Ictalurus punctatus (channel catfish): 108269949 Help Entry 108269949         CDS       T04658                                  Symbol syne1b Name (RefSeq) nesprin-1 isoform X1   KO K19326   nesprin-1 Organism ipu  Ictalurus punctatus (channel catfish) Pathway ipu04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:ipu00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     108269949 (syne1b)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:ipu03036]     108269949 (syne1b) Chromosome and associated proteins [BR:ipu03036]  Eukaryotic type   Centrosome formation proteins    LINC complex     108269949 (syne1b) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Spectrin Spectrin_SYNE1 CH SYNE1 KASH Spectrin_Anc-1 P53_C Motif Other DBs NCBI-GeneID:  108269949 NCBI-ProteinID:  XP_017331610 Ensembl:  ENSIPUG00000002546 UniProt:  A0A2D0RNS2 LinkDB All DBs Position 9:18711267..18791036 Genome browser AA seq 8783 aa AA seqDB search MAQFKDVAMKKTTSLNLVTGFFQYLRDEQELVQKRTFTKWINSHLAKRKPPLEINDLFED IKDGVKLLALLEVLSGQRLPCEQGRQLKRIHWVSNIGTALKFLEGRKIKLVNINATDIAD GRPSIVLGLMWTIILYFQIEELTSNLPALQALSNSASSVDSMANSETKSPPMKRKVLKFQ GNAKKAMLRWVQCTATNRLGIEVKDFGSSWRNGVAFHSVIYAIRPDLVDMELVKRRSNRE NLEEAFTVAENELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDPHQSETDGQQEER EERKILREWKAWLDQLERDILRAQGAEGNLTDKYQAFKNFRVQYELRKKQIETLLQPVHK DGKLSVDQAVVKQAWEQVSVRLLDWHIHLDKSLPGPLGAIGAWLHRAEFALREDIPIQQA HDETANIIHRKLEQHKEVLINLEGHRQTFQQIHRDRAVNGVPVPLEQLQDMAERFNYVST SSHVHLIKLEFWEMKYRLMAFLILAESKLKSWIIKYGRRDSVELLLQNYIAFIEGHKFFE QYETTFQTLKQAADIYIKSDSSGCRISRRAEECEGMNKFLSETMAQWRNLSVEVRSVRSM LEEVISNWEKYSSKVASLQAWLEDAEQMLNHSENDKREFFRNLPHWIQQHMDMNDAGNFL IETCDETVSRDLKQQLLLLNGRWRELFVKVKHYARADEVDKLRKDYEDGILALKIFVDTS NERMNTPVQVSFLNIRTFLQDIEDIKHKVPSMEAVYKTATRNAQQLTKDTSQEEITDMLG VMETIKEELSKIREKVVPLQRDSQALLPPLEEMEKHITGFYQSLEKASRITSARESETPG DFQQKCQELVTYQQSCKKCLTVIDKNHQIIMKALEGSKTLRHLDTSLLQKRVVELQASSQ AMVEETTEWKKHVEANSSMMKRFEESRLELEKVLKVARGCMTERGNPEDLLKKHTEFFSQ LDERVLNSFLKACDELTDILPEQEQQTLQETVRKLHKQWKDVQTEIPYHLLQLKVEVERN RLMASLQECEAELARENRSLPGMGSERLVKEHRAFFRDKGPQMLCVKRLQHMEDLCLKLT DSEQARQTLEKSRTAFAEVQDEIESTHQKLMQHPDKWKEFNTRFSELAAWLSSKESQLRL LRNRASDPSKLREVKSTIESLRNDAELQEGNVSWLKSRLAVLIEISTVSDAQRQAAVLTK LSTDFKSLLSSLSESEKVALAVGDCVQFQEEVKNTLDELTQGQQELQAEVTKILNSESAK EAQQLLLIHQQQLKRLRLKRRDMQQQISRGQQLQVQEGLGESLQDDLHKLDTSLSQMDQS MEAQEQSLEATLSSWQEFDSQQAAVGEFVSRVRSVREREMTFSSPESLTTELKQTKELLK QSETEAEVVNTLLKRAAEIQLGPKNASLLHTQAHSLSDQLDKTVASLKKDVKTFEDIKNQ WESFGSEFDAFSSWISEKEKELDSLKSSNEPLEQQISTAKAVTAELQERAEILSQLEDRA QALSQFVSSGESARIKARLTQIGRYWEELKESMEHLNGQLEDSANHQQKFNTNLQQVQSE IDAIQTKLDTPLTFCASSSDTYKALQDHMDVFQSLEKVKVTLLSLCTGARRLSEREKAES AVAALQHSYEQSLKQAKDKQSHMESLLSLWQKLEKDCCSLQSCLESCESLSASVTQYLTV DKTKLDGELMELKHLHSELQSLESLYEGLLTQAPALYSTASDEQVKTLKEDHEQLKKRWS SQCTAIPNRIQVLQDHISRVDEHEQALQKFFKWGEYFLSSLHSSSQVNITDLQLIAIEIK EKAQSLQSENSERENLQQQTESLCTSCEPVEQHYLQSRLENSLQPYMQAQQLVMQRGESV EKLEAFLQTHNVAAGVLRGLRHTVESAGSWDKSRVDELQRDLEGIIPDISRLESLAISLD SSLCKAHLHLVDAKEARTLCRSLADTLSTELDGVKTLLGSKQSEAEALGALWSSFRQRKE QLLKSVEDIEEKADQQILKEPNLLTLQQRLRFFNQLEDELQSHQHEEQWLRDKGQQLSQR DTELAGEVLREINLLKTTWEDTEKLITERQEQCTNMIELMKDYQSLKSSINAIVENAEAV IKLGLKDQEDTRRSLSKHEAIKMELTANQGELDQFSSKAKQLVCELNRIPDCETQVIKTE MEAVVDQWLDVSERIEDNLEKLRMSSSIWEDVYHINEEIDSWSNSCVMELTDSLNKFNDS QKAENRLAEVKVEVEQKEKTLDTIQAKVLELKRLCNTKDIPTSLQVMEADLQKKINNVQE LCAQAKNNLSDFCSQKKQLEDFLSQMTEWLMTVEGSLLDTTSGSPPEEICRVKDIQKELQ NQQSCIDSSRESLNTLCRKYPSEELASLGTSLTDLIKKYETVNQRCVKRLGSMQQGLQQL FSDLLKQFHAWLAGQKDIVRECSDYSGDISVVERKLQKLKGALERVEDGESRLMEVCQEG EKLLLHLPKASAGQVQQSLSCIQQDWDSYVEQCRLSQQSLEESASLLNGFENNLQRLSRW LERMEVRLSTELSESKHGEQEKTTLDRVEAFYEEALKERDSFESLCQEAQTLIEGGHGSG SELRVSTQLQMQQQTLLKAVRERLRSCQLSLQEQQSFDETLQTTWAWLSNIQERLTALSS TTGNKETLEKRLGLVQDILLMKGEGEVKLNMTVGKGEQVVKNCSKDKQKAIRSQLQSLKD SWANMLMNAMSCHSRLEWTVTQWSSYQEGKAQLQQWMDTVEQEVEVALPQQPGLKEKISL LERLRAIEADIDSHSAALGRLNEKATELFEKTGDQAFAEEPRAELNAQFSDITAVIKSKV QQMGEIVKEHELYLEAVRELNDWLTSAKEDLQRWSDMSGDAASVQKKLCRVQELLNSRKQ GRERLERVQRCGAAARDHTSTVGCEALEREEAGLLSAWEQWEHGTKHVHSGLEATLAQMA SSDQEFSTLAAQLEQDLQEFSSRLHEWRGTLQQVEAMDTSEEAVQAWQIAKDTLEALLNA EPMSDSLKSQLNDLCRFSRDLGTQSTRVSTLIKEYNSLSLHASRECQRKEKLLEQKFRAA FREFQQWLVSAKISTAKCFDAPQNLSEASSSLQKIQDFLSDREQGHGKLNALAASGDLLI SIAPKERVNAVRAKVSSAREDWKTLMTNLHQRENALQNLHAQMRDFESSVEPLQDWLNQR EVTVQESSSRLHDLPAKKHELHKLQSVLEELASQEAQLSRLREKAQQLWDRHMAGKGFVH RVSQLSAQYLALSNQTKEKASRIERIVSEHQLFSQGLKELQNWVADTSHMLQTYCTPTAD KNVLDSRMIKLEALLTARQEKEIQLKMLVTRGESVRRNTSAEGVPLVCKQIEDLKNSWDS LLSAAIQCKSQLEGALSQWTSYQEDVRQFVSWIESVEESLNSTDKQCSEMRDKAANLGKA KLLYEEVLSHSSVLDTVSVKGSNMAEHYVTQLEIQDLQERYKIIKDRAQAGVGKAEELLI AHQEYQNNLHEFKDWLEQQQEKLSCYTQLEGDVDTLEETLHKLQELQVHCTQGQALLNMV LVSREQVIPWGIPQLEDRTLETVQQEWGSYQTRLSETRSQLNSAIAKLRQMEQKFQRLDN WLKGMENKGQLRSSRRSDKATKEAQLELLKGWHEEVLAYQEEIEGLSTLAQQVLEETHIS SRVSTRATQLTSRYHALLLHLLETIKQLKAEVSGIEEAHSIFSTFSDWLSTAQKNFSSVA ISIDAIDCVAMERKMKKLEALQGDMELGRTFLKTMREKTERAMAFLEESEAEQLKEEING RLSQLEGLTGALRAELSAQEKCIQLSKDFLDKYKAQTQWLNERKSLLVSSVELKAELYQK KAQLAKYKTIHQTMQSHESSVKSVIEKGEALLEIIHDPTISENMTKLQNDYQDLCNKAKT HVQKLAEGVKEHEDYNSELQEVEKWLLQMSSRLVTSDSMQSGNLEMATQQLARHKAIMEE IANFEECLTSLKEKGDGLVSRCSEQVQAKLSQQIQAHQQGTKDSYSAICSTAQRVYQSLD RELQKHVSHQDTLQQCETWLSTVQEEIQLHSQTPFGLQEALKQVKHLRALQEQASTYLDL VCSVCDLSDEAVKATATKIQQIKTMFEERITRAQQLSDCWREIKEQKQELSALFQDLEQQ LHSLSRRPAELEPKIALNMLDQAKEFGEQLHSRQCTLTRMTEYVSKLTEGRASPEHTELN RLSHAWLELCHEANKLQAQREEDLLRTREYHECISALEALFEQISKEWDTLARTEAESSS EHLEALRKLSVVLKEKKNMLEDLKDQKQKVMYHLNLDDKELVKEQISHFEQRWAHLESLI ERKIQDSILTLEDMTQVEARLKEAREWAEEQKPALSEAMKMSPPPEVAQSFLFDHLSICS ELEAKQILLVQAMSDADRVLAHLGLNERQRLQQLISETQAEVESLSIKVAQRRKNLSKAF TERTQFLLAVSRAITWLQQNEKKAHSDDYIALLPDDLTKQVRTCRNIQSSLRAYQSELTS LWSQGRDLMKDATEDEKAEMLTKLQELQNSFEAALQKCNQRLQELEKVLVTRKYFKADLE KICQWLKQADIVTFPEINLMNGDAELKAQLSKYQQILDQAAEYENLLLIVQRAGQEILPT LNEVDHCYLDEKLNGLPQQYNNILAVAKEKQEKIQQAILARQEYSSFIDVTHKALKELEE QFHNLGTQPVGLQTEQVISLQHDYKALLEELTNLGQAVSELNQKKEGFRSTGQPWQPEEM TQLVSLYNGLKRLIEQKVEHLDDTLESFEDHQAMAMQVDSELKATKEQLVKVNAETQSAE ERLKNYHSLAASLQGASSHLSRLMEQMGNLASLMDPAAHEASKQRVISWQEELQSLQSAV GELIVECENRFVQSKDFETEVKRTLTWLQQVRDELGCAVVVDVKVEKVQEEIRKQQIMQE EVQSRLRIMAALSTREKQKYTSANELVPAHVDSTLQEMAKLEADVQQALSSKQLTLEQAL ALCQKYHSRMQAACEWLEDAVGFLQQASLGVDVENYEECLRQQEDIMATEQDFLSVLQEL EALPPQLENLVNHTAKEQLRLSVESAQQRGVEVRDQLQCHQDVLNSCVEQWKSYQEARQT VIDLMNEAEKKLTEFSTAKAATIQEAEEKLKSHKSLVSMVNGFQEKLTGLEEQASQLELI GSDTSKATISRSMTTVWQRWTRLRSMARGQERVLEDTAYEWRTFREKIIKVRACAEELKS RVPECSVEKASKATLQSHQEQHELVTQDLERELSSLTLLRQYALSLLHDVEVSVPTTDLD QLPSLKEIKAVQDQFESLLQKSKTGRAHVQQELKDREEVERGLSLVKSWIQDSRELLLNP TADMQILTQELEAMHGELIAHRQNVDKIAEQQQSKYLDLYTILPSEISMQLAEVALALGS IEDQVQAKERDIQKTRVIKEEFKSRISDVSEKLKSISTTLKEKATDIDQAKEETQGFYVE LECCSRTLAELIAAVQDLGRRHPLLSKQLSDSIAKLGEIHHHTLRLAEYRTVWLKKADAH LDEYNEMLEFIVKWTEQARSLVKTNIIWNSSSQLQEQIRMYQSVLHESRELHGDLEAMQE KVELLSECLQVEAMGLQVAELSRRTEELEQAIKSRLQSLQEAAMDMEKFESEVKALHMAL EQVQTTLTSPELARLSLKEQLTQRQHLLSDMESFKQQVDAVQACQSALRMPEEVVNSLSI CRTALNLQQEASQLQHTAIQQCNILQEAVVQYEQYEQEVQHLQGLIEDSHRVIQDRPVPT SNIQELQSQIRHHEELAQKIKGYQEQIASLNSKCKMLTVKAKHATMLLTVRDAEGLTEEA QELDRAAKTQSQSSMVMVTPGHSHTHLSPVTEESGEEGTNSEISTPLCRADSPITNTEAS LSMLSMGPATLVRAPIQELYDPTLESVAKLDDLQRSWETLKNVISEKQKTLYEALERQQR YQGSLQSISLKMESIEASLNEPPLHDLSPGRQMILHQNLMGDITKLQDDIEELQLNFAED LISENVDTDTAEQLAMQSTLTVLSDRMATIQMKASGKQQLLEDRLSDRLEKQQQEKALQL YLSQVDELDQWLLSTRKTLSSTPQDSDMNEQLSDCQNMLLEIEEKVLALSELSLHSEALL LEGRPETRDEAQRLARKLHTLKSSLVELQRMLQDKQINIQGLLQEQSDSESESSLSQSPN VQDWLAHAHSTRNQHQQDTLQRQRELEEELAEQKKLLKSVASRGEEILNQQASPSSASIC EVLSPELENVSQAVFGQRRQRWESLRKDLTTKLQLLQSTLEQDTKQPFYSRTARVNTSPP FYKREAQVKDKSTLKSLYSEFSQAVENAEVTGSAEEQGMQIEHQLYSAVTATSSWLDDVE NTLFSRSMLLTENAETQLSNHEALGKDVAEVTGEVGNSQGLLGSVVGLPGEKQTLMEDTL DCLSQRLETLDSAVERRCESMRSRIQDLAAFQTELELLFSEISESKFHILQKLAGILDCP PDKQLETITVVEESLRELEHKITDLKTRGAVLQPDQISNNELMKLQDTYEDLVMTVGSRR SGLNQNMALKSQYERALQDLVDLVDTAQDKMAADQKIIAGSVDEVHSLLDKHKEFFQGLE WHMVLTETFYKKISAFVLPQESQALEDTLAQAQDVLKQAHKKGVELEYILETWSRMVLDY QCLNRHLEAVEGRMPAVPLLEETEERLTERIALYQGMKSILAEHQHKLHQVLEEGKSLLQ SVACHTLENQLTLLGEHWLSNTTNVNKELQRLESILKHWIRYQSESAELNEWLQDALERL EFWNNQSVTVPEEVETVRDHLSAFLEFSKEVEAHSSLKASVFNEGNQLLRLKKADTGILR AELARVEAQWAELLTRIPVVQEKLHQSQMDKLASCHAITELVNWISLMERVMEEDEENLK GAVGSKVIQEYLQHYKGFRVDVNCKQLTVDFVNQSVLQISGQDMESKRSDKTDFAEKLGA MNRHWQILQARITERVQYLEGLLQSWLDYESNVECLKTWLCAQEERLKRKHKIEDLSSVQ NALRDCQEMELMVKEKEREVERVEEQACALVQNKTDEACAVVMETLQALNHTWANLDHLI GQLKISLKSVSDQWSQYRQAAEEINSYLTEGRYSVSRFRLLTGSLEAVQLQVDSLQNLQE ELEKQESSLRKFGAITHQLLKECHPSVSDSLNNTLKDVNARWSSLLEEIVERLKSSKALL QLWQSYRDLYEQSTGSIQSLEDKAEQLLKIANKKDISEEEVSTWIQDCTDLLRSQAPVKA SLQVLLELGEQLKQQVDTSAAASIQSDHQFLSQRLSSLDQTLSRQQAALQAGMQDYETFS EQLGTLGRWTVEAEEVLKGQDPNSSFDQSAIQDRMEELKKQMLKFSSMAPDLEHLNELAY RLPLSESEIKRMQNLNRNWATLSAQTTERFSKLQATLLQQQTFLEKCETWMEFLVQTEEK LAVEISGNFQSLMEQQKTHELFQAEMFSRQQILHSIISDGQHMLEHGQVDDRDEFKLKLA LLSNQWQGVVRRTQQRRGIIDSLLRQWQRYREMLEKLGKWLAEISQHSDTLQPESTVPLQ QARAMLDAVQLKEKVLQRQQGSYILTVEAGRQLLLSADSRAEASLHEELLSIQERWRHAN ICLEEQKRELAVLLRDWQRCEEGIGGSQEKLRAFKRQLSQPLPNHHEELQAEQMRCKDLE SMFDGWTEDLAHLTVLRESLSSYISSEDLCVLQERIELLQRQWEEICHQLSLRRQQVSEK LNEWAIFNEKYKELCEWLTHMENKVSQNGDISIEEMIEKLRKDYQEELTAAQEDKQQLQQ MGERLVRASHESKASEIEHKLVKVSDRWQHLLDLIGARTKKLRETLVAVQQLDKNMSSLR SWLAHIETELSRPIVYDTCDFQEIQRKLDLQQELQRDIEKHSTGVASVLNLCEVLLHDCD ACATDTECDSIQQATRSLDRRWRSICAMSMERKLRIEETWRLWQKFLDDFSHFEEWLAMS ERTAALPNSSGVLYTVAKEELKKFETFQRQVHESLTQLELINKQYRRLARENRTDAACRL REMAHDGNQRWDNLQRRVSSILRRLKHFISQREEFETARDSILVWLTEMDLQLTNIEHFS ECDVQAKIKQLRAFQHEISLNTTKIEHILQHGEALIEKSEPLDAAVIEEELEELQRYCQE VFGRVERYYKKLIRLPVQFTDDDISYSDREFDLDEVADASSLPWSEHLGDSQLSPLPSSS RSASLAVPLRTERSGRDTPASVDSIPLEWDHDYDLSRGLESVTRSSELGEECKDGTYLQG SASALSDVVIPESPEAYAKLTEKTLRSISGETASLETHFRQLAKALDTSHFRLQQTENII RSRTPTGPELDASYMGYMRLLGECRDSIDTVKKVGCELKEEEHKLGGFVNPNSSESQTSG VIERWELLQAQALNKELRMKQNLQQWQQFNSDLNSIWTWLDQAEEELEQQRRLDASTDIH AIELRIKKLKELQKALDKRKAIVLSINLCSSEFVQSDSKDSQELQGRLKEMNNRWERLTG SLDEWRSSLQDALMQCQDFHEMSHGLLLWLENIDRRRNEIVPIDHNQDTDTLHEHHKTLS QIRRELLDSQLKVASLQDMSLQLLVHSEGSECLEAKEKVHVIGNRLKMLLKEVTRDIREL DKTLDITSSQQDLSSWSSADELDTSGSLSPVSGRSTPSRHRSKRGKSSLSQPGPSVSSPH YRSLSVAGSDSSHSEEEELPSWCRTFLRRVLWVSLPVQLLLLLLLTVACLVPMSEEDYSC SQSNNFAHSFHPMLSYTNGPPPM NT seq 26352 nt NT seq  +upstreamnt  +downstreamnt atggctcagtttaaggatgtagctatgaaaaagaccacatctctgaacctggtgacagga ttctttcagtatctgcgtgatgaacaggagttggtccagaaacgaactttcacaaagtgg attaattcacatctggccaagcgtaaacctcctttagaaatcaatgacctttttgaggac atcaaggatggggtgaaactgctggctctgttggaggtactatctgggcagagattacca tgtgaacagggtcggcagttgaagagaatccactgggtgtccaacatcggcactgctctg aagttcttggagggcaggaagatcaagctagtaaatataaatgccactgacattgctgat ggaagaccatccattgtcttggggttaatgtggaccataatcctatactttcagattgaa gagctgacgagtaacctcccagccctacaggccctatccaacagtgcatcctctgtagat agcatggctaattctgagaccaaaagcccacccatgaagagaaaagtcctcaagttccag ggcaacgctaagaaagccatgctccgatgggtgcaatgtacagcaaccaaccgcttgggg attgaggtaaaagacttcggttctagctggcggaacggtgtggccttccactctgtcata tatgctattcgcccagacctggtggatatggagcttgtaaagagaagaagcaaccgtgag aacctggaggaagcctttactgtggcagagaatgagctgggcatcccacgcctcctagat cctgaagatgtggatgtggataagcctgatgagaagtccataatgacctatgtggctcaa ttccttaagcactacccagacccccaccagtctgagacagatggacagcaagaggagaga gaggaaagaaagattctacgggagtggaaggcctggctggatcagctggagagagacata ctccgtgcacaaggagcagagggcaacctcactgacaaatatcaggccttcaagaacttc cgtgtgcagtatgagctgaggaaaaagcagatagagactctgctgcagcctgtgcataag gacggtaaactgtctgtggaccaggcagtggtgaaacaggcatgggagcaggtgtctgtc cggcttctggactggcatatccatctggataagtctctgccaggtcccctgggagcgatt ggggcctggctgcatcgggcagaattcgctctcagagaagacattcccattcaacaggcc catgatgagacggccaacatcatccacaggaagctggagcagcataaggaggtgctaata aatctggaagggcacaggcagacatttcagcagattcacagggatagagcagttaacggt gtaccagtaccacttgaacagctccaagatatggcagaaagattcaattatgtgtccacc tcatctcatgttcacctaattaaactggaattctgggaaatgaagtatcgtctcatggca ttccttatcctggctgagtctaagctcaagtcttggatcatcaaatatggccgacgggat tctgtggagttgcttctacagaactacattgcatttattgagggtcacaagttctttgag cagtatgagacaacatttcagacccttaaacaagctgcagacatctacattaagtctgat agctcaggctgtagaatctcccggagagctgaggagtgtgaggggatgaataagttctta agtgaaacgatggcacagtggagaaacttgtcagtggaggtgcgcagtgtgcgcagcatg ctggaagaggttatctccaactgggagaaatacagcagcaaagtggccagtctgcaggcc tggctggaggacgctgagcagatgctcaaccactcggaaaatgataaacgtgaattcttc cggaaccttccacactggatacagcagcacatggacatgaacgatgcagggaacttcctg attgagacttgtgatgagactgtgtctagagacctgaagcagcagctactcctcctcaat ggtagatggagggagttgtttgtcaaagtcaaacattacgcaagagcagatgaagtggac aagctaaggaaagactatgaggatggcatcttagctttaaagatttttgtagatacatcc aacgagaggatgaatactcctgtccaagtgtcctttttgaacataagaacatttcttcaa gacattgaggatatcaaacataaagtgccctcaatggaggcagtgtataaaacagccaca cgcaacgcccagcagctgaccaaagacacttcacaggaagagatcacagacatgctgggt gtcatggaaaccattaaagaggagcttagcaagataagggagaaggttgtgcctttgcag agggattcacaggccttgctgcctcctttagaagaaatggagaagcacatcactgggttt tatcagtctctggagaaggctagtcgcattaccagtgcacgcgagtctgagacaccagga gacttccaacagaagtgtcaggaacttgtgacataccagcaaagctgtaaaaaatgtctt acagtgatagataagaaccatcagatcataatgaaagccctagaaggcagtaaaacattg aggcacctggatacatctctgctgcaaaagagagtagtagagcttcaggcctcctcccag gctatggtagaagagaccactgagtggaagaagcacgtggaagccaacagcagcatgatg aagcggtttgaagagtctcgtctggagctggagaaggttcttaaagtagccagaggttgc atgacagagagaggaaacccagaggacctgctaaaaaagcacacagagttcttttcacag cttgatgagcgagtccttaattcatttctgaaggcctgtgatgaacttactgatattctg cctgaacaagaacagcagactctacaggaaacagtcagaaaactgcacaaacagtggaag gatgtacagacagagatcccataccacctcctacaactgaaagtggaggtggagcgcaat cgtttgatggcctctctgcaggagtgtgaagctgaactggctcgagagaatcgcagcctg ccaggcatgggcagtgagagactggtgaaagaacacagggcttttttcagggacaagggc cctcagatgctgtgtgtgaagcgattgcaacatatggaggatctctgtttgaagctgaca gacagtgagcaggcacgccaaactctggaaaaatctagaactgcatttgctgaggttcaa gatgagatagagagcactcatcagaaactcatgcagcaccctgacaaatggaaagagttt aacaccagattttctgaactggctgcctggctgtcttcgaaggaaagccagctcaggctt ttgcgaaaccgtgctagtgaccccagtaaactcagggaggtgaaatccactatagagagt ctaaggaatgatgcagagctacaggaaggaaatgtgagctggctgaaatctcgtctggct gttctaatagaaatcagcactgtgagtgatgcccaacggcaggccgctgtcctcaccaaa ctgtccactgacttcaagagccttctcagttccctctctgagtctgagaaggtggcattg gcagttggagattgtgtgcagttccaggaggaagtgaagaacactctggatgaactaaca caaggtcagcaggagctgcaggcagaggtaaccaagatcctgaactctgagtctgcaaaa gaagctcagcaactgctgctcattcaccagcaacaattgaaacgtttgcgactcaaaagg agggacatgcagcagcagatcagccgaggccagcaactccaggttcaggagggcctgggg gagagccttcaggatgacctgcacaaattagataccagcctgagccagatggaccaaagc atggaggcacaggaacagagtctagaagcaacactgtcttcttggcaggagtttgacagc cagcaagcggcagtaggggagtttgtgagcagagtacgctcagtcagagagagagaaatg actttcagtagcccagagagcttaacaacagaactgaaacaaactaaggagctgctgaaa cagagtgagactgaggcagaggtggtgaacacactactaaagagggctgcagagatccag cttggtcctaaaaatgcttctctgctccatacacaagctcactccctcagtgaccaactg gacaaaactgtggcaagcctcaagaaagatgtgaagacttttgaggacataaaaaatcag tgggagtcatttgggagtgagtttgatgctttctcctcatggatctctgagaaggaaaag gagcttgactcgctaaaaagctctaatgaaccactggagcagcagatcagtactgctaag gctgtgacagcagagctacaggagcgagcagaaattctgtcccaactagaagacagagct caggctctatcccagtttgtatcatcaggagaatctgcacgaatcaaagctcgcctgaca cagattggcaggtactgggaggaacttaaggagagcatggagcatctgaatggacagttg gaagatagcgctaatcaccagcaaaagtttaatacaaaccttcaacaggtgcaatcagag attgatgccattcagacgaaactggacacacctctcacattctgtgcatcctcatctgat acctataaagctctacaggaccacatggatgtgttccagtctctggagaaggtgaaggtc accttgctgtctctgtgcactggggctcgcaggctaagtgagcgagagaaagctgaaagt gcagtagcagctctacagcacagctatgagcagagcctaaagcaggccaaagacaaacag agccatatggaaagcctgttgtctctctggcagaagttagaaaaagactgctgttctttg caatcatgccttgaaagctgtgagtctttgtctgcttctgtaacccagtatctcactgtt gacaagacaaagcttgatggagagctaatggagctgaaacaccttcactctgagctacag tcattggagtcattatatgagggattactgacccaagctccagccctttactccactgca tcagatgaacaagtgaagacacttaaagaggatcatgagcagctgaagaaaagatggagc tctcaatgtacagccatacccaacaggatccaggtgctccaggaccatatttcacgggta gacgagcatgaacaagcgctgcaaaagttcttcaagtggggagagtatttcctctcatct cttcactcatcctcccaagttaatattacagatttacagttgattgccatagaaataaag gagaaggcacagtcgcttcagagtgagaacagtgaaagagagaatctccagcagcagaca 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actgctgatatgcagattctcacacaagagctagaggcaatgcatggagaactgatagcc catcgtcagaatgtggataaaattgcagagcaacagcagagcaaatacctggacttgtac actatcctgccttcagagatctctatgcagttagcagaggttgctttggccctaggctca attgaagatcaggtccaagccaaggaaagggacattcagaagactagagttatcaaagag gaattcaaatccaggatcagtgatgtttctgagaaattgaaaagtatttcaacaacactc aaagaaaaggccactgatattgatcaagccaaagaagaaactcaaggtttctatgttgaa ttggagtgctgtagtagaacacttgctgaactcattgctgctgtgcaggaccttggtcga cgtcatccacttctgtccaaacaattaagtgatagcattgctaagttaggagagatccac catcacactctccgtttagcagagtacagaacagtctggctaaagaaggctgatgcacat ctagatgagtacaatgagatgcttgagtttatagtgaagtggacagagcaagctcgaagc ttagttaagaccaatatcatctggaactcctcctctcaattgcaggagcagatcagaatg taccagtctgtgttgcatgaatcaagggagctccatggtgatctggaagctatgcaggag aaggtggaactgctgtccgagtgtctgcaggtagaggcaatgggcctgcaggtggctgag ctgagtcgccgcacagaggaactggaacaggccatcaagtctcgattgcagagtctacag gaagctgctatggacatggaaaagtttgagagtgaggtaaaagccttgcatatggctctg gaacaagtccagacaaccctcacctctccggaactagctcgcctgagtctcaaagaacag ctgactcaaagacagcatctgttatcagacatggagagctttaagcagcaggtggatgca gtgcaggcctgtcagagtgcacttcgcatgccagaggaggtggtgaacagcctgtccatc tgccgtacagctcttaacctgcagcaggaagccagccagctgcagcacactgccattcaa caatgcaacattcttcaggaggcagtggtgcagtatgagcagtatgagcaagaagtacag catttgcagggactgattgaggattctcaccgggtcattcaagaccgacccgttcccacc agcaatatccaggagctacagagccagatacgccatcatgaggagctggcccagaaaatc aaaggataccaggagcagattgcatcattaaactctaagtgtaagatgttaacagtgaaa gccaagcatgccaccatgctgctgactgtgagagatgcagaaggcctgactgaggaagca caggaactagacagagctgcaaagacacagtcacagtcttctatggtcatggtaacacct ggtcacagtcacacccacctgtctcctgtcacagaggagtctggtgaagaaggcactaac agtgagatttccactcctctttgtcgtgccgactctcctatcacaaacactgaggcttca cttagcatgttgtcgatgggcccagctactcttgtcagagctcctatacaggagctgtat gatccgacccttgagtctgtggctaagcttgatgaccttcagcgttcatgggagacactg aaaaatgtgatcagtgaaaagcagaagacactttacgaggctctggagagacaacagcga tatcaaggctctttgcagtccatttccttgaagatggagtccattgaggccagcctgaat gagccccctttgcatgaccttagcccaggcagacagatgatcctgcatcagaatctgatg ggagacattaccaagcttcaggatgatatagaagagttgcaattgaactttgcagaggat ctgatctctgagaatgtagacactgacacagccgaacagctagccatgcagtccactctc actgtgctatctgatcgtatggccaccatccaaatgaaagcctctggaaaacagcagctt ctggaggatcgattgagtgaccgtcttgagaagcagcagcaagagaaggccttacagctc tatctcagccaggtggatgagctcgaccaatggttgctaagtacacgcaaaacgctcagc tccacccctcaggattcagacatgaacgagcagctctcagactgtcagaacatgctgttg gagatcgaggagaaggtgctcgctctctctgagctctccttgcacagtgaagctctgctg ctggagggtcggcctgagaccagagatgaagctcaacggctagccaggaaactgcacact ttaaagagcagcctggtggagctgcagcggatgctacaagacaaacagataaatatccag ggattactacaggagcagtctgatagtgaatcagagtccagtctctctcagagtccgaat gtgcaggactggctggcacatgcccattccacacggaaccagcaccaacaggacactttg cagagacagagggaacttgaggaggagttggctgagcagaaaaagcttctgaaatctgtc gctagccgtggagaagagatcctaaaccagcaggcttcacccagcagtgccagcatttgt gaggtactcagtccagaactggagaatgtgagccaggctgtatttggacagaggagacag agatgggagagtctgagaaaggatttgaccaccaaactgcagcttctgcagagcactttg gagcaggataccaagcaaccattttattccaggactgctcgtgtaaacacctctcctcct ttctataaaagagaggcccaggtcaaggacaaatctacactgaagtcattatacagtgaa ttcagccaggctgtggagaatgctgaggttacaggttcagcagaagagcaaggcatgcag atagaacatcaactatattcagcagttacagcgacttcctcttggctagatgatgtagag aacacactgttctccaggtcaatgcttttgacagagaatgcagagacacagctctccaac catgaggctttagggaaagatgtggctgaggtcacaggagaggtgggcaacagccaagga ctgctagggagtgtcgtagggttgcctggagaaaagcagaccctgatggaggatactctt gactgcctgtctcagcgactggaaaccttagactcagcagttgagcgtcgctgtgagagc atgaggagcaggatacaggatctcgctgccttccagactgagctcgagcttctcttctct gaaataagtgagagcaagtttcatattctacagaagctagcagggatcctcgactgccca ccagataaacagctagagacaattactgtggtagaagaatcccttagagagttagagcat aaaattacagatttaaaaacgagaggagcggttctgcagccggatcagatttctaacaac gaactgatgaagctccaggacacttatgaagatctggtgatgacagtgggctctcgtcgg agtgggctgaaccagaacatggctctgaagagccagtatgagcgagcattacaagacctg gtggatctggtggatacagctcaggacaagatggctgctgaccagaagataattgctggc tcagtggacgaagtccatagtctgttagacaaacacaaggagttcttccaagggctggag tggcatatggtcttaactgagacgttctacaagaaaattagtgcctttgtcctaccacaa gagagccaagctctagaggacactttggcccaagcgcaggacgttctaaagcaggctcac aaaaaaggagtggaactggagtacatcctggagacatggagccgtatggtcctggactat cagtgtctgaataggcatttggaggcagtggagggccgcatgcctgctgttcccctgttg gaggagacagaggagaggttaactgaaagaatagcactatatcagggcatgaagtccatt ctggcagagcaccagcacaagcttcatcaggtactagaggagggcaagtccctactgcag tctgtggcctgccacactctggagaaccagcttactctgctgggggagcactggctgagc aacaccaccaacgtcaataaggaactgcagcgtctggagtcaatcctcaaacactggatc agatatcagagtgaatctgctgagctaaacgagtggctacaggatgctttggaacgtctg gaattctggaacaatcagtcagtaactgtacctgaagaggtggagacagttagagaccat ctgtcagctttcttggaattcagtaaagaagttgaggctcattccagtttgaaagcctca gtattcaatgaaggcaaccagctactgaggctgaaaaaagcagacacaggcattctcagg gcagagttggcccgtgtggaggcccagtgggctgagctgctcactcgcatccctgttgtg caagagaaactgcaccagtctcaaatggacaagttagcctcatgccatgccatcactgaa ctggtaaactggatttcactgatggagagagtgatggaggaagatgaagaaaaccttaaa ggagctgtggggtcaaaggttatccaggagtacctgcagcactataagggttttcgtgta gatgtgaactgtaagcagttgactgtggactttgtgaaccagtcagtgctgcagatcagt gggcaggatatggagagcaagcgcagcgataagacagactttgcagagaagttgggagcc atgaaccgccactggcaaatcctacaggctcgcatcacagagagggtccaatacttggag ggcttgttgcagtcctggctagactatgaaagcaatgtggagtgccttaaaacctggcta tgtgctcaggaggagcgactcaagaggaaacacaagattgaggatctctcctctgtgcaa aatgctctccgagactgccaggagatggaactgatggttaaggagaaggagcgagaggtg gagagagtagaagagcaggcgtgcgctcttgtccagaacaaaacagatgaagcctgtgct gttgtcatggaaactctccaggcactgaatcacacttgggccaatcttgaccatttaatc ggacagctgaagatcagcctgaagtcagtatccgatcaatggagtcagtacaggcaggca gctgaagagattaacagctacctgacagaggggaggtactctgtgtctcgctttagactg cttactggttctctggaggccgtgcagctccaggtggacagtctgcagaatctgcaagaa gagttggagaagcaggagagcagtctgaggaagtttggagcaattacacatcaactacta aaggagtgccacccatctgtgtctgattctctgaacaacacccttaaagacgtcaatgcc aggtggagcagcctgttagaagagatagtggaacgtttgaagagcagtaaagctttgcta cagctgtggcagagctatagggacctgtacgagcagagcactggcagcatccagagcctg gaggacaaagcagagcaactcctgaagatagcaaacaaaaaagacatctcagaggaggag gtgtctacctggattcaagactgtactgacttgctgcgatctcaggcaccagtgaaagcc tctctacaggttttgctggagctaggcgaacagctcaaacagcaggtggacacctcagct gcagcctccatccagtcagatcaccaattcctttctcagcgtcttagctccttggatcag actctcagccgtcagcaggctgccctgcaggccggaatgcaggactatgagaccttcagt gaacagctgggcactctcggtcgttggacagttgaagctgaggaggttctaaagggtcag gaccccaatagctcctttgaccaatcagccatccaggaccgcatggaagagctcaagaaa cagatgctgaagtttagcagcatggctccagacctggagcatctcaatgagctggcctac aggctgcccctcagtgaatcggagattaaacgcatgcagaacttgaacagaaactgggcc accctatcagcccagaccactgagagattcagtaaactgcaggccaccctgctgcagcag cagacatttctggagaagtgtgagacgtggatggagttcttggtgcagacggaggagaag ctggctgtggagatctcaggaaacttccagagcttaatggagcaacagaaaacacatgag ttgtttcaggcagagatgttcagtagacagcagatccttcactccatcatcagtgatgga cagcatatgcttgagcatggacaggtggatgacagagatgagttcaagctgaagttggct ctgttaagtaaccagtggcagggggtggtgaggcggacgcagcagcggaggggcatcata gacagcctccttcgccagtggcagcgctacagagagatgctagagaagctgggcaaatgg ctggcagagatctcacagcatagcgacactctgcagcctgaatctacagtaccactgcag caagcccgagctatgctggatgctgtgcagttgaaagagaaggtgctgcaaaggcagcaa ggcagttacattctgacagtggaggctgggaggcagcttttgctctctgcagatagtcgg gcagaggcatccctgcatgaggagctgctcagcattcaggagcgctggagacatgccaac atttgcctggaggagcaaaaacgagaactggctgtcttactcagggattggcagagatgt gaggaaggcattggagggtctcaggagaaactgcgggcttttaagcgtcagctctctcag cctctaccaaatcatcatgaggagctgcaggctgaacagatgcgttgcaaggacttggag agtatgtttgatggttggacagaggacttggctcatctgactgtgctgagagaatctctt tcaagctatattagcagcgaagacctgtgtgtgctgcaggaacgcattgaactgctgcag cgccagtgggaggagatctgtcaccagttgtctttgcgcaggcagcaggtgagtgagaag ctgaatgagtgggccatctttaatgagaagtacaaagagctgtgtgagtggctcacacat atggaaaacaaggtctcccagaatggtgacatcagcattgaagagatgattgagaaactc agaaaggactatcaggaagaactaacagctgctcaggaagataagcagcagctccagcag atgggagagcgtttagtcagagctagccatgagagtaaagcctcagagattgaacacaaa ctcgtcaaggtcagcgatcgctggcagcacctactcgacctcatcggtgctaggacaaaa aaactgagggagactctggtagctgtgcagcagctggataagaacatgagcagcctgcgt tcctggctggcccacattgagacagagctctctcgtcctattgtgtacgacacctgtgac tttcaggagattcagagaaaacttgacctacagcaggagctgcagagagacatagagaag cacagcacaggtgtggcctctgtgttgaacctgtgtgaggtgctgcttcatgactgtgat gcttgtgccacagacacagaatgtgactctatccaacaggccacccgcagcctggaccgc cgatggaggagcatctgtgccatgtcaatggagagaaagctcaggattgaagagacatgg cgactctggcagaagtttctggatgacttctcccattttgaagaatggttggcaatgtct gaaaggacagctgctttaccaaactcttctggtgtgctttacacagtggccaaggaggag ctgaagaaatttgagactttccagcggcaggtgcatgagagcctgacccagcttgaactg attaataaacaatacagacggttggcacgagagaatcgcacagatgcagcttgccgtcta cgggagatggcacatgatggaaaccagcgctgggataacctgcagagaagagtgtcctct atcctgcgccggctcaagcactttattagccaaagagaggagtttgagacagcccgagac agcatactggtgtggctaacagagatggacctccaactaactaacattgagcacttctct gagtgcgatgtccaggccaaaatcaaacagctcagggcattccagcatgagatctcgctg aacacaaccaagattgagcacatcttgcagcatggggaagcactgatagagaagagtgag cctctggatgctgcagttattgaagaagagttggaggagttacagcgctactgccaggag gtttttggacgcgtggaacgctactacaagaaactcatccgtctacctgtacagtttaca gatgatgatatttcctactcggaccgagaattcgacttagacgaggtagccgatgcatcc agccttccatggagtgagcatttaggtgacagtcaactctctccgctgccctcctcaagc cgatctgcctctctagcagtcccacttcggactgagcggtcaggacgagacactccagct agtgttgactccatccccctggaatgggaccatgactatgatctgagtcgtggcctagag agcgtcaccagatcctcagaactaggagaggagtgcaaggatggcacataccttcagggc tcagcatctgcactctccgatgtagtgatcccagagagcccagaggcatatgcaaaacta acagagaaaacactgagatccatctctggggagacagcctcacttgagactcatttccgg cagcttgcgaaggccctcgacaccagccacttccgcctccagcaaactgagaacatcatc cgcagccgcacacctactggccctgagctggatgcctcctatatgggctatatgcggttg cttggggagtgtcgtgacagtattgacacggtgaagaaagtcggctgtgagctgaaggag gaagaacacaagctgggaggatttgtgaaccccaacagctcagaatcacagacctccggg gtaattgagcgctgggaactgctgcaggcacaggctcttaataaagagctacgcatgaaa cagaatctgcagcagtggcaacaatttaactcagaccttaacagcatatggacctggctg gaccaggctgaagaggagttggagcagcagcggaggctagatgctagcactgatatccac gccattgaactgcgcatcaagaagctcaaggaactacagaaggctctagacaagcggaag gccatagtgctgtccataaatctttgcagttctgagtttgtacagtcagacagtaaagat tctcaggagctgcagggccgactgaaggaaatgaataaccgatgggagcggctaactggc tctctagacgaatggaggagttctctccaagatgcactaatgcagtgccaggacttccat gaaatgagtcatggtcttttgctgtggctagagaatattgaccgcaggagaaatgagatt gtccccatcgaccacaatcaagacactgacactctgcatgaacatcataaaactctctcg caaatccgtcgggaactgcttgactctcagctgaaggtggcgtcattgcaggacatgtct ctgcagctattagtccactcagagggcagtgagtgcctggaagccaaggagaaggtccat gtcattggcaaccggctcaagatgctattgaaagaggtgacacgagacatcagagagctg gataaaactctggacatcaccagcagtcagcaggatctgtcatcttggtcatctgctgat gaactggacacatctggttccttgagtcctgtgtctggacgaagcactcccagtcgccac cgatcgaaacggggcaaaagtagtctgtcacagcctggaccctctgtgagcagtccacac tacaggtctctcagcgtcgctggatccgattcctcccattctgaggaggaggagttgccc tcctggtgtagaactttcctccgacgagtcctttgggtctcgctgcctgtgcagctgcta ttgctgctgttgctgaccgtggcctgtctggtgcctatgtctgaggaggactacagttgc tcccagtctaacaacttcgcccactccttccatcctatgctcagctacacaaatgggcct cctcctatgtga

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