Ictalurus punctatus (channel catfish): 108269589 Help Entry 108269589         CDS       T04658                                  Symbol ryr2b Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism ipu  Ictalurus punctatus (channel catfish) Pathway ipu04020   Calcium signaling pathway ipu04260   Cardiac muscle contraction ipu04261   Adrenergic signaling in cardiomyocytes ipu04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:ipu00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     108269589 (ryr2b)    04020 Calcium signaling pathway     108269589 (ryr2b)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     108269589 (ryr2b)    04261 Adrenergic signaling in cardiomyocytes     108269589 (ryr2b)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:ipu04040]     108269589 (ryr2b)    04990 Domain-containing proteins not elsewhere classified [BR:ipu04990]     108269589 (ryr2b) Ion channels [BR:ipu04040]  Voltage-gated cation channels   Ryanodine receptor    108269589 (ryr2b) Domain-containing proteins not elsewhere classified [BR:ipu04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    108269589 (ryr2b) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 Motif Other DBs NCBI-GeneID:  108269589 NCBI-ProteinID:  XP_053538754 Ensembl:  ENSIPUG00000014686 UniProt:  A0A9F7TIU1 LinkDB All DBs Position 9:complement(28315030..28403395) Genome browser AA seq 4919 aa AA seqDB search MTMAPAEGEDEVQFLRTSDELVLRCCLAVPLQQKLCLAADGFGGRLCFLESTSNSKNVPA DLSLCVFVLDRCVSVRALQEMLSNHEDPHTGSAETAGHRTLLYGQALLLRHAHSNMYLSC LTSSAISADKLAFDVGLQEDVAGETCWWTVHPASKQRSEGEKVRVGDDLIFISVSSERYL HVSWGTGVYQECINTTVDAAFQQTLWSVAPVSSCSTQAQGHLRGGDCLRLLHGHTDECLT VSPAGHIEDERRSVHFEAGCVSSQARSLWRIEMLRVSWSGSHIRWAEPFRLYHVTMGKYL GLTPDRGLLLLDREHADVKSTAFCLRPTKDAGQEFPLCVWKKDGMGIPEIKYGDSVCLVQ HVDSGLWLTYQTSDSKRRKETQSHKQAILHSEGHMDDGLTLSRSQTEECKAASLIRSSTL LFTSIIRRLDDLTHRANVAAVDLPIEMLRLSLCDLIGYFRLPDECWSHETRQSSSGALKN RQNLFQEEGVITLVLDCIDHLHLYSSAAHFAEAAGKEAGDAWEAILSSFYVLLAALIRGN QNNCSQFSSSLDWLISRLERLEASTGILEVLHCVLMESPEALSFIKEEHIRSIITLLDKH GRNHKILEVLCSLCVCHGTAVRSNQHLICDTLLPERDLLLQSRLMNHVTSVRPNIYLCMG DYSAQYRKWYYEVVVEKAEPFVTPEPSHLRVGWACSAGYHPPPTGGHSWGSNGVGDDLRS YGFDGLHLWTGGVGRRVSSVSQRLLREDDVISCCLDLGAKCISFRVNGQPVQGMLENFNT GALMFPVVSFSAGVRVRLLFGGQQGEFKFLPPAGFSPCAEALLPRGRCRLELCEEVTRGQ GNSGRELLGPAVSAEPVVFTPTPVDTNQVTLPPQLELIRERLAENLHELWLLEKTEQGWT HGPVRDDSKQVHPGLVEFSKLPDQEKRSNLQAAEHTLRSLLALGARIGLSDDHVEEKVKY VRLSKKHELWNGYMPAPVDQSGVSLSAAQEALVEALAENEHNIWAREHIREGWSYAPQQD IKGKRSPHLVPFSLLDERSRQCAKESARDVLGTLLGFGYTVEASEEWQSLGPDVKAASEE RVRIFRVEHTFAVHDGKWYFEFEAVTAGEMRVGWARVGCQADMELWSDEQAYVFDGSKGQ WWHGSTAPFGHVWQKGDVIGCLLDLTRRTMMVTLNGELQLNTYGSEIASKGFTATGGFVP VCVLGVNQVGQLNLGQQVNSLKYFSVCGLQEGYQPFALNMSKDPPLWMSWREPLFVQIPE DHPRLQVSYIDGTVGHLPALKVTQRSVGLPDSLSTDVEFYRLSLPIECVQVFTNPVDGTV PPASSVACHIKEPEEGEVDSDFEMLMKSAHRHTGTRDELNNHKDHAQEKTSRLKQRFLLK KKPGLNTSGSSARLLEEVLAIERDSANQFANCTKYYYSVKILHGQDPSCVWVGWVTSNFH SYDRTFDPERVCSVSVTLGDQWGKVLKSIKCSCCYMVCAGEGSSLSHSQSSIRLEIGCLV DTATGFLTFTANGKEIGIFYQVEPGTKLFPAVFAKATSSDVFQFDLGRIKGALPLSAGLF RSERKNMEPQCHPRLTVQSLIPMRWTRIPEHAPQVELIRLEERHGWRAQCTDSLQVMTLH IPEEDRSIDILELSELDNLLKFHDHTLRLYSALCAHGNIPVSHALCSHIDQSQLLFALHC SRMPGNLRAGFYDLLMTAHLSVHSSARQATIHEYIVPMTDAMRTSTRSQNNRKQHRLPGS NTSTSLRPRMHFSSPCFVRASGNSFDNRTNRSEEGSCQYSPEFPMDMLKAVMTAMLEEAV HSVGKSIRDPVGGSIELMLVPLLQLLHTLLLMGVYHHSDLRRVLSFILPSVYMRENNAGE LIDGDGENYYEILGKEKEGRALPEQKTLLQMKLPEAVKLQLCHLLQYLCDCEVRYRVEAI MTLSADLVGRLQGNQRSRYMNVMEALNMSAALTARKTKEFRSPPQEQMNMLLNFRDMEQD CPCPEKIRELLWDFHLDLRSNCGVETDENLGAEDDESQPIRNRLRDLVDKMSRLKRRMSG VVEKDVVAKPVSLQWLISDTVMRWTHEGPLEDPVLVRAAFGLLRYQYAGLSGKMAAPLQK AYCITQNSVEDTLGLQEALGRIRSLLTARMGIEEEELMIRGLGDIMKNKVFYQHPNLMRA LGMHETVMEVMVNVLGTRESKFSPHKEIRFPKMVAHCCRFLCYFCRISRHNQKAMFDHLS YLLDHSSVGLASPSMRGSTPLDVAAASVMDNYELALALTEPDLEKVVQYLAGCGLQSCTL LLSKGYADIGWNPVEGERYLDLLRFAVFCNGESVEENAYVVVRLLIRRPECFGPALRVEG GNGLLATMEDAIKISEEESGECFSKAYQSSSTLDTLDDEDDNVIHMGHAIMTFYSALIDL LGRCAPELHLIEAGKGEAVRIRAILRSLIPVNDLEGVISIPFPLPFLDKDGCMMEPDMSR CFCPDHKASMVLFLDRVYGVQDQNFLLHLLEKGFLPDLQAAVSMDNSGLGSTDMALALNR YLCGSVLPLLSKCSSLLRGLPLVRTGTVDDFLQALYRLSKASSLTKAQHDAIQTCLLSVC GKLKPSLLQPLLRSLAVDVPRLSESTKMPLKLLTDHYEQNWKYYCTTGGRGAFGSASEEE LQLSRKLFWHVFRALTKKTYDAETSEASVGCLVAVSGAVPPDHVDLTCTAGLDTHSSLDS EGRFCPQPLDTSDVTVPEGLEYVVNKYAEHTHEKWSLEKFANGWVHGEQMCESSKVHPLL KPYRALSERDKEKYRAAIKETVKSMLVLGWTIERSKEGDARDLHHLSRRISQSGQLSFEG TSMFSPKPADTSSIMLTWDQYAMAEQLAENYHNIWAQKKLQELQAKGGGSHALLVPYESL SGREKSRIRDRARDVLKFFHINGYTVWRERKPPESDCPSVSGRFAYRLLHQALSCTEQVQ EKMLELEVAQARGQPGTAEDMCHEQQMRFFIKVLLPLIDHYFKNHHLYFLPSAMCSLSST AHASNKEREMVSRLFCTLAALTRRRISLFGKDARCVVSCLQILARSLDAKVAMKMVTECV RSALHSFFEAAAVDLELAVDSVTPGVIQFRGDREVLTYTTAALLPVLTSLFKHTAHGQSS LDLMVDEVQASCYRILRSLYTLGTCSNTFMERQRPFIGECLAALSSAFPLCFLEISLDYM SNAQREIGVSIAAKDSSWTLPSLQEALADVEDVLEAESAARHALLSRVMEVTVPLLCSYV CRWGEEDSLGSEGQQGASCSSLTPSHTNALLGQILAIIHVHLGRHECTWMKRIVGFVQPM VRSAEPGLLTSRILPLMEKLKKRAELVLQEEESMKIEGCGDVAEMELAVQEKFAVLVQDI YAVYPLLIPFVEHHRILWLREMNADAERLFSLVADVFTFWAKSHNFKWEEQNFVVQNDIN NMTYLVNSRNSQMTKRECEEERRKVKRSKDERYSTHTSLIVASLKKLLSVGLNRCCQRDR DLITLAKNRFAEKDTEEEVRAFICISLQQVNQDVSHSLLDERRVEGVLAVARVLFYLDQV ESPQGSKRAVWQKLLSKQRKRAIVACFRMTPLYNLPRHRAVNLFLQSYRRIWVEGEDDLY EEKLIEDLAKAGDGGSVVEEEGRSEGTAESKKIDPLYQLITLFHQSALTERSRLEEDGLY LAYTDIMAKSCQAEDEDGRDEVKSFEEKELEKQRLLYQQARLHERGAAEMVLQRLSASRG VTGHSVEATLKLGIAMLNGGNTDVQQKMLDYLRVKRDVGFFHSLASLMQSCSVLDLNAFE RQMKAEGLGTAADGNAGDKVMADGPLTCDLFRFLQLLCEGHNADFQNYLRTQTGNNTTVN IVISTVDYLLRLQESISDFYWYYSGKDVIDEHGQRNFSKAIRVAKQVFNTLTEYIQGPCT GNQQSLAHSRLWDAVVGFLHVFAHMQRKLSQDSSQIELLKELMDLLKDMVVMLLSMLEGN VVNGTIGKQMVDMLVESSSNVEMILKFFDMFLKLKDLVSSDAFKEYDPDVQGLISKKDFQ KAMEGYKRYTVSEMDYLLSCAETNETKLLDYRAFVARFHEPAKDIGFNVAVLLTNLSEHM SHDARLRNFLELADSVLRYFQPHLGRIEIMGSGKRVERVYFEISESSRMQWEKPQVKESK HQFIFDIVNKGGEKEKMELFVNFCEDTIFEMQLAAQISAPDRDDEVLGIEDDGVDEKEED KNPATDNDDTKVEQRGFSLMAMMKRLLLAPLRALMMIMCLLSIRNVKRQIKRMTMKGLIL AIALFFQKVLSAMLHTILDTICFFLHVLYLVFLSGCIIEFAKETKLSDFFRDLTDPTLDD VTGVNEGVIHKNKGPSQTRSYHGDLQAIDLSAVSKNPQILTDIFGLQLRKDGGQYMLISR DSNASIGEAVVSEEDLEDEEDEEKHSENEKAEGEDNEKKDKRKEDEAKRRFRRMSLHKAA EPEVQESATWKIIDSQKTKLLNYFARNFYNMRVLALCVTFGINFILLFYKVSSSEAEGVA MPDLGDENDDSTSVRFILGESGYMKSVLHTLALLHTLISFCSIIGYYCLKVPLVVFKREK ELARKLEFDGLYVTRQPADDDIRGQWDRLVINTLSFPSNYWDKFVKRKVMAKYSELYGSE RISGLLGLDKTTLDFSYEARNGRRPARELLKSIDMKYQIWKLGVVFTDNSFLYLAWYMLL SILGHYNNFFFAAHLLDVAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNF FRKFYNTSEDGQTLDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDESEFYRVVFDI TFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSEYFDAVPHGFETH TLHEHNLANYLFFVQYLINKDVTEHTGQESYVWKMYQERCWEFFPVGDCFRKQYEDQLG NT seq 14760 nt NT seq  +upstreamnt  +downstreamnt atgacgatggcgcctgcagaaggagaagatgaagttcagttcctgcgtacatcggatgaa ttggtattgcgctgctgcttggctgtccccctccagcagaagctgtgtttggctgcagat ggtttcgggggccgactgtgtttcctcgagtccacttcaaactccaagaatgttccggca gatctgtccctgtgtgtgtttgtgctggacaggtgtgtgtcagtccgagctctgcaggaa atgctctccaaccatgaggacccacacacggggtcagctgagaccgctggccatcgcact ctcctctatggacaggcactgctactcagacacgcccacagcaacatgtatctgagctgt ctgacctcgtcggcgatctcggctgataagctggcgtttgatgtcggccttcaggaggat gtcgcaggtgagacgtgttggtggacggtccacccagcttccaagcagaggtcagagggg gagaaggtcagagtgggtgatgacctcatcttcatcagcgtttcctctgagagatacctg cacgtctcatggggaaccggtgtgtatcaggagtgtataaatacgacagtggacgcagct ttccagcagactctatggagtgtggctcccgtttcctcttgctcgactcaagctcaaggt cacctcaggggaggagactgtctacgtctcctacacggccacacggatgagtgtttgacc gtttcacccgctgggcacatagaagacgagcgcagatctgttcattttgaagccggctgc gtctcatctcaagctcgttcactgtggaggattgagatgttacgtgtgtcctggagtggg agccatattcgttgggcggaaccatttcgtctgtatcatgtgaccatgggaaaatacctg ggcctgaccccggaccgtggtctgctgctactggacagagagcacgctgacgtcaaatct accgccttctgtctccgcccaacgaaggacgctggccaagaattcccactctgtgtctgg aagaaagacgggatgggaattccggagatcaaatacggtgactctgtctgtttagtccag catgtggactccgggttatggctcacctaccagaccagcgactcgaagaggaggaaggag acgcagtcgcacaaacaggccatactccattcagaaggtcacatggatgatggactcaca ctctctcgctcgcagacggaggagtgtaaagctgccagtctcatccggagctcgactctc ctgttcacaagcattatacggagattagatgatctcactcaccgagccaacgttgcagcc gtggatcttccgatagaaatgctgcgtttgagtttgtgtgatctgattggttatttccgg ctgcctgacgaatgctggagccacgagaccagacagagcagcagcggagcgctaaagaac agacagaacctgttccaggaagagggtgtaattactttggtcctagactgcatcgatcac ctgcacctgtatagcagtgcggctcattttgccgaggctgctgggaaagaggcgggagat gcatgggaagccattttgagctccttctatgtgcttctggcggcgctgatccgggggaat cagaataactgctctcagttctccagctctctggactggctgatcagcagactggagaga cttgaggcctccactggaattcttgaagtgctgcactgtgtattaatggaaagtccagaa gccctgagttttattaaagaagaacacattcgctccatcatcacacttttagacaaacac ggacgcaaccacaagatcctggaggtgctgtgttcactgtgtgtgtgtcatggtacagca gtgcgctctaatcagcacctgatctgtgacacactgctgcctgagcgagacttactgctg cagagccgcctgatgaaccacgtcaccagtgttcgcccgaacatctacctctgcatggga gactactccgcacagtacaggaagtggtattatgaggtggtggtggagaaggcggagcct ttcgtgacacctgagccgtctcacctgagggtgggttgggcctgtagcgcaggttaccac ccccctccaacgggaggtcacagctgggggtcaaacggagtcggagacgacctgcgctca tacggcttcgacggcctgcacctatggacaggtggcgtgggtcgcagggtcagctcggtc agtcagcgtctgctgagggaggatgatgtcatcagctgttgcctcgacctcggtgcgaag tgtatttctttccgagtgaacgggcagccggtgcagggcatgctggagaatttcaacacc ggcgcgctcatgtttcctgtggtcagtttctccgctggagtcagggtgcgtttgctgttc ggaggtcagcagggggagtttaaattcctgcctcctgccggattctcaccgtgtgctgag gctttactccccagggggcgctgcagactggagctgtgtgaagaggtcacacggggtcag ggaaacagcgggcgtgaacttttaggccctgctgtatccgctgagccggtggtctttacc cctacaccagtggacaccaatcaggtgacgctgcctcctcagctggagctgatcagagag agactggctgagaatctgcatgagctctggctgctggagaaaaccgagcagggatggaca cacgggccggtgagggatgacagtaaacaggttcacccgggactggtggagttttccaaa cttccagatcaggagaaacgcagcaacctccaggccgctgaacacaccctgaggtctctg ttggctctcggagctcgtatcggactgtctgatgaccacgtagaggagaaggtcaagtac gtccggctctcaaagaagcatgaactgtggaacggttacatgccggctccggtggatcag tccggagtttctctaagcgctgctcaggaagctctggtggaagcgctggctgagaacgag cacaacatctgggccagagagcacatcagggagggctggagctacgcaccacagcaggac attaaggggaagaggagccctcatctggtgccgttctctctgttggatgagagaagcaga caatgtgcaaaagagtcagcgagggatgtgttaggaaccctgcttggttttggatacact gtagaagcatcagaggaatggcagtccctgggccctgacgtgaaggctgcgagtgaggag agggttcggatattccgtgtggagcacacgtttgcagtgcatgatgggaaatggtatttt gagtttgaggcagtcactgctggagagatgagagtgggatgggctcgagtgggatgtcaa gcagatatggagttgtggtcagacgagcaggcctacgtgtttgatggctcaaagggtcag tggtggcatgggagcactgccccatttggtcatgtttggcagaagggggatgtgattggc tgtttgttggatttgactcggagaaccatgatggtcactttaaacggagagctgcagctg aacacttatggctctgaaattgcttccaaagggttcactgcaactggtggctttgttcct gtgtgtgttttgggtgtgaatcaggtgggacagttgaatttaggccagcaggtcaactca ctgaaatacttcagtgtgtgtgggcttcaggagggctaccagccttttgccctgaacatg agcaaagatccacctctctggatgagctggagagagcccttatttgtacaaataccagag gaccatccccgcttacaggttagttacattgatgggacggttggtcaccttccagctctg aaggtcacccagcggtcagtgggattacccgacagtctcagcactgatgttgagttctat cgcctgagcttgcccatagagtgtgtacaagtattcaccaatcctgtagatggcacagta cctccagctagcagtgtagcctgccacattaaggaaccagaagaaggggaggtggactct gactttgaaatgctgatgaagtcggcccacagacacacaggaactagagatgaactaaac aaccataaggatcatgcccaagaaaagacttccagacttaagcaaaggtttcttttgaag aagaaaccaggattgaacactagtggctcttcagcccggctgctggaggaggtgctagcg attgagagggacagcgctaaccaatttgccaactgcactaagtactactattctgtgaag atcctacatgggcaggatccatcctgtgtctgggttggatgggtaacttcaaacttccac tcttatgatcgaacctttgacccggagagagtgtgtagtgtgtctgtcacacttggggac caatggggcaaagttcttaagagtatcaagtgcagttgctgttacatggtgtgtgctgga gagggcagtagtctctcccacagccaaagtagcataaggctggagataggctgtttggtt gacactgcgactggatttcttacctttactgctaatggaaaggagataggaatcttctat caggtggaaccaggcactaaactgttcccagcagtttttgccaaagccaccagttctgat gtcttccagtttgatcttggacgaattaagggtgcgttgccactgtctgctggtttgttt cggagcgaaaggaaaaacatggagcctcagtgtcatcccaggcttactgtccaatccctg atacccatgaggtggacacggatccctgaacatgccccacaggtagagctgatacggctt gaggagaggcatggctggagggcacagtgtacagacagtctacaggtcatgaccctgcac atccctgaggaggacaggagcatcgacattctcgaactctctgaattggacaacctgctc aagttccatgaccacactctccgtctctattccgccctctgtgcccatggaaacataccc gtaagccacgccttgtgcagccacatcgaccagtcacagcttctgtttgcgttgcattgt tctagaatgcctggaaatctgcgagcaggtttctatgacttattaatgactgcccacctc agtgtccatagcagtgccaggcaggctaccatccacgagtatattgtgcccatgactgat gccatgcggactagtacacgttctcaaaacaacagaaagcaacacagactcccaggcagt aacaccagcacttctctgcgaccgagaatgcacttcagctcaccttgttttgttagagct agcggcaacagttttgataacaggaccaatagatctgaggagggttcctgtcaatatagt cctgaattcccaatggatatgctgaaagctgtaatgacagccatgttggaggaggcagtg cactcagtagggaagagtataagagaccctgtaggaggcagcatagagctaatgcttgtt cctcttctccaactcctccacacactcctactcatgggtgtatatcatcactcagatcta cggcgtgtgctttccttcatccttccctctgtttacatgagggaaaataatgcaggagaa ttaatagatggagatggagagaattattacgagatactggggaaggagaaagaaggaaga gcccttcctgaacaaaagactttgttacagatgaagctaccagaagcagttaaactacag ttgtgtcacctgctacagtatctgtgtgactgtgaggtgcgttacagggtcgaggccata atgaccttgtctgctgaccttgtgggtcgtctccagggcaaccagcgctctcgctacatg aatgtcatggaggcacttaacatgtctgctgctctcactgctcgcaagaccaaggagttt cgctctccacctcaagaacagatgaacatgttgcttaacttccgagacatggagcaggat tgcccctgccctgagaagattagagagttgctctgggatttccatctggacctcagaagt aattgtggagttgaaactgatgaaaacttgggtgctgaagatgatgagagtcagcctatc cggaatcgattaagagacctggtggacaaaatgtctcgtctaaagaggaggatgtctggt gtggttgaaaaggatgttgtggctaaacctgtttctcttcagtggctgatctcagacact gtgatgcgttggactcacgagggaccgttggaagacccggttttggtacgggccgcattt ggactcctacgttaccagtacgccggcctgtctggcaaaatggccgccccgttacaaaaa gcctactgcatcacgcaaaactcggtagaggacacgcttggcctgcaggaggcactggga cgtatccgctcactacttacagctagaatgggcatagaagaagaggaactcatgatccga ggacttggtgatatcatgaaaaataaagtgttctaccagcacccgaacctgatgagggca ctgggtatgcacgagaccgtcatggaggtgatggttaatgtcctgggcaccagagaatcc aagttctctccccataaggaaatcaggtttccaaagatggtggcccactgctgccgtttc ctgtgttatttttgtcgaatcagccgccacaaccagaaagccatgtttgatcacctgagc tatctattggaccacagcagcgtcggacttgcatctccctccatgcgaggctcaactcct ctggatgtggctgcggcttctgtgatggacaactacgagctggcattagcgctcacagag ccagacttggagaaggtggtgcagtatttggcaggctgcggtttgcagagttgtacactg ctgctctctaaaggatacgcagacatcggctggaatcctgtcgagggcgagcgatacctg gatttactgcgctttgctgtcttctgcaacggtgaaagtgtggaagagaacgcatatgtc gtcgtccggctcctgattcgccgccccgaatgctttggccccgccctccgagtagaggga ggaaacggtctcttagcaaccatggaggatgccatcaagatctcagaagaggagagtgga gagtgcttttctaaagcctaccagtccagtagcacactcgacactcttgatgatgaagat gataatgtcatccacatgggacacgccatcatgaccttttactccgctcttatagacctg ctgggccgctgcgctccagagttgcacctgatagaggccggtaaaggcgaggctgttcgt ataagggccatcttgagatctctgatccccgtgaacgacctggaaggagtcatcagcatc cctttcccactcccttttctggacaaagatggttgcatgatggagccggacatgtccagg tgcttctgtccagatcacaaggcatccatggtgctgtttctggaccgagtctatggtgtc caggaccagaacttcctgctccacctccttgagaaaggtttcctgccagatcttcaagca gccgtcagcatggataatagtggactgggtagtacggacatggcgttggctctgaaccgt tacttgtgcgggtccgtgctaccattgttaagtaagtgctcgtcgctgctgcgtggactt cctctcgttaggacaggaacggtggacgacttcctacaagcactctaccgtctctctaaa gccagcagcctcaccaaagcccaacacgatgccatccagacctgcctgctctctgtgtgt ggaaaactgaagccgtccctgttgcagcccctactgcgaagtctagcggttgacgtccca cggctgtccgagagcaccaagatgccacttaagcttctgaccgatcattatgagcagaac tggaagtactactgcacgactggtggacgtggagcgtttggctccgcctcagaggaggag cttcagctcagcaggaagctgttttggcatgttttcagagcattgaccaaaaagacgtat gacgccgagacgtccgaggcgtccgtcggatgtctggttgccgtgtccggtgctgttcct cctgatcacgtcgacctcacctgcacagctggcttggacacgcactcttcactcgactca gagggacgcttctgtcctcaacctctggacacgtccgatgtaacagtgcctgagggattg gagtatgtggtgaataaatacgcagaacacacacacgagaagtggtcactggagaagttt gctaatggttgggttcacggagagcagatgtgtgagagctctaaagttcacccactcctg aagccctacagagccttatcggaacgagataaagagaagtacagagcggccattaaagag accgtgaaaagcatgctggtcttgggctggaccatcgagcggtcgaaagagggggatgcg agggacctccatcacctctccaggaggatctcacagtctggccagctgtcatttgaggga acctccatgttcagtcccaaaccagcagacaccagcagcatcatgctgacctgggatcag tatgctatggcggaacaactggcggaaaattaccacaacatctgggcccagaagaaactc caggaactgcaagctaaaggagggggcagtcacgcactgctggtgccgtatgagtctctg agtggccgagagaagagccgaatccgagacagagcgcgggacgtcctgaagttcttccac atcaatggatacacagtgtggagagagagaaaacctcccgagtccgattgtccctctgtc tcgggccgctttgcgtaccgtctcctccatcaggcgctctcctgtaccgaacaagtgcag gaaaagatgctggagctggaggttgctcaggctagagggcaaccgggaacagcagaggac atgtgtcacgagcagcagatgcgtttcttcatcaaagttttattaccgctaattgatcac tattttaaaaaccatcatctctacttcctgcccagtgcgatgtgttctcttagcagcacc gcacacgcttccaataaagagagagagatggtttctaggttgttctgtacgctggcagct ctcaccagacgcaggatttctctgttcggtaaagatgctcggtgtgtggtgagctgtctg cagatcctggcacgctctctggacgcgaaggtagcgatgaagatggtgacggaatgtgtg cgttcagccctgcactcattcttcgaggctgcggcggtggatttggagctggcggtagac agcgtgaccccgggggtcatccagtttcgaggagatagagaagttctgacctacaccacc gctgcactgctcccagtcctgacctctctgtttaaacatacagctcacggccagagctca ctcgacctcatggtggacgaagtgcaggcgtcctgttacaggatcctccgcagcctttac actctcggcacttgcagtaacactttcatggaaaggcagaggccttttataggcgagtgc ctcgctgccttgtcatctgccttccctctgtgcttcctcgagatttccctggactacatg agcaacgcacagagagaaataggcgtgtccatcgcagccaaggattcgtcctggaccctc ccctccttacaggaagcattggcagatgtcgaagatgttctggaggcggagtcagcggct cgccacgcccttctatcccgagtcatggaggtaactgttcctctactgtgcagctacgtg tgtcgttggggtgaagaggatagtctggggtctgaggggcagcagggggcatcatgctcc tctctcacaccctcacacaccaacgccctgctgggacaaatcctcgccatcatccacgtc cacctaggcagacacgagtgcacctggatgaaacggattgtgggttttgtccagccgatg gtccgtagtgcggaacccggtctcctgacgagtcgcatcctgcctctgatggaaaagctg aagaagagggcggagttagtgctgcaggaagaggagagcatgaagattgaggggtgtggt gatgtggcagagatggagctggcggtgcaggagaagtttgcggtgttggtgcaggacatc tacgctgtttatccccttctcatcccgtttgtcgagcatcacaggatactctggctgagg gagatgaacgcagatgctgagagactcttcagtctggttgctgatgttttcactttctgg gccaaatctcataactttaagtgggaggagcagaactttgtagtacagaacgacatcaac aacatgacctacctggtcaacagcaggaacagccaaatgacaaagagagagtgtgaagag gagaggaggaaggtgaagaggagcaaagacgagcggtactccacacacacttctcttatc gtggcctctctgaagaagctcctctctgtcggtctgaatcgatgctgtcagagagataga gacctcattactctcgccaagaaccgcttcgctgagaaagatacggaggaggaagttcga gctttcatttgcatcagccttcaacaggtaaaccaggatgtttctcactctttactggat gaacgtcgtgttgaaggtgttttggctgtggcccgtgtgcttttctatctggatcaggtg gagtctcctcagggcagtaagagagctgtgtggcagaaactgctctctaaacagaggaaa cgagccatagtggcctgcttcaggatgactcctttatacaacctgccacggcacagggcg gtgaatttgtttctgcagagctacaggaggatttgggtggagggagaagacgacttgtat gaggagaagctgattgaagatttagctaaagcaggagatggagggagcgtggtagaggaa gagggacggagtgagggaacggcggaaagcaaaaagatcgaccctctttatcagctcatt actctcttccaccaaagtgccctgacagagaggagcaggttggaggaagacggtctgtac ctggcctacactgacatcatggccaagagctgccaggccgaggacgaggacgggcgtgat gaggtgaaatcctttgaggagaaagagctggagaaacagagactcttgtatcaacaagcc aggctacatgaacgaggagctgcggagatggttctccagaggctcagtgccagcagaggt gttacggggcactcagtggaggccactcttaaactcggcatcgccatgctgaacggagga aacacagacgtacagcagaaaatgctggactatctgagagtgaaacgagatgtgggattc tttcacagcctggcgagcctcatgcagtcctgcagtgttttagacctgaacgctttcgag aggcagatgaaagccgagggtttaggaactgcagctgatggcaacgcgggtgataaggtt atggcagatgggccgctgacttgtgatctcttccgcttcctccagttgctttgtgaagga cataatgcagattttcagaactatctgaggactcagacaggaaacaataccacagtaaat attgtcatctctactgtggactacctgctccgactgcaggagtccatcagtgacttttac tggtattactctgggaaagatgtgattgatgaacacggccagcgtaacttctctaaagcc atcagggtggccaaacaggtcttcaacaccctcacagagtatatccagggtccatgcact ggcaaccagcagagtttggcccacagtcggctgtgggacgctgtggtgggctttctccat gttttcgcccacatgcagaggaagctttctcaggattcgagtcagattgagctgctgaag gaactgatggatctgctaaaagacatggtggtgatgctgttgtctatgctagaaggaaac gttgtgaatggcacaatcggcaaacagatggtggacatgctggtggagtcatccagcaac gttgaaatgatcctcaagttctttgacatgttcttgaaactcaaagacctcgtatcctct gatgccttcaaagaatatgaccctgacgtacaaggacttatctccaagaaggacttccag aaggccatggagggctacaaacggtacactgtatctgagatggattacctcttgtcttgc gcagagacgaacgagaccaagctcctggactatcgcgcgtttgtggcgcgttttcacgaa cccgccaaagacatcggtttcaacgtggctgtccttttgaccaacctgtcagagcacatg tctcatgacgctcgactacggaactttctggagttagctgacagcgtgctcaggtatttc cagcctcacctgggcaggattgagatcatgggcagcgggaaacgggtcgagagggtctac tttgaaatcagcgagtcgagccggatgcagtgggagaaaccacaggtcaaggagagcaag catcagttcatcttcgacattgttaacaagggaggagagaaagaaaagatggagctcttc gtgaacttctgcgaggacaccatctttgagatgcagctggccgcccagatctctgccccc gaccgtgatgatgaggtgctgggaatagaggatgatggagtggatgagaaggaggaggat aagaaccctgctacagataatgatgacactaaagtagagcagagaggcttttctttgatg gcgatgatgaagcggcttctcctggcccctctccgtgccctgatgatgataatgtgtctc ctctccataaggaacgtgaagcggcagataaaaaggatgaccatgaagggtctcattttg gccatcgctctcttcttccagaaggttttgtcagccatgttgcataccatcttagacacc atctgctttttcctacacgtcctctatcttgtctttctcagtggttgcattatcgagttc gccaaagagaccaaactctctgatttcttcagagatctgacggacccgaccctggatgac gtcacaggggtaaacgaaggggtaatccacaagaacaaaggtccatcacagaccagatcg taccatggtgaccttcaagcaatcgacttatcggctgtgtccaaaaaccctcagatactt accgatatatttggtctccagttaagaaaggatggagggcagtatatgctaattagtcga gattccaatgccagcattggtgaggcagtggtgtctgaggaggatttagaggatgaggag gacgaggagaagcattccgagaatgaaaaagctgaaggtgaggacaatgagaagaaggac aagaggaaggaagatgaggcgaaacgcagattcaggaggatgagcttgcacaaagcagcg gagcccgaggttcaagaatcagccacgtggaaaataatcgactctcagaagacaaaactg ctcaattattttgccaggaatttctacaacatgcgagtgctggcgctgtgtgtgaccttc ggcatcaacttcattcttctgttctacaaggtttcttctagtgaagctgaaggcgtggcc atgccggacctcggcgatgagaatgatgactctacgagtgtgcgttttattctgggagaa agtggttatatgaagtctgtgctccacactctggctctgttacacactcttatctccttc tgctccatcatcggctactactgtctgaaggttcctttagtagtgttcaagcgggagaag gagctagcacgtaagctggagttcgatggtttgtacgtcacacggcaacctgccgatgat gacatcaggggccagtgggaccggctggtcataaacacgctatcgtttccgagtaattat tgggacaaatttgtgaagaggaaggtgatggccaagtacagcgagttgtacggctcagag aggatcagtgggctgctgggtttggataagacaacactggatttcagctacgaagcccgg aacggaagaagaccagcccgagaactactgaagtccattgacatgaaatatcagatctgg aaacttggagtggtgttcactgacaactcattcctctatcttgcctggtacatgctgctg tccattttgggccactacaataatttcttcttcgccgctcacctcttggacgtcgccatg ggctttaaaacgttacgcaccatactgtcttccgtcacgcacaatggaaaacagttggtt ctgactgtgggactgttggccgtggttgtatatctctacaccgtcgtcgccttcaacttc ttccgcaagttttacaatacaagtgaagatggccaaactctggacatgaagtgtgatgac atgctgacgtgttacatgttccacatgtacgtgggcgtgcgtgccggaggggggatcggc gatgagatcgaagacccggccggagacgaatctgagttctaccgcgtcgtcttcgacatc acgttcttcttcttcgtcatcgtcatcctcttggccatcattcagggtctgatcatcgac gcgttcggagagctgagagaccagcaggagcaggtgaaagaggacatggagacgaaatgt tttatctgcggcattgggagtgaatattttgatgccgtccctcatggctttgagactcac acgctgcatgaacacaacctggccaactacttgttctttgtgcagtacctcatcaataaa gatgtgacggaacacacagggcaggagtcctacgtgtggaagatgtaccaggaacgctgc tgggagtttttcccagtcggagactgtttccgaaaacagtatgaggatcagcttggttaa

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