Hyla sarda (Sardinian treefrog): 130295062 Help Entry 130295062         CDS       T11475                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism hsq  Hyla sarda (Sardinian treefrog) Pathway hsq04020   Calcium signaling pathway hsq04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:hsq00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     130295062 (RYR3)    04020 Calcium signaling pathway     130295062 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:hsq04040]     130295062 (RYR3) Ion channels [BR:hsq04040]  Voltage-gated cation channels   Ryanodine receptor    130295062 (RYR3) SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  130295062 NCBI-ProteinID:  XP_056401287 LinkDB All DBs Position 11:61235350..62227167 Genome browser AA seq 4881 aa AA seqDB search MAEGGEVEDEIQFLRTDDEVVLQCVATIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVPP DLCICNFVLEQSLSVRALQEMLANTTANGQEGPSDLSKWKFTRKASQGGGHRTLLYGHAI LLRHSFSGMYLTCLTTSRSLTDKLAFDVGLQDTATGEACWWTIHPASKQRSEGEKVRIGD DLILVSVSSERYLHLSISNGMGNIQVDASFMQTLWNVHPTCSGSSVEEGYLLGGHVVRFF HGHDECLTIPSTDPAEAQHRKVNYEAGGAGIRARSLWRVEPLRISWSGSHIRWGQTFRLR HITTGQYLALTEDQGLVLQDRAKSDTKSSAFCFRASKEKLDSGPKRDIDGMGAAEIKYGD SICFIQHVDSGLWLTYKSQDAKTARLGPLKRRAILHQEGHMDDGVTLQKCQHEESQAARI IRNTTGLFSQFISYLDSLTGNNRTVTAPIALPIEEVVQTLQDLITYFQPPEEELEHEDKQ NKLRSLKNRQNLFKEEGMLALVLNCIDRLNVYSSAAHFAEIIGEKAGPAWKEILNLLYEL LAALIRGNRSNCAQFSNNLDWLISKLERLESSSGILEVLHCILIESPEALNLIEKGHIRS IISLLDKHGRNHKVLDVLCSLCVCNGVAVRTNQNLICDNLLPRRDLLLQTRLVNDVTSMR PNIFLGVAEGSAQYKKWYFEMIIDQVDPFLTPEPTHLRVGWASTSGYAPYPGGGEGWGGN GVGDDLFSYGFDGLHLWSGRVPRAVASSNQHVLASDDVVSCCLDLGVPSISFRINGQPVQ GMFENFNTEGLFFPVVSFSAGVKVRFLLGGRHGEFKFLPPAGYAPCYEALLPKEKMRVEP VKEYKRDCEGVRDLLGTTHFLSQASFIPCPIDTSQIVLPPHLEKIRDKLAENIHELWGMN KIELGWIYGKVRDDNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCLIVHSNQT AEENLRKVKLPKNYMMSNGYKPAPLDLSDVKLLPAQEVLVDKLAENAHNVWAKDRIKQGW TYGIQQDLKNKRNPRLVPYALLDERTKKSNRDSLREAVRTFIGYGYNIEPPDQEITDQMM ERVGIDKIRFFRVEQTYAVDSGKWYFEFEVVTGGDMRIGWARPSCRPDIELGADDRAFVF EGSRAQCWNMGSSFFGRNWQPGDVVGCLINLDDKSMIFTLNGELLITNQGSELAFADFEI ENGFVPVCSLGLSQIGRMNFGRDASTFKYYTMCGLQEGFQPFAVNTNRDVAMWFSKRLPT FVNVPKDHSHIEVTRKDGTVEAPPCLKVTHKTFGTQNSNEDMIYCRLSMPVEFHSAFSNE ENFQKRNVLQEGSHTTTLYYYSVRIFAGQDPSSVWVGWVTPDYHFYSENFDLSKNCTVTV TLGDERGRVHESVKRSNCYMVWGGDHSTGSQRSSRSNVDIDIGCLVDLATGLLSFTANGK DLGTCYQVEPNTKLFPAVFLQPTSTNLFQFELGKLKNTMPLSAAIFKSEEKNPVPQCPPR LDVQTITPVLWSRMPNIFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCIDILELS EQEDLMKFHYHTLKLYCAVCALGNNRVAHALCSHVDQSQLLYTIDNQYLPGLLRSGFYNL LISIYLESAKEGKLMMNNEFIIPITDETRQIRLFPDESKRHGLPGVGRSTCLKSDLHFTV PCLILTGEDRQQHGPQIPVDILKSKAISMLTEAVQSSGDHIRDPVGGRVEFQFVPVLKLI ATLLIMGVFEDEDVRQILLLIDPNVFGDHKEEDAEENFEKEEVAQDEEKAVEAGEKATRE ARAPVKGLLQTRLPESVKLQMCELLHYFCDCELKHRVESIVSFSDNFVSKLQYNQKFRYN ELMQALNMSAALTAKKTREFRSPPQEQINMLLNFQLQEDSPCPEEIRDELYEFHEDLLMH CGIPLDEEEDEEEDTSWTGRLRSLVHKIKGRPKTEEQDPAEEEEKSPTTLKELISQTMVR WAQEDHIQDPELVRIMFSLLRRQYDSIGELLQAMRKTYTISAASVEDTINLLASLGQIRS LLSVRMGKEEEMLMIDGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKSQQIA FPKMVASCCRFLCYFCRISRQNQKAMFEHLGYLLENSSVGLASPSMRGSTPLDVAAASVM DNNELALALQEPDLEKVVTYLAGCGLQSCPMLIAKGYPDIGWNPIEGERYLSFLRFAVFV NCESVEENASVVVKLLIRRPECFGPSLRGEGGNGLLAAMQEAIKISENPALDLPSQGYQR EVVEEDEEEEEIVHMGNAIMSFYSALIDLLGRCAPELHLIQAGKGEAIRIRSILRSLVPT EDLVGIISIPLKLPAFNKDGTVYEPDMAASFCPDHKAPMVLFLDRVYGIKDQSFLLHLLE VAFLPDLRASASLDTALLSVTEMALALNRYICSAVLPLLTRCAPLFSGTEHYAALIDSTL HTIYRLSKGRSLTKAQRDTIEECLLSICHHMRPSMLQQLLRRLVFDVPLLNEYCKMPLKL LTNHYEQCWKYYCLPSGWGSYGLASEEELHLTEKLFWGIFDSLSHKFLSLLQKYEAELFR MSMPCLSAIAGALPPDYVDTRIKATPEKQMSLDAEGNFDPKPINTANLTLPEKLEYIVNK NAEHSHDKWAYDKLHSGWKYGTSLDENVKTHPLLRPFKTLSEKEKEIYRWPVRESVKTML AMGWSVERTKEGEALALHRENEKLRSISQTNQGNGYSPTPIDLSNVVLSRELQGMVEVMA ENYHNIWAKKKKMELETKSAGSHPLLVPYDTLTAKEKARDREKAQELFKFLQVNGYAISR GLKDMELDASSMEKRFAFKFLKKVLHYVDSAQEFIAHLEAVVGSGKSEKSPHEQEIKFFA KVLLPLVDQYFKNHCLYFLSSPIKTLSSSGYASNKEKEMVASLFCKLAALVRHRISLFGN DSATMVSCLHILAQTLDTRTVMKSGSELVKAGVRAFFENAAEDLEKTLENLKLGKFTHSR TQMKGVSQNINYTTVALLPILTSIFEHVARHQFGVDLLLDDVQVSCYRILSSLYSLGTGK NIYVERQRPALGECLAALAGAIPVAFLEPSLNHNNPLSVFNTKSPRERAILGMPDSVEEM CPEMPHLEGLMKEINDLAESGARYTEMPHVIEVVLPMLCNYLSYWWERGTENVPENARPC CTQVTSEHLSVILGNILKIINNNLGIDEASWMKRIAVYAQPIISKAQPDLLKSHFIPTLE KLKKKAIKIVQEEEQLKADSKTDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNW LKKPDADSDELFRMVAEVFILWCKSHNFKREEQNFVIQNEINNLAFLTGNNKSKMSKSGG QDQERKRTKRRGDLYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYLLKDTDDE VKEHLRSNLHLQEKSEDPAVKWQLNLYKDILKSEDTDPEKTVERVQKISAAVFHLEQVEQ PLRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHKINNFFLSSYQRIWLEKVHENSDY DSLILVLTNPKKKEEDEEEETEKKPDPLHQIILHFSRNALTERSKLEDDPLYTAYAAMMA KSCQNEEEDEEKEKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVET LKLGIAILNGGNTVVQQKMLDYLKEKKDAGFFQSLSGLMMSCSVLDLNAFERQNKAEGLG MVTEEGTLIVRERGEKVLQNDEFTRDLFRFLQLLCEGHNNDFQNFLRTQMGNTTTVNIII STVDYLLRLQESISDFYWYYSGKDVIDESGQHNFSKSLAVTKQIFNSLTEYIQGPCIGNQ QSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKQLLDLLQDMVVMLLSLLEGNVVN GTIGKQMVDTLVESSSNVEMILKFFDMFLKLKDLTSSDAFKEYDPEGKGIISKKEFQKAM EGQKQYAQSEIEFLLSCAEADENDMFNYVEFVDRFHEPAKDIGFNVAVLLTNLSEHMPND SRLQCLLDPANSVLNYFSPYLGRIEIMGGAKRIERVYFEISESSRTQWEKPQVKESKRQF IFDVVNEGGEQEKMELFVNFCEDTIFEMQLASQISESDAVDRPEDEEEEEPHHMIEVGEE DEEEQSLESSSAFIVACTALRKNMSNFFKMLTLKNISKQFRKVKKMTLKELVKVFFSFFW TLFVGLFQFVFTIVWGIFQILWSTVFGGGLVEGAKNIKVTKILGDMPDPTQFGIHDDVLE AEKADSLEHTSPAELAHLGKGDKGDMDMPDIYGMHTKKEGSKHGLEIGLGDYSENVSSEN ATSLESAVNKKRKALAAEIAKENEDNSKAESEKADMEDGEKKDKAKAEEQSELLESKTGP RIKRRRGQKKEVPEAFMANFLAGLEIYQTKMLNYLARNFYNLRFLALFVAFAINFILLFY KVTEEPATEDNDNDSNIWNTYTEDEEDAEEGAVYFVLQENTGYMAPTLRILAIIHTIISF LCVIGYYCLKVPLVVFKREKEIARNVEFDGLYITEQPSDDDIKGQWDRLVINTPSFPNNY WDKFVKRKVINKYGDLYGADRIAELLGLDKNALDFSPVEKTKIEEGSLVSWLSSIDMKYH IWKLGVVFTDNSFLYLAWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQ LVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDDPDMKCDDMMTCYLFHMYVGVRAGGG IGDEIEDPAGDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMET KCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYIINKDETEHTGQESYVWKMYQE RCWDFFPAGDCFRKQYEDLLG NT seq 14646 nt NT seq  +upstreamnt  +downstreamnt atggctgaagggggcgaagtggaggatgagatacaattcctccgcactgacgatgaagtt gtccttcagtgtgtcgctaccatccataaggagcagaggaagttctgcttggcagctgaa ggacttgggaatcgactttgcttcctggaaccaacatcagaagccaaatatgttcctcct gacctttgcatatgtaattttgttctggagcaatccctttctgtcagggcacttcaagaa atgctggcaaacaccactgcaaatggccaagaagggcctagtgacctgtccaaatggaag tttacacggaaggcatcacaaggaggcgggcatagaacattactttatggccatgcaatc ttacttcgacattcattcagtggtatgtacttgacatgtttgacaacatccagatccctt acagataaacttgcttttgatgttggactgcaggatacagcaacaggagaggcttgctgg tggacaatacatcctgcatccaagcagagatcagaaggagagaaagttcgtattggggat gatctgattttagtcagtgtgtcctctgaaagatatcttcatctatccatatccaatgga atgggcaacatccaggtggatgcctcttttatgcagaccctctggaatgtccatccaaca tgctctgggagtagtgtggaagaagggtatcttctcggtggacatgtggtccggtttttc catggccatgatgaatgtttgacaatcccatctactgatccagcagaagctcagcatagg aaagttaactatgaagcaggaggagcaggtatccgtgcccggtcactatggagagtggaa cccctcagaataagctggagtggaagtcacatcagatgggggcagacatttcgcctacgg catattacaactgggcaatatttggcactgacagaggaccaaggattagtgctgcaagac cgagcaaaatctgataccaagtcttcagcattctgcttcagagcatcaaaggaaaagttg gactctgggccaaagcgagacattgatggaatgggagctgccgagataaagtatggggat tccatttgctttattcaacatgtagacagcggcctttggctgacctataaatcccaagat gccaagacagcacgactgggaccactaaaaagaagagcaattctgcaccaggaaggccat atggatgatggcgtcacattacagaagtgtcagcatgaagagtcccaagctgctagaatc attcgtaacaccacaggcctgttcagtcagtttatcagttacctggattctctgacaggg aacaaccggacagtaacagcccccatcgccctgcctattgaggaggtagttcaaaccctg caagacttgatcacttatttccagcctcccgaggaagaactagaacatgaagacaaacaa aataagctccgctcactcaagaacaggcagaacctttttaaagaggagggaatgctggcc cttgtgctaaactgtattgaccgtctaaatgtatacagcagtgccgcacactttgctgaa atcatcggggaaaaagctggaccagcatggaaggaaatcctgaaccttctctatgaatta ctagctgctctaattcgcggaaatagaagcaactgtgcacaattttccaataatttggat tggcttataagtaaattggagcgtcttgaatcatcttcaggaatactggaggttctacac tgcatcttgatcgaaagccctgaggctttgaatttaattgagaagggacacatacgctcc ataatttctcttttggacaaacatggacgaaaccacaaggttctggatgtgctgtgttct ctgtgtgtatgtaatggtgttgcagtgcgtaccaaccagaacctcatttgtgacaacctg ctgcccaggagagacttgttgttacaaacccgtttggttaatgatgttaccagcatgagg cccaatatcttcctgggtgtagcagaggggtcagcacagtacaaaaagtggtactttgag atgattattgatcaggtggatccatttctaactccagaaccaactcacctacgtgtaggc tgggcttccacctcaggctatgccccatatcctggtggaggtgaaggatggggaggcaac ggtgtaggagatgatcttttctcttatggctttgatggtcttcacttatggtctggacga gtaccgagggccgtggcttcaagtaaccagcatgtattagcatctgatgatgtggtcagc tgctgcctggatttgggagtgcctagtatttcttttcgtattaatggtcagccagtccaa ggcatgtttgagaactttaacaccgaaggtctgtttttcccagtcgtgagcttttctgct ggggtcaaggtccgatttcttcttggtggtcgccatggtgaattcaagttcttacctccg gctggctatgcgccatgctatgaggccttgttgcctaaagagaagatgagagtggagcct gtaaaggagtacaaaagagattgtgagggagttcgggatttgttgggtacaacacacttt ctgtcccaagcttcattcattccttgtcccattgataccagccagattgttttacctcct catcttgagaaaatccgagacaaattagcagaaaacatccatgaactttggggcatgaac aaaattgaacttggttggatctacggcaaggtgcgagatgataacaaacgccaacatcct tgcttggtagaattttccaagcttccagaaacagaaaagaattataaccttcagatgtca actgagacgttaaagactttgttagctctcggatgtctcattgttcattcaaatcaaaca gctgaagaaaatctaagaaaagttaagctcccaaaaaactacatgatgtccaatggctac aaaccggcccctttggacctctctgatgtaaaactgttaccagcccaagaagttctagtt gataaacttgccgagaatgcacacaacgtctgggcaaaagatagaatcaaacaaggatgg acctatggcattcaacaggatctgaaaaataaaagaaaccctcgcttggtgccatatgct ttacttgatgaacggactaagaaatctaatagagacagtttacgtgaagccgtcagaaca ttcattggatatggctataacatcgagccaccagaccaagaaataactgatcaaatgatg gagagagtcggtattgataagattcgcttctttagggtggaacagacctatgctgtggac tcaggaaaatggtattttgagtttgaggtagtaaccggaggagacatgcgtataggctgg gccaggcccagttgtagaccagatattgaacttggtgcagatgatcgggcatttgtattt gaaggaagcagagcacaatgttggaacatgggtagctctttctttggccggaactggcag cctggagatgtggtgggatgcctgattaacttggatgataaatcaatgattttcacttta aatggagaacttctcatcacaaatcaaggctctgagctggcgtttgctgactttgaaatt gagaatggttttgtcccagtctgctccctggggttgtctcagattggtcgcatgaacttt ggtagagatgccagcacatttaagtactacacaatgtgtggcctacaggagggcttccaa ccatttgctgtgaacacaaacagagacgtagccatgtggttcagcaagcgcttaccgact tttgtcaacgtgccaaaagatcattctcacattgaggtgacaaggaaagatggaactgta gaagccccgccatgcttgaaggttacacataaaacctttggcacccagaatagcaatgaa gatatgatctactgcaggttgagtatgcctgtggagttccactctgctttcagcaatgag gagaacttccaaaagagaaatgtgcttcaagaaggatctcacacaaccacattgtattac tactctgtccggatatttgctggacaagacccatcttcagtatgggtaggatgggtaact cctgactaccacttctattctgaaaactttgacttaagcaagaactgcactgtcactgtc actttaggagatgaaaggggcagagtgcatgaaagtgttaaacggagcaattgctacatg gtatggggaggtgaccactctacgggctctcagaggtcaagccgcagcaatgtagatatt gatattgggtgccttgttgatctggccacagggctgctgtcattcacagccaatggaaaa gatttggggacctgctaccaggttgaaccaaacaccaagctgtttccagcagtttttctg cagccgactagcactaatctctttcagtttgaacttgggaaattaaagaacaccatgcct ctatcagctgcaatatttaaaagtgaagagaaaaatcctgtgccacagtgccctcctcgc ttggatgtacagactataacgcctgttctctggagccgtatgccaaatatttttctaaag gtggaaacagaacgtgtgagtgagcgtcatggctgggtagtgcagtgtttggaacccttg caaatgatggcattacatatacccgaggagaacaggtgtattgacattttagagctttca gagcaggaagatttgatgaaattccattatcacaccctgaagctgtattgtgctgtttgt gctctgggtaacaatcgtgtggcccatgccttgtgcagccatgtggatcagtcccaactt ttgtataccattgataaccaatacctacctggtctcttaagatcaggtttctataacctt cttatcagtatctacctggagtctgccaaagagggaaagctaatgatgaacaatgagttt attattccaataactgatgagacaaggcaaatccgactgttccctgatgagtccaaaaga catggcctacctggggtaggtcgcagtacctgcctgaaatctgatcttcattttacagta ccttgcttaatattgactggagaagacagacagcaacatggcccacagattcctgttgat atcctcaagtccaaagcaatcagcatgttaacagaggcagtacaaagcagtggagaccat atccgagatcccgtggggggcagagtggagttccagtttgtgccagtgctaaagctcatt gcaactcttcttataatgggagtttttgaggatgaggatgtccgtcaaattctgctactt attgatccaaatgtttttggtgaccacaaagaagaggatgcagaagagaactttgagaag gaggaggtagcacaagatgaggaaaaagctgtggaggctggagagaaagcgacaagggaa gccagagctcctgttaaaggtcttctgcagactcgattaccagaatctgttaagcttcag atgtgtgagttacttcattatttttgtgactgtgagctgaagcatcgcgtggagtccatt gtttccttctctgataactttgtgtccaagcttcaatataatcagaagttccgttacaat gaactgatgcaggcactgaacatgtctgctgccctgacagccaagaaaacaagggaattc cgctctcctccacaagaacagattaacatgcttctaaatttccaactacaagaagatagc ccttgccctgaagagatacgggatgaactatatgagttccacgaggatcttctaatgcac tgcggcatcccactagatgaagaggaggatgaggaagaagatacatcatggacaggtcgt cttcgatcactggtgcacaaaatcaaaggaaggccaaagactgaagaacaggatccagca gaggaggaggaaaagtctcctaccacacttaaagagcttatctcacaaaccatggtgcgt tgggcacaagaagaccacattcaagatcctgagcttgttcgtataatgtttagtctcctg cggaggcaatatgacagcattggagagttgttacaggccatgagaaaaacctatacgatc agcgctgcctctgtggaagatactataaacctgctggcttctctggggcagatacgctca ctgttgagtgtgagaatgggcaaagaagaggagatgctcatgattgatggattgggtgat atcatgaacaacaaagtcttctatcagcatccaaacttgatgcgagttttagggatgcat gaaacagttatggaagtcatggtgaatgtactgggaggagacaagtctcagcaaattgct ttcccgaagatggtggcaagttgctgcaggtttctctgctatttctgcagaattagtcgt caaaaccaaaaggccatgtttgagcatctcggctacctgttggagaacagcagtgttggc cttgcatctccctccatgagaggttctacgcctctagatgtcgctgcagcatctgttatg gataacaatgaacttgccttggctttgcaggaaccagatctggagaaggttgtgacatac ttggcaggttgtgggctgcagagttgtccaatgttaatagccaaaggatacccagacatt ggatggaatcccatagagggcgagcgctacctatcattcctgcgttttgcagtcttcgta aactgtgagagtgttgaagaaaatgccagtgtggtggtgaagcttctcatccgtcgccct gagtgttttggaccttccctgagaggagaagggggaaatggtttgctggcggctatgcag gaggctattaaaatctctgaaaatccagctctggaccttccttctcaggggtatcagagg gaagtggtcgaagaagacgaagaagaagaagagattgtacacatgggaaatgctataatg tccttttattctgcccttattgatcttctgggacgctgcgcaccagaactacatttgatc caagctggtaaaggtgaagctataagaattcgctcaatcctccgatccctggtgcctacg gaggatcttgttgggattatcagcatcccattaaaactgccggcttttaacaaagatggc acagtttatgagcctgacatggctgccagcttctgccctgatcacaaggctcccatggtg cttttcctggaccgtgtctatggtattaaggaccaaagcttcctcctccatttactggag gtggccttcttacctgatcttagagcttcggcatcccttgacacagctttactaagtgtc acagagatggctcttgccttgaatcgatatatttgctcagcggtgctaccattgctcact cgctgtgctcccctcttttcgggcactgagcactatgcagcattaatcgattccaccctg catacaatatacagactgtccaaggggcgctctctaaccaaagctcagagagatacaatt gaggaatgcctgctttccatatgccatcatatgcggccttccatgctccagcagcttctg agacgtctggtatttgatgtcccgttgctcaacgaatactgtaaaatgccccttaagcta ctgacaaatcactatgagcagtgctggaaatattactgcctcccttctggatgggggagc tatggtttggcctcagaggaggaattgcatttgacagagaagctgttctgggggattttt gactctctttctcataagttcctatctctcctgcagaagtatgaggctgagctcttcaga atgtccatgccatgtctcagtgcaatagctggtgctttgcctcctgattatgttgataca agaattaaagcaacacctgagaagcagatgtcattagatgctgaaggaaattttgatcca aagcccatcaatacagctaatctgacattacctgaaaagctggaatatatcgtcaataag aatgccgagcattcacatgataaatgggcctatgacaagctacatagtggttggaagtat ggaacgtcgcttgatgagaatgtaaagacacatcctctactgagacctttcaagacactc tctgaaaaggagaaagaaatttatcgctggccagtaagggagtctgtaaaaactatgttg gcaatgggctggagcgtagaaaggactaaagaaggagaagctttagcacttcaccgggaa aatgaaaagttgcgaagcatttcccaaactaaccagggaaatggctatagtcccacccca attgatttgagcaatgttgtcctttccagagagctccaggggatggtagaagtgatggca gaaaactaccataacatctgggctaaaaagaagaaaatggagttggaaactaaaagtgca ggaagtcacccactgttggtgccttatgacacgttaacagcaaaagaaaaagcacgggat cgtgagaaagctcaagaactctttaaattcttacaagtcaatggttatgctatatccaga ggattaaaagatatggaactagatgcatcttctatggaaaaaagatttgcttttaagttt ctgaagaaagtcctacattatgtagattctgcgcaggaatttattgcacatttagaggct gttgtgggcagtggtaaatctgagaagtcgccacatgaacaagaaatcaagttttttgct aaagttcttcttcctcttgttgaccaatattttaagaatcactgcctatactttctgtcc tccccaattaaaactctaagcagtagtggatatgcatctaacaaagagaaagagatggta gcaagtctgttctgcaaactggcagcacttgtaagacataggatatcactgtttggaaat gactccgccacgatggtgagctgtctgcacatcctggctcagacgctcgacacacgcacc gtgatgaagtctggttctgagctggtaaaagcgggcgttagagctttctttgaaaatgct gctgaagatttagaaaagaccttggaaaatttaaagcttggaaaatttacccattcaaga acccaaatgaagggtgtctctcagaatattaactacaccacagtggccctccttccaatc ttgacttccatttttgaacatgtggctcggcatcagtttggtgttgacttgctgttggat gatgttcaagtttcctgttataggatcctctccagtctgtattcccttgggacgggaaaa aatatctacgttgaaaggcagagaccagccttgggagaatgtttggcagcactggctgga gccatacctgtagctttccttgaaccatcactaaaccacaacaaccctctctcggttttt aacaccaaatcacccagagagagagccattctaggtatgccagattccgtggaagagatg tgtccagaaatgcctcatttggaaggtttgatgaaagaaatcaatgatctggctgagtct ggagccaggtatactgagatgccccatgttattgaagttgtgcttccaatgttatgcaac tatctctcctactggtgggagaggggaacagaaaatgttccagaaaatgccaggccgtgc tgtactcaagtgacttcagaacatctaagtgtcatcttgggcaacatcctaaaaattatt aacaacaatctgggaatagatgaagcttcatggatgaagagaattgcagtttatgctcag ccaattatcagcaaggctcagccagacctcctgaaaagccatttcatccccacgctggag aaactgaagaagaaagcaataaagattgtgcaagaggaggagcagctaaaagcagacagc aagactgacacgcaggaagcagagctgctaattctggatgagtttgctgttttatgcaga gatctttatgcgttctacccaatgttgatccgatatgtagataacaacagatccaactgg ctcaaaaaaccagatgcagattctgatgagctgttcagaatggtggctgaagtgttcatt ctttggtgcaaatcacataactttaagagagaagaacagaattttgtgattcaaaatgaa attaacaatctggcatttctaactggaaacaacaagagtaagatgtcaaaatctggaggg caagaccaggagaggaagagaaccaaacgcagaggagacctttactccatacagacttcc ctgattgtagctgccctgaagaagatgttacccatcggcctgaatatgtgcactccaggc gaccaggaactgatatccctggcaaagagcagataccttcttaaagatacggatgatgaa gttaaagaacacctgcgcagtaaccttcacttgcaggaaaaatccgaagaccctgcagtg aaatggcagttgaatctgtacaaggatattttgaaaagtgaggacacagatcctgagaaa acggtggaacgtgtgcagaaaatctctgctgcagtcttccatcttgaacaggtggagcag ccattgaggtctaagaaggctgtctggcacaagctcctgtcgaaacagagaaaaagggct gttgtggcatgctttcgcatggctcctttgtacaatctgccaagacacaaaattaacaat ttcttcctgagctcctaccaacgtatttggctggaaaaagtacatgagaactcagactat gacagtctaatactcgtgttaacgaatcctaagaagaaggaagaagatgaagaggaagag acagagaaaaagcctgatcctcttcaccagattattttacacttcagtcgcaatgccctg actgagaggagcaagcttgaggatgatcccctgtatacagcatatgcagctatgatggct aagagctgccaaaatgaagaggaagatgaggaaaaggaaaagacatttgaagaaaaggaa atggaaaaacaaaaaaccttgtatcagcaggcccgcctacatgaaagaggggctgcagaa atggtgttgcagatgatcagcgcaagtaaaggtgaaatgagccccatggttgtagagaca ctaaaacttggaattgcaattctgaatggtggaaatactgttgtgcaacagaaaatgtta gattacctaaaagagaaaaaggatgctggatttttccagagtttgtctggcttaatgatg tcgtgcagcgttcttgacttgaatgcatttgaaagacagaacaaagcagaaggccttgga atggtaacagaagaaggaacactcattgtccgggaacgaggtgaaaaggttttacagaat gatgaatttacaagagatctcttcaggttcctgcaacttctgtgtgaaggacacaacaat gactttcaaaacttcctaagaacgcaaatgggtaatacaacaacagtgaatattataatt agcacggtggattatcttctacgcttgcaggaatctatcagtgacttctactggtactac tcagggaaagacgtgattgatgaatctgggcagcataacttctcaaagtctctggctgtg accaaacaaatatttaattcacttacagaatacattcagggtccgtgcataggtaaccag cagagtttggcgcacagcaggctgtgggatgcagtggtcggtttcctccatgtttttgca aacatgcagatgaagctgtcacaggattcaagccagattgaactccttaaacaacttctt gatctccttcaagacatggtggtgatgctgctttcccttctagaaggcaatgttgtaaat gggactattggaaaacagatggttgacactcttgtggagtcatctagtaatgttgaaatg attctaaaattctttgatatgttcctgaagttgaaagacctaaccagttctgatgcattt aaggaatatgacccagaaggaaagggtatcatttccaaaaaagaattccaaaaagccatg gagggacaaaaacaatatgcacagtcagaaattgaattccttctctcctgcgcggaagcg gatgagaatgacatgtttaactatgtagagtttgtagaccgcttccatgaaccagctaaa gacattggtttcaatgtggctgttttgttaaccaatctctcagagcacatgccaaatgac tctcggctccagtgtttgttagacccagcaaacagtgttcttaactacttttctccatac ttagggcgcattgagatcatgggtggagcaaaaagaatagaaagagtgtattttgagatc agtgaatcaagtagaacacagtgggagaaaccacaagtcaaggagtctaaaagacaattt atatttgatgtggtcaatgaaggtggagaacaagaaaagatggaactatttgttaacttc tgtgaagatacaatttttgagatgcagttggcatctcagatctctgaatcagatgcagtt gacagacctgaagatgaggaagaggaggaacctcaccatatgattgaagttggtgaagag gacgaagaggagcagtctctagaatcatcatctgcttttattgtagcttgcacagctctt aggaaaaatatgtccaatttcttcaaaatgttaaccttaaaaaacattagtaaacagttt cgaaaagtgaaaaagatgactctcaaagaattagtcaaagtcttcttttctttcttttgg acgctgtttgttggtttgttccagtttgtgtttacaatagtatggggaatatttcagatt ctttggagcacagtgtttggaggtggcttagttgaaggggccaaaaacattaaagtaacc aaaatattaggagacatgcctgatcccacacagtttggaatccacgatgatgtcttggaa gctgaaaaagctgattcactcgagcacacctcacctgcagagcttgcacatcttggtaaa ggagacaagggagatatggatatgcctgatatttatggcatgcacaccaaaaaagaaggt tccaaacatggtttagaaattggccttggggattactcagaaaatgtgagctcagaaaat gcaactagtttggaaagtgctgtaaacaagaagagaaaagctcttgcagcggaaattgct aaagaaaatgaggacaactcaaaggcagaatcggaaaaggctgacatggaagacggtgag aaaaaggacaaagctaaagctgaagaacagtctgaattattggaaagtaaaacagggcca agaattaagaggagaagaggccagaaaaaagaagtgcctgaagcatttatggctaatttc ctggcaggactggagatttaccagaccaaaatgctgaattacctggccagaaatttctac aatctcagattcctcgctctctttgtggcatttgccattaactttattctattgttctac aaggtcacagaggagccagcaactgaagacaacgataatgattccaacatatggaacact tacacagaagatgaggaagatgcagaagaaggagctgtatattttgtattgcaagaaaac actggttacatggctccaacattgcgcatcttggctattattcacaccataatctctttt ctctgtgttatcggttattattgtcttaaggttcctctggtcgtgtttaaaagagagaaa gaaattgctcgcaatgtagagtttgatggcctgtatattacagaacaaccctcagatgac gacatcaaagggcaatgggatcgtcttgttataaataccccgtcttttcctaataattac tgggataaatttgttaaaagaaaggttatcaataaatatggagacttatatggagctgac agaattgctgaactcctgggacttgacaaaaatgccttggactttagccctgtggaaaag accaaaatagaagagggatcactggtgtcatggttaagctccattgacatgaagtatcac atctggaagcttggagtggtatttacggacaactcttttctttacctcgcctggtacaca accatgtcgattcttggacattataacaactttttctttgctgctcatcttttggacatt gcaatgggctttaagaccctgaggacaattctttcatcagtcacgcacaacggaaaacaa ctggtgttaactgttggtctcctggctgttgttgtctatctttacacggttgtggcattc aattttttccggaaattttacaacaagagtgaggatgaagatgatcctgatatgaagtgt gatgacatgatgacgtgctatctgtttcatatgtatgtgggggtgagagccggaggtggc attggagatgagattgaggaccctgctggtgacccttatgaaatgtatcgtattgtgttt gacatcaccttcttcttctttgttatcgtcattctccttgccattattcaaggtttgatc attgatgcctttggggaactgagagatcaacaagaacaagtcagagaagatatggagaca aaatgcttcatttgtgggattggaaatgattactttgatacaacgccgcatggctttgaa acacacacgttacaagaacacaacctggctaactatctgtttttcctcatgtatatcatt aataaggatgagacggaacatactggccaggaatcttatgtctggaagatgtatcaagag aggtgttgggacttcttcccagctggtgactgcttccgcaagcaatatgaagacctgctt ggataa

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