460769 (MAPK8)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
116460769 (MAPK8)
05208 Chemical carcinogenesis - reactive oxygen species
116460769 (MAPK8)
05231 Choline metabolism in cancer
116460769 (MAPK8)
09162 Cancer: specific types
05210 Colorectal cancer
116460769 (MAPK8)
05212 Pancreatic cancer
116460769 (MAPK8)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
116460769 (MAPK8)
05170 Human immunodeficiency virus 1 infection
116460769 (MAPK8)
05161 Hepatitis B
116460769 (MAPK8)
05171 Coronavirus disease - COVID-19
116460769 (MAPK8)
05162 Measles
116460769 (MAPK8)
05167 Kaposi sarcoma-associated herpesvirus infection
116460769 (MAPK8)
05169 Epstein-Barr virus infection
116460769 (MAPK8)
09171 Infectious disease: bacterial
05132 Salmonella infection
116460769 (MAPK8)
05135 Yersinia infection
116460769 (MAPK8)
05133 Pertussis
116460769 (MAPK8)
05152 Tuberculosis
116460769 (MAPK8)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
116460769 (MAPK8)
05142 Chagas disease
116460769 (MAPK8)
09164 Neurodegenerative disease
05010 Alzheimer disease
116460769 (MAPK8)
05012 Parkinson disease
116460769 (MAPK8)
05016 Huntington disease
116460769 (MAPK8)
05017 Spinocerebellar ataxia
116460769 (MAPK8)
05020 Prion disease
116460769 (MAPK8)
05022 Pathways of neurodegeneration - multiple diseases
116460769 (MAPK8)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
116460769 (MAPK8)
05418 Fluid shear stress and atherosclerosis
116460769 (MAPK8)
05415 Diabetic cardiomyopathy
116460769 (MAPK8)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
116460769 (MAPK8)
04936 Alcoholic liver disease
116460769 (MAPK8)
04932 Non-alcoholic fatty liver disease
116460769 (MAPK8)
04931 Insulin resistance
116460769 (MAPK8)
04933 AGE-RAGE signaling pathway in diabetic complications
116460769 (MAPK8)
09176 Drug resistance: antineoplastic
01522 Endocrine resistance
116460769 (MAPK8)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hmh01001
]
116460769 (MAPK8)
Enzymes [BR:
hmh01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.24 mitogen-activated protein kinase
116460769 (MAPK8)
Protein kinases [BR:
hmh01001
]
Serine/threonine kinases: CMGC group
MAPK family [OT]
116460769 (MAPK8)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
Kdo
ABC1
RIO1
Kinase-like
FTA2
APH
DUF530
Motif
Other DBs
NCBI-GeneID:
116460769
NCBI-ProteinID:
XP_031997767
LinkDB
All DBs
Position
Unknown
AA seq
427 aa
AA seq
DB search
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEASA
GPLGCCR
NT seq
1284 nt
NT seq
+upstream
nt +downstream
nt
atgagcagaagcaagcgtgacaacaatttttatagtgtagagattggagattctacattc
acagtcctgaaacgatatcagaatttaaaacctataggctcaggagctcaaggaatagta
tgcgcagcttatgatgccattcttgaaagaaatgttgcaatcaagaagctaagccgacca
tttcagaatcagactcatgccaagcgggcctacagagagctagttcttatgaaatgtgtt
aatcacaaaaatataattggccttttgaatgttttcacaccacagaaatccctagaagaa
tttcaagatgtttacatagtcatggagctcatggatgcaaatctttgccaagtgattcag
atggagctagatcatgaaagaatgtcctaccttctctatcagatgctgtgtggaatcaag
caccttcattctgctggaattattcatcgggacttaaagcccagtaatatagtagtaaaa
tctgactgcactttgaagattcttgacttcggtctggccaggactgcaggaacgagtttt
atgatgacgccttacgtagtgactcgctactacagagcacccgaggtcatcctcggcatg
ggctacaaggaaaacgtggatttatggtctgtggggtgcattatgggagaaatggtttgc
cacaaaatcctctttccaggaagggactatattgatcagtggaataaagttattgaacag
cttggaacaccatgtcctgaattcatgaagaaactgcaaccaacagtaaggacttacgtt
gaaaacagacctaaatatgccggatatagctttgagaaactcttccctgatgtccttttc
ccagctgactcggaacacaacaaacttaaagccagtcaggcaagggatttgttatccaaa
atgctggtaatagatgcatctaaaaggatctctgtagatgaagctctccaacacccgtac
atcaatgtctggtatgatccttctgaagcagaagctccaccaccaaagatccctgacaag
cagttagatgaaagagaacacacaatagaagagtggaaagaattgatatataaggaagtt
atggacttggaggagagaaccaagaatggagttatacgggggcagccctctcctttaggt
gcagcagtgatcaatggctctcagcatccatcatcatcgtcgtctgtcaatgatgtgtct
tcaatgtcaacagatccgactttggcctcggatacagacagcagtctagaagcatcagct
gggcctctgggctgctgtagatga
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