KEGG   VARIANT: 1956v4
Entry
1956v4                      Variant                                
Name
EGFR overexpression
Type
Gain of function
Gene
EGFR  epidermal growth factor receptor [KO:K04361]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
overexpression
Network
nt06210  ERK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06260  Colorectal cancer
nt06265  Bladder cancer
nt06266  Non-small cell lung cancer
nt06270  Breast cancer
nt06273  Glioma
nt06526  MAPK signaling
nt06530  PI3K signaling
Disease
H00014  Non-small cell lung cancer
H00020  Colorectal cancer
H00022  Bladder cancer
H00031  Breast cancer
H00042  Glioma
Reference
PMID:16474624
  Authors
Wolff EM, Liang G, Jones PA.
  Title
Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer.
  Journal
Nat Clin Pract Urol 2:502-10 (2005)
DOI:10.1038/ncpuro0318
Reference
PMID:26925626
  Authors
Alanazi IO, Khan Z
  Title
Understanding EGFR Signaling in Breast Cancer and Breast Cancer Stem Cells: Overexpression and Therapeutic Implications.
  Journal
Asian Pac J Cancer Prev 17:445-53 (2016)
DOI:10.7314/APJCP.2016.17.2.445
Reference
PMID:23007009
  Authors
Hegi ME, Rajakannu P, Weller M
  Title
Epidermal growth factor receptor: a re-emerging target in glioblastoma.
  Journal
Curr Opin Neurol 25:774-9 (2012)
DOI:10.1097/WCO.0b013e328359b0bc
Reference
PMID:16112428
  Authors
Panani AD, Roussos C.
  Title
Cytogenetic and molecular aspects of lung cancer.
  Journal
Cancer Lett 239:1-9 (2006)
DOI:10.1016/j.canlet.2005.06.030
Reference
PMID:9815883
  Authors
Radinsky R, Risin S, Fan D, Dong Z, Bielenberg D, Bucana CD, Fidler IJ
  Title
Level and function of epidermal growth factor receptor predict the metastatic potential of human colon carcinoma cells.
  Journal
Clin Cancer Res 1:19-31 (1995)
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