KEGG   VARIANT: 1956v5
Entry
1956v5                      Variant                                
Name
EGFR mutation in glioblastoma
Gene
EGFR  epidermal growth factor receptor [KO:K04361]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
EGFRvIII (deletion of exons 2–7 or amino acids 6-273)
Network
nt06210  ERK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06273  Glioma
nt06526  MAPK signaling
nt06530  PI3K signaling
Disease
H00042  Glioma
Reference
  Authors
Gan HK, Cvrljevic AN, Johns TG
  Title
The epidermal growth factor receptor variant III (EGFRvIII): where wild things are altered.
  Journal
FEBS J 280:5350-70 (2013)
DOI:10.1111/febs.12393
Reference
  Authors
An Z, Aksoy O, Zheng T, Fan QW, Weiss WA
  Title
Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies.
  Journal
Oncogene 37:1561-1575 (2018)
DOI:10.1038/s41388-017-0045-7
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