KEGG   VARIANT: 7030v1
Entry
7030v1                      Variant                                
Name
PRCC-TFE3 fusion
Gene
TFE3  transcription factor binding to IGHM enhancer 3 [KO:K09105]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
translocation t(X;1)(p11;q21)
COSF: 806 813 808
Network
nt06240  Transcription (cancer)
nt06264  Renal cell carcinoma
Disease
H00021  Renal cell carcinoma
Reference
PMID:19233641
  Authors
Prensner JR, Chinnaiyan AM
  Title
Oncogenic gene fusions in epithelial carcinomas.
  Journal
Curr Opin Genet Dev 19:82-91 (2009)
DOI:10.1016/j.gde.2008.11.008
Reference
PMID:25048860
  Authors
Kauffman EC, Ricketts CJ, Rais-Bahrami S, Yang Y, Merino MJ, Bottaro DP, Srinivasan R, Linehan WM
  Title
Molecular genetics and cellular features of TFE3 and TFEB fusion kidney cancers.
  Journal
Nat Rev Urol 11:465-75 (2014)
DOI:10.1038/nrurol.2014.162
Reference
PMID:8872474
  Authors
Sidhar SK, Clark J, Gill S, Hamoudi R, Crew AJ, Gwilliam R, Ross M, Linehan WM, Birdsall S, Shipley J, Cooper CS
  Title
The t(X;1)(p11.2;q21.2) translocation in papillary renal cell carcinoma fuses a novel gene PRCC to the TFE3 transcription factor gene.
  Journal
Hum Mol Genet 5:1333-8 (1996)
DOI:10.1093/hmg/5.9.1333
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