KEGG   Hylobates moloch (silvery gibbon): 116480683
Entry
116480683         CDS       T08803                                 
Symbol
AKT2
Name
(RefSeq) RAC-beta serine/threonine-protein kinase
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
hmh  Hylobates moloch (silvery gibbon)
Pathway
hmh01521  EGFR tyrosine kinase inhibitor resistance
hmh01522  Endocrine resistance
hmh01524  Platinum drug resistance
hmh04010  MAPK signaling pathway
hmh04012  ErbB signaling pathway
hmh04014  Ras signaling pathway
hmh04015  Rap1 signaling pathway
hmh04022  cGMP-PKG signaling pathway
hmh04024  cAMP signaling pathway
hmh04062  Chemokine signaling pathway
hmh04066  HIF-1 signaling pathway
hmh04068  FoxO signaling pathway
hmh04071  Sphingolipid signaling pathway
hmh04072  Phospholipase D signaling pathway
hmh04140  Autophagy - animal
hmh04150  mTOR signaling pathway
hmh04151  PI3K-Akt signaling pathway
hmh04152  AMPK signaling pathway
hmh04210  Apoptosis
hmh04211  Longevity regulating pathway
hmh04213  Longevity regulating pathway - multiple species
hmh04218  Cellular senescence
hmh04261  Adrenergic signaling in cardiomyocytes
hmh04370  VEGF signaling pathway
hmh04371  Apelin signaling pathway
hmh04380  Osteoclast differentiation
hmh04510  Focal adhesion
hmh04517  IgSF CAM signaling
hmh04518  Integrin signaling
hmh04550  Signaling pathways regulating pluripotency of stem cells
hmh04611  Platelet activation
hmh04613  Neutrophil extracellular trap formation
hmh04620  Toll-like receptor signaling pathway
hmh04625  C-type lectin receptor signaling pathway
hmh04630  JAK-STAT signaling pathway
hmh04660  T cell receptor signaling pathway
hmh04662  B cell receptor signaling pathway
hmh04664  Fc epsilon RI signaling pathway
hmh04666  Fc gamma R-mediated phagosome formation
hmh04668  TNF signaling pathway
hmh04722  Neurotrophin signaling pathway
hmh04725  Cholinergic synapse
hmh04728  Dopaminergic synapse
hmh04810  Regulation of actin cytoskeleton
hmh04910  Insulin signaling pathway
hmh04914  Progesterone-mediated oocyte maturation
hmh04915  Estrogen signaling pathway
hmh04917  Prolactin signaling pathway
hmh04919  Thyroid hormone signaling pathway
hmh04920  Adipocytokine signaling pathway
hmh04922  Glucagon signaling pathway
hmh04923  Regulation of lipolysis in adipocytes
hmh04926  Relaxin signaling pathway
hmh04929  GnRH secretion
hmh04931  Insulin resistance
hmh04932  Non-alcoholic fatty liver disease
hmh04933  AGE-RAGE signaling pathway in diabetic complications
hmh04935  Growth hormone synthesis, secretion and action
hmh04936  Alcoholic liver disease
hmh04973  Carbohydrate digestion and absorption
hmh05010  Alzheimer disease
hmh05017  Spinocerebellar ataxia
hmh05132  Salmonella infection
hmh05135  Yersinia infection
hmh05142  Chagas disease
hmh05145  Toxoplasmosis
hmh05152  Tuberculosis
hmh05160  Hepatitis C
hmh05161  Hepatitis B
hmh05162  Measles
hmh05163  Human cytomegalovirus infection
hmh05164  Influenza A
hmh05165  Human papillomavirus infection
hmh05166  Human T-cell leukemia virus 1 infection
hmh05167  Kaposi sarcoma-associated herpesvirus infection
hmh05168  Herpes simplex virus 1 infection
hmh05169  Epstein-Barr virus infection
hmh05170  Human immunodeficiency virus 1 infection
hmh05200  Pathways in cancer
hmh05205  Proteoglycans in cancer
hmh05207  Chemical carcinogenesis - receptor activation
hmh05208  Chemical carcinogenesis - reactive oxygen species
hmh05210  Colorectal cancer
hmh05211  Renal cell carcinoma
hmh05212  Pancreatic cancer
hmh05213  Endometrial cancer
hmh05214  Glioma
hmh05215  Prostate cancer
hmh05218  Melanoma
hmh05220  Chronic myeloid leukemia
hmh05221  Acute myeloid leukemia
hmh05222  Small cell lung cancer
hmh05223  Non-small cell lung cancer
hmh05224  Breast cancer
hmh05225  Hepatocellular carcinoma
hmh05226  Gastric cancer
hmh05230  Central carbon metabolism in cancer
hmh05231  Choline metabolism in cancer
hmh05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hmh05415  Diabetic cardiomyopathy
hmh05417  Lipid and atherosclerosis
hmh05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:hmh00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    116480683 (AKT2)
   04012 ErbB signaling pathway
    116480683 (AKT2)
   04014 Ras signaling pathway
    116480683 (AKT2)
   04015 Rap1 signaling pathway
    116480683 (AKT2)
   04370 VEGF signaling pathway
    116480683 (AKT2)
   04371 Apelin signaling pathway
    116480683 (AKT2)
   04630 JAK-STAT signaling pathway
    116480683 (AKT2)
   04668 TNF signaling pathway
    116480683 (AKT2)
   04066 HIF-1 signaling pathway
    116480683 (AKT2)
   04068 FoxO signaling pathway
    116480683 (AKT2)
   04072 Phospholipase D signaling pathway
    116480683 (AKT2)
   04071 Sphingolipid signaling pathway
    116480683 (AKT2)
   04024 cAMP signaling pathway
    116480683 (AKT2)
   04022 cGMP-PKG signaling pathway
    116480683 (AKT2)
   04151 PI3K-Akt signaling pathway
    116480683 (AKT2)
   04152 AMPK signaling pathway
    116480683 (AKT2)
   04150 mTOR signaling pathway
    116480683 (AKT2)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    116480683 (AKT2)
   04518 Integrin signaling
    116480683 (AKT2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    116480683 (AKT2)
  09143 Cell growth and death
   04210 Apoptosis
    116480683 (AKT2)
   04218 Cellular senescence
    116480683 (AKT2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    116480683 (AKT2)
   04550 Signaling pathways regulating pluripotency of stem cells
    116480683 (AKT2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    116480683 (AKT2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    116480683 (AKT2)
   04613 Neutrophil extracellular trap formation
    116480683 (AKT2)
   04620 Toll-like receptor signaling pathway
    116480683 (AKT2)
   04625 C-type lectin receptor signaling pathway
    116480683 (AKT2)
   04660 T cell receptor signaling pathway
    116480683 (AKT2)
   04662 B cell receptor signaling pathway
    116480683 (AKT2)
   04664 Fc epsilon RI signaling pathway
    116480683 (AKT2)
   04666 Fc gamma R-mediated phagosome formation
    116480683 (AKT2)
   04062 Chemokine signaling pathway
    116480683 (AKT2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    116480683 (AKT2)
   04922 Glucagon signaling pathway
    116480683 (AKT2)
   04923 Regulation of lipolysis in adipocytes
    116480683 (AKT2)
   04920 Adipocytokine signaling pathway
    116480683 (AKT2)
   04929 GnRH secretion
    116480683 (AKT2)
   04915 Estrogen signaling pathway
    116480683 (AKT2)
   04914 Progesterone-mediated oocyte maturation
    116480683 (AKT2)
   04917 Prolactin signaling pathway
    116480683 (AKT2)
   04926 Relaxin signaling pathway
    116480683 (AKT2)
   04935 Growth hormone synthesis, secretion and action
    116480683 (AKT2)
   04919 Thyroid hormone signaling pathway
    116480683 (AKT2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    116480683 (AKT2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    116480683 (AKT2)
  09156 Nervous system
   04725 Cholinergic synapse
    116480683 (AKT2)
   04728 Dopaminergic synapse
    116480683 (AKT2)
   04722 Neurotrophin signaling pathway
    116480683 (AKT2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    116480683 (AKT2)
  09149 Aging
   04211 Longevity regulating pathway
    116480683 (AKT2)
   04213 Longevity regulating pathway - multiple species
    116480683 (AKT2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    116480683 (AKT2)
   05205 Proteoglycans in cancer
    116480683 (AKT2)
   05207 Chemical carcinogenesis - receptor activation
    116480683 (AKT2)
   05208 Chemical carcinogenesis - reactive oxygen species
    116480683 (AKT2)
   05230 Central carbon metabolism in cancer
    116480683 (AKT2)
   05231 Choline metabolism in cancer
    116480683 (AKT2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    116480683 (AKT2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    116480683 (AKT2)
   05212 Pancreatic cancer
    116480683 (AKT2)
   05225 Hepatocellular carcinoma
    116480683 (AKT2)
   05226 Gastric cancer
    116480683 (AKT2)
   05214 Glioma
    116480683 (AKT2)
   05221 Acute myeloid leukemia
    116480683 (AKT2)
   05220 Chronic myeloid leukemia
    116480683 (AKT2)
   05218 Melanoma
    116480683 (AKT2)
   05211 Renal cell carcinoma
    116480683 (AKT2)
   05215 Prostate cancer
    116480683 (AKT2)
   05213 Endometrial cancer
    116480683 (AKT2)
   05224 Breast cancer
    116480683 (AKT2)
   05222 Small cell lung cancer
    116480683 (AKT2)
   05223 Non-small cell lung cancer
    116480683 (AKT2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    116480683 (AKT2)
   05170 Human immunodeficiency virus 1 infection
    116480683 (AKT2)
   05161 Hepatitis B
    116480683 (AKT2)
   05160 Hepatitis C
    116480683 (AKT2)
   05164 Influenza A
    116480683 (AKT2)
   05162 Measles
    116480683 (AKT2)
   05168 Herpes simplex virus 1 infection
    116480683 (AKT2)
   05163 Human cytomegalovirus infection
    116480683 (AKT2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    116480683 (AKT2)
   05169 Epstein-Barr virus infection
    116480683 (AKT2)
   05165 Human papillomavirus infection
    116480683 (AKT2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    116480683 (AKT2)
   05135 Yersinia infection
    116480683 (AKT2)
   05152 Tuberculosis
    116480683 (AKT2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    116480683 (AKT2)
   05142 Chagas disease
    116480683 (AKT2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    116480683 (AKT2)
   05017 Spinocerebellar ataxia
    116480683 (AKT2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    116480683 (AKT2)
   05418 Fluid shear stress and atherosclerosis
    116480683 (AKT2)
   05415 Diabetic cardiomyopathy
    116480683 (AKT2)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    116480683 (AKT2)
   04932 Non-alcoholic fatty liver disease
    116480683 (AKT2)
   04931 Insulin resistance
    116480683 (AKT2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    116480683 (AKT2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    116480683 (AKT2)
   01524 Platinum drug resistance
    116480683 (AKT2)
   01522 Endocrine resistance
    116480683 (AKT2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hmh01001]
    116480683 (AKT2)
Enzymes [BR:hmh01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     116480683 (AKT2)
Protein kinases [BR:hmh01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   116480683 (AKT2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_20 Seadorna_VP7
Other DBs
NCBI-GeneID: 116480683
NCBI-ProteinID: XP_032028808
LinkDB
Position
Unknown
AA seq 481 aa
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC
QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPM
DYKCGSPSDSSMAEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM
KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH
LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG
ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFE
LILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQK
KLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIR
E
NT seq 1446 nt   +upstreamnt  +downstreamnt
atgaacgaggtgtctgtcatcaaagaaggctggctccacaagcgtggtgaatacatcaag
acctggaggccacggtacttcctgctgaagagcgacggctccttcattgggtacaaggag
aggcccgaggcccctgatcagaccctaccccccttaaacaacttctctgtagcagaatgc
cagctgatgaagaccgagaggccgcgacccaacacctttgtcatacgctgcctgcagtgg
accacagtcatcgagaggaccttccacgtggattctccagatgagagggaggagtggatg
cgggccatccagatggtcgccaacagcctcaaacagcgggccccaggcgaggaccccatg
gactacaagtgtggctcccctagtgactcctccatggctgaggagatggaagtggcggtc
agcaaggcacgggctaaagtgaccatgaatgacttcgactatctcaaactccttggcaag
ggaacctttggcaaagtcatcctggtgcgggagaaggccactggccgctactacgccatg
aagatcctgcggaaggaagtcatcattgccaaggatgaagtcgctcacacagtcaccgag
agccgggtcctccagaacaccaggcacccattcctgactgcgctgaagtacgccttccag
acccacgaccgcctgtgcttcgtgatggagtacgccaacgggggtgagctattcttccac
ctgtcccgggagcgtgtcttcacagaggagcgggcccggttttatggtgcagagatcgtc
tcggctcttgagtacttgcactcgcgggacgtggtatatcgcgacatcaagctggaaaac
ctcatgctggacaaagatggccacatcaagatcactgactttggcctctgcaaagaaggc
atcagtgacggggccaccatgaaaaccttctgtgggaccccggagtacctggcgcctgag
gtgctggaggacaatgactatggccgggccgtggactggtgggggctgggcgtggtcatg
tacgagatgatgtgcggccgcctgcccttctacaaccaggaccacgagcgcctcttcgag
ctcatcctcatggaagagatccgcttcccgcgcacgctcagccccgaggccaagtccctg
cttgccgggctgcttaagaaggaccccaagcagaggcttggtggggggcccagcgatgcc
aaggaggtcatggagcacaggttcttcctcagcatcaactggcaggacgtggtccagaag
aagctcctgccacccttcaaacctcaggtcacgtccgaggtcgacacaaggtacttcgat
gatgaattcaccgcccagtccatcacaatcacaccccctgaccgctatgacagcctgggc
ttactggagctggaccagcggacccacttcccccagttctcctactcggccagcatccgc
gagtga

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