Ictalurus punctatus (channel catfish): 108257968 Help Entry 108257968         CDS       T04658                                  Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism ipu  Ictalurus punctatus (channel catfish) Pathway ipu04020   Calcium signaling pathway ipu04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:ipu00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     108257968    04020 Calcium signaling pathway     108257968  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:ipu04040]     108257968 Ion channels [BR:ipu04040]  Voltage-gated cation channels   Ryanodine receptor    108257968 SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 Phage_TAC_15 EF-hand_6 EF-hand_8 Ago_Mid Motif Other DBs NCBI-GeneID:  108257968 NCBI-ProteinID:  XP_017311641 Ensembl:  ENSIPUG00000023575 UniProt:  A0A2D0Q1S8 LinkDB All DBs Position 25:complement(1295565..1394297) Genome browser AA seq 4859 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCVAAIQKENRKFCLSAEGLGNRLCYLEPTSEAKYVPP DLCICNFVLEQSLSVRALQEMLANTGPNGEGNPDHERWAGQGGGHRTLLYGHAILLRHSF SGMYLACLKTSRSLTDKLSFDVGLQEDSSGEACWWTIHPASKQRSEGEKVRIGDDLILVS VSSERYLHLSISNGNIQVDASFMQTLWNVQPTCSGSNVAVGYLLGGHVLRLFHGHDESLT IPGADQSTEQQRLVNYETGKSGSRARSLWRLEPLRISWSGSHIRWGQPFRLRHLSTGHYL GQTEDRGLELVDREISDTASTAFCFRPSKEKVDSGPKRDIDGMGVAEIKYGDSVCFIMHV ASGLWLSYQAPDAKSSRLGPLKRRAFLYPEGHMDDGLILQLCQHEESRAARIIRNTTQLF TQFIRGLDELKGEKAPGVSLPVGELLQTLNDLITYFQQPDSELEHEEKQRQLRSLIKRQD LFKEEGMLTLVSICIDRLNMYNSAAEFEEFAGEEAGEAWKDILNLFYELLAALIRGNRPN CTQFSRKLDWLVSKLERLESSSGILEALHCILTESPEALNIIQKDHIRSIISLLYKHGRN HKILDILCSLCVCNGVAVRANQNIICDHLLPRRDLLLQTRLVNDVQSMRPNIFLGVSEGS AQYKKWYFELMIDQVDHFVTSEATHLRVGWASTKGYAPYPGGGEGWGGNGVGDDLYSYAF DGLHLWSGRIPRAVASINQHLLTSDDVVSCCLDLGAPSMSFRINGQPVQGMFEDFNTDGF FFPVVSFSAGVKVRFLLGGRHGDFKFLPPAGYAPCYEALLPKEKMRVEPVKEYKRDVEGV RNLLGTTQFLSQASFIPIPVNTSQIVLPPHLENVRDKLAENIHELWGMNKIELGWTYGKV RDDNKRQHPCLVDFSKLPETEKNYNLQMSTETLKTLLALGCHVVQINVNAEDDLKKIKLP KDYVMSNGYKPSPLELSDVKLTPGQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKSR RNPRLVPYSLLDERTKKSNRDSLREAIRTLIGYGYNIEPPDQEAAHVVEKRSVENIRFFR VEKSYAVKSGKWYYEFEAVTGGEMCVGWARPSCRPDVELGMDDQAYVFDGYRGRRVHMGS HFFGRTWSKGDVVGCMINMEDKSMIFTLNGEILITNKGSELCFTDFDADDGFIPVCSLGL SQIGRMNLGKDASTFKYYTMCGLQEGFEPFAVNMNREVTMWFSKRLPTFVNVPADHEHIE VTRIDGTVDSPPCLNVSHKTFGTQASNNDMIYCRLSMPVEFYSSPRKITNVNEVISDGQK SKKDNSGKTDYGSITKYFYSVRVFAGQDPASVWVGWVTPDYHYYSKNFNLSKVRTVTVTL GDERGRVHESVRRSNCYMVCAGDISSSSSGRSNADLIIGCHIDLASGLVSFTANNKELPI AYQVEPNTKLFPAVFVQPTSPNLFQFEFPKIKDAMPLSSAIFKSLHSNPEPQCPPRLDVQ TIVAVLWSRMPNTFLSVETARVSERHGWVLQCLEPLQMMAVHIPEENRCIDIMELSEDEA LRQFHYHTLKLYCALCALGNTRVAHALCSHLDQSQLLYTIDNQYLTGQLREGFYDVLISI HLETAKEAQLMMKNEFIIPITDETCSIHLFSDDSKRHSLPGVGLSTSLSPRLNFSPACFI TTKREHLYSPQIPLGILKEKAISMLTEAVQGGGTHIRDPVGGSVEYQFVPILKLIATLLI MGSLTSEEVRIILLLIEPNVFGESKEEETQLVAAEEPAEKEEASSNEEKAVEAGEEESKE HKQPPKGLLEKSLPESVKHQMCELLHYFCDCELKQRIEAIVAFSDSFVAKLQYNQKFRYN ELMQALNMSAAVTAKKTKEFRSPPQEQINMLLDFSAGEDCPCPEDIQEELHAFHEDLRLH CGIPMEEEEEEPDTSIKGRLLSLLYKIKGRPQKTEEQPSEEKQAAPTNLKELISQTMVSW AQECKMQNPALVRSMFSLLRRQYDGIGELLRAMRKSYTISEKSVQDAINLLASLGQIRSL LSVRMGEEEGQLMIDGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKSKEIAF PKMVASCCRFLCYFCRISRENQKAMFEHLSYLLENSSVGLACPAMRGSTPLDVAASSVMD NNSLALALEEPDLEKVVTYLAGCGLQSCPMLVAKGYPDIGWNPIEGERYLSFLRFAVFVN GESVEENANVVVKLLIRRPECFGPALRGEGGQGLLAAMLEAIKISEDPALDLPNLPEGGA PVSGEDGEEEEEVAHMGNSIMSFYSALIDLLGRCAPEMHLINTGKGEALRIRAILRSLVP TKDLVGIISIPLKVPVLNKDGSVTEPDMNASFCPEHKSPMVLFLDRVYGIEDQSFLLNLL EVGFLPDFRVSASLDTEVLSTTETALALNRYIGSAVLPLLTRCAHLFAHTEHYATLMDST LHTIYRLSKGRSLTKAQRDSIEECLLAICKHLRPSMLQQLLRRLVFDVPQLTEYCKMPIK LLTNHYEQNWKYYCLPSGLGSYGMASEEELHLTKKLFWGLFDALSQKKYDAELFKMAMPC LSAIGGAIPPDYVDMSPANTLVKQASVDGQGNFDPKPISTANISLPEKLDYIANKYAEHC HEKWSSEKFALGWTAGEKVDDQAKTHPLLKQYKALSEKERETYRYPVKESLKSMLAMGWT IERTKEGEAMFQQRESGKQISEASQGDGFHPAPVDLENVILSRELQSMVETVAENYHNIW AKKKKMELSSKGGGTHPLLVPYDTLTAKEKFRDREKAQELFKFLQINGYAISRGLKDIEQ DSSSMEKRIAYKFLKRLLSYVDSAQEFIAHLEAMASSGKTDKSPHEQEIKFFAKVLLPLL DQYFKNHCLYFLSSPSINLSSSGYASNKEKEMITSLFYKLASLVRHRISLFGSDSATMVS CLHILAHSLDFRTVMKSGSELVKAGVRTFFENAAEDLEKTVENLKLGKLGQSRTQMKGVA QIINYTSVALLPILTALFQHITEHQFGADLLLDDVQLSCYRILTSLYSLGTGKNIYVEKQ LPVLGECLATLVGAMPVAFLEPHLNMHNPRSVFNTKTPRERAILSMPDTVEEMCPEMPRL DGLMKDIHDISESGARYTEMPHVIEVILPLLCNYLSYWWEKGPENSPSHVSCCTTVTSEH LSLILGNILKILNNNLGIDEASWMKRLAVYTQPIISKAGADLLRTHFLPTLEKLKKKTVK VVAEEEMIRAESRADTQEAELQILDEFAVLCRDLYAFYPMLIRYVDNNRSKWLKKPNADS TELFKMVSEIFILWCKSHNFKREEQNFVVQNEINNLAFLTGDSKTKMSKSGGQDQERRGK KRKRELYSIQTSLIVAAHKKLLPIGLNMCTAGDQELISLAKIRYSLKDTDDEVKDHLRQN LHLQEKTEDPAVQWQLNLYKDVEVKSEEPLNTDHIIEKIQGISAAVFHLDQVEQPLRCKK LTWQKQLSKQRKRAVVACFRMAPLYNLPRHRSINLFLMGYQKLWIVAEEYSFEEKLVQDL AKTPMAAEKEEEEAEAEVQPDPLNQLILHFSHNALTERSVLEVDPLYIAYADMMAKSCAE DEEEEEEEGKEKTFEEKEMEKQKILYQQARLHARGAAEMVLQMISASKGRLGPMVTFTLK LGISILNGGNVVVQQKMLDYLKDKRDAGFFKSLSGLMQSCSVLDLNAFERQKKAESLGMV TEEGSVNVSERGSKVLQNDEFTKDLFRFLQLLCEGHNDDFQNFLRTQTGNTTTVNIIIST VDYLLRLQESISDFYWYYSGKDIIDEHGQLNFSRALAVAKQIFNSLTEYIQGPCIGNQQS LAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELMDLQKDMVVMMLSLLEGNVVNGT IGKQMVDTLVESSSNVEMILKFFDMFLKLKDLTTSDNFKEYDPEGKGIISKKEFQKSMES QKQYTQSEIEFLLSCAEADENDMFNYMEFVERFHEPAKDISFNVAVLLTNLSEHMPHDSR LATFLDLAESVLGYFEPYLGRIEIMGGAKRIERVYFEISQSSREQWEKPQVKESKRQFIF DMVNEGSESEKMELFVNFCEDTIFEMQLASQISEPGAVERPEEEEEPHSLLEDLSEEEDQ SLESASAFTVACNSLKNKISQFRQTLTLKNMRKQFKKFKKLTIKEMITGFFLFFWMLFTG FFKGIFSLIFGFFHIIWSSMFGGGLVEGAKNMKVTDILGNMPDPTQFGIHGDVMEPEKAE NGEIVVSTEMVQMVGTVDKLEADAIIDLISPPTKREGKHGHEPGLGDVSEIMTEASPRVE KKKRQKAAAEEFEPEKADTENHEKEDKAKEEKPEEPVVEEIPAPRKRRGPTKEEPPALMA AFFAGLEVYKTKMLNYLARNFYNLRMLALFVAFAINFILLFYKVTGEADDEEEEESWGGG GDDDDDDDDIEFYVLQESTGYMAPTLTFLAILHTVISLLCVVGYYCLKVPLVVFKREKEI ARKLEFDGLYITEQPSDDDIKGQWDRLVIATPSFPNNYWDKFVKRKVINKYGDLYGAERI AELLGLDKSALDFDPTEEAVVKEASLLSWLSSIDTKYHIWKMGVVLTDNSFLYLIWYTTM SILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNF FRKFYNKSEDDDAPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYELYRILFDI TFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTTPHGFETH TLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14580 nt NT seq  +upstreamnt  +downstreamnt atggctgaagggggagaaggggaagatgaaatccagttcttgcgaactgatgatgaagtg gtgctccagtgtgtcgctgctattcagaaggagaatcgtaaattctgcctgtctgcagag ggactcggaaatcgactgtgttacctcgagcccacctcagaagctaagtatgttcctcct gacctgtgcatctgtaactttgtgctggagcagtctctgtctgtgcgagccctgcaggag atgctggctaacacaggcccaaatggggaaggtaatcctgatcatgagcgatgggcggga caggggggtggacaccggacactgctgtatggtcacgccatcctactgaggcattcgttc agtggaatgtatctagcctgtctaaagacatcaaggtctctgacagacaagctgtcattt gatgtaggattacaggaggactcctcaggcgaggcctgttggtggaccatccatccagcc tcgaaacagaggtccgagggtgaaaaggttcgcattggggatgatctgattttggtcagt gtgtcctcagagagatacctgcatctgtccatctccaatggaaacatacaagtggatgct tctttcatgcaaacactgtggaatgtgcagcctacctgctcgggcagcaacgtggcagtg ggatatttactgggggggcatgtgctacgcctgttccatggacatgatgagagccttact ataccaggagcggatcagtccactgagcagcagaggctggtgaattatgagaccgggaaa tcagggtccagggccaggtccctgtggaggttagagccacttcggatcagctggagtggg agccatattcgttggggtcagcccttccgcctacgccatctctccactggccactacctg ggtcagacagaggaccgtggcctggagctcgtggacagagagatatccgacactgcttcc acggcattctgcttcagaccaagcaaggagaaagtggactccggcccaaagcgggacatc gatggcatgggggtggcggagatcaagtacggtgattcggtctgcttcatcatgcatgtg gcgtcaggtctgtggctgtcctatcaggcaccggatgcaaaatcctcccgcctcgggcca ctcaagagaagggccttcctgtatccagagggccatatggatgatgggctgattctgcag ctctgccagcatgaggagtccagggcggctcgcatcatccgcaacaccacacagctcttc acccagttcatcagagggctggatgaactgaagggggagaaagcaccgggagtgagtctg ccagtgggagagctactacagaccctgaacgacctcatcacctacttccaacagcctgac tcggagctggagcacgaggagaagcagaggcagctccgctcgctcatcaaacgccaggac cttttcaaagaggagggaatgcttacactggtgtctatctgcatcgaccggctcaacatg tacaacagtgctgctgagtttgaggagtttgcaggcgaggaggcaggagaggcctggaag gacatcctcaacctcttctatgagctgcttgctgctctgatccgaggaaaccgacccaac tgtacgcagttctcccggaaactggactggctcgtcagcaaactggagcggctggagtcc tcctcaggcattctggaggcgctgcactgcatcctaacagagagtccagaggcgctaaac atcatccagaaagaccacattagatccatcatttcccttctctataagcatggacgcaac cacaagattctggatattctctgctcgctttgtgtctgcaatggagtggcagtccgagcc aatcagaacatcatctgtgaccacctgcttcccagaagggatctgctgctccaaacacga ttggtcaatgatgtgcaaagcatgagacccaacatcttcctgggcgtaagtgagggatca gctcagtataagaagtggtactttgagctgatgattgatcaggtggaccattttgtcaca agtgaagccactcatctccgtgtaggctgggccagcactaaaggctatgccccctaccct gggggtggagagggatgggggggcaacggtgttggtgatgatctctactcctatgccttt gatgggcttcatctgtggtcagggagaatcccacgggccgtggcctccattaaccagcac ttgctgacctccgatgatgtggtgagctgctgcctggacctcggcgcccccagcatgtcc ttccgcattaacggccagcccgtgcagggaatgttcgaggatttcaacacggacgggttc ttcttccccgttgtcagcttctcagcaggggtcaaggttcgtttcttgttgggcggtcgc catggtgacttcaagttcctaccccctgctggctatgcaccttgttatgaagcccttctc cccaaagaaaagatgcgggtggagcctgtgaaggagtataagagagatgtagagggagtg aggaacttgctgggaaccacccaattcctgtctcaagcatccttcattcccatccctgtc aataccagccagattgttctgcctccacaccttgaaaatgtgcgtgataagctagccgag aacatccatgaactctgggggatgaacaaaatcgagcttggctggacctatggcaaggta cgtgatgacaacaagaggcagcatccttgcctggttgacttctccaagctgcctgaaact gaaaaaaattataacctgcaaatgtcaacagaaaccttaaagaccttactagctttggga tgtcatgttgtacaaatcaatgttaatgctgaagatgacctgaagaagatcaaacttccc aaagactatgtgatgtcaaatggttataagccttcgccactagagctttctgatgtgaaa ctgacacctggtcaggaggttctggttgataaactggctgaaaacgctcataacgtttgg gccaaagatcgcattaagcaaggatggacttatggtattcagcaggatttaaagagcaga cgcaatcctcggttggtgccatattctttgttagatgaacgcacaaagaagtctaacaga gacagccttcgagaggccatccgaacacttattggatatggatacaacatcgagccccca gatcaagaggctgcccatgtggtggagaagaggagtgttgaaaacattcggtttttccgt gtggagaagagctatgcggtgaaatcagggaagtggtattatgagtttgaggccgtgact ggaggagaaatgtgcgtaggatgggctcggcccagttgcagacctgatgtcgaactgggc atggatgaccaagcgtatgtttttgatggctaccgaggtcgacgggtacacatgggcagc cacttctttgggagaacatggagcaagggtgacgtggtgggatgcatgattaacatggag gataagtccatgatctttactctcaatggagagatccttatcaccaacaagggctctgag ctctgcttcactgactttgacgctgacgatggcttcatcccagtttgcagtcttgggctc tctcagattggccgtatgaacctgggcaaagatgccagcaccttcaagtactacaccatg tgtggccttcaggagggttttgagcctttcgctgtcaacatgaaccgagaggtcactatg tggttcagcaaacgccttcctacattcgtcaatgtgccagcggaccatgagcacattgag gtgactagaattgatggcactgtggactctccaccatgtctgaatgtgagccataagacc tttgggacacaagctagcaacaatgatatgatctactgccgcttgagcatgcctgttgag ttttattccagtcccaggaaaatcactaatgtcaacgaggtgatcagtgatggccaaaaa tctaagaaggataacagcggaaagactgattatggcagcattacaaagtatttctactcc gtgagagtgtttgcgggtcaggaccctgcctcggtatgggtaggctgggtaacaccagac tatcactactacagcaagaactttaacctgagcaaagtccgcacagtgactgtaactctt ggggacgagcgtggtcgtgttcatgagagtgtgaggaggagtaattgctacatggtgtgc gctggcgacatttctagtagctcttctggacgaagtaatgctgacctcataattggatgt catattgatctggcctctggccttgtctcattcactgccaacaacaaggagctgcctatt gcatatcaggttgagcccaacacaaaactgttccctgctgtgtttgttcagcccacaagt cccaacctgtttcagtttgaatttccaaagatcaaagatgccatgccactgtcttcagct atttttaaaagtcttcacagtaacccagagccacagtgtcctccacggctggatgtgcaa accatcgtagctgttctgtggagcaggatgcccaacactttcctctcagtggagaccgca cgggtcagtgagaggcatggctgggtgctgcagtgtctggagcccttgcagatgatggca gtgcatattcctgaggaaaacaggtgcatagacatcatggaactctcagaggacgaggcc ctgcgacagtttcactaccacactctgaaactctactgcgctctctgcgctctgggaaac actcgtgtagcccacgccctctgcagtcaccttgaccaatcacagcttctttacaccatt gacaaccaatacctgacaggacagctgcgtgagggcttttatgatgttcttatcagcatc catctggagacagcgaaagaagcgcaactcatgatgaagaatgagtttatcatacccatc acagacgagacctgtagcatccaccttttctccgatgactccaaacgccactcgttgcct ggcgtgggactgagcacgtcgcttagccctcggctcaacttctcaccggcgtgcttcatc accactaagcgggagcacttatacagtccacagatccctctgggcattttgaaggagaag gccatcagtatgctgacggaggcggtgcagggcggaggcactcatatccgtgaccctgta gggggcagtgtggagtaccagtttgtgcccattcttaagctgattgccactctgctgatt atgggatctctgactagtgaggaggtgagaatcatcctcctgcttattgaacccaatgtt tttggggaaagtaaggaggaggagacacaacttgtggctgcagaggagccagctgaaaaa gaagaggcaagcagtaatgaggaaaaagctgtggaggcaggggaggaagagagcaaagaa cacaagcagccacccaaaggccttttggagaagagcctgcctgagtcagtcaaacatcag atgtgtgaactcttgcactacttctgtgactgtgaactgaagcagcgtatcgaggctatt gtggcattctcagatagttttgtggccaaactgcagtacaaccagaagttccgctacaac gagctcatgcaggccctcaacatgtccgctgccgtcactgccaagaagaccaaggaattc cgctctcctccccaagagcagattaacatgcttttggacttcagtgctggagaggattgt ccctgtcctgaggacattcaagaggagcttcatgccttccatgaagacctgagactccac tgtggtattcccatggaagaagaagaggaggaacctgatacatctataaaaggtcgtctg ctctccctgttatataaaatcaaaggtcgcccacagaaaactgaggaacaaccatcagag gaaaagcaagcagctccaactaacctgaaggagctgatctctcagacaatggtgagctgg gctcaggaatgcaaaatgcagaacccagcgttggtgcgaagcatgttcagcctgctccgg aggcagtatgatggcattggtgagctgctacgtgccatgagaaaaagctacaccatcagc gagaaatctgtgcaggatgccattaacctactggcctcgctgggtcagatccgctctctg ctcagcgtcagaatgggtgaagaggagggccagctcatgatcgatggcctgggggatata atgaacaacaaagtgttttatcagcatccaaatctgatgcgggttctgggcatgcacgag acagtcatggaggtcatggtcaatgtgcttggaggagacaaatctaaggagattgctttc cccaaaatggtggccagttgctgccgcttcctctgctacttctgtcgcatcagccgtgag aatcagaaagccatgtttgaacacctgagctacctactggagaacagcagtgtggggctg gcttgtccagccatgaggggctccactcctctggatgtggctgcgtcctcagtgatggac aacaacagtctggccctggctttagaggaaccggacctggagaaggtggtgacatacttg gctggttgtggtctacagagctgtcctatgctggtagctaagggataccctgacatcggc tggaatcctatagaaggagaacgttacctgtctttcctccgattcgctgtctttgtcaat ggtgagagtgtagaggagaatgccaatgtggtggtaaagttgttgatcaggcgtcctgag tgctttggccctgctctgaggggagaggggggacaaggtctgttggctgccatgctggag gccatcaagatctctgaggaccctgctctcgatctgcccaacctgcctgaaggaggagct cctgtgtctggggaggatggggaggaagaggaagaggtggcacacatgggcaactcgatc atgtccttctactcagcccttattgatctgctgggacgttgtgctcctgagatgcattta atcaacacaggcaagggtgaagctttgcgtatccgtgccatcctgcgttccctagtgcct accaaagacttagtgggcatcatcagcataccactcaaagtgccagtactcaacaaagat ggcagtgtgaccgagccagacatgaatgctagtttctgtccagagcacaaatcaccaatg gtgctcttcttggatcgtgtgtatggtatcgaggaccaaagcttcttgctaaacctttta gaggtgggcttcctgcctgacttcagggtctcggcgtctctggacacggaggtgctgagc accacagagacggcactggccttgaacaggtatatcggctcagccgtgctgcctttgttg acgcgatgtgcgcacctctttgctcatacggagcactacgctacactcatggactccaca cttcacaccatctacagactgtccaagggccgctcgctcaccaaggcccagagagactcc atcgaggagtgcctgcttgccatctgcaaacacctgcggccatctatgctgcagcagctc cttcgccgtctggtctttgatgtaccacaactcacagaatactgcaagatgcccataaaa cttttgaccaatcactatgaacagaactggaaatactactgcctgccctccggcctgggc agttacggcatggcatcagaagaggagctccacctcaccaagaagcttttctggggactt tttgacgcactctctcagaagaaatacgacgcagagcttttcaaaatggctatgccatgt ctgagtgccataggtggagcgatcccacctgattacgtcgacatgagcccagccaacact ctggtaaagcaggcctctgtggatggacaaggaaactttgatcccaagcctatcagcact gccaacatttcactgcctgaaaaactggattacattgccaacaaatatgctgagcattgc catgagaaatggtcttctgagaagtttgcactcggctggactgcaggtgagaaggtagat gaccaagccaaaactcaccctcttctgaagcaatataaagcactgagtgagaaggagcgg gagacctaccgctatcccgtgaaggagtctctgaagagcatgttggctatgggttggacc atcgagaggaccaaagaaggagaggccatgttccagcagcgtgagtcagggaaacagatc tcagaggcttcccagggagatggatttcatccagcacctgtggatttagaaaatgtaatc ttgtctagagaattacagagtatggtagagactgtagcggaaaattaccacaatatttgg gcgaagaaaaagaaaatggaactcagcagcaaaggaggtgggactcacccactgctggta ccctatgacactctgacagcaaaggagaagttcagagaccgagaaaaggctcaggagctc ttcaaattcctgcagatcaacggatatgcaataagcagaggtttgaaggacatagagcag gattcttcctctatggaaaagaggatcgcctacaagttccttaagaggctgttgagttac gtagactcggcacaggaattcatagcacatctggaggcgatggcctccagcggaaaaacg gacaaatcgcctcacgagcaagagattaagttcttcgcgaaggtcctgctgccgttactg gaccagtactttaagaatcactgcctttacttcctgtcttctcccagcatcaacctgagc agcagtggatatgcttctaacaaagagaaggagatgatcaccagtcttttctataagctg gcttctctggttagacaccggatctctctgtttggaagtgactctgctacaatggtgagc tgtctgcacatcctggcacattcactggacttcaggacagtgatgaagtccggctctgag ctggtgaaggctggagtcaggacgttctttgagaacgctgcagaagacctggagaagact gtggagaacctgaagctgggaaagctgggccaatctcggacccagatgaagggagtggca cagatcatcaactacacctcagtggcgctgctgcccattcttactgctctgtttcagcac atcactgagcaccagttcggggcggacttgctgttggatgacgttcagctgtcctgctat cgaattctgaccagcctatactccctgggaacgggcaaaaacatctacgttgaaaagcag cttcctgtgctgggagaatgcttggcgactctagtgggagccatgcccgtggctttcctg gagcctcatctgaacatgcacaacccacgctctgtcttcaataccaagacaccccgtgag agagcaattctgagcatgcctgacaccgtagaggaaatgtgtcccgagatgccacgtctg gacggcctgatgaaagacattcatgacatctcggagtctggggctcgctacacggagatg ccgcatgtcatcgaggtcatcttgcccttgctgtgtaactatctttcttactggtgggaa aagggtccagagaattcccccagtcacgtgagctgctgtaccaccgtcacctctgagcac ctcagcctcatcctgggcaacatcctcaagatcctcaacaacaacctgggtatagatgaa gcctcctggatgaagaggcttgcagtgtacacacaaccaatcattagcaaggcaggagca gacctcttacggactcacttcctccccaccctggagaagctgaagaagaagacggtgaag gttgtggctgaggaggagatgataagggctgaaagcagggccgatacccaggaggccgag ctgcagatcctggatgagtttgctgtgctctgtagggacctgtacgcgttttaccccatg ctcatccgctacgtggacaacaacaggtccaaatggctgaagaaaccaaatgcggattca acagaactcttcaaaatggtgtcggagattttcatactctggtgtaaatctcataatttc aaaagggaagagcaaaactttgtggtgcaaaatgaaatcaacaaccttgccttcctcacc ggagacagcaagaccaagatgtcgaagtcaggaggccaggaccaggagaggagagggaag aagagaaaaagagaattgtactctattcagacatctttaattgtggcagctcacaagaaa ctgctgcctattggcctcaacatgtgcacagctggagaccaggagctcatctctctggcc aagatccgctacagtctgaaagacaccgacgacgaggtgaaggatcaccttagacagaac ctacatctccaagagaagacggaggacccggcagtgcagtggcagctaaacctctataag gatgtggaggtgaagagcgaggagcctctaaatactgaccacattatcgagaaaatccaa ggcatctcagccgccgtcttccatcttgatcaggtggagcagcctcttaggtgtaaaaaa ctgacatggcagaagcagctgtccaaacagcgcaagcgtgctgtggttgcctgtttccgc atggcacctctttacaacctacctaggcatcgctctattaacctcttcctcatgggctat cagaaactttggatagtagcagaggagtactcctttgaggagaaactagtgcaggacctg gcaaaaacccccatggctgcggaaaaggaagaggaggaagcagaggccgaggttcagccg gaccctcttaaccagctcatcctccacttcagtcataacgccctgacggaaagaagtgtc ctggaagtagatcccttgtatatcgcatacgcggatatgatggcaaagagctgtgctgag gatgaagaagaggaggaggaggaaggaaaagaaaagacgttcgaggagaaggagatggag aagcagaaaattctgtatcagcaggccaggctgcacgctcgaggagcggccgagatggtg ctccagatgatcagtgccagcaaaggacgacttggccccatggtgaccttcacgctgaaa ctggggatctctattctcaatggaggcaatgtagttgttcagcagaaaatgctggactac ctgaaagacaaaagagatgctgggtttttcaaaagtttatccggactcatgcagtcttgc agtgtactggatctgaacgcattcgagagacaaaagaaggcagaaagtcttggaatggta accgaggaaggttcggtcaacgtgagtgagcggggttccaaagtactacaaaatgatgaa tttacaaaggatttgtttaggtttttgcagctgttatgtgagggccacaatgatgatttc caaaacttcctgcgaactcaaacaggaaatacgaccacagtcaacatcattattagcaca gtggactatctcttacgtttgcaggaatccataagtgatttctactggtattactctgga aaagatatcatcgacgagcacggacagctgaacttctccagagcgttggcagtagcgaaa cagatcttcaattcgctcactgagtacattcagggtccttgtattgggaaccagcagagt ctggctcacagcaggctgtgggacgccgtggttggattcctgcacgtctttgccaacatg cagatgaaactatcacaggactctagccagattgagctgctgaaagagttgatggatttg cagaaggatatggtggtcatgatgttatctctactggagggtaatgtggtgaacggcaca atcgggaagcagatggtcgacacgttggtggagtcttcgagtaatgttgaaatgatcctc aaattcttcgatatgttcctcaagctgaaggatcttaccacctctgataactttaaagaa tacgaccctgaagggaaaggaatcatctctaaaaaggagttccagaagtcaatggagagc caaaagcagtacacgcaatccgagatcgagtttcttctgtcttgtgccgaggccgatgaa aacgacatgtttaactacatggaatttgtggaacgcttccatgagccggcgaaggatatt agcttcaacgtggctgtactgctcaccaatctgtccgagcacatgccccacgattcacgc ctcgccaccttcctggacctggctgagagcgtgctcggttatttcgagccctacctgggc cgcatcgagatcatgggaggtgccaagcggatcgaacgtgtctactttgagatcagtcaa tctagcagagagcagtgggagaagcctcaggtgaaggagtccaagcggcagttcatcttt gacatggtcaacgaaggcagtgaaagtgagaagatggagctgtttgtaaacttctgtgaa gacaccatttttgagatgcagctggcttcccagatatctgagcctggggctgtagaacgc cccgaagaggaggaggaaccgcacagtctgttggaggatctgtccgaagaggaagatcag tcccttgagtctgcttcagctttcactgttgcctgcaactctctgaagaataaaatatcc cagttccgtcaaacgctgaccctcaagaacatgcgtaaacagttcaagaagtttaagaaa ctgactattaaggaaatgatcacagggttctttttgttcttctggatgcttttcactggc ttctttaaaggcatttttagcctgatctttggattctttcatataatctggtcctcaatg tttggcggcggccttgttgaaggagctaaaaacatgaaggtgactgacatcttgggcaac atgccagatcccactcagtttggaattcatggcgatgtcatggagccagagaaagcagag aatggcgaaatagtggtatctacagaaatggtacagatggttggcacggtggacaaactg gaagccgatgccatcatagatctcataagtccaccgactaagcgagagggaaagcatgga catgagcctggacttggggatgtctcggagattatgacagaagccagccctcgcgttgaa aagaagaagcggcagaaagctgcggcggaggagttcgaacctgagaaagccgacacagag aatcatgaaaaagaagataaggccaaagaggaaaagcccgaggagccagtagtggaggag attccggcgccaagaaaacgacgtggaccaaccaaggaggaacctccggcgttaatggcc gccttctttgctggcctcgaagtctacaagaccaagatgcttaactatttggctcgtaat ttctacaacctcaggatgctggcgttgtttgtggcgttcgcaatcaacttcatcctgctc ttctacaaggtgaccggtgaagctgacgacgaggaagaggaggagtcctggggtggcggt ggtgatgatgatgatgatgatgatgatatagaattctatgtacttcaggagagcactgga tatatggctccaactctgactttcttggctatactgcatacagttatttctctcctttgt gtggtgggatattactgcctcaaggtccctttggtggtgtttaagcgagagaaggagatc gcaaggaagcttgagtttgatggcttgtacatcactgagcagccgtctgatgatgacatc aagggtcaatgggatcgtttggttatcgccactccatcgttccctaataattactgggac aaatttgtcaagaggaaggtcattaataaatacggagatttgtatggagcggagcgtatt gccgaactcctcggtctggataagagtgcgctcgactttgatcccacagaggaagctgtg gtgaaagaggcttcgctgttgtcctggttgagctctattgacacgaagtaccacatttgg aaaatgggagttgtcctaactgacaattctttcctgtacctgatctggtacaccaccatg tctattctgggccattacaacaacttcttctttgctgctcacttgctggatattgctatg ggcttcaagaccttgagaaccatcctatcctctgtaactcacaatggaaaacagttggtg ttgaccgtgggcctgctcgccgtcgtggtttacttgtacactgttgtggcgttcaacttc ttccgcaagttctacaacaagagcgaggatgatgatgcaccggacatgaagtgtgatgat atgatgacttgctacctgttccacatgtatgtgggtgtgagagctggtggaggcatcggt gatgagattgaggacccagccggcgacccttatgagctttaccgcatcctctttgacatt actttcttcttctttgtcattgttatcttgttggccatcattcaaggtttgatcattgat gcgtttggtgagttgagagatcagcaggaacaagtgaaggaggacatggagacaaaatgt tttatctgtggaattggaaatgactactttgacaccacaccgcatggcttcgagacccat actctgcaagagcacaacttggccaactatctgttcttcctgatgtatctcattaataaa gatgaaactgaacatacgggtcaggagtcctatgtatggaagatgtatcaggagaggtgc tgggacttcttccctgctggagactgcttccgcaagcaatacgaggaccagttgggctag

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