Ictalurus furcatus (blue catfish): 128613085 Help Entry 128613085         CDS       T09387                                  Symbol ryr2b Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism ifu  Ictalurus furcatus (blue catfish) Pathway ifu04020   Calcium signaling pathway ifu04260   Cardiac muscle contraction ifu04261   Adrenergic signaling in cardiomyocytes ifu04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:ifu00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     128613085 (ryr2b)    04020 Calcium signaling pathway     128613085 (ryr2b)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     128613085 (ryr2b)    04261 Adrenergic signaling in cardiomyocytes     128613085 (ryr2b)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:ifu04040]     128613085 (ryr2b)    04990 Domain-containing proteins not elsewhere classified [BR:ifu04990]     128613085 (ryr2b) Ion channels [BR:ifu04040]  Voltage-gated cation channels   Ryanodine receptor    128613085 (ryr2b) Domain-containing proteins not elsewhere classified [BR:ifu04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    128613085 (ryr2b) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR SPRY RR_TM4-6 RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 Motif Other DBs NCBI-GeneID:  128613085 NCBI-ProteinID:  XP_053489623 LinkDB All DBs Position 9:complement(27855410..27934348) Genome browser AA seq 4319 aa AA seqDB search MLRLSLCDLIGYFRLPDECWSHETRQSSSGALKNRQNLFQEEVKCAAKDYGCLVMRVYYI NKNLCSSSLFLSQGVITLVLDCIDHLHLYSSAAHFAEAAGKEAGDAWEAILSSLYVLLAA LIRGNQNNCSQFSSSLDWLISRLERLEASTGILEVLHCVLMESPEALSFIKEEHIRSIIT LLDKHGRNHKILEVLCSLCVCHGTAVRSNQHLICDTLLPERDLLLQSRLMNHVTSVRPNI YLCMGDNSAQYRKWYYEVVVEKAEPFVTPEPSHLRVGWACSAGYHPPPTGGHSWGSNGVG DDLRSYGFDGLHLWTGGVGRRVSSVSQRLLREDDVISCCLDLGAKCISFRVNGQPVQGML ENFNTDALMFPVVSFSAGVRVRLLFGGQQGEFKFLPPAGFSPCAEALLPRGRCRLELCEE VTRGQGNSGRELLGPAVSTEPVVFTPTPVDTNQVTLPPQLELIRERLAENLHELWLLEKT EQGWTHGPVRDDSKQVHPGLVEFSKLPDQEKRSNLQAAEHTLRSLLALGARIGLSDDHAE EKVKYARLSNKHELWNGYMPAPVDQSGVSLSAAQEALVEALAENEHNIWAREHIRQGWSY APQQDIKGKRSPHLVPFSLLDERSRQCAKESARDVLGTLLGFGYSVEASEEWQSLGPDVK AASEERVRIFRVEHTFAVHDGKWYFELEAVTAGEMRVGWARVGCQADMELWSDEQAYVFD GSKGQWWHGSTAPFGHVWQKGDVIGCLLDLTRRTMMVTLNGELQLNTYGSEIASKGFSAT GGFVPVCVLGVNQVGQLNLGQQVNSLKYFSVCGLQEGYQPFALNMSKDPPLWMSWREPLF VQIPEDHPRLQVSYIDGTVGHLPALKVTQRSVGLPDNLSTDVEFYRLSLPIECVQVFTNP VDGTVPPASSVACHIKEPEEGEVDSDFEMLMKSAHRHTGTRDELNNHKDHAQEKTSRLKQ RFLLKKKPGLNTSGSSARLLEEVLAIERDSANQFANCTKYYYSVKILHGQDPSCVWVGWV TSNFHSDDRTFDPERVCSVSVTLGDQWGKVLKSIKCSCSYMVCAGEGSSLSHSQSSIRLE IGCLVDTATGFLTFTANGKEMGIFYQVEPGTKLFPAVFAKATSSDVFQFDLGRIKGALPL SAGLFRSERKNMEPQCHPRLTVQSLIPMRWTRLPEHAPQVELIRLEERHGWRAQCADSLQ VMTLHIPEEDRSIDILELSELDNLLKFHDHTLRLYSALCAHGNIPVSHALCSHIDQSQLL FALRCSRMPGNLRAGFYDLLMTAHLSVHSSARQATIHEYIVPMTDAMRTSTRSQNNRKQH RLPGSNTSTSLQPRMHFSSPCFVRASGNSFDNRSNRSEQGSCQYSPEFPMDMLKAVMTAM LEEAVHSVGKSIRDPVGGSIELMLVPLLQLLHTLLLMGVYHHSDLRRLLSFILPSVYMRE NNAGELIDGDGENYYEILGKEKEGRALPEQKTLLQMKLPEAVKLQLCHLLQYLCDCEVRH RVEAIMTLSADLVGRLQGNQRSRYMNVMEALNMSAALTARKTKEFRSPPQEQMNLLLNFR DMEQDCPCPEKIRELLWDFHLDLRSNCVETDENLGAEDDESQPIRNRLRDLVDKMSRLKR RMSGVVEKDVVAKPVSLQWLISDTVMRWTHEGPLEDPVLVRAAFGLLRYQYAGLSGKMAA PLQKAYCITQNSVEDTLGLQEALGRIRSLLTARMGIEEEELMIRGLGDIMKNKVFYQHPN LMRALGMHETVMEVMVNVLGTRESKEIRFPKMVAHCCRFLCYFCRISRHNQKAMFDHLSY LLDHSSVGLASPSMRGSTPLDVAAASVMDNYELALALTEPDLEKVVQYLAGCGLQSCTLL LSKGYADIGWNPVEGERYLDLLRFAVFCNGESVEENAYVVVRLLIRRPECFGPALRVEGG NGLLATMEDAIKISEEESGECFSKAYQSSSTLDTLGDEDDNVIHMGHAIMTFYSALIDLL GRCAPELHLIEAGKGEAVRIRAILRSLIPVNDLEGVISIPFPLPFLDKDGCMMEPDMSRC FCPDHKASMVLFLDRVYGVQDQNFLLHLLEKGFLPDLQAAVSMDNSGLGSTDMALALNRY LCGSVLPLLSKCSSLLRGLPLVRTGTVDDFLQALYRLSKASSLTKAQHDAIQTCLLSVCG KLKPSLLQPLLRSLAVDVPQLSESTKMPLKLLTDHYEQNWKYYCTTGGRGGFGSASEEEL QLSRKLFWHVFRALTKKTYDAETSEASVGCLVAVSGAVPPDHVDLTCTAGLDTHSSLDSE GRFCPQPLDTSDVTVPEGLEYVVNKYAEHTHEKWSLEKFANGWVHGEQMCESSKVHPLLK PYRALSERDKENYRAAIKETVKSMLVLGWTIERSKEGDTRDLHHLSRRISQSGQLSFEGT SMFSPKPADTSSIMLTWDQYAMAEQLAENYHNIWAQKKLQELQAKGGGSHALLVPYDSLS GREKSRIRERARDVLKFFHINGYTVWRERKPPESDCPSISGRFAYRLLQQALSCTEQVQE KMLELEVAQARGQPGTAEDMCHEQQMRFFIKVCTRSPLRISVSGFLGKDARCVVSCLQIL ARSLDAKVAMKMATECVRSALHSFFEAAAVDLELAVDSVTPGVIQFRGDREVLTYTTAAL LPVLTSLFKHTAHGQSSLDLMGVSIAAKDSSWTLPSLQEALADVEDVLEAESAARHALLS RVMEVTVPLLCSYVCRWGEEDSLGSEGQQGASCSSLTPSHTNALLGQILAIIHVHLGRHE CTWMKRIAGFVQPMVRNAEPGLLTSRILPLMEKLKKRAESVLQEEESMKIEGCGDVAEME LAVQEKFAVLVQDIYAVYPLLIPFVEHHRILWLREMNADAERLFSLVADVFTFWAKSHNF KWEEQNFVVQNDINNMTYLVNSRNSQMTKRECEEERRKVKRSKDERYSTHTSLIVASLKK LLSVGLNRCCQRDRDLITLAKNRFAEKDTEEEVRAFICISLQQVNQDVSHSLLDERRVES VLAVARVLFYLDQVREIFRVIRSANLFISSFIICTHSFCELFVYSHIIEFRLEEDGLYLA YTDIMAKSCQAEDEDGRDEVKSFEEKELEKQRLLYQQARLHERGAAEMVLQRLSASRGVT GHSVEATLKLGIAMLNGGNTDVQQKMLDYLRVKRDVGFFHSLASLMQSCSVLDLNAFERQ MKAEGLGTAADGNAGDKVMADEPLTCDLFRFLQLLCEGHNADFQNYLRTQTGNNTTVNIV ISTVDYLLRLQESISDFYWYYSGKDVIDEHGQRNFSKAIRVAKQVFNTLTEYIQGPCTGN QQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLLKDMVVMLLSMLEGNVV NGTIGKQMVDMLVESSSNVEMILKFFDMFLKLKDLVSSDAFKEYDPDVQGLISKKDFQKA MEGYKRYTLSEMDYLLSCAETNETKLLDYRAFVARFHEPAKDIGFNVAVLLTNLSEHMSH DARLRNFLELADSVLRYFQPHLGRIEIMGSGKRVERVYFEISESSRMQWEKPQVKESKHQ FIFDIVNKGGEKEKMELFVNFCEDTIFEMQLAAQISASDRDDEVLGIEDDGVDEKEEDKN SATDNDDTKVEQRGFSLMAMMKRLLLAPLCGLMMIMCLLSIRNVKRQIKRMTMKGLILAI ALFFQKVLSAILHTILDTICFFLHVLYLVFLSGCIIEFAKETKLSDFFRDLTDPTLDDVT GVNEGVIHKNKGPSQTRSSHGDLQAMTLDLSAVSKNPQILTDIFGLQLRKDGGQYMLISR DSNASIGEVMNPSKYQVIHTHILGEDNEKKDKRKEDEAKRRFRRMSLHKAAEPEVEESAT WKIIDSQKTKLLNYFARNFYNMRVLALCVTFGINFILLFYKVSSSEAEGVAMPDLGDEND DSKSVRFILGESGYMKSVLHSLALLHTLISFCSIIGYYCLKVPLVVFKREKELARKLEFD GLYVIRQPADDDVRGQWDRLVINTLSFPSNYWDKFVKRKSVVLFVLWQVMAKYSELYGSE RISGLLGLDKTTLDFSYEARNGRRPARELLNSIDMKYQIWKLGVVFTDNSFLYLAWYMLL SILGHYNNFFFAAHLLDVAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNF FRKFYNTSEDGQTLDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDESEFYRVVFDI TFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSEYFDAVPHGFETH TLHEHNLANYLFFVQYLINKDVTEHTGQESYVWKMYQERCWEFFPVGDCFRKQYEDQLG NT seq 12960 nt NT seq  +upstreamnt  +downstreamnt atgctgcgtttgagtttgtgtgatctgattggttatttccggctgcctgacgaatgctgg agccacgagaccagacagagcagcagcggagcgctaaagaacagacagaacctgttccag gaagaggtaaaatgtgctgcaaaggattatgggtgtttggttatgcgtgtgtactatata aacaaaaatctgtgtagctcatctctctttctctctcagggtgtaattactttggtccta gactgcattgatcacctgcacctgtatagcagtgcggctcattttgccgaggctgctggg aaagaggcgggagatgcatgggaagccattttgagctccctctatgtgcttctggcggcg ctgatccgggggaatcagaataactgctctcagttctccagctctctggactggctgatc agcagactggagagacttgaggcctccactggaattcttgaagtgctgcactgtgtatta atggaaagtccagaagccctgagttttattaaagaagaacacattcgctccatcatcaca cttttagacaaacacggacgcaaccacaagatcctggaggtgctgtgttcactgtgtgtg tgtcatggtacagcagtgcgctctaatcagcacctgatctgtgacacactgctgcctgag agagacttactgctgcagagccgcctgatgaaccacgtcaccagtgttcgcccgaacatc tacctctgcatgggagacaactccgcacagtacaggaagtggtattatgaggtggtggtg gagaaggcggagcctttcgtgacacctgagccttctcacctgagggtgggttgggcctgt agcgcaggttaccacccccctccaacgggaggtcacagctgggggtcaaacggagtcgga gacgacctgcgctcatacggcttcgacggcctgcacctgtggacaggtggcgtaggtcgc agggtcagctcggtcagtcagcgtctgctgagggaggatgatgtcatcagctgttgcctc gacctcggtgcgaagtgtatttctttccgagtgaacgggcagccggtgcagggcatgctg gagaatttcaacaccgacgcgctcatgtttcctgtggtcagtttctccgctggagtcagg gtacgtttgctgttcggaggtcagcagggggagtttaaattcctgcctcctgccggattc tcaccgtgtgctgaggctttactccccagggggcgctgcagattggagctgtgtgaagag gtcacacggggtcagggaaacagcgggcgtgaacttttaggccctgctgtatccactgag ccggtggtctttacccctacaccagtggataccaatcaggtgacgctgcctcctcagctg gagctgatcagagagagactggctgagaatctgcatgagctctggctgctggagaaaacc gagcagggatggacacacgggccggtgagggatgacagtaaacaggttcaccctggactg gtggagttttccaaacttccagatcaggagaaacgcagcaacctccaggccgctgaacac accctgaggtctctgttggctctcggagctcgtatcggactgtctgatgaccacgcagag gagaaggtcaagtacgcccggctctcaaacaagcatgaactgtggaacggttacatgccg gctccggtggatcagtccggagtttctctaagcgctgctcaggaagctctggtggaagcg ctggctgagaacgagcacaacatctgggccagagagcacatcaggcagggctggagctac gcaccacagcaggacattaaggggaagaggagccctcatctggtgccgttctctctgttg gatgagagaagcagacaatgtgcaaaagagtcagcgagggatgtgttaggaaccctgctt ggttttggatactctgtagaagcatcagaggaatggcagtccctgggccctgacgtgaag gctgcgagtgaggagagggttcggatattccgtgtggagcacacgttcgcagtgcatgat gggaaatggtattttgagcttgaggcagtcactgctggagagatgagagtgggatgggct cgagtgggatgtcaagcagatatggagttgtggtcagacgagcaggcctacgtgtttgat ggctcaaagggtcagtggtggcatgggagcactgccccatttggtcatgtttggcagaag ggggatgtgattggctgtttgttggatttgactcggagaaccatgatggtcactttaaac ggagagctgcagctgaacacttatggctctgaaattgcttccaaagggttcagtgcaact ggtggctttgttcctgtgtgtgttttgggtgtgaatcaggtgggacagttgaatttaggc cagcaggtcaactcactgaaatacttcagtgtgtgtgggcttcaggagggctaccagcct tttgcactgaacatgagcaaagatccacctctctggatgagctggagagagcccttattt gtacaaataccagaggaccatccccgcttacaggttagttacattgatgggacggttggt caccttccagctctgaaggtcacccagcggtcagtgggattacccgacaatctcagcact gatgttgagttctatcgcctgagcttgcccatagagtgtgtacaagtattcaccaatcct gtagatggcacagtacctccagctagcagtgtagcctgccacattaaggaaccagaagaa ggggaggtggactctgactttgaaatgctgatgaagtcggcccacagacacacaggaact agagatgaactaaacaaccataaggatcatgcccaagaaaagacttccagacttaagcaa aggtttcttttgaagaagaaaccaggattgaacactagtggctcttcagcccggctgctg gaggaggtgctagcgattgagagggacagcgctaaccaatttgccaactgcactaagtac tactattctgtgaagatcctacatgggcaggatccatcctgtgtctgggttggatgggtg acttcaaacttccactctgatgatcgaacctttgacccggagagagtgtgtagtgtgtct gtcacacttggggaccaatggggaaaagttcttaagagtatcaagtgcagttgcagttac atggtgtgtgctggagagggcagtagtctctcccacagccaaagtagcataaggctggag ataggctgtttggttgacactgcgactggatttcttacctttactgctaatggaaaggag atgggaatcttctatcaggtggaaccaggcactaaactgttcccagcagtttttgccaaa gccaccagttctgatgtcttccagtttgatcttggacgaattaagggtgcgttgccactg tctgctggtttgtttcggagcgaaaggaaaaacatggagcctcagtgtcatcccaggctt actgtccaatccctgatacccatgaggtggacacggctccccgaacatgccccgcaggta gagctgatacggcttgaggagaggcatggctggagggcacagtgcgcagacagtctacag gtcatgaccctgcacatccctgaggaggacaggagcatcgacattctcgaactctctgaa ttggacaacctgctcaagttccatgaccacactctccgtctctattccgccctctgtgcc catggaaacatacccgtaagccacgccttgtgcagccacatcgaccagtcacagcttctg tttgcgttgcgctgttctagaatgcctggaaatctgcgagctggtttctatgacctatta atgactgcccacctcagtgtccatagcagtgccaggcaggctaccatccacgagtatatt gtgcccatgactgacgccatgcggactagtacacgttctcaaaacaacagaaagcaacat agactcccaggcagtaacaccagcacctctctgcaaccgagaatgcacttcagctcacct tgttttgttagagctagcggcaacagttttgataacaggtccaatagatctgagcagggt tcctgtcaatatagtcctgaattcccaatggatatgctgaaagctgtaatgacagccatg ttggaggaggcagtgcactcagtagggaagagtataagagaccctgtaggaggcagcata gagctaatgcttgttcctcttctccaactcctccacacactcctactcatgggtgtatat catcactcagatctacggcgtctgctttccttcatccttccctctgtttacatgagggaa aataatgcaggagaattaatagatggagatggagagaattattacgagatactggggaag gagaaagaaggaagagcccttcctgaacaaaagactttgttacagatgaagctaccagaa gcagttaaactacagttgtgtcacctgctacagtatctgtgtgactgtgaggtgcgtcac agggtcgaggccataatgaccttgtctgctgaccttgtgggtcgtctccagggcaaccag cgctctcgctacatgaatgtcatggaggcactcaacatgtctgctgctctcactgctcgc aagaccaaggagtttcgctctccacctcaagaacagatgaacctgttgcttaacttccga gacatggagcaggattgcccctgccctgagaagattagagagttgctctgggatttccat ctggatctcagaagtaattgtgttgaaactgatgaaaacttgggtgctgaagatgatgag agtcagcctatccggaatcgattaagagacctggtggacaaaatgtctcgtctaaagagg aggatgtctggtgtggttgaaaaggatgttgtggctaaacctgtttctctacagtggctg atctcagatactgtgatgcgttggactcacgagggaccgctggaagacccggttctggta cgggccgcctttggactcctacgttaccagtacgccggcctgtctggcaaaatggccgcc ccgttacaaaaagcctactgcatcacgcaaaactcggtagaggacacgcttggcctgcag gaggcacttggacggatccgctcactactcacagctagaatgggcatagaagaagaggaa ctcatgatccgaggacttggtgatatcatgaaaaataaagtgttctaccagcacccgaac ctgatgagggcactgggtatgcacgagactgtcatggaggtgatggttaatgtcctgggc accagagaatccaaggaaatcaggtttccaaagatggtggcccactgctgccgtttcctg tgttatttttgtcgaatcagccgccacaaccagaaagccatgtttgatcacctgagctac ctattggaccacagcagcgtcggacttgcatctccctccatgcgaggctcaactcctctg gatgtggctgcggcttctgtgatggacaactacgagctggcattagcgctcacagagcca gacctggagaaggtggtgcagtatttggcaggctgcggtttgcagagttgtacactgctg ctctctaaaggatacgcagacatcggctggaatcctgtcgagggcgagcgatacctggac ttactgcgctttgctgtcttctgcaacggtgaaagtgtggaagagaacgcatatgtcgtt gtccggctcctgattcgccgccccgaatgctttggccccgccctccgagtagagggagga aacggtctcttagcaaccatggaggatgccatcaagatctcagaagaggagagtggagag tgcttttctaaagcctatcagtccagtagcacactcgacactcttggtgatgaagatgat aatgtcatccacatgggacacgccatcatgaccttttactccgctcttatagacctgctg ggccgctgcgctccagagttgcacctgatagaggccggtaaaggcgaggctgttcgtata agggccatcttgagatctctgatccccgtgaacgacctggaaggagtcatcagcatccct ttcccgctcccttttctggacaaagatggttgcatgatggagccggacatgtccaggtgc ttctgtccagatcacaaggcatccatggtgctgtttctggaccgagtctatggtgtccag gaccagaactttctgctccacctccttgagaaaggtttcctgccagatcttcaagcagcc gttagcatggataatagtggactgggtagtacggacatggcgttggctctgaaccgttac ttgtgcgggtccgtgctaccattgttaagtaagtgctcgtcgctgctacgtggacttcct ctcgttaggacaggaacggtggacgacttcctacaagcactctaccgtctctctaaagcc agcagcctcaccaaagcccaacacgatgccatccagacctgcctgctctctgtgtgtgga aaactgaagccgtccctgttgcagcccctactgcgaagtctcgcggttgacgtcccacag ctgtccgagagcaccaagatgccacttaagcttctgaccgatcattatgagcagaactgg aagtactactgcacgactggtggacgtggggggtttggctccgcctcagaggaggagctt cagctcagcaggaagctgttttggcatgttttcagagcattgaccaaaaagacgtatgac gccgagacgtccgaggcgtccgtcggatgtctggttgccgtgtccggtgctgttcctcct gatcacgtcgacctcacctgcacagctggcttggacacgcactcttccctggactcagag ggacgcttctgtcctcaacctctggacacgtccgatgtaacagtgcctgagggattggag tatgtggtgaataaatacgcagaacacacacacgagaagtggtcactggagaagtttgct aatggttgggttcacggagagcagatgtgtgagagctctaaggttcacccactcctgaag ccctacagagccttatcggaacgagataaagagaactacagagcggccattaaagagacc gtgaaaagcatgctggtcttgggctggaccatcgagcggtcgaaagagggggatacgagg gacctccatcacctctccaggaggatctcacagtctggccagctgtcatttgagggaacc tccatgttcagtcccaaaccagcagacaccagcagcatcatgctgacctgggatcagtat gctatggcggaacaactggcggaaaattaccacaacatctgggcccagaagaaactccag gaactgcaagctaaaggagggggcagtcacgcactgctggtgccgtatgactctctgagt ggccgagagaagagccgaatccgagagagagcgcgggacgtcctgaagttcttccacatc aatggatacaccgtgtggagagagagaaaacctcccgagtccgattgtccctctatctca ggccgctttgcgtaccgtctcctccagcaggcgctctcctgtaccgaacaagtgcaggaa aagatgctggagctggaggttgctcaggctagagggcaaccgggaacagcagaagacatg tgtcacgagcagcagatgcgtttcttcatcaaagtttgtacacgcagtccactccgtatt tcagtttcaggcttcttgggtaaagatgctcggtgtgtggtgagctgtctgcagatcctg gcacgctctctggacgcgaaggtagcgatgaagatggcgacggaatgtgtgcgttcagcc ctgcactcattcttcgaggctgcggcggtggacttggagctggcggtagacagcgtgacc ccgggggtcatccagtttcgaggagatagagaagttctgacttacaccaccgctgcactg ctcccagtcctgacctctctgtttaaacatacagctcacggccagagctcactcgacctc atgggcgtgtccatcgcagccaaggattcgtcctggaccctcccctccttacaggaagca ttggcagatgttgaagacgttctggaggcggagtcagcggctcgccacgcccttctgtcc cgagtcatggaggtaactgttcctctactgtgcagctacgtgtgtcgttggggtgaagag gatagtctggggtctgaggggcagcagggggcatcatgctcctctctcacaccctcacac accaacgccctgctgggacaaatcctcgccatcatccacgtccacctaggcagacacgag tgcacctggatgaaacggattgcgggttttgtccagccgatggtccgtaatgcggaaccc ggtctcctgacgagtcgcatcctgcctctgatggaaaagctgaagaagagggcggagtca gtgctgcaggaggaggagagcatgaagattgaggggtgtggtgatgtggcagagatggag ctggcggtgcaggagaagtttgcggtgttggtgcaggacatctacgctgtttatcccctt ctcatcccgtttgtcgagcatcacaggatactctggctgagggagatgaacgcagatgct gagagactcttcagtctggttgctgatgttttcactttctgggccaaatctcataacttt aagtgggaggagcagaactttgtagtacagaacgacatcaacaacatgacctacctggta aacagcaggaacagccaaatgacaaagagagagtgtgaagaggagaggaggaaggtgaag aggagcaaggacgagcgttactccacacacacttctcttatcgtggcctctctgaagaag ctcctctctgttggtctgaatcgatgctgtcagagagatagagacctcattactctcgcc aagaaccgcttcgctgagaaagatacggaggaggaagttcgagctttcatttgcatcagc cttcaacaggtaaaccaggatgtttctcactctttactggatgaacgtcgtgttgaaagt gttttggctgtggcccgtgtgcttttctatctggatcaggtacgagagatcttcagggtc attagatctgccaatttgttcatcagctcttttataatttgtactcattcattctgtgag ctgtttgtttattctcacatcattgagttcaggctggaggaagacggtctgtacctggcc tacactgacatcatggccaagagctgccaggccgaggacgaggacgggcgtgatgaggtg aaatcctttgaggagaaagagctggagaaacagagactcttgtatcaacaagccagacta catgaacgtggagctgcggagatggttctccagaggctcagtgccagcagaggtgttacg gggcactcagtggaggccactcttaaactcggcatcgccatgctgaacggaggaaacaca gacgtacagcagaaaatgctggactatctgagagtgaaaagagatgtgggattctttcac agcctggcgagcctcatgcagtcctgcagtgttttagacctgaatgctttcgagaggcag atgaaagccgagggtttaggaactgcagctgatggcaacgcgggtgataaggttatggca gatgagccgctgacttgtgatctcttccgcttcctccagttgctttgtgaaggacataat gcagattttcagaactatctgaggactcagacaggaaacaataccacagtaaatattgtc atctctactgtggactacctgctccgactgcaggagtccatcagtgacttttactggtat tactctgggaaagatgtgattgatgaacacggccagcgtaacttctctaaagccatcagg gtggccaaacaggtcttcaacacgctcacagagtatatccagggtccatgcactggcaac cagcagagtttggcccacagtcggctgtgggacgctgtggtgggctttctccatgttttc gcccacatgcagatgaagctttctcaggattcgagtcagattgagctgctgaaggaactg atggatctgctaaaagacatggtggtgatgctgttgtctatgcttgaaggaaacgttgtg aatggcacaatcggcaaacagatggtggacatgctggtggagtcatccagcaacgttgaa atgatcctcaagttctttgacatgttcctgaaactcaaagacctcgtatcctctgatgcc ttcaaagaatatgaccctgacgtacaaggacttatctccaagaaggacttccagaaggcc atggagggctacaaacggtacactctatctgagatggattacctcttgtcttgcgcagag acgaacgagaccaagctcctggactatcgtgcgtttgtggcgcgttttcacgaacccgcc aaagacatcggtttcaacgtggctgtccttttgaccaacctgtcagagcacatgtctcat gacgctcgactacggaactttctggagttagctgacagcgtgctcaggtatttccagcct cacctgggcaggattgagatcatgggcagcgggaaacgggtcgagagggtctactttgaa atcagcgagtcgagccggatgcagtgggagaaaccacaggtcaaggagagcaagcatcag ttcatcttcgacattgttaacaagggaggagagaaagaaaagatggagctcttcgtgaac ttctgcgaggacaccatcttcgagatgcagctggccgcccagatctctgcctccgaccgt gatgatgaggtgctgggaatagaggatgatggagtggatgagaaggaggaggataagaac tctgctacagataatgatgacactaaagtagagcagagaggcttttctttgatggcgatg atgaagcggcttctcctggcccctctctgtggcctgatgatgataatgtgtctcctctcc ataaggaacgtgaagaggcagataaaaaggatgaccatgaagggtctcattttggccatc gctctcttcttccagaaggttttgtcagccattttgcataccatcttagacaccatctgc tttttcctacacgtcctctatcttgtctttctcagtggttgcattatcgagttcgccaaa gagaccaaactctctgatttcttcagagatctgacggacccgaccctggatgacgtcaca ggggtaaacgaaggggtaatccacaagaacaaaggtccctcacagaccagatcgtcccat ggtgaccttcaagcaatgactctcgacttatcggctgtgtccaaaaaccctcagatactt accgatatatttggtctccagttaagaaaggatggaggacagtatatgctaattagtcga gattccaatgccagcattggtgaagtaatgaatccttctaaatatcaggtgatacataca catatactaggtgaggacaatgagaagaaggacaagaggaaggaagatgaggcgaaacgc agattcaggaggatgagcttgcacaaagcagcggagcctgaggttgaagaatcagcgacg tggaaaataatcgactctcagaagacaaaactgctcaattattttgccaggaatttctac aacatgcgagtgctggcgctgtgtgtgaccttcggcatcaacttcattcttctgttctac aaggtttcttctagtgaagctgaaggcgtggccatgccggacctcggcgatgagaatgat gactctaagagtgtgcgttttattctgggagaaagtggttatatgaagtctgtgctccac agtctggctctgttacacactcttatctccttctgctccatcatcggctactactgtctg aaggttcctttagtagtgttcaagcgggagaaggagctagcacgtaagctggagttcgac ggtttgtacgtcatacggcaacctgccgatgatgacgtcaggggccagtgggaccggctg gtcataaacacgctatcttttccgagtaattactgggacaaatttgtgaagaggaagtcc gtggttttgtttgtattgtggcaggtgatggccaagtacagcgagttgtacggctcagag aggatcagtgggctgctgggtttggataagacaacactggatttcagctacgaagcccgg aacggaagaagaccagcccgagaactactgaactccattgacatgaaatatcagatctgg aaacttggagtggtgttcaccgacaactcattcctctatcttgcctggtacatgctgctg tccattttgggccactacaataatttcttcttcgccgctcacctcttggacgtcgccatg ggctttaaaacgttacgcaccatactgtcttccgtcacgcacaatggaaaacagttggtt ctgactgtgggactgttggccgtggtcgtatatctctacaccgtcgtcgccttcaacttc ttccgcaagttttacaatacaagtgaagatggccaaactctggacatgaagtgtgatgac atgctgacgtgttatatgttccacatgtacgtgggcgtgcgtgccggaggggggatcggc gatgagatcgaagacccggccggagacgaatctgagttctaccgcgtcgtcttcgacatc acgttcttcttcttcgtcatcgtcatcctcttggccatcattcagggtctgatcatcgac gcatttggagagctgagagaccagcaggagcaggtgaaagaggacatggagacgaaatgt tttatctgcggcattgggagtgaatattttgatgccgtccctcatggctttgagactcac acgctgcatgaacacaacctggccaactacttgttctttgtgcagtacctcatcaataaa gatgtgacggaacacacagggcaggagtcctacgtgtggaagatgtaccaggaacgctgc tgggagtttttcccagtcggagactgtttccgaaaacagtatgaggatcagcttggttaa

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