Baron DM, Fenton AR, Saez-Atienzar S, Giampetruzzi A, Sreeram A, Shankaracharya, Keagle PJ, Doocy VR, Smith NJ, Danielson EW, Andresano M, McCormack MC, Garcia J, Bercier V, Van Den Bosch L, Brent JR, Fallini C, Traynor BJ, Holzbaur ELF, Landers JE

ALS-associated KIF5A mutations abolish autoinhibition resulting in a toxic gain of function.

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DOI:10.1016/j.celrep.2022.110598

Pant DC, Parameswaran J, Rao L, Loss I, Chilukuri G, Parlato R, Shi L, Glass JD, Bassell GJ, Koch P, Yilmaz R, Weishaupt JH, Gennerich A, Jiang J

ALS-linked KIF5A DeltaExon27 mutant causes neuronal toxicity through gain-of-function.

EMBO Rep 23:e54234 (2022)
DOI:10.15252/embr.202154234