KEGG   VARIANT: 8312v1
Entry
8312v1                      Variant                                
Name
AXIN1 mutation
Gene
AXIN1  axin 1 [KO:K02157]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
mutation P345L
COSM: 142849
Variation
mutation L106R
COSM: 142850
Variation
mutation G425S
COSM: 4387483
Network
nt06215  WNT signaling
nt06263  Hepatocellular carcinoma
  Element
N00242  Mutation-inactivated AXIN to Wnt signaling pathway
Reference
  Authors
Satoh S, Daigo Y, Furukawa Y, Kato T, Miwa N, Nishiwaki T, Kawasoe T, Ishiguro H, Fujita M, Tokino T, Sasaki Y, Imaoka S, Murata M, Shimano T, Yamaoka Y, Nakamura Y
  Title
AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1.
  Journal
Nat Genet 24:245-50 (2000)
DOI:10.1038/73448
Reference
  Authors
Salahshor S, Woodgett JR
  Title
The links between axin and carcinogenesis.
  Journal
J Clin Pathol 58:225-36 (2005)
DOI:10.1136/jcp.2003.009506
Reference
  Authors
Taniguchi K, Roberts LR, Aderca IN, Dong X, Qian C, Murphy LM, Nagorney DM, Burgart LJ, Roche PC, Smith DI, Ross JA, Liu W
  Title
Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas.
  Journal
Oncogene 21:4863-71 (2002)
DOI:10.1038/sj.onc.1205591
Reference
  Authors
Mazzoni SM, Fearon ER
  Title
AXIN1 and AXIN2 variants in gastrointestinal cancers.
  Journal
Cancer Lett 355:1-8 (2014)
DOI:10.1016/j.canlet.2014.09.018
Reference
  Authors
Li J, Quan H, Liu Q, Si Z, He Z, Qi H
  Title
Alterations of axis inhibition protein 1 (AXIN1) in hepatitis B virus-related hepatocellular carcinoma and overexpression of AXIN1 induces apoptosis in hepatocellular cancer cells.
  Journal
Oncol Res 20:281-8 (2013)
DOI:10.3727/096504013X13639794277608
LinkDB

DBGET integrated database retrieval system