KEGG   VARIANT: 3480v1
Entry
3480v1                      Variant                                
Name
IGF1R overexpression
Gene
IGF1R  insulin like growth factor 1 receptor [KO:K05087]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
overexpression
Network
nt06210  ERK signaling
nt06214  PI3K signaling
nt06263  Hepatocellular carcinoma
  Element
N00237  IGF1R-overexpression to RAS-ERK signaling pathway
N00238  IGF1R-overexpression to PI3K signaling pathway
Reference
  Authors
Whittaker S, Marais R, Zhu AX
  Title
The role of signaling pathways in the development and treatment of hepatocellular carcinoma.
  Journal
Oncogene 29:4989-5005 (2010)
DOI:10.1038/onc.2010.236
Reference
  Authors
Alexia C, Fallot G, Lasfer M, Schweizer-Groyer G, Groyer A
  Title
An evaluation of the role of insulin-like growth factors (IGF) and of type-I IGF receptor signalling in hepatocarcinogenesis and in the resistance of hepatocarcinoma cells against drug-induced apoptosis.
  Journal
Biochem Pharmacol 68:1003-15 (2004)
DOI:10.1016/j.bcp.2004.05.029
Reference
  Authors
Minguez B, Tovar V, Chiang D, Villanueva A, Llovet JM
  Title
Pathogenesis of hepatocellular carcinoma and molecular therapies.
  Journal
Curr Opin Gastroenterol 25:186-94 (2009)
DOI:10.1097/MOG.0b013e32832962a1
LinkDB

DBGET integrated database retrieval system