KEGG   Hylobates moloch (silvery gibbon): 116461202
Entry
116461202         CDS       T08803                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
hmh  Hylobates moloch (silvery gibbon)
Pathway
hmh00562  Inositol phosphate metabolism
hmh01100  Metabolic pathways
hmh04015  Rap1 signaling pathway
hmh04020  Calcium signaling pathway
hmh04022  cGMP-PKG signaling pathway
hmh04062  Chemokine signaling pathway
hmh04070  Phosphatidylinositol signaling system
hmh04071  Sphingolipid signaling pathway
hmh04072  Phospholipase D signaling pathway
hmh04081  Hormone signaling
hmh04082  Neuroactive ligand signaling
hmh04261  Adrenergic signaling in cardiomyocytes
hmh04270  Vascular smooth muscle contraction
hmh04310  Wnt signaling pathway
hmh04371  Apelin signaling pathway
hmh04540  Gap junction
hmh04611  Platelet activation
hmh04613  Neutrophil extracellular trap formation
hmh04621  NOD-like receptor signaling pathway
hmh04713  Circadian entrainment
hmh04720  Long-term potentiation
hmh04723  Retrograde endocannabinoid signaling
hmh04724  Glutamatergic synapse
hmh04725  Cholinergic synapse
hmh04726  Serotonergic synapse
hmh04728  Dopaminergic synapse
hmh04730  Long-term depression
hmh04742  Taste transduction
hmh04750  Inflammatory mediator regulation of TRP channels
hmh04911  Insulin secretion
hmh04912  GnRH signaling pathway
hmh04915  Estrogen signaling pathway
hmh04916  Melanogenesis
hmh04918  Thyroid hormone synthesis
hmh04919  Thyroid hormone signaling pathway
hmh04921  Oxytocin signaling pathway
hmh04922  Glucagon signaling pathway
hmh04924  Renin secretion
hmh04925  Aldosterone synthesis and secretion
hmh04926  Relaxin signaling pathway
hmh04927  Cortisol synthesis and secretion
hmh04928  Parathyroid hormone synthesis, secretion and action
hmh04929  GnRH secretion
hmh04933  AGE-RAGE signaling pathway in diabetic complications
hmh04934  Cushing syndrome
hmh04935  Growth hormone synthesis, secretion and action
hmh04961  Endocrine and other factor-regulated calcium reabsorption
hmh04970  Salivary secretion
hmh04971  Gastric acid secretion
hmh04972  Pancreatic secretion
hmh04973  Carbohydrate digestion and absorption
hmh05010  Alzheimer disease
hmh05016  Huntington disease
hmh05017  Spinocerebellar ataxia
hmh05022  Pathways of neurodegeneration - multiple diseases
hmh05142  Chagas disease
hmh05143  African trypanosomiasis
hmh05146  Amoebiasis
hmh05163  Human cytomegalovirus infection
hmh05200  Pathways in cancer
hmh05415  Diabetic cardiomyopathy
hmh05417  Lipid and atherosclerosis
Module
hmh_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:hmh00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    116461202 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    116461202 (PLCB4)
   04310 Wnt signaling pathway
    116461202 (PLCB4)
   04371 Apelin signaling pathway
    116461202 (PLCB4)
   04020 Calcium signaling pathway
    116461202 (PLCB4)
   04070 Phosphatidylinositol signaling system
    116461202 (PLCB4)
   04072 Phospholipase D signaling pathway
    116461202 (PLCB4)
   04071 Sphingolipid signaling pathway
    116461202 (PLCB4)
   04022 cGMP-PKG signaling pathway
    116461202 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    116461202 (PLCB4)
   04081 Hormone signaling
    116461202 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    116461202 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    116461202 (PLCB4)
   04613 Neutrophil extracellular trap formation
    116461202 (PLCB4)
   04621 NOD-like receptor signaling pathway
    116461202 (PLCB4)
   04062 Chemokine signaling pathway
    116461202 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    116461202 (PLCB4)
   04922 Glucagon signaling pathway
    116461202 (PLCB4)
   04929 GnRH secretion
    116461202 (PLCB4)
   04912 GnRH signaling pathway
    116461202 (PLCB4)
   04915 Estrogen signaling pathway
    116461202 (PLCB4)
   04921 Oxytocin signaling pathway
    116461202 (PLCB4)
   04926 Relaxin signaling pathway
    116461202 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    116461202 (PLCB4)
   04918 Thyroid hormone synthesis
    116461202 (PLCB4)
   04919 Thyroid hormone signaling pathway
    116461202 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    116461202 (PLCB4)
   04916 Melanogenesis
    116461202 (PLCB4)
   04924 Renin secretion
    116461202 (PLCB4)
   04925 Aldosterone synthesis and secretion
    116461202 (PLCB4)
   04927 Cortisol synthesis and secretion
    116461202 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    116461202 (PLCB4)
   04270 Vascular smooth muscle contraction
    116461202 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    116461202 (PLCB4)
   04971 Gastric acid secretion
    116461202 (PLCB4)
   04972 Pancreatic secretion
    116461202 (PLCB4)
   04973 Carbohydrate digestion and absorption
    116461202 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    116461202 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    116461202 (PLCB4)
   04725 Cholinergic synapse
    116461202 (PLCB4)
   04728 Dopaminergic synapse
    116461202 (PLCB4)
   04726 Serotonergic synapse
    116461202 (PLCB4)
   04720 Long-term potentiation
    116461202 (PLCB4)
   04730 Long-term depression
    116461202 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    116461202 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    116461202 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    116461202 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    116461202 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    116461202 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    116461202 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    116461202 (PLCB4)
   05142 Chagas disease
    116461202 (PLCB4)
   05143 African trypanosomiasis
    116461202 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    116461202 (PLCB4)
   05016 Huntington disease
    116461202 (PLCB4)
   05017 Spinocerebellar ataxia
    116461202 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    116461202 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    116461202 (PLCB4)
   05415 Diabetic cardiomyopathy
    116461202 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    116461202 (PLCB4)
   04934 Cushing syndrome
    116461202 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hmh04131]
    116461202 (PLCB4)
Enzymes [BR:hmh01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     116461202 (PLCB4)
Membrane trafficking [BR:hmh04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    116461202 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    116461202 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 116461202
NCBI-ProteinID: XP_031998580
LinkDB
Position
Unknown
AA seq 1206 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVL
ECSLINSIRSGAIPKDPKILAALDAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRTLPSPNDLKRKILIKNKRLKPEVEKKQLEALRSM
MEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKASD
DLEHENNKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQ
SSSELRPTTTAALASGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKSTQEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLINAHEQQTQQLKLS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSSM
KLQNAN
NT seq 3621 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaactggcagaaggaagttccttcctttttgcaagaagga
gcagttttcgacagatacgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtggatgagtttggcttctttctgacatggaaaagtgaaggcaaggaaggacaggtgcta
gaatgctccctcatcaacagtattcggtcgggagccataccaaaggatcccaaaatcttg
gctgctcttgacgctgttggaaaatcagaaaatgatctggaagggcggatagtttgtgtc
tgcagtggtacagatctagtgaacattagttttacctacatggtggctgaaaatccagaa
gtaactaagcaatgggtagaaggcctgagatcaatcatacacaacttcagggccaacaac
gtcagtccaatgacatgcctcaagaaacactggatgaaattggcatttatgaccaacaca
aatggtaaaattccagttagaagtattaccagaacatttgcatcggggaaaacagaaaag
gtgatctttcaagcactcaaggagttaggtcttcccagtggaaagaatgatgaaattgag
cccacggcattttcttatgaaaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaagatcttttcaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagatcctcgattgaatgaaattttattt
ccattttatgatgccaaaagggcaatgcagatcattgagatgtatgaacctgatgaagat
ttgaagaaaaaaggccttatatcaagtgatgggttttgcagatatctgatgtcagatgaa
aatgccccagtcttcctagatcgtttagaactttaccaagaaatggaccatcctctggct
cactacttcatcagttcttcccataacacttatctcactggcagacagtttggtgggaag
tcttcggtagaaatgtacagacaggttctcctggctggttgcagatgtgttgaacttgac
tgctgggatggaaaaggtgaagaccaagaaccaataataactcatggaaaagcaatgtgt
acagatatcctttttaaggatgtaattcaagccatcaaggaaactgcatttgtcacatca
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatattgcgaagatctatttggggatctcctgttgaaacaagcacttgaatcacat
ccacttgaaccaggcaggactttgccatcccccaatgacctcaaaagaaaaatactcata
aaaaacaagcggctgaaacctgaagttgaaaaaaaacagctggaagctttgagaagcatg
atggaagctggagaatctgcctccccagcaaacatcttagaggacgataatgaagaggag
attgaaagtgctgaccaagaggaggaagctcaccctgaattcaaatttggaaatgaactt
tctgctgatgacttgggtcacaaggaagctgttgcaaatagcgtcaagaaggcttcagat
gaccttgaacatgaaaacaacaaaaagggcctggtcactgtagaagatgagcaggcgtgg
atggcatcttataaatatgtaggtgctaccactaatatccatccatatttgtccacaatg
atcaactacgcccagcctgtaaagtttcaaggtttccatgtggcagaagaacgcaatatt
cattataacatgtcttcttttaatgaatcagtcggccttggctacttgaagacacatgca
attgaatttgtcaattacaacaaacggcaaatgagtcgcatttaccccaagggaggccga
gttgattccagtaattacatgcctcagattttctggaacgctggctgccagatggtttca
ctgaactatcaaaccccagatttagcgatgcaattgaatcagggaaaatttgagtataat
ggatcgtgcgggtaccttctcaaaccagatttcatgaggcggcctgatcgaacatttgac
cccttctctgaaactcctgttgatggcgttattgcagccacttgctcggtgcaggttata
tcaggtcaattcttatcagataagaaaattggcacctatgtagaagtagatatgtatggg
ttgcccactgacaccatacgtaaggaattccgaactcgcatggttatgaataacggactc
aatccagtttacaatgaagagtcattcgtgtttcggaaggtgatcctgccggacctggct
gtcttgagaatagccgtgtatgatgataacaacaagctgattggccagaggatcctcccg
cttgatggcctccaggcaggatatcgacacatttcccttcgaaacgaaggaaataaacca
ttatcactgccaacaattttctgcaatattgttcttaaaacatatgtgcctgatggattt
ggagatattgtggatgctttatcagatccaaagaaatttctctcaattacagaaaagaga
gcagaccaaatgagagctatgggcattgaaactagtgacatagccgatgtgcccagtgac
acttccaaaaatgacaagaaaggaaaggccaacaccgccaaagcaaatgtgacccctcag
agtagctctgaactcagaccaacaaccacggctgccctggcctctggtgtggaagccaag
aaaggtattgaacttatccctcaagtaaggatagaagacttaaagcagatgaaggcttac
ttgaagcatttaaagaaacagcagaaggagctaaattctttaaagaagaaacatgcaaag
gaacacagtaccatgcagaagttacactgcacgcaagttgacaaaattgtggcacagtat
gacaaagagaagtcgactcaggagaaaatcctagagaaggcaatgaagaagaagggggga
agtaattgtctcgaaatgaaaaaagaaacagaaatcaaaattcagacgctgacatcagat
cacaaatctaaggtcaaagagattgtagcacagcacacgaaggaatggtcagaaatgatc
aatacccacagtgctgaggagcaagaaatccgagacctgcacctcagccagcagtgtgag
ctgctgaaaaagctactcatcaatgcccacgagcagcaaacccagcagctgaaactgtcc
catgacagggaaagcaaagaaatgcgagcacaccaggctaagatttctatggaaaatagc
aaagccatcagccaagataaatctatcaagaataaagcagagcgggaaaggcgagtcagg
gagttaaacagcagcaacactaaaaagtttctggaagaaagaaaaagactcgcaatgaag
cagtccaaagaaatggatcagttgaaaaaagtccagcttgaacatctagaattcctagag
aaacagaatgagcagcttttgaaatcctgtcatgcagtgtcccaaacgcaaggcgaagga
gatgcagcagatggtgaaattggaagccgagatggaccgcagaccagcaacagtagtatg
aaactccaaaatgcaaactga

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