VARIANT: 861v4
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Entry
861v4 Variant
Name
TEL-AML1 fusion
Gene
RUNX1
RUNX family transcription factor 1 [KO:
K08367
]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
translocation t(12;21)(p12;q22)
COSF:
2246
2258
2248
Variation
translocation t(12;21)(p13;q22)
COSF:
2246
2258
2248
Network
nt06240
Transcription (cancer)
Disease
H00001
B-cell acute lymphoblastic leukemia
Reference
PMID:
14630078
Authors
Sawinska M, Ladon D
Title
Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia.
Journal
Leuk Res 28:35-42 (2004)
DOI:
10.1016/S0145-2126(03)00160-7
Reference
PMID:
17237815
Authors
Morrow M, Samanta A, Kioussis D, Brady HJ, Williams O
Title
TEL-AML1 preleukemic activity requires the DNA binding domain of AML1 and the dimerization and corepressor binding domains of TEL.
Journal
Oncogene 26:4404-14 (2007)
DOI:
10.1038/sj.onc.1210227
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