KEGG   VARIANT: 4005v1
Entry
4005v1                      Variant                                
Name
LMO2 rearrangement
Gene
LMO2  LIM domain only 2 [KO:K15612]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
translocation t(11;14) (p13;q11)
Variation
translocation t(7;11)(q35;p13)
Variation
deletion del(11)(p12p13)
Network
nt06240  Transcription (cancer)
Disease
H00002  T-cell acute lymphoblastic leukemia
Reference
PMID:26108219
  Authors
Chambers J, Rabbitts TH
  Title
LMO2 at 25 years: a paradigm of chromosomal translocation proteins.
  Journal
Open Biol 5:150062 (2015)
DOI:10.1098/rsob.150062
Reference
PMID:23904235
  Authors
Larmonie NS, Dik WA, Meijerink JP, Homminga I, van Dongen JJ, Langerak AW
  Title
Breakpoint sites disclose the role of the V(D)J recombination machinery in the formation of T-cell receptor (TCR) and non-TCR associated aberrations in T-cell acute lymphoblastic leukemia.
  Journal
Haematologica 98:1173-84 (2013)
DOI:10.3324/haematol.2012.082156
Reference
PMID:16873670
  Authors
Van Vlierberghe P, van Grotel M, Beverloo HB, Lee C, Helgason T, Buijs-Gladdines J, Passier M, van Wering ER, Veerman AJ, Kamps WA, Meijerink JP, Pieters R
  Title
The cryptic chromosomal deletion del(11)(p12p13) as a new activation mechanism of LMO2 in pediatric T-cell acute lymphoblastic leukemia.
  Journal
Blood 108:3520-9 (2006)
DOI:10.1182/blood-2006-04-019927
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