KEGG   VARIANT: 1956v5
Entry
1956v5                      Variant                                
Name
EGFR mutation in glioblastoma
Gene
EGFR  epidermal growth factor receptor [KO:K04361]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
EGFRvIII (deletion of exons 2–7 or amino acids 6-273)
Network
nt06210  ERK signaling
nt06214  PI3K signaling
nt06273  Glioma
  Element
N00513  Mutation-activated EGFR to RAS-ERK signaling pathway
N00514  Mutation-activated EGFR to PI3K signaling pathway
Reference
  Authors
Gan HK, Cvrljevic AN, Johns TG
  Title
The epidermal growth factor receptor variant III (EGFRvIII): where wild things are altered.
  Journal
FEBS J 280:5350-70 (2013)
DOI:10.1111/febs.12393
Reference
  Authors
An Z, Aksoy O, Zheng T, Fan QW, Weiss WA
  Title
Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies.
  Journal
Oncogene 37:1561-1575 (2018)
DOI:10.1038/s41388-017-0045-7
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