KEGG   VARIANT: 3084v1
Entry
3084v1                      Variant                                
Name
NRG1 fusion
Gene
NRG1  neuregulin 1 [KO:K05455]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
CD74-NRG1
Variation
ATP1B1-NRG1
Variation
SLC3A2-NRG1
Variation
SDC4-NRG1
Reference
  Authors
Schram AM, Odintsov I, Espinosa-Cotton M, Khodos I, Sisso WJ, Mattar MS, Lui AJW, Vojnic M, Shameem SH, Chauhan T, Torrisi J, Ford J, O'Connor MN, Geuijen CAW, Schackmann RCJ, Lammerts van Bueren JJ, Wasserman E, de Stanchina E, O'Reilly EM, Ladanyi M, Drilon A, Somwar R
  Title
Zenocutuzumab, a HER2xHER3 Bispecific Antibody, Is Effective Therapy for Tumors Driven by NRG1 Gene Rearrangements.
  Journal
Cancer Discov 12:1233-1247 (2022)
DOI:10.1158/2159-8290.CD-21-1119
Reference
  Authors
Zhang C, Mei W, Zeng C
  Title
Oncogenic Neuregulin 1 gene (NRG1) fusions in cancer: A potential new therapeutic opportunities.
  Journal
Biochim Biophys Acta Rev Cancer 1877:188707 (2022)
DOI:10.1016/j.bbcan.2022.188707
Reference
  Authors
Fernandez-Cuesta L, Plenker D, Osada H, Sun R, Menon R, Leenders F, Ortiz-Cuaran S, Peifer M, Bos M, Dassler J, Malchers F, Schottle J, Vogel W, Dahmen I, Koker M, Ullrich RT, Wright GM, Russell PA, Wainer Z, Solomon B, Brambilla E, Nagy-Mignotte H, Moro-Sibilot D, Brambilla CG, Lantuejoul S, Altmuller J, Becker C, Nurnberg P, Heuckmann JM, Stoelben E, Petersen I, Clement JH, Sanger J, Muscarella LA, la Torre A, Fazio VM, Lahortiga I, Perera T, Ogata S, Parade M, Brehmer D, Vingron M, Heukamp LC, Buettner R, Zander T, Wolf J, Perner S, Ansen S, Haas SA, Yatabe Y, Thomas RK
  Title
CD74-NRG1 fusions in lung adenocarcinoma.
  Journal
Cancer Discov 4:415-22 (2014)
DOI:10.1158/2159-8290.CD-13-0633
Reference
  Authors
Shin DH, Lee D, Hong DW, Hong SH, Hwang JA, Lee BI, You HJ, Lee GK, Kim IH, Lee YS, Han JY
  Title
Oncogenic function and clinical implications of SLC3A2-NRG1 fusion in invasive mucinous adenocarcinoma of the lung.
  Journal
Oncotarget 7:69450-69465 (2016)
DOI:10.18632/oncotarget.11913
Reference
  Authors
Aguirre AJ
  Title
Oncogenic NRG1 Fusions: A New Hope for Targeted Therapy in Pancreatic Cancer.
  Journal
Clin Cancer Res 25:4589-4591 (2019)
DOI:10.1158/1078-0432.CCR-19-1280
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