Hyla sarda (Sardinian treefrog): 130294596 Help Entry 130294596         CDS       T11475                                  Symbol UBR4 Name (RefSeq) E3 ubiquitin-protein ligase UBR4   KO K10691   E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27] Organism hsq  Hyla sarda (Sardinian treefrog) Brite KEGG Orthology (KO) [BR:hsq00001]  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:hsq04121]     130294596 (UBR4) Enzymes [BR:hsq01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.27  RING-type E3 ubiquitin transferase      130294596 (UBR4) Ubiquitin system [BR:hsq04121]  Ubiquitin ligases (E3)   Single Ring-finger type E3    UBR box proteins     130294596 (UBR4) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  E3_UBR4_N E3_UbLigase_R4 UBR4 zf-UBR Motif Other DBs NCBI-GeneID:  130294596 NCBI-ProteinID:  XP_056400653 LinkDB All DBs Position 10:1612507..1726577 Genome browser AA seq 5141 aa AA seqDB search MSSSGGSSGPGWDVAVRPLLSASYSAFDMKELPQLLSSVIESESEILHHDKQYEPFYSSF VALSTHYITTVCNQIPRNQLQSVAAACKVLLEFSLLRLESPDEACAVSQKHLILLIKGLC TGSSRLDRTEIITFTAMMKSSKLPQTIQTLSDVEDQKETAVLLSPELRQKEVKMNFLNQL TSVFNPRGSSSSSTSSHTQVESEVDDTTSEQASAAKTKSIFIAQNVASLQELGGSEKLLR VCLNLPYFLRYINRFQDAVSANSFFIMPATVGDATAVRNGFHSLVIDVTMALDTLSLPVM EPLTPPRLKDVTLLALSCLYAGVSVATCMAILHVGSTQQVRTGSTSCKEEDYENDAATIV QKCLEIYEMIGQAINSSRRAGGEHYQNFQLLGAWCLVNSLYLILNLSPTALADKGKEKDP LAALRVRDIARAKEGVGSPKLGPGKGHQGFGVLSVVLANHAIKLLTSLFQDLQVETLHKA TWDKDGPLAELSITAQSTSTQRIQRLIDSVPLTNLLFTILSTSYRKACVLQRQRKGSMSS DASASTDSNTYYEDDFSSTEEDSSQDDDSEPILGQWFEETISPTKEKVPPPPPPPPPLES SPRAKSPSKQNSAGNGNILASRKDPELFLSLASNSLNFITSCMLNSRSNFIRNYLSVSLT EQHMSSLACIIKDVDKDGLKGSSDEDFAVALYQFNHCLVTSDLQSPTLQSALLQHLGIAP LGEGPWPLYIHPQSLSVLSRLLLLYQHKASIQGEPDVPECLRVWERFVGTLKQNALQGVV PGDTEDVNVDHLQLLLLIFHNLSEKGRQSILLLCIQTLQDLASNLESQLPAVPLLLARLL LVFDYLLHQYSKPPLYLFEQVQYNLLTPPLGSGASHDGTGRTSALYYGFKEVEENWTKHC TTDSAPQPRFYSILTQEASEDDLHRLDSEVCEVLFSRVLKYDDLYTALISLLAAGSQLDT VRRNENKSITALEACALQYHFLILWRILGILPPSKHYMKQLSHNVSGPSECEILHTLRWA SRLRVPSYLLWIKDHLVKQGMKPEQAASLTEQTSAKCSTIKYDVEVAEEYIARQISTYCS SNGYTFEQLRKGPNLQCIYTLDAMICKVQVSLDEHFSKLSAETDPHKSSQVAKNLLPAAL QLLDMYASLTRCYLLRSLPEEGIEEKKLQGYAAVIAIGSSCCKANTLGPVLIQNLPTAVQ TLCETWNNIHTNEFPSIGSWRNAFANDTIPSESYIGAVQAAHLGTLCSPSLSLAASLKHV LLSLVRLTGDLIVWCPEDLNSHQLIQSLLPLLLESSTESVSELCSTSLERVLGPAESDEF LSRLYEKLNTGCYNILAHHSDPSSGLDESILEECLQFLEKQLESSLARKAMEEFFTERGE LVQIMMATANEALSAKFCNRVLKLFTKLFQLTEKNPSPSLLRLCGTLAQLACVEPSQLQS WLVRMTTPPPKDSDQAEIVQENRQLLQLLTAYIVRENSQVGEGVCTVLLSTLIPMATELL ANGDGSGFPELMVVMATLASSGQGAGHLQLHRAAMDWLARCKKYLSQKNVVEKVNNNVMH GKHVTILECTCHIVSYLADVTNALSHSAGQGHCHLPVDGEERAIEVDSDWVEELAVEEDD SQAEDSDEDSLCNKLCTFTITQKEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISY AKYGSFFCDCGAKEDGSCMALVKRTPSSGIGSTMKESAFQSEPRLPESAIRHPGSALTDK GKVTISDGKGDDEKPKRSSLCRNVEGCREELVCQANVSFAPLILDMLNFLMSAVRNNFQQ ASAVGSSSRAQQALDQLHSLEKSVEMTDQLMVPTLGSQEGAFENVRMNYSGDQGQTIRQL ISAHVLRRVAMCVLSSPHGRRQHLAVSHEKGKITVLQLSALLKQADSSKRKLTLTRLASA PVPFTVLSLTGNPCKEDYLAVCGLKDCHVLTFSGSGSVSDHLVLHPQLATGNFIIKAVWL PGSQTELAIVTADFVKVYDLSSDALSPTFYFLLPSSKIRDVTFLFNEEGKNIIVIMSSAG YVYTQLMEESSSAKHGPFYVTNVLEVSHEDLKDSNGQVAGGGVSVYYSHVLQMLFFSYCQ GKSFAATINRSSMEIILLFPINIKSSNGGSKTSPALCQWSEVMNHPGLVCCVQQTTGVPL VVMVKPDSFLIQEIKTLPAKAKIQDMVAIRHTASNDQQRTTMILLCEDGSLRIYMANVEN TSYWLQPSLQPSSSIGIMKPVRKRKPAAVMTRASSQVTFPIDFFEHNQQLTDVEFGGNDL LQLYNAQQIKHRLNSTGMYVANTKPGGFTVEVTNNNSTMVMTGMRLQIGTQAIERAPSYI EMFGRTMQLNLSRARWFDFPFTREEALQADKKLTIFIGASVDPAGVTMIDAIKIYGKTKE QFGWPDEPPEEFPSASVSSVCPPNLNQGNGSTDSETATPPSTNGTVIERLVGSSLEALES CFGFGPVPEKEKNKASALELATVLLSMPTPSSVQLQTKSLLASLHTSRSAYHNHKDQALL SNAVQCLNASAHDGKDLDPEIFQRLVITARSIAIMRPNNLVHYTESRLLSAETDIDEGKD VVKTSEGEDTYAFITQLVNQFWKLHASKPKNAFLAPACLPGLTHVEATVNALVDIIHGYC TCELDCINLASEIYMQMLLCPDPSVSFSCKQALIRVLRPRNKRRHVTLPSSPRSNTPMGD KDDDDDDDAEDKIQTSTIPNGEPVRQQSQEQNEVDHGDFEMVSESMVLESADSVNNGNPS PLEALLAGAEGFPPMLDIPPDADDETMVELAIALSLQQDQQRSSSSALGLQSLGLSGQAP SSSSLDAGTLSDTTASAPASDDEGSTAATDGSTLRTSPADHGGSVGSESGGSAVDSVAGE HSVSGRSSAYGDTAVEGHPTGPGSISSSTGAISTATGQHEGEGSEGEGETEGDAHTSNRL HMVRLMLLERLLQTMPSLRTVGGVRAIPYMQVVLMLTADLDGEDEKDKGALDNLLAQLIA ELGLDKKDVSKKNERTPLNEVHLVVMRLLSVFMSRTKSGSKSSICESSSLISSATATALL SSGAVDYCLHVLKSLLDFWKSQQSDEEPVASSQLLKPHTTSSPPDMSPFFLRQYVKGHAA DVFQAYTQLLTEMVLRLPYQIKKIADTNSRIPPPVFDHSWFYFLSEYLMIQQTPFVRRQV RKLLLFICGSKEKYRQLRDLHTLDSHVRGIKKLLEEHGIFLRASVVTASSGSALQYDTLI NLMEHLKACAEIASQRTVNWQKFCIKDDSVLYFLLQVSFLVDEGVSPVLLQLLSCALCGS KVLSPSSGSSVPSSSSGQPQSKSSTKKSKKEDKDKDKEGEGSSSQEEQLCTALVNQLNKF ADKETLIQFLRCFLLESNASSVRWQAHCLALHIYRNSNKSQQELLLDLMWSIWPELPAYG RKAAQFVDLLGYFSLKTPQTEKKFKEYSQKAVEILRTQNHILTNHPNSNIYNTLSGLVEF DGYYLESDPCLVCNNPEVPLCNIKLSSIKVDTRYTTTQQVVKLIGSHTISKVTVKIGDLK RTKMVRTINLYYNNRTVQAIVELKNKPARWHKAKKVQLTPGQTEVKIDLPLPIVASNLMI EFADFYENYQASSETLQCPRCSASVPANPGVCGNCGENVYQCHKCRSINYDEKDPFLCNA CGFCKYARFDFMLYARPCCAVDPIENEEDRKKAVTNINTLLDKADRVYHQLMGHRPQLEN LLYKVNEAAPEKPQDDSANAGGISSTSASVNRYILQLAQEYCGDCKNSFDELSKIIQKVF ASRKELLEYDLQQREAATRSSRTTVQPTFTASQYRALSVLGCGHTSSTKCYGCASAVTEH CITLLRALATNSTIRHILVSQGLIRELFDYNLRRGPASMRDEVRQVMCLLTRDNPEATQQ MNDLIIGKVSTALKGHWANPDLASSLQYEMLLLTDSISKEDNCWELRLRCALSLFLMAVN IKTPVVVENITLMCLRILQKLIKPPTPTSKKNKDVPMEALTTVKPYSNEIHAQAQLWLKR DHKASYEAWKKCLPARGVDNSGNAPSKAELRQMYLQEKYVWKWKQFLSKKGKRTTPLDLK LGHNNWLRQVLFTPATQAARQAACTIVEALSSIPSRRQQVLDLLTSYLDELSVAGECSAE YLALYQKLIKPAHWKIYLAARGVLPYVGNLITKEIARLLALEEATLSTDLQQGYALKSLT GLLSSFVEVESIKRHFKSRLVGTVLNGYLCLRKLVVQRTKLIDETQDMLLEMLEDMTTGT ESETKAFMAVCIETAKRYSLDDYRTPVFIFERLCSIIYPEENEVTEFFVTLEKDPQQEDF LQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALLEDDSGMELLVNNKIISLDLPVA EVYKKVWCPTNEGEPMRIIYRMRGLLGDATEEFIESLDSTTDEEEDEEEVYKMAGVMAQC GGLECMLNRLAGIKDFKQGRHLLTVLLKLFSYCVKVKVNRQQLVKPEMNTLNVMLGTLNL ALVAEQESKDSGGAAVAEQVLSIMEIILDESNAEPLSEDKGNLLLTGDKDQLVMLLDQIN STFVRSNPSVLQGLLRIIPYLSFGEMEKMQILVDRFKPYCTFEKYDDEHCTDDKVFLDCF CKIAAGIKNNSNGHQLKDLILQKGITQNALDYMKKHIPSAKNLDADIWKKFLSRPALPFI LRLLRGLATQHLPTQALIGTDSITNLHKLEQVSSDEGIGTLAENLLEALREHPDVNKKID AARKETRAEKKRMAMAMRQKALGTLGMTTNEKGQVVTKTALLKQMEELIEEPGLTCCICR EGYKFQPTKVLGIYTFTKRVSLEEAENKPRKQQGYSTVSHFNIVHYDCHLAAVRLARGRE EWESAALQNANTKCNGLLPVWGPHVPESAFATCLARHNTYLQECTGQREPTYQLNIHDLK LLFLRFANEQSFSADTGGGGRESNIHLIPYIIHTVLYVLNTTRAISREEKNVQNFLEQPK EKWVESAFEVDGPHYFTALALHLLPTEKWKTIRIEVLRRLLVVSHVRAVAPSGANRLTDK AMKEYSVYRSSLLFWALVDLIYNMFKKVPNSNTEGGWSYSLADYIRLNDMPIYEAADRAL KTFQDEFMPVESFSEFMDVAGLLSEINDPDDFLKDLLNSVP NT seq 15426 nt NT seq  +upstreamnt  +downstreamnt atgtcgtcgagcggtggcagctcgggccccggctgggatgtggcggtccggccgctcctc tccgcctcatactcggcctttgacatgaaggagctgccgcagctgctgtcctcggtgata gagagtgaatctgagattcttcaccatgacaaacagtatgaaccgttctactcgtcattt gtggccctgtccactcattacatcacaacagtgtgcaaccagattcccaggaaccagtta cagtccgtagcggctgcctgtaaagtcttgcttgagttctctttgctgcggctggagagc cccgatgaggcctgtgctgtgtctcagaagcatctgatcctcctgatcaagggcctgtgt acgggcagcagccgcctggatcgcacagagatcatcacttttactgcaatgatgaaatcc tccaaactgccgcagacgatacagacgctctctgacgtcgaagatcagaaagaaacagct gttcttctgagtcctgagttgcgccagaaagaggtgaaaatgaactttcttaaccaattg acgtctgtttttaaccccagaggctcctcgtcgtcctcgacctcctcacacacacaggtg gaatcagaggtggatgacacaacatcagagcaggcgtctgcagcgaaaacaaagagcata tttatagcccagaacgtggccagtctccaagaactgggtggatcagagaagctgcttaga gtttgcttgaacctgccctactttttgagatatattaaccgtttccaagacgcagtgtcc gccaactccttcttcattatgcctgcaacggttggagatgccacagccgtccgtaatggg tttcattcacttgtgattgatgtgactatggcactggacactctgtctctgcctgtaatg gagccactcacccctcctcggctaaaagacgttactctcctggccctgagctgcttatat gcaggtgtcagcgttgctacatgcatggcaatcctccatgttgggagcactcagcaggtg cggaccggatctacaagctgtaaagaggaagactatgaaaacgatgctgccaccattgtg cagaaatgtctggaaatctacgagatgattggacaggcaataaacagttctagaagagcc ggtggagagcactatcagaacttccagctgctgggggcctggtgtctggtgaacagtctg tacctgatcctcaacctcagccccaccgccctggcagacaaagggaaagagaaagatcca ctggcagcgctcagagtccgagacattgcccgggcaaaggaaggggtgggctccccaaag ctggggcctggtaaaggacaccagggttttggcgtcctgtcagtcgtgctcgcaaaccat gctatcaagctgctcacctctctcttccaagatctgcaagtggagaccttacacaaggca acctgggataaagacggacccctggccgagcttagcatcaccgctcagagcacgtccacc cagagaatacagaggctcattgattccgtccctctgacaaacctgctcttcacaatccta tccacctcctatcgaaaggcctgtgtcttacaacggcagaggaaaggctctatgagtagt gatgccagcgcgtccacagattccaacacttactatgaagatgacttcagcagcacagag gaagacagcagccaagatgatgatagtgaacccatcctgggtcagtggtttgaagaaaca atctctccaactaaagagaaggtgcccccaccgcccccaccaccgccgcctctcgagagc tcccccagagccaaaagtccgagcaaacagaactctgctgggaacggcaacatcttggcc agtcgcaaggacccagagctgttcctcagccttgcctccaatagcctgaatttcatcacc agctgcatgctgaattctcgcagcaatttcatccggaactaccttagtgtgtccctgact gagcagcacatgtccagcctggcctgtatcatcaaagacgtggacaaggatggactcaaa ggttcatcagatgaggattttgcagtcgctttgtaccagtttaatcattgtttggtgact tctgatcttcagtctcccacactacagagcgctcttctgcagcaccttggaatcgctcct ctcggtgagggcccttggcccctgtacatccatccccaaagtctttccgtactgtcacgt ctcctgttgctgtatcagcacaaggctagcatccagggagaaccagacgtaccagaatgt ctccgtgtatgggagaggtttgttgggaccctgaagcagaatgccctccagggcgtggta ccaggagacactgaagatgtcaacgtggatcatcttcaactgctgctcctgatctttcac aatttatcagagaaggggcgccagagtatcctgctgctctgtatacagacactgcaggac ttggccagtaacctggaatcccagttaccagctgttccccttctccttgcaagattgctc ctagtgtttgactatctcttgcaccagtactctaagccacccctctacctctttgagcag gtgcaatacaatcttcttacacccccccttggctctggggcatcacatgacgggaccggt cgcacgtctgctttgtattacggatttaaagaagtggaagaaaactggacaaaacactgc acaacagattcggccccacagccccgattttacagtatcctcactcaggaggcctctgaa gatgacctgcatcggctggatagtgaggtgtgtgaagtcctcttctcccgagtgctgaag tacgatgacctgtacaccgccctcatttctttactggcggctggatcccagcttgacaca gtacggaggaatgagaataaaagcatcacagccctggaggcttgtgcccttcagtatcac ttccttatactgtggaggattctgggaatcttaccaccctccaagcactacatgaagcag ctgtcacacaatgtgtctggccctagtgaatgcgagattcttcacaccttgcgttgggcg tctcgactccgagtcccatcatacctgctctggataaaggatcatcttgtgaagcaggga atgaaaccagagcaagcagcgtcactgacagagcaaacctcagccaaatgcagcactatc aaatatgatgtagaagtggccgaagagtacattgcccggcagatctcaacttattgcagc tctaatggatacacgtttgaacagctccgtaaggggcccaacctgcagtgtatttacaca ttggatgccatgatctgcaaagtgcaagtgtccctggacgaacatttctctaagctgtca gccgagaccgatccccacaagtcttctcaggtcgccaagaacctcctgccggctgcgtta cagctcctagacatgtacgcctctctcacccgctgttacctgctccgaagcctacctgag gaaggtatcgaggagaagaagctgcagggctacgctgctgtcattgccattggatcttcc tgctgcaaagcaaacacgctgggtcccgtattgattcagaatctccctactgctgtgcag actttatgtgagacctggaacaacattcacaccaatgaattccccagcattggatcatgg cgcaatgcctttgccaatgatactattccatcagaaagctacattggagccgttcaggca gcccacctgggtacattgtgtagccccagcctgtcgctcgctgcttccctcaagcacgta cttctgtctctggttcggctgacgggcgacctcatagtatggtgcccagaagatctgaat tctcaccagttaatccagtcgctgcttcctcttcttctggagagcagcactgagagtgtt tctgaactctgcagcacgtccctggagcgagtcctcggccccgcagagtccgatgagttt ttgtctcggttgtatgagaagttgaacactggttgttacaatatccttgcccaccactct gacccaagcagtggcctggatgagtctatcctggaggagtgtctgcagttcttagagaaa cagctcgagagcagcttggctcggaaagccatggaggagttttttacggagagaggtgaa ctggtgcagataatgatggcgactgcaaatgaagcgctctctgccaaattctgtaacaga gtcctgaagttgttcacaaaactcttccagctaactgagaagaacccaagccccagtctg ctgcgtctgtgcgggacattggcgcagctcgcctgtgtggagccatcgcagcttcaatct tggctcgtccgtatgacaactccccctcctaaggattctgaccaggctgagatagtccag gagaacagacagctcctccagctgctcactgcatacattgtacgagagaacagccaagtc ggggaaggtgtgtgcacagtgcttctcagcaccctcatcccaatggccacagagcttttg gctaatggagatgggtctggcttcccagaactcatggtggtgatggccactctggcaagt tcaggacagggtgctgggcatctacagctgcaccgcgctgcaatggactggctggcaaga tgtaagaaatatttatcccaaaaaaatgttgtggaaaaagtgaacaacaatgtaatgcat ggaaagcatgtcaccatcctggagtgcacgtgtcatatagtgtcctacctcgcggatgtc actaatgcattgagccacagtgctgggcagggacactgccaccttcccgtggatggagaa gagcgagcgatcgaggtggactctgactgggtggaggagctggctgtagaagaggacgat tcccaggctgaagattcggatgaagattctctttgtaacaagctgtgtacattcacaatc actcagaaagagttcatgaatcagcactggtatcactgccacacctgcaagatggtggat ggggtcggtgtgtgcacggtctgcgccaaggtctgccacaaagaccacgaaatttcttat gcaaaatacggctcatttttctgtgactgcggggccaaagaagatggcagctgcatggcc ttggttaagagaactccaagcagtggtataggatccaccatgaaagaatcggccttccag agcgaacctcgcctgccagaaagtgccatccgacaccctggctctgctctcacagacaaa ggcaaagtgacaatcagtgacggcaaaggggacgacgagaagccgaaaaggagcagcttg tgccgtaacgttgagggctgccgagaagagcttgtgtgtcaggcaaatgtttcatttgca ccgttgattctggatatgttgaactttttgatgagcgccgtacggaacaacttccagcag gcttcggcggtggggagtagtagtcgagctcagcaggcgctggaccagctgcactcattg gagaaaagtgtggagatgaccgaccagctgatggtcccgactctgggctcacaggaagga gcgttcgagaacgtaaggatgaattatagcggcgatcagggccaaaccatccgacagctg atcagtgctcatgtactgcgcagagtggccatgtgtgtgctgtcctctcctcacggcagg aggcaacatctcgctgtcagccatgagaagggaaagatcacagtattacagctctcagcg ctgctgaaacaggcagattctagtaaaaggaagctcaccctgacacgtctcgcctcggca ccggtcccgttcacagtccttagcctcaccgggaacccctgcaaagaggattacctggct gtgtgcggactgaaggactgtcacgtcctgacgttcagcggctcaggatctgtttccgac cacttggtcctccatccccaactcgccaccggcaacttcatcatcaaagccgtctggctg cccggatcccagactgagctggccattgttactgctgactttgtcaaggtttatgatctg tcgtcggatgctctaagcccaaccttttacttcctgctgcccagctcaaagattagagac gtcaccttcctgtttaatgaagaagggaagaacattatagtgatcatgtcgtctgccggt tatgtctacactcagctgatggaggagtccagcagtgccaagcacgggcccttctatgtc accaatgttctggaggtctctcatgaagacctgaaggatagtaacgggcaggtcgctggt ggaggtgtgtctgtgtattactctcatgtactccagatgctgttctttagttattgccaa ggcaaatcttttgctgccaccataaaccgatcatcaatggagataattctgcttttcccc atcaacataaagagctccaatggaggaagcaagacctcgccggccctctgtcagtggtct gaagtcatgaaccatcctggtttagtttgttgtgttcagcaaactacaggagtgcctctt gtcgtcatggtcaaacctgatagtttcctcattcaggagataaagactcttccagcaaaa gccaagattcaggatatggtagcaatacggcacacagccagcaatgatcagcagaggaca accatgatccttctctgtgaagatggcagcctgcggatctatatggccaacgtggagaac acctcatactggctccagccttccttgcagcccagcagcagtattggcatcatgaaacct gtgcgcaaacgcaagccggcggctgtcatgacacgggcctccagtcaggtgacctttccc atcgatttcttcgagcacaaccaacaacttacagatgtggagtttggtgggaacgacctg ctgcagttatacaatgcccagcaaataaagcatcgcctgaattctactgggatgtacgtg gcaaacactaagccgggaggatttacagtggaagtcaccaataacaacagcaccatggtg atgacaggaatgcggctccagatcggcacacaggccatcgagagggccccttcttacatt gagatgtttggccgcacgatgcagctcaatctcagccgagcgcgatggtttgactttcca tttacacgggaagaagccttacaggctgataaaaagctcacgatattcattggtgcgtcg gtggatccggccggagtcactatgatagatgccattaaaatatatggaaagacaaaggag cagtttggctggccagacgaacccccagaagagttcccctctgcctccgtgagcagcgtc tgtcctccgaacctcaatcaaggcaatggatccacagacagcgagacagcgacgccgccc tccactaacggcactgtcattgagaggttggtgggaagctcccttgaagctctggaaagc tgtttcggcttcggaccagtgccggagaaggagaaaaataaagcttcagctctggaactg gcgacggtcctgctctccatgccaacaccctccagtgtacagctccagacaaagagtctc ctggccagtctgcacacaagccggtccgcgtaccacaaccacaaggatcaagcgctgctg agcaatgctgtacaatgtctgaacgccagcgctcacgatggaaaggacctggatccagaa atattccagagactggtcatcaccgctcgctccatcgccatcatgcgcccaaacaacctt gttcactacacagagtccaggctgctttcagcagagacagatattgacgaaggcaaagac gttgtgaagaccagtgaaggagaagacacttatgccttcattacgcagctggtcaaccag ttctggaaactacatgcatctaaacccaagaacgccttcctggctcctgcttgtctgcct ggtctgacccatgtggaagcgacagtcaatgccttggtggatatcatacatggatactgc acgtgtgaactggactgcattaacctggcatctgaaatctacatgcaaatgttgctgtgc ccggatccatctgtaagcttctcctgcaaacaggccctcattcgggtcctccgtcctcga aataaacgtcgtcatgtgactcttccatcctctccacgtagcaacacgccaatgggagac aaagatgacgatgacgacgatgacgcggaagataagatccagacctctacaataccaaat ggagaacctgtccgacagcagagtcaggagcagaatgaggtcgaccatggagactttgag atggtgtctgagtccatggtcctggagagtgcagacagcgttaacaatggcaacccgtca cctttagaggctctgctggctggagccgagggcttcccaccaatgctggacatcccacct gatgccgatgatgagaccatggtggagttagccatcgcccttagtctgcagcaagatcag caacgaagcagcagcagtgctcttggtctgcagagtttgggattgtccggacaggcaccc agctcatcatctttggatgctgggactttatcggacaccactgcatcagctccagcatcg gatgacgaaggcagcacggccgcaaccgatggttccacactgcgcacctccccggccgac cacggagggagcgtgggctcggagagtggcggcagtgccgtggattcggtggctggtgag catagtgtatcaggtcgcagcagtgcatatggagacacagcggtcgagggtcaccctaca ggacctggaagtattagttctagcacgggagcgatcagcactgcaaccggacagcacgaa ggggaaggctctgaaggagaaggagagacggaaggtgacgcacatacgagcaacagactt cacatggtgcgtttaatgcttctggagcgcctccttcagacaatgccgagtctccgcact gtaggaggagtccgggccattccgtacatgcaggtggttctgatgctgaccgctgatctg gatggtgaagatgagaaggataaaggagccttggataacctcctggcccagctcattgca gaactaggtttagataaaaaggacgtctccaagaagaacgagcgtacccccctgaatgag gtccatctggtggtcatgaggcttctgagtgtcttcatgtctaggacaaagtctggttcc aaatcgtccatctgtgagtcgtcttctctgatttctagcgcaacagcgaccgcgcttcta agctctggtgcggtggattattgccttcatgtccttaagtctctcctggacttttggaag agccaacagagtgatgaggagccggtggccagcagccagctcctaaaaccccacaccacg tcgtctccacccgacatgagccctttcttcctccgccagtatgtcaagggtcatgctgca gacgtcttccaggcctacactcagctgctgacagaaatggttctccggctgccgtaccag attaagaaaattgccgacaccaattccaggattcctccgccagtgttcgatcattcttgg ttctacttcctttctgagtacctgatgattcagcagacaccatttgtgcgccgccaagtg cggaaacttctcctgttcatctgtggctccaaggagaaataccgacagctccgggacctt catacactcgattcccacgtccgcggcatcaagaagttgctggaggagcatgggattttc ctgcgtgcgagcgtggtgaccgcgagctccggatcagctcttcagtatgacaccctaatc aatctgatggaacatctcaaagcctgtgccgaaattgcctcccagcgaactgtgaactgg cagaaattctgcatcaaagatgattcggtcctgtacttcttgcttcaggtgagcttcttg gtggatgaaggggtgtctccggtcctcctgcagctgctctcgtgtgctctctgcggcagc aaagtcctttccccatcttcaggttcttccgttccatcctcaagctctggtcagcctcaa agtaagtcttcaaccaagaaaagcaaaaaggaagataaagacaaagacaaggaaggggag gggtccagtagtcaagaggagcagctctgcaccgcactcgtcaaccaactaaataagttt gcagacaaggaaacgctgatccagttcctgcgctgcttccttctggagtccaatgcttct tctgtccgctggcaggctcattgcttagcgcttcacatctacaggaattccaacaagtcc cagcaggaactcctcctagatctcatgtggtcaatctggcccgagctcccagcctatgga cgaaaagccgctcagtttgttgatcttctcggatacttctccctgaagacgcctcagaca gaaaagaagtttaaggaatattcccaaaaggctgtggagatcctgcggacccagaaccac atcttgaccaatcatcccaactccaacatctacaacacgctttctggtttggtagaattt gatggttactatctcgagagtgacccttgtctggtctgcaacaaccccgaagtcccattg tgtaacatcaaactttcttcaattaaagtggacacacgctacacaaccacacaacaagtg gtcaagctcataggaagccacactatcagcaaagtgaccgtgaagatcggtgacttgaag agaacgaagatggtccgaaccattaatctgtactacaacaaccgcaccgtgcaagccatt gtggagctgaagaacaaacccgcacgctggcacaaagctaaaaaggtccagttgactccg ggacaaaccgaagtgaagatcgatcttccgctccctattgtggcctcaaacctaatgatc gagtttgccgacttctatgaaaactaccaggcgtcttcagaaactctccagtgtcctcgt tgcagcgcctccgttcctgccaaccccggggtgtgtgggaactgtggtgaaaacgtctac cagtgtcacaagtgcagatccattaactatgatgagaaggacccgttcctgtgcaacgct tgcgggttttgcaagtatgcacgttttgacttcatgctgtatgcaagaccttgctgtgct gttgatcccattgagaatgaagaggatcggaagaaggcggtcaccaacatcaacaccctg ctggacaaggcggacagagtctatcaccagctcatgggtcacagaccgcagctagaaaac cttctctacaaagtgaatgaagccgccccggagaagccgcaggatgattctgccaacgcc ggaggaataagctccacgtccgccagcgtgaaccgctacatcctgcagctggcccaggaa tactgcggggactgcaaaaactcttttgatgaactttctaaaatcatccagaaagtgttc gcctcccggaaggagcttttggagtatgatctgcagcagagagaagccgccacgcgatcc tcccgcaccacggtacagcccacgttcactgccagtcagtacagagccttatcggtgctg ggctgcggccatacatcctccaccaagtgctacggctgcgcttctgctgtgaccgagcat tgtatcactctgctccgtgccctggccaccaacagcaccatacggcacatcctggtgtca caaggcctcatccgagaactctttgattacaacctgcgccgtggccccgcctccatgcgc gacgaagtgcggcaggtcatgtgcctgctgaccagggacaatccagaagccactcagcag atgaatgacttaattattggaaaagtatcaacggcccttaaagggcattgggccaatcca gatttggccagtagtctacagtatgagatgctgctgcttacggactccatatccaaggag gacaactgctgggagcttcgtctgcgctgtgcgctgagtctcttcctgatggccgtgaac atcaagacccccgtagtggtggagaacattacattaatgtgcctgagaatcctacagaag cttattaagcctcccaccccaaccagcaagaagaataaggacgttccaatggaagcatta actacagtaaagccgtacagcaatgaaatccatgcacaggcccaactgtggctgaagagg gatcacaaagcgtcatatgaagcctggaagaaatgtctcccagcccgaggtgtagacaac agtggtaatgcaccaagtaaagctgagctgcggcagatgtatctgcaggagaagtatgtg tggaagtggaaacagtttttgagcaagaaaggcaagaggacgaccccgctggatctgaaa ctgggacataacaactggctcagacaggtgttgttcaccccggccacacaagccgcccgt caggccgcgtgcaccattgttgaggcgctgtcatccattccgagccgcagacagcaggtc ctggaccttctcaccagctatttggatgaactcagcgttgctggagaatgttctgcagaa tatctcgctttgtatcagaagctcattaagcccgctcattggaagatctacctggcagca cggggcgtgttaccgtatgttgggaatctcatcactaaggaaattgcccgtcttctggcg ttagaagaggcgacgctcagcacagacctgcagcagggatatgctctgaagagtctcaca ggtctcctctcttccttcgtggaggtggaatccatcaagcgtcacttcaagagccgcctg gttggcaccgtgcttaatggttacctgtgtctccggaagctggtggtgcagagaaccaag ctgattgatgagacccaggacatgttactggagatgctggaggacatgaccacaggtacc gagtcagaaacaaaggctttcatggccgtttgcattgagacagccaagcggtacagcctg gatgattacaggacgcctgtcttcatattcgagaggctgtgcagtatcatatacccggag gagaatgaagtgaccgaattctttgtgacccttgagaaagacccacaacaagaagatttc ctccagggccgaatgccagggaacccgtacagcagcaatgagccaggaatcggacctctc atgagggacatcaagaataagatctgccaggattgtgatctagttgccctgctagaggat gacagtgggatggagcttctagtgaataataagatcatcagtctagatctgccggtggcc gaggtgtacaagaaggtttggtgtccaaccaatgagggggaaccaatgagaataatctac agaatgaggggtcttctaggagacgcaacagaagaattcattgagtcgctggactccacc acagacgaggaagaagatgaggaggaagtgtacaagatggcgggagtcatggctcagtgt ggtggactggaatgcatgttgaaccgtctggccggcatcaaggactttaagcagggacgt catctcctcacggtccttctgaagctcttcagctactgcgtcaaggtgaaggtgaatcgc cagcagctggtaaaacccgaaatgaacaccctgaatgtaatgctgggcaccctgaacctg gccctggtggcagaacaggaaagcaaagatagcggcggcgcggctgtagctgaacaagtg ctgagtatcatggagatcatactggacgagtccaatgctgagcccctgagcgaggacaag gggaacctgctgctcaccggggataaggatcagctggtaatgctgctcgatcagatcaac agcacatttgtgcgatcgaatcccagtgtcctgcagggcctgctgcgcatcatcccgtac ctgtccttcggagagatggaaaaaatgcagattctggtggatcgcttcaagccgtactgc acgtttgagaagtatgacgatgagcactgcacagatgacaaggtgttcctggactgtttc tgtaagatcgctgccggcatcaagaacaacagcaatggccaccagctcaaagacctcatc cttcagaaagggatcacacagaacgccctggactacatgaagaagcacatccccagcgca aagaatttggatgctgatatctggaagaagttcctctcccggccagcccttccctttatt ctgaggttacttagaggattagctacacagcatctccccacacaggctcttattggtaca gactccatcacaaaccttcacaagctagaacaagtgtccagtgatgaggggatcgggacc ctcgcagaaaacctattggaagcccttcgggaacatccggatgtcaacaagaagatcgat gccgcaaggaaggagactcgagccgagaagaaacgtatggccatggcgatgaggcagaaa gcactgggtaccctgggcatgactactaatgagaaggggcaagtggtgactaagacggcc ctactgaagcagatggaggaactgatagaagagcccggactcacctgctgtatctgcaga gaaggctacaagttccagcccaccaaagttctcggcatctacacgttcactaagagggtg tcactggaggaagcagagaacaagcctcgcaaacagcagggatacagcacagtctcacac ttcaacattgtgcactacgactgtcacctggcggccgtgaggttagctcgtggtcgggag gaatgggagagcgcagctctgcagaacgccaatacaaagtgtaacggcctgcttcctgtc tggggcccccatgttccggagtcggcctttgccacgtgtttggccaggcacaatacctac ctccaggagtgtacggggcagcgggagcccacctaccagctcaacatccacgacctgaag ctgctcttcctgagatttgccaacgagcaatcgttcagtgcggataccgggggcggggga agggagagcaacatccatctcatcccttacatcatacacaccgtgctttatgtcctgaac acaacccgcgccatatcccgtgaggagaaaaatgtccagaatttcctagaacagcccaaa gagaagtgggtagaaagtgccttcgaggtggacggaccccattacttcacagcccttgcg ttacatctcctccctacagagaagtggaaaaccatccgcatagaagtgctgcgccggctt ctcgtggtcagccatgtgcgggccgtggcacccagcggggccaacagattgacagacaag gctatgaaggagtattccgtgtatcgctccagtctcctcttctgggccctggttgacctc atctataacatgtttaagaaggtaccgaacagtaacacagagggtggctggtcctactcg ctggcagactacatccggctcaatgacatgcccatctacgaggcggccgaccgggcgctc aagaccttccaggacgagtttatgcctgtagagtccttctccgagttcatggacgtcgct ggacttttatctgaaatcaatgacccggacgacttcctgaaggatctcctgaactctgtg ccctga

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