| Entry |
|
| Symbol |
Plcb1
|
| Name |
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1
|
| KO |
|
| Organism |
iti Ictidomys tridecemlineatus (thirteen-lined ground squirrel)
|
| Pathway |
| iti04070 | Phosphatidylinositol signaling system |
| iti04072 | Phospholipase D signaling pathway |
| iti04261 | Adrenergic signaling in cardiomyocytes |
| iti04270 | Vascular smooth muscle contraction |
| iti04613 | Neutrophil extracellular trap formation |
| iti04621 | NOD-like receptor signaling pathway |
| iti04723 | Retrograde endocannabinoid signaling |
| iti04750 | Inflammatory mediator regulation of TRP channels |
| iti04919 | Thyroid hormone signaling pathway |
| iti04925 | Aldosterone synthesis and secretion |
| iti04927 | Cortisol synthesis and secretion |
| iti04928 | Parathyroid hormone synthesis, secretion and action |
| iti04933 | AGE-RAGE signaling pathway in diabetic complications |
| iti04935 | Growth hormone synthesis, secretion and action |
| iti04961 | Endocrine and other factor-regulated calcium reabsorption |
| iti04973 | Carbohydrate digestion and absorption |
| iti05022 | Pathways of neurodegeneration - multiple diseases |
| iti05163 | Human cytomegalovirus infection |
|
| Module |
| iti_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
| Brite |
KEGG Orthology (KO) [BR:iti00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
101954421 (Plcb1)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
101954421 (Plcb1)
04310 Wnt signaling pathway
101954421 (Plcb1)
04371 Apelin signaling pathway
101954421 (Plcb1)
04020 Calcium signaling pathway
101954421 (Plcb1)
04070 Phosphatidylinositol signaling system
101954421 (Plcb1)
04072 Phospholipase D signaling pathway
101954421 (Plcb1)
04071 Sphingolipid signaling pathway
101954421 (Plcb1)
04022 cGMP-PKG signaling pathway
101954421 (Plcb1)
09133 Signaling molecules and interaction
04082 Neuroactive ligand signaling
101954421 (Plcb1)
04081 Hormone signaling
101954421 (Plcb1)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04540 Gap junction
101954421 (Plcb1)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
101954421 (Plcb1)
04613 Neutrophil extracellular trap formation
101954421 (Plcb1)
04621 NOD-like receptor signaling pathway
101954421 (Plcb1)
04062 Chemokine signaling pathway
101954421 (Plcb1)
09152 Endocrine system
04911 Insulin secretion
101954421 (Plcb1)
04922 Glucagon signaling pathway
101954421 (Plcb1)
04929 GnRH secretion
101954421 (Plcb1)
04912 GnRH signaling pathway
101954421 (Plcb1)
04915 Estrogen signaling pathway
101954421 (Plcb1)
04921 Oxytocin signaling pathway
101954421 (Plcb1)
04926 Relaxin signaling pathway
101954421 (Plcb1)
04935 Growth hormone synthesis, secretion and action
101954421 (Plcb1)
04918 Thyroid hormone synthesis
101954421 (Plcb1)
04919 Thyroid hormone signaling pathway
101954421 (Plcb1)
04928 Parathyroid hormone synthesis, secretion and action
101954421 (Plcb1)
04916 Melanogenesis
101954421 (Plcb1)
04924 Renin secretion
101954421 (Plcb1)
04925 Aldosterone synthesis and secretion
101954421 (Plcb1)
04927 Cortisol synthesis and secretion
101954421 (Plcb1)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
101954421 (Plcb1)
04270 Vascular smooth muscle contraction
101954421 (Plcb1)
09154 Digestive system
04970 Salivary secretion
101954421 (Plcb1)
04971 Gastric acid secretion
101954421 (Plcb1)
04972 Pancreatic secretion
101954421 (Plcb1)
04973 Carbohydrate digestion and absorption
101954421 (Plcb1)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
101954421 (Plcb1)
09156 Nervous system
04724 Glutamatergic synapse
101954421 (Plcb1)
04725 Cholinergic synapse
101954421 (Plcb1)
04728 Dopaminergic synapse
101954421 (Plcb1)
04726 Serotonergic synapse
101954421 (Plcb1)
04720 Long-term potentiation
101954421 (Plcb1)
04730 Long-term depression
101954421 (Plcb1)
04723 Retrograde endocannabinoid signaling
101954421 (Plcb1)
09157 Sensory system
04742 Taste transduction
101954421 (Plcb1)
04750 Inflammatory mediator regulation of TRP channels
101954421 (Plcb1)
09159 Environmental adaptation
04713 Circadian entrainment
101954421 (Plcb1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
101954421 (Plcb1)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
101954421 (Plcb1)
09174 Infectious disease: parasitic
05146 Amoebiasis
101954421 (Plcb1)
05142 Chagas disease
101954421 (Plcb1)
05143 African trypanosomiasis
101954421 (Plcb1)
09164 Neurodegenerative disease
05010 Alzheimer disease
101954421 (Plcb1)
05016 Huntington disease
101954421 (Plcb1)
05017 Spinocerebellar ataxia
101954421 (Plcb1)
05022 Pathways of neurodegeneration - multiple diseases
101954421 (Plcb1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
101954421 (Plcb1)
05415 Diabetic cardiomyopathy
101954421 (Plcb1)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
101954421 (Plcb1)
04934 Cushing syndrome
101954421 (Plcb1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:iti04131]
101954421 (Plcb1)
Enzymes [BR:iti01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
101954421 (Plcb1)
Membrane trafficking [BR:iti04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
101954421 (Plcb1)
Endocytosis
Macropinocytosis
Phospholipase C
101954421 (Plcb1)
|
| SSDB |
|
| Motif |
|
| Other DBs |
|
| LinkDB |
|
| Position |
Unknown
|
| AA seq |
1216 aa
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGRLEHRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPDVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLAKKGQISVDGFMRYLS
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
KLSEQVSNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPVWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETPTETPSETKTTPSENGVNHTTSLAPKPPSQALHSQPAPGSVKAPAKTEDLIQS
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL
RRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQGKRQEKLLEKHKEIRQQILDEKP
KLQMELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHSSAPPSLASDPGKVNHKPPSS
EEVEGENPGKEFDTPL |
| NT seq |
3651 nt +upstreamnt +downstreamnt
atggctggggctcaacccggagtgcacgccttgcaactcaagcctgtgtgcgtgtccgac
agcctcaagaagggcaccaaattcgtcaagtgggatgatgactccactattgttactcca
attattttgaggactgaccctcagggatttttcttttactggacagatcaaaataaggag
acggagctgttagatctcagccttgtcaaggatgccaggtgtgggaagcatgccaaagct
cccaaggatccaaaattacgtgaacttctggatgtggggaacattgggcgcttggagcat
cggatgataacagtggtgtacgggccagacctagttaatatctcccatttgaatctcgtg
gctttccaagaagaagtagccaaggaatggacaaatgaggttttcagtctggcaacaaac
ctgttggcccaaaacatgtccagggacgcatttctggaaaaagcctatactaaactcaag
ctacaagtcactccagaagggcgcattcctcttaaaaacatatatcgcttgttttcagca
gaccggaaacgagttgaaactgcattagaggcttgtagtcttccatcttcaaggaatgat
tccatacctcaagaagacttcactccagacgtgtacagagttttcctgaataatctttgc
cctcgacctgaaatcgataacatcttttcagaatttggtgccaaaagcaaaccatacctt
actgttgatcagatgatggattttatcaacctgaagcagcgagatccccggctaaatgaa
atactttacccacctctgaaacaagaacaagtccaagtactgattgagaagtatgagccc
aataacagcctcgccaagaaaggacagatatcagtggatggatttatgcgctatctgagt
ggagaagaaaatggagtcgtttcacctgagaaactggatttgaatgaagacatgtctcag
cccctgtctcactatttcattaattcctcgcacaacacctacctcacagctggccagctg
gctggaaactcctctgtggagatgtatcgccaagtgcttctgtctggttgtcgctgtgtg
gagctggactgctggaagggaaggactgcagaagaagaacctgtcatcacccacggattc
accatgacgacggaaatatccttcaaggaagtgatagaagcaatcgcagagtgtgcattt
aagacctcaccttttccaattcttctgtcatttgagaaccacgtggattccccaaagcag
caagccaagatggcggagtactgccgactaatctttggtgatgcccttctcatggagcca
ctggaaaaatacccactggaatctggagttcctcttcccagccctatggatttaatgtat
aaaatcttggtgaaaaacaagaagaagtcacacaagtcatcagaaggaagtggcaagaag
aagctctctgaacaagtgtccaacacatacagtgattcctctagcgtgttcgagccctca
tctcccggagcaggggaagctgataccgaaagtgatgatgatgacgatgatgatgactgt
aaaaaatcttcaatggatgaggggactgctgggagtgaagccatggccacggaggagatg
tctaacctggtgaactatatccagccagtcaagtttgagtcatttgaaatctcaaaaaaa
agaaacaagagttttgaaatgtcttcctttgtggaaaccaaaggactcgaacaacttacg
aagtctccggtggaatttgtggaatataacaaaatgcagctgagcagaatatatccaaaa
ggaacacgtgtggactcatccaactacatgccccagctcttctggaacgcaggctgtcag
atggtggcccttaacttccagactgtggacctggcaatgcaaatcaacatgggcatgtat
gaatacaatgggaagagtggctacaggttgaagccagagttcatgaggaggccggacaag
cattttgatccgtttacggaaggcatcgttgatgggatagtggccaacactttatctgtc
aagattatttcaggtcagtttctttctgataagaaagttgggacttatgttgaagtggat
atgtttggtttgcctgtggacaccaggaggaaggcattcaaaaccaagacttcccaaggg
aatgctgtaaatcctgtctgggaagaagagccaattgtgttcaaaaaggtggttcttcct
tctctggcctgtttgaggatagcagtttatgaagaaggaggtaaatttattggccaccgg
atcttgccagtacaagccattcggccaggctatcactacatctgtctgaggaatgaaagg
aaccagcccctaatgctgccagctgtctttgtctacatagaagtgaaagactatgtgcca
gacacatatgcagatgtgatcgaagctttgtcaaacccaatccgatatgtgaatctgatg
gagcagagagccaagcaactggctgctttgacactggaggatgaagaagaagtaaagaaa
gaggctgatcctggggaaacaccaacagagactccaagcgaaaccaagacgactccttca
gaaaatggggtgaatcacactacatccctggcacccaaaccaccttcccaggctctgcac
agccaacctgctccaggttctgtcaaggctcctgccaaaacagaagatcttattcagagc
gtcctaacagaagtggaagcacagacgattgaagagctaaagcaacagaaatcatttgtg
aaacttcaaaagaagcactacaaagaaatgaaagacctggtgaagagacaccacaagaaa
actactgacctgatcaaagaacacactacaaagtataatgagattcagaatgactacttg
agaaggagggcagctctggagaagtcagccaaaaaggacagcaagaaaaaatcagagccc
agcagccctgaccatggctcatcaacaattgagcaagatcttgctgccctggacgccgaa
atgacccagaagttaatagacctgaaggataaacaacagcagcagctgcttaatcttcgg
caagaacaatattatagtgaaaaataccagaagcgagaacatattaaactgctcattcaa
aagttgacagatgttgctgaagagtgtcagaacaaccaattaaagaagctcaaagaaatc
tgtgagaaagagaagaaagaattaaagaagaaaatggataaaaagaggcaggagaagata
acagaagctaaatccaaagacaaaagccagatggaagaggagaagacagagatgatccgg
tcctacatccaggaggtggtgcagtatatcaaaaggttagaagaggcacaaggtaaacga
caagaaaaactcttggagaaacacaaggaaatccgccagcagatactggacgagaagccc
aagctacagatggagttggagcaagaataccaagacaagttcaaaagattgcccctggag
attttggaatttgtgcaggaagccatgaaagggaagatcagtgaagacagcaatcacagt
tctgcccctccctccttggcctctgaccctggaaaagtgaaccacaagcctccctccagt
gaggaggtggaaggagagaacccaggaaaagagtttgatactcctctgtga |