Hylobates moloch (silvery gibbon): 116470775
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Entry
116470775 CDS
T08803
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1
KO
K05859
phosphatidylinositol phospholipase C, gamma-2 [EC:
3.1.4.11
]
Organism
hmh
Hylobates moloch (silvery gibbon)
Pathway
hmh00562
Inositol phosphate metabolism
hmh01100
Metabolic pathways
hmh01521
EGFR tyrosine kinase inhibitor resistance
hmh04012
ErbB signaling pathway
hmh04014
Ras signaling pathway
hmh04020
Calcium signaling pathway
hmh04062
Chemokine signaling pathway
hmh04064
NF-kappa B signaling pathway
hmh04066
HIF-1 signaling pathway
hmh04070
Phosphatidylinositol signaling system
hmh04072
Phospholipase D signaling pathway
hmh04360
Axon guidance
hmh04370
VEGF signaling pathway
hmh04380
Osteoclast differentiation
hmh04611
Platelet activation
hmh04613
Neutrophil extracellular trap formation
hmh04625
C-type lectin receptor signaling pathway
hmh04650
Natural killer cell mediated cytotoxicity
hmh04662
B cell receptor signaling pathway
hmh04664
Fc epsilon RI signaling pathway
hmh04666
Fc gamma R-mediated phagocytosis
hmh04670
Leukocyte transendothelial migration
hmh04722
Neurotrophin signaling pathway
hmh04750
Inflammatory mediator regulation of TRP channels
hmh04919
Thyroid hormone signaling pathway
hmh04933
AGE-RAGE signaling pathway in diabetic complications
hmh04935
Growth hormone synthesis, secretion and action
hmh05167
Kaposi sarcoma-associated herpesvirus infection
hmh05169
Epstein-Barr virus infection
hmh05170
Human immunodeficiency virus 1 infection
hmh05171
Coronavirus disease - COVID-19
hmh05200
Pathways in cancer
hmh05205
Proteoglycans in cancer
hmh05206
MicroRNAs in cancer
hmh05214
Glioma
hmh05223
Non-small cell lung cancer
hmh05225
Hepatocellular carcinoma
Module
hmh_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:
hmh00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
116470775 (PLCG2)
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
116470775 (PLCG2)
04064 NF-kappa B signaling pathway
116470775 (PLCG2)
04066 HIF-1 signaling pathway
116470775 (PLCG2)
04070 Phosphatidylinositol signaling system
116470775 (PLCG2)
04072 Phospholipase D signaling pathway
116470775 (PLCG2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
116470775 (PLCG2)
04613 Neutrophil extracellular trap formation
116470775 (PLCG2)
04650 Natural killer cell mediated cytotoxicity
116470775 (PLCG2)
04662 B cell receptor signaling pathway
116470775 (PLCG2)
04664 Fc epsilon RI signaling pathway
116470775 (PLCG2)
04666 Fc gamma R-mediated phagocytosis
116470775 (PLCG2)
04670 Leukocyte transendothelial migration
116470775 (PLCG2)
04062 Chemokine signaling pathway
116470775 (PLCG2)
09152 Endocrine system
04935 Growth hormone synthesis, secretion and action
116470775 (PLCG2)
04919 Thyroid hormone signaling pathway
116470775 (PLCG2)
09156 Nervous system
04722 Neurotrophin signaling pathway
116470775 (PLCG2)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
116470775 (PLCG2)
09158 Development and regeneration
04360 Axon guidance
116470775 (PLCG2)
04380 Osteoclast differentiation
116470775 (PLCG2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
116470775 (PLCG2)
05206 MicroRNAs in cancer
116470775 (PLCG2)
05205 Proteoglycans in cancer
116470775 (PLCG2)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
116470775 (PLCG2)
05214 Glioma
116470775 (PLCG2)
05223 Non-small cell lung cancer
116470775 (PLCG2)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
116470775 (PLCG2)
05171 Coronavirus disease - COVID-19
116470775 (PLCG2)
05167 Kaposi sarcoma-associated herpesvirus infection
116470775 (PLCG2)
05169 Epstein-Barr virus infection
116470775 (PLCG2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
116470775 (PLCG2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
116470775 (PLCG2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hmh04131
]
116470775 (PLCG2)
Enzymes [BR:
hmh01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
116470775 (PLCG2)
Membrane trafficking [BR:
hmh04131
]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
116470775 (PLCG2)
Endocytosis
Macropinocytosis
Phospholipase C
116470775 (PLCG2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PI-PLC-X
SH2
PI-PLC-Y
EF-hand_PLCG2
C2
SH3_1
SH3_9
PH
PH_12
EF-hand_PLCG1
SH2_1
SH3_2
PH_14
EF-hand_like
GDPD
Motif
Other DBs
NCBI-GeneID:
116470775
NCBI-ProteinID:
XP_032012228
LinkDB
All DBs
Position
Unknown
AA seq
1265 aa
AA seq
DB search
MSTIVNVDSLAEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAV
NWLSGLKILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSA
KFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDC
WDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEQHCSVEQQRHMAKA
FKEVFGDLLLMKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNVEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTVEEEVPQDIPPTELHFGEKWFHKKVEKR
TSAEKLLQEYCLETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYY
LTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDML
MRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY
EKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADVEELEKQII
EDNPLGSLCRGILDLNTYNVVKAPQGKNQKPFVFILEPKKQGDPPVEFATDRVEELFEWF
QSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSIIRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKY
MQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSI
ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKAIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALIKEFNVNENQLQLYQEKCNKRLREKRVSN
SKFYS
NT seq
3798 nt
NT seq
+upstream
nt +downstream
nt
atgtccaccatagtcaatgtggattcccttgcggagtatgagaagagccagatcaagaga
gccctggagctggggacggtgatgactgtgttcagcttccgtaagtccacccctgagcgg
aggaccgtccaggtgatcatggagacgcggcaggtggcctggagcaagaccgctgacaag
atcgagggcttcttggatatcatggaaataaaagaaatccgcccagggaagaactccaaa
gatttcgagcgagcaaaagcagttcgccagaaagaagactgctgcttcaccatcctgtat
ggcactcagttcgtcctcagcacgctcagcttggcagctgactctaaagaagatgcagtt
aattggctctctggcttgaaaatcttacaccaagaagcaatgaatgcgtccacacccacc
attatcgagagttggctgagaaagcagatatattctgtggatcaaaccagaagaaacagc
atcagtctccgagagttgaagaccatcttgcccctgatcaactttaaagtgagcagtgcc
aagttccttaaagataagtttgtggaaataggagcacacaaagatgagctcagctttgaa
cagttccatctcttctataaaaaacttatgtttgaacagcaaaaatcgattcttgatgaa
ttcaaaaaggattcgtccgtgttcatcctggggaacactgacaggccggatgcctccgct
gtttacctgcatgacttccagaggtttctcatacatgaacagcaggagcattgggctcag
gatctgaacaaagtccgtgagcggatgacaaagttcattgacgacaccatgcgtgaaact
gctgagcctttcttgtttgtggatgagttcctcacatacctgttttcacgagaaaacagc
atctgggatgagaagtatgatgcggtggacatgcaggacatgaacaaccccctgtctcat
tactggatctcctcgtctcataatacgtacctcacaggtgaccagctgcggagcgagtca
tccccggaagcttacatccgctgcctgcgcatgggctgtcgctgcattgaactggactgc
tgggacgggcccgatgggaagccggtcatctaccacggctggacgcggaccaccaagatc
aaatttgacgacgtcgtgcaggccatcaaagaccacgcgtttgttacctcgagcttccca
gtgatcctctccattgagcagcactgcagcgtggaacagcagcgccacatggccaaggcc
ttcaaggaagtgtttggcgacctgctgctgatgaagcccacggaggccagcgctgaccag
ctgccctcacccagccagctgcgggagaagatcatcatcaagcataagaagctgggcccc
cgaggcgacgtggatgtcaacgtggaggacaagaaggatgagcacaagcaacagggagag
ctgtacatgtgggattccattgaccagaaatggactcggcactactgcgccatcgccgat
gccaagctgtccttcagtgatgacattgaacagactgtggaggaggaagtgccccaggat
ataccccccacagagctacattttggggagaaatggttccacaagaaggtggagaagagg
acgagtgccgagaagttgctgcaggaatactgcctggagacggggggcaaggatggcacc
ttcctggttcgggagagtgagaccttccccaatgactacaccctgtccttctggcggtca
ggccgggtgcagcactgccggatccgctccaccatggagggcgggaccctgaaatactac
ctgactgacaacctcaccttcagcagcatctatgccctcatccagcactaccgtgagacg
cacctgcgctgcgctgagttcgagctgcggctcacggaccctgtgcccaaccccaacccc
catgagtcgaagccgtggtactatgatagcctgagccgtggagaggcagaggacatgctg
atgaggattccccgggacggagccttcctgatccggaagcgagagggaagcgactcctac
gccatcaccttcagggctaggggcaaggtaaagcactgtcgcatcaaccgggacggccgg
cactttgtgctggggacctccgcctattttgagagcctagtggagctcgtcagttactac
gagaagcattcactctaccgaaagatgagactgcgctaccccgtgacccccgagctcttg
gagcgctacaatatggaaagagatataaactccctctacgatgtcagcagaatgtatgtg
gatcccagtgaaatcaatccgtccatgcctcagagaaccgtgaaagctctgtatgactac
aaagccaagcgaagcgatgagctgagcttctgccgtggggccctcatccacaatgtctcc
aaggagcctgggggctggtggaaaggagactatggaaccaggatccagcagtacttccca
tccaactacgtcgaggacatttcaactgcagatgtcgaggagctagaaaagcagattatt
gaagacaatcccttagggtctctttgcagaggaatattggacctcaatacctataacgtc
gtgaaagcccctcagggaaaaaaccagaagccctttgtctttatcctggagcccaagaag
cagggcgatcctccggtggagtttgccacagacagggtggaggagctcttcgagtggttt
cagagcatccgagagatcacctggaagattgacaccaaggagaacaacatgaagtactgg
gagaagaaccagtccatcgccatcgagctctctgacctggttgtctactgcaaaccaacc
agcaaaaccaaggacaacttagaaaatcctgacttccgagaaatccgctcctttgtggag
acaaaggctgacagcatcatcagacagaagcccgtcgacctcctgaagtacaatcaaaag
ggcctgactcgcgtctacccaaagggacaaagagttgactcttcaaactacgaccccttc
cgcctctggctgtgcggttctcagatggtggcactcaatttccagacagcagataagtac
atgcagatgaatcacgcgttgttttctctcaatgggcgcacgggctacgttctgcagcct
gagagcatgaggacagagaaatatgacccgatgccacccgagtcccagaggaagatcctg
atgacgctgacggtcaaggttctcggtgctcgccatctccccaaacttggacgaagtatt
gcctgtccctttgtagaggtagagatctgtggagccgagtatgacaacaacaagttcaag
acgacggttgtgaatgataatggcctcagccctatctgggctccaacacaggagaaggta
acgtttgaaatttatgacccaaacctggcatttctgcgcttcgtggtttacgaagaagac
atgttcagcgatcccaactttcttgcccatgccacttaccccattaaagcaatcaaatca
ggattcaggtccgttcctctgaagaatgggtacagcgaggacatagaactggcttctctc
ctggttttctgtgagatgcggccggtactggagagcgaagaggaactttactcttcctgt
cgccagctgaggaggcggcaagaagaactgaacaaccagctctttctgtatgacacacac
cagaacttgcgcaatgccaaccgggatgccctgattaaagagttcaatgttaatgagaac
cagctccagctgtaccaggagaaatgcaacaagaggttaagagagaagagagtcagcaac
agcaagttttattcatag
DBGET
integrated database retrieval system
