Hylobates moloch (silvery gibbon): 116480074
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Entry
116480074 CDS
T08803
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
hmh
Hylobates moloch (silvery gibbon)
Pathway
hmh05012
Parkinson disease
hmh05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
hmh00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
116480074 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
116480074 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hmh01001
]
116480074 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hmh04131
]
116480074 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
hmh04147
]
116480074 (LRRK2)
Enzymes [BR:
hmh01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
116480074 (LRRK2)
Protein kinases [BR:
hmh01001
]
Serine/threonine kinases: TKL group
LRRK family
116480074 (LRRK2)
Membrane trafficking [BR:
hmh04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
116480074 (LRRK2)
Exosome [BR:
hmh04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
116480074 (LRRK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
Roc
LRR_8
COR
LRR_4
Ras
LRR_14
WDR55
LRR_9
LRR_13
Arf
Ank_2
GTP_EFTU
Beta-prop_EML_2
Beta-prop_RSE1_2nd
nSTAND3
T2SSE
LRR_NXF1-5
AAA_22
Beta-prop_WDR19_1st
ABC_tran
TrwB_AAD_bind
AAA_7
Beta-prop_BBS7
MMR_HSR1
Kdo
PduV-EutP
SRPRB
AAA_16
NACHT
WD40_CDC20-Fz
Septin
cobW
WD40_like
G-alpha
MobB
Beta-prop_RIG_2nd
WD40_Prp19
ResIII
AAA_29
FtsK_SpoIIIE
LRR_6
TniB
TsaE
AAA_23
WD40_WDHD1_1st
Motif
Other DBs
NCBI-GeneID:
116480074
NCBI-ProteinID:
XP_058282174
LinkDB
All DBs
Position
Unknown
AA seq
2324 aa
AA seq
DB search
MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSEHASKLFQGKNI
HVPLLIVLDSYMRVASVQQVGWSLLCKLIEICPGTMQSLMGPQDVGNDWEVLGVHQLILK
MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG
CKALCVLFERVSEEQLIEFVENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVE
VLMSGNVRCYNIVVEAMKAFPISEQIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ
QYPENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEDKLFWLEACYKALTWH
RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQASAN
ALSTLLEQNGKQWTISSNKGKHIFGFQTILAILKLSASFSKLLVHHSFDLLIFHQMSSDI
MEQKDKQFLNLCCKCFAKVAMDDDLKNVMLERACDQNNSIMVECLLLLGADANQTKEGSS
LICQVCEKGSSPKLVELLLNSGSREQDVRKALTISIGKGDSQIISLLLRRLALDVANNSI
CLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLARMVIRYQMKSAVEEGTASGSDGN
FSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEGSFLVKKKSNSISVGEFYQDAVLQ
RCSPNLQRHSNSLGPIFDHEDLLRRKRKILSSDDSLRSSKLQSHMKHSDSISSLASEREY
ITSLDLSANELRDIDVLSQKCCISGHLEHLEKLELHQNALTSFPQQLCETLKSLTHLDLH
SNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLT
DVVEKLEQLILEGNKISEIYFPLRLKELKILNLNKNHISSLSENFLEACPKVESFSARMN
FLAAMPFLPPSMTSLKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLR
ELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRS
FPNEMGKLSKIWDLPLDELRLNFDFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNT
GSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQIRGKRKRDLILNVWDFAGHEEFYS
THPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRK
ACVSKITKELLNKRGFPAIRDYHFVNATEESDALAKLRKTIINESLNFKIRDQLVVGQLI
PDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVRENQLQLDENELPHAVHFLNESGVLL
HFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPKHPKGIISRRDVEKFLSKKRRFPK
NYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMG
FWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFL
KITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEEHQ
KILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEF
LLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPR
MLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF
TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL
YDILTTGGRIVEGLKFPNEFDELAIQGKLPDPVKEYGCAPWPVVEKLIKKCLKENPQERP
TSAQVFDTLNSAELVCLMRHILLPKNVIVECMVATRHNSRNASIWLGCGHNDRGQLSFLD
LNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTKDGKKRHTLEKMTD
SVTCLYCNSFSKQSKQKNFLLVGTADGNLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCL
SESTNSTERNVTWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTAL
YIAKQNSPVVEVWDKKTEKLCELIDCVHFLREVTVKENKESKHKMSYSGRVKTLCLQKNT
ALWIGTGGGHILLLDLSTRRVIRIIYNFCDSVRVMMTAQLGNLKNVMLVLGYNWKSTEGT
QQQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMRGTSVE
NT seq
6975 nt
NT seq
+upstream
nt +downstream
nt
atggctagtggcagctgtcaggggtgcgaggaggacgaggaaactctgaagaagttgata
gtcaggctgaacaatgtccaggaaggaaaacagatagaaacgctggtccaaatcctggag
gatctgctggtgttcacgtactccgagcacgcctccaagttatttcaaggcaaaaatatc
catgtgcctctgttgatcgtcttggactcctatatgagagtcgcgagtgtgcagcaggtg
ggttggtcacttctgtgcaaattaatagaaatctgtccaggtacaatgcaaagcttaatg
ggaccccaggatgttggaaatgattgggaagtccttggtgttcaccaattgattcttaaa
atgctaacagttcataatgccagtgtaaacttgtcagtgattggactgaagaccttagat
ctcctcctaacttcaggtaaaatcaccttgctgatattggatgaagaaagtgatattttc
atgttaatttttgatgccatgcactcatttccagccaatgatgaagtccagaaacttgga
tgcaaagctttatgtgtgctgtttgagagagtctcagaggagcaactgattgaatttgtt
gagaacaaagattatatgatattgttaagtgcattaacaaattttaaagatgaagaggaa
attgtgcttcatgtgctgcattgtttacattccctagcgattccttgcaataatgtggaa
gtcctcatgagtggcaatgtcaggtgttataatattgtggtggaagctatgaaagcattc
cctatcagtgaacaaattcaagaagtgagttgctgtttgctccataggcttacattaggt
aattttttcaatatcctggtattaaacgaagtccatgagtttgtggtgaaagctgtgcag
cagtacccagagaacgcagcattacagatctcagcgctcagctgtttggccctcctcact
gagactattttcttaaatcaagatttagaggaaaagaatgagaatcaagagaatgatgat
gagggtgaagaagataaattgttttggctggaagcctgttacaaagcattaacatggcat
agaaagaacaagcacgtgcaggaggccgcgtgctgggcactaaataatctccttatgtac
caaaacagtttacatgagaagattggagatgaagatggccatttcccagctcatagggaa
gtgatgctctccatgctgatgcattcttcatcaaaggaagttttccaggcatctgcgaat
gcattgtcaactctcttagaacaaaatggtaagcagtggaccatatcgtcaaataaaggg
aaacacatttttggatttcagacaatcttagcaatcctcaaattgtcagcatctttttct
aagctgctggtgcatcattcatttgacttattaatattccatcaaatgtcttccgatatc
atggaacaaaaggataaacagtttctaaacctctgttgtaagtgttttgcaaaagtagct
atggatgatgacttaaaaaatgtgatgctagagagagcatgtgatcagaataacagcatc
atggttgaatgcttgcttctgttgggagcagatgccaatcaaacaaaggagggatcttct
ttaatttgtcaggtatgtgagaaagggagcagtcccaaattggtggaactcttactgaat
agtggatctcgtgaacaagatgtacgaaaagcgctgacgataagcattgggaaaggtgac
agccagatcatcagcttgctcttaaggaggctggccctggatgtggccaacaatagcatt
tgccttggaggattttgtataggaaaagttgaaccttcttggcttggtcctttatttcca
gataagacttctaatttaaggaaacaaacaaatatagcatctacactagcaagaatggtg
atcagatatcagatgaaaagtgctgtggaagaaggaacagcctcaggcagcgatggaaat
ttttctgaagatgtgctgtctaaatttgatgaatggacgtttattcctgactcttctatg
gacagtgtgtttgctcaaagtgatgacctggatagtgaaggaagtgaaggctcatttctt
gtgaaaaagaaatctaattcaattagtgtaggagaattttaccaagatgccgtattacag
cgttgctcaccaaatttgcaaagacattccaattccttggggcccatttttgatcatgaa
gatttactgaggcgaaaaagaaaaatattatcttcagatgattcgctcaggtcatcaaaa
cttcaatcccatatgaagcattcagacagcatttcttctctggcttctgagagagaatat
attacatcactagatctttcagcaaatgaactaagagatattgatgtcctgagccagaaa
tgctgtataagtggtcatttggagcatcttgaaaagctggagcttcaccagaatgcactc
acgagctttccacaacagctgtgtgaaactctgaagagtttgacacatttggacttgcac
agtaataaatttacatcatttccttcttacttgttgaaaatgagttgtattgctaacctt
gatgtctctcgaaatgacattggaccctcagtggttttagatcctacagtgaaatgtcca
actctgaaacagtttaacctgtcatataaccagctgtcttttgtacctgagaacctcact
gatgtagtagagaaactggagcagctcattttagaaggaaataaaatatcagagatatac
ttccccttgagactgaaggaactgaagattttaaaccttaataagaaccacatttcatcc
ctatcagagaactttcttgaggcttgtcctaaagtggagagtttcagtgccagaatgaat
tttcttgctgctatgcctttcttgcctccttccatgacaagcctaaaattatctcagaac
aaattttcatgtattccagaagcaattttaaatcttccacacttgcggtctttagatatg
agcagcaatgatattcagtatctaccaggtcctgcacactggaaatctttgaacttaagg
gaactcttatttagccataatcagatcagcatcttggacttgagtgaaaaagcatattta
tggtctagagtagagaaactgcatctttctcacaataaactgaaagagattcctcctgag
attggctgtcttgaaaatctgacgtctctggatgtcagctacaacttggaactaagatcc
tttcccaatgaaatggggaaattaagcaaaatatgggatcttcctttggatgaactgcgt
cttaactttgattttaaacatataggatgtaaagccaaagacatcataaggtttcttcaa
cagcggttaaaaaaggctgtgccttataaccgaatgaaacttatgattgtgggaaatact
gggagtggtaaaaccaccttattgcagcaattaatgaaaaccaagaaatcagatcttgga
atgcaaagtgccacagttggcatagatgtgaaagactggcctatccaaataagaggcaaa
agaaagagagatctcatcctaaatgtgtgggattttgcaggtcatgaggaattctatagt
actcatccccattttatgacgcagcgagcattgtaccttgctgtctatgacctcagcaag
ggacaggctgaagttgatgccatgaagccttggctcttcaatataaaggctcgcgcttct
tcttcccctgtgattctcgttggcacacatttggatgtttctgatgagaagcaacgcaaa
gcctgcgtaagtaaaatcaccaaggaactcctgaataagcgagggttccctgccatacga
gattaccactttgtgaatgccaccgaggaatctgatgctttggcaaaacttcggaaaacc
atcataaacgagagccttaatttcaagatccgagatcagcttgttgttggacagctgatt
ccagactgctatgtagaacttgagaaaatcattttatccgagcgtaaaaacgtgccaatt
gaatttcctgtaattgaccggaaacgattattacaactagtgagagaaaatcagctgcag
ttagatgaaaatgagcttcctcacgcagttcactttttaaatgaatcaggagtccttctt
cattttcaagacccagcactgcagttaagtgacttgtactttgtggaacccaagtggctt
tgtaaaatcatggcacagattttgacagtgaaagtggaaggttgtccaaaacaccctaag
ggaattatttcgcgtagagatgtggaaaaatttctttcaaagaaaaggagatttccaaag
aactacatgtcacagtattttaagctcctagaaaaattccagattgctttgccaatagga
gaagaatatttgctggttccaagcagtttgtctgaccacaggcctgtgatagagcttccc
cattgtgagaactctgaaattatcatccgtttatatgaaatgccttattttccaatggga
ttttggtcaagattaatcaatcgattacttgagatttcaccttacatgctttcagggaga
gaacgagcacttcgcccaaacagaatgtattggcgacaaggcatttacttaaattggtct
cctgaagcttattgtctggtaggatctgaagtcttagacaatcatccagagagtttctta
aaaattacagttccttcttgtagaaaaggctgtattcttttgggccaagtagtggaccac
attgattctctcatggaagaatggtttcctgggctgctggagattgacatttgtggtgaa
ggagaaactctgttgaagaaatgggcgttatatagttttaatgatggtgaagaacatcaa
aaaatcttacttgatgacttgatgaagaaagcagaggaaggagatctcttagtaaatcca
gatcaaccaaggctcaccattccaatatctcagattgcccctgacttgattttggctgac
ctgcctagaaatattatgttgaataatgatgagttggaatttgaacaagctccagagttt
ctcctaggtgatggcagttttggatcagtttatcgagcagcctatgaaggagaagaagtg
gctgtgaagatttttaataaacatacatcacttaggctgttaagacaagagcttgtggtg
ctttgccacctccaccaccccagtttgatatctctgctggcagctgggattcgtccccgg
atgttggtgatggagttagcctccaagggttccttggatcgcctgcttcagcaggacaaa
gccagcctcactagaactctacagcacaggattgcactccatgtagctgatggtttgaga
tacctccactcagccatgattatatacagagacttgaaaccccacaatgtgctgcttttc
accctgtatcccaatgctgccatcattgcaaagattgctgactacggcattgctcagtac
tgctgtagaatggggataaaaacatcagagggcacaccagggtttcgtgcacctgaagtt
gccagaggaaatgtcatttataaccaacaggctgatgtttattcatttggtttactactc
tatgacattttgacaactggaggtagaatagtagagggcttgaagtttccaaatgagttt
gatgaattagcaatacaaggaaaattacctgatccagttaaagaatatggttgtgcccca
tggcctgtggttgagaaattaattaaaaagtgtttgaaagaaaatcctcaagagaggcct
acttctgcccaggtctttgacactttgaattcagctgaattagtctgtctgatgagacac
attttattacctaaaaacgtaattgttgaatgcatggttgctacacgtcacaacagcagg
aatgcaagcatttggctgggctgtgggcacaacgacaggggacagctctcatttcttgac
ttaaatactgaaggatacacttctgaggaagttgccgatagtagaatattgtgcttagcc
ttggtgcatcttcctgttgaaaaggaaagctggattgtgtctgggacacagtctggtact
ctcctggtcatcaataccaaagatgggaaaaagagacataccctagaaaagatgactgat
tctgtcacttgtttgtattgcaattccttttccaagcaaagcaaacaaaaaaattttctt
ttggttggaaccgctgatggcaatttagcaatttttgaagataagactgttaagcttaaa
ggagctgctcctttgaagatactaaatataggaaatgtcagtactccattgatgtgtttg
agtgaatccacaaattcaacggaaagaaatgtaacgtggggaggatgtggcacaaagatt
ttctccttttctaatgatttcaccattcagaaactcattgagacaagaacaagccaacta
ttttcttatgcagctttcagtgattccaacatcataacagtggtggtagacaccgctctc
tatattgctaagcaaaatagccctgttgtggaagtgtgggataagaaaactgaaaaactc
tgcgaactaatagactgcgtgcactttttaagggaggtaacagtaaaagaaaacaaggaa
tctaaacacaaaatgtcttattctgggagagtgaaaactctctgccttcagaagaacact
gctctttggataggaactggaggaggccatattttactcctggatctttcaactcgtcga
gttatacgtataatttacaacttttgtgattcggtcagagtcatgatgacagcacagcta
ggcaaccttaaaaatgtcatgctggtattgggctacaactggaaaagtactgaaggtaca
caacagcagaaagagatacaatcttgcttgactgtttgggacatcaatcttccacatgaa
gtgcaaaatttagaaaaacacattgaagtgagaaaagaattagctgaaaaaatgagagga
acatctgttgaataa
DBGET
integrated database retrieval system
