Haemophilus pittmaniae: NCTC13334_02006
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Entry
NCTC13334_02006 CDS
T06001
Symbol
thrA
Name
(GenBank) fused aspartokinase I and homoserine dehydrogenase I
KO
K12524
bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:
2.7.2.4
1.1.1.3
]
Organism
hpit
Haemophilus pittmaniae
Pathway
hpit00260
Glycine, serine and threonine metabolism
hpit00261
Monobactam biosynthesis
hpit00270
Cysteine and methionine metabolism
hpit00300
Lysine biosynthesis
hpit01100
Metabolic pathways
hpit01110
Biosynthesis of secondary metabolites
hpit01120
Microbial metabolism in diverse environments
hpit01230
Biosynthesis of amino acids
Module
hpit_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
hpit_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
hpit_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
hpit00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
NCTC13334_02006 (thrA)
00270 Cysteine and methionine metabolism
NCTC13334_02006 (thrA)
00300 Lysine biosynthesis
NCTC13334_02006 (thrA)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
NCTC13334_02006 (thrA)
Enzymes [BR:
hpit01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
NCTC13334_02006 (thrA)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
NCTC13334_02006 (thrA)
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Ortholog
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Gene cluster
GFIT
Motif
Pfam:
Homoserine_dh
AA_kinase
ACT_9
NAD_binding_3
ACT_7
ACT
DUF1131
Sacchrp_dh_NADP
PAC2
DUF3158
Motif
Other DBs
NCBI-ProteinID:
SNV89374
LinkDB
All DBs
Position
1:complement(2107126..2109573)
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AA seq
815 aa
AA seq
DB search
MRVLKFGGTSLANPERFSQAARLIEQAHLADQAAGVLSAPAKITNHLVALSEKAALNQPT
DSHFNEAIEIFYNIINGLHAENNQFDLAATKSLIDAEFAQIKGLLEEIRQAGKVEDKVKA
TIDCRGEKLSIAMMKAWFEARGYSVHVVDPVKQLLAQGSYLESSVDIEESTKRVDAKSIG
KDKVVLMAGFTACNEKGELVLLGRNGSDYSAACLAACLGADVCEIWTDVDGVYTCDPRLV
SDARLLPALSYREAMELSYFGAKVIHPRTIGPLLPQRIPCVIKNTGNPTAAGSVIDGNVK
SEGLQVKGITNLDNVAMFNVSGPGMQGMVGMAARVFSAMSKAGISVILITQSSSEYSISF
CVPVKSAEAAKAVLEQEFAAELKAHQLEPIEVAKDLSIISVVGDGMKQAKGIAARFFSAL
AQANISLVAIAQGSSERSISAVVAQNKAIEAVKATHQALFNNKKVVDMFLVGVGGVGGEL
IEQIKQQKEYLAKKDIEIRVCALANSTKMLLDENGLNLDNWKADLENATQPSDFDVLLSF
IKLHHVVNPVFVDCTTAESVAGLYARALKEGFHVVTPNKKANTRELAYYHELRRNAQASQ
HKFLYETNVGAGLPVIENLQNLLAAGDELEYFEGILSGSLSFIFGKLEEGLSLSEVTALA
REKGFTEPDPRDDLSGQDVARKLLILAREAGLELELADVEVEGVLPQGFSEGKSADEFMA
MLPQLDAEFKARVEAAKAEGKVLRYVGQIKDGHCKVSIIAVDQNNPLYKVKDGENALAFY
TRYYQPIPLLLRGYGAGNAVTAAGIFADILRTLHH
NT seq
2448 nt
NT seq
+upstream
nt +downstream
nt
atgcgcgtattaaaattcggcggtacttcattagccaatccggagcgtttttcgcaagct
gcccgtttaattgaacaggctcatttagccgaccaggccgcaggtgttttatctgcccct
gccaaaataaccaatcatctggttgccctttctgaaaaagctgctttaaatcaacccacc
gattcccactttaatgaagccattgaaattttctataacatcattaatggcctacatgct
gaaaataatcaatttgatcttgccgcgacaaaatcccttattgatgcggaatttgcacaa
attaaaggcttgttagaagaaatccgtcaagcgggtaaagtagaagacaaggtaaaagcc
acaattgactgccgtggtgaaaaattatcaattgccatgatgaaagcttggtttgaagcc
agaggttatagtgttcatgtagtggatccggttaaacaattgttagctcaaggcagttat
ttagaatcttcagttgatattgaagaatccacaaaacgtgttgatgcgaaaagtatcggt
aaagataaagttgtgttaatggctggttttaccgcttgtaatgaaaaaggtgaattagtg
ctattaggccgtaatggttccgattattctgcagcttgtttggccgcttgtttaggggcg
gatgtttgtgaaatttggaccgatgtggatggcgtttatacctgtgatccccgcttagtg
tcggatgcccgtctattaccggctctgtcctaccgtgaagcaatggagctttcctatttt
ggggcgaaagtgatccatccgcgcactatcggcccattgttgccacaacgaattccttgc
gtgattaaaaatactggaaatccaactgcagcaggctcagtaattgatggcaatgtgaaa
tctgaaggtttgcaagtgaagggtattaccaatcttgataatgtagcaatgtttaacgta
tctggtcctggtatgcaggggatggtgggaatggctgcccgagttttctccgccatgtcc
aaagccggtatttccgtgatcttgattactcaatcttcttctgaatacagtattagtttt
tgtgttccggtgaaatcagcggaagcagcaaaagccgttttagagcaagaatttgccgca
gaattaaaagcacatcagttagaaccaattgaagttgccaaagatctttctattatctct
gttgtcggtgatggcatgaaacaggctaaaggtatcgcagctcgtttcttctccgcattg
gctcaagcgaatatcagcttagtggcaattgcacaaggttcttctgagcgttcaatttca
gcagttgtcgcacaaaataaagcaattgaagcagtgaaagcgactcaccaagcccttttt
aataataagaaagtcgtcgacatgtttctagtcggtgttggtggtgttggcggtgagttg
attgagcaaatcaagcagcaaaaagaatacctcgcaaagaaggacattgaaatccgtgtt
tgtgccttagcgaattcaacaaaaatgcttttggatgaaaacgggttgaatttagataat
tggaaagctgatcttgaaaatgcaacccaaccttctgatttcgatgtgttgttatctttc
attaagttgcaccacgtagtgaacccagtctttgtagattgtacaactgctgaatcggtc
gcagggctttatgcgcgcgcattaaaagaaggcttccacgtggtaaccccaaacaaaaaa
gcgaatacccgtgaattagcctattaccacgaattacgtcgcaatgcacaagcaagccaa
cataaattcttatacgaaaccaacgtaggggcaggcttaccggttattgaaaacttacaa
aacttattggctgcaggtgatgagcttgagtattttgaaggtattttatcgggctcactt
tctttcattttcggtaaattagaggaaggactttctctttcagaagtgaccgcacttgca
cgtgaaaaaggctttacagagccagatcctcgtgacgatttatcggggcaagatgtggca
cgtaaattgcttattttggcgcgtgaagccggtttagagcttgagcttgccgatgtggaa
gtggaaggggtattaccacaaggcttctctgaaggaaaatctgcagatgaatttatggca
atgttgccacaattagatgcggaatttaaagcacgcgttgaagccgcgaaagctgaaggc
aaagtattgcgttatgtaggccaaattaaagatggtcactgcaaagtatcaatcatcgcc
gtggatcaaaataatccattgtataaggtgaaagatggtgaaaacgcccttgcattctat
acgcgttattatcaaccaattccgttgttattacgtggttatggtgcgggtaacgcagtg
actgcagcgggcatctttgctgatattttaagaacattacaccactaa
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