KEGG   VARIANT: 6790v1
Entry
6790v1                      Variant                                
Name
AURKA mutation
Type
Loss of function
Gene
AURKA  aurora kinase A isoform 1 [KO:K11481]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
mutations
OmimVar: 603072
Network
nt06515  Regulation of kinetochore-microtubule interactions
Disease
H00020  Colorectal cancer
Reference
  Authors
Ewart-Toland A, Briassouli P, de Koning JP, Mao JH, Yuan J, Chan F, MacCarthy-Morrogh L, Ponder BA, Nagase H, Burn J, Ball S, Almeida M, Linardopoulos S, Balmain A
  Title
Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human.
  Journal
Nat Genet 34:403-12 (2003)
DOI:10.1038/ng1220
Reference
  Authors
Yan M, Wang C, He B, Yang M, Tong M, Long Z, Liu B, Peng F, Xu L, Zhang Y, Liang D, Lei H, Subrata S, Kelley KW, Lam EW, Jin B, Liu Q
  Title
Aurora-A Kinase: A Potent Oncogene and Target for Cancer Therapy.
  Journal
Med Res Rev 36:1036-1079 (2016)
DOI:10.1002/med.21399
Reference
  Authors
Naso FD, Boi D, Ascanelli C, Pamfil G, Lindon C, Paiardini A, Guarguaglini G
  Title
Nuclear localisation of Aurora-A: its regulation and significance for Aurora-A functions in cancer.
  Journal
Oncogene 40:3917-3928 (2021)
DOI:10.1038/s41388-021-01766-w
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