KEGG   VARIANT: 5621v2
Entry
5621v2                      Variant                                

Name
PRNP oligomeric conformation
Gene
PRNP  prion protein [KO:K05634]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
oligomer
Network
nt06419  Microtubule-based transport
nt06465  Prion disease
  Element
N01202  Oligomeric conformation PrPc to anterograde axonal transport
Reference
  Authors
Simoneau S, Rezaei H, Sales N, Kaiser-Schulz G, Lefebvre-Roque M, Vidal C, Fournier JG, Comte J, Wopfner F, Grosclaude J, Schatzl H, Lasmezas CI
  Title
In vitro and in vivo neurotoxicity of prion protein oligomers.
  Journal
PLoS Pathog 3:e125 (2007)
DOI:10.1371/journal.ppat.0030125
Reference
  Authors
Chiesa R, Piccardo P, Biasini E, Ghetti B, Harris DA
  Title
Aggregated, wild-type prion protein causes neurological dysfunction and synaptic abnormalities.
  Journal
J Neurosci 28:13258-67 (2008)
DOI:10.1523/JNEUROSCI.3109-08.2008
Reference
  Authors
Zamponi E, Buratti F, Cataldi G, Caicedo HH, Song Y, Jungbauer LM, LaDu MJ, Bisbal M, Lorenzo A, Ma J, Helguera PR, Morfini GA, Brady ST, Pigino GF
  Title
Prion protein inhibits fast axonal transport through a mechanism involving casein kinase 2.
  Journal
PLoS One 12:e0188340 (2017)
DOI:10.1371/journal.pone.0188340
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