KEGG   Ictidomys tridecemlineatus (thirteen-lined ground squirrel): 101965906
Entry
101965906         CDS       T10664                                 
Name
(RefSeq) LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
iti  Ictidomys tridecemlineatus (thirteen-lined ground squirrel)
Pathway
iti00562  Inositol phosphate metabolism
iti01100  Metabolic pathways
iti01521  EGFR tyrosine kinase inhibitor resistance
iti01522  Endocrine resistance
iti01524  Platinum drug resistance
iti04012  ErbB signaling pathway
iti04014  Ras signaling pathway
iti04015  Rap1 signaling pathway
iti04024  cAMP signaling pathway
iti04062  Chemokine signaling pathway
iti04066  HIF-1 signaling pathway
iti04068  FoxO signaling pathway
iti04070  Phosphatidylinositol signaling system
iti04071  Sphingolipid signaling pathway
iti04072  Phospholipase D signaling pathway
iti04081  Hormone signaling
iti04140  Autophagy - animal
iti04150  mTOR signaling pathway
iti04151  PI3K-Akt signaling pathway
iti04152  AMPK signaling pathway
iti04210  Apoptosis
iti04211  Longevity regulating pathway
iti04213  Longevity regulating pathway - multiple species
iti04218  Cellular senescence
iti04360  Axon guidance
iti04370  VEGF signaling pathway
iti04380  Osteoclast differentiation
iti04510  Focal adhesion
iti04550  Signaling pathways regulating pluripotency of stem cells
iti04611  Platelet activation
iti04613  Neutrophil extracellular trap formation
iti04620  Toll-like receptor signaling pathway
iti04625  C-type lectin receptor signaling pathway
iti04630  JAK-STAT signaling pathway
iti04650  Natural killer cell mediated cytotoxicity
iti04660  T cell receptor signaling pathway
iti04662  B cell receptor signaling pathway
iti04664  Fc epsilon RI signaling pathway
iti04666  Fc gamma R-mediated phagocytosis
iti04668  TNF signaling pathway
iti04670  Leukocyte transendothelial migration
iti04722  Neurotrophin signaling pathway
iti04725  Cholinergic synapse
iti04750  Inflammatory mediator regulation of TRP channels
iti04810  Regulation of actin cytoskeleton
iti04910  Insulin signaling pathway
iti04914  Progesterone-mediated oocyte maturation
iti04915  Estrogen signaling pathway
iti04917  Prolactin signaling pathway
iti04919  Thyroid hormone signaling pathway
iti04923  Regulation of lipolysis in adipocytes
iti04926  Relaxin signaling pathway
iti04929  GnRH secretion
iti04930  Type II diabetes mellitus
iti04931  Insulin resistance
iti04932  Non-alcoholic fatty liver disease
iti04933  AGE-RAGE signaling pathway in diabetic complications
iti04935  Growth hormone synthesis, secretion and action
iti04960  Aldosterone-regulated sodium reabsorption
iti04973  Carbohydrate digestion and absorption
iti05010  Alzheimer disease
iti05017  Spinocerebellar ataxia
iti05020  Prion disease
iti05100  Bacterial invasion of epithelial cells
iti05132  Salmonella infection
iti05135  Yersinia infection
iti05142  Chagas disease
iti05146  Amoebiasis
iti05160  Hepatitis C
iti05161  Hepatitis B
iti05162  Measles
iti05163  Human cytomegalovirus infection
iti05164  Influenza A
iti05165  Human papillomavirus infection
iti05166  Human T-cell leukemia virus 1 infection
iti05167  Kaposi sarcoma-associated herpesvirus infection
iti05168  Herpes simplex virus 1 infection
iti05169  Epstein-Barr virus infection
iti05170  Human immunodeficiency virus 1 infection
iti05171  Coronavirus disease - COVID-19
iti05200  Pathways in cancer
iti05203  Viral carcinogenesis
iti05205  Proteoglycans in cancer
iti05206  MicroRNAs in cancer
iti05207  Chemical carcinogenesis - receptor activation
iti05208  Chemical carcinogenesis - reactive oxygen species
iti05210  Colorectal cancer
iti05211  Renal cell carcinoma
iti05212  Pancreatic cancer
iti05213  Endometrial cancer
iti05214  Glioma
iti05215  Prostate cancer
iti05218  Melanoma
iti05220  Chronic myeloid leukemia
iti05221  Acute myeloid leukemia
iti05222  Small cell lung cancer
iti05223  Non-small cell lung cancer
iti05224  Breast cancer
iti05225  Hepatocellular carcinoma
iti05226  Gastric cancer
iti05230  Central carbon metabolism in cancer
iti05231  Choline metabolism in cancer
iti05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
iti05415  Diabetic cardiomyopathy
iti05417  Lipid and atherosclerosis
iti05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:iti00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101965906
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    101965906
   04014 Ras signaling pathway
    101965906
   04015 Rap1 signaling pathway
    101965906
   04370 VEGF signaling pathway
    101965906
   04630 JAK-STAT signaling pathway
    101965906
   04668 TNF signaling pathway
    101965906
   04066 HIF-1 signaling pathway
    101965906
   04068 FoxO signaling pathway
    101965906
   04070 Phosphatidylinositol signaling system
    101965906
   04072 Phospholipase D signaling pathway
    101965906
   04071 Sphingolipid signaling pathway
    101965906
   04024 cAMP signaling pathway
    101965906
   04151 PI3K-Akt signaling pathway
    101965906
   04152 AMPK signaling pathway
    101965906
   04150 mTOR signaling pathway
    101965906
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    101965906
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    101965906
  09143 Cell growth and death
   04210 Apoptosis
    101965906
   04218 Cellular senescence
    101965906
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101965906
   04550 Signaling pathways regulating pluripotency of stem cells
    101965906
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101965906
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101965906
   04613 Neutrophil extracellular trap formation
    101965906
   04620 Toll-like receptor signaling pathway
    101965906
   04625 C-type lectin receptor signaling pathway
    101965906
   04650 Natural killer cell mediated cytotoxicity
    101965906
   04660 T cell receptor signaling pathway
    101965906
   04662 B cell receptor signaling pathway
    101965906
   04664 Fc epsilon RI signaling pathway
    101965906
   04666 Fc gamma R-mediated phagocytosis
    101965906
   04670 Leukocyte transendothelial migration
    101965906
   04062 Chemokine signaling pathway
    101965906
  09152 Endocrine system
   04910 Insulin signaling pathway
    101965906
   04923 Regulation of lipolysis in adipocytes
    101965906
   04929 GnRH secretion
    101965906
   04915 Estrogen signaling pathway
    101965906
   04914 Progesterone-mediated oocyte maturation
    101965906
   04917 Prolactin signaling pathway
    101965906
   04926 Relaxin signaling pathway
    101965906
   04935 Growth hormone synthesis, secretion and action
    101965906
   04919 Thyroid hormone signaling pathway
    101965906
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    101965906
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101965906
  09156 Nervous system
   04725 Cholinergic synapse
    101965906
   04722 Neurotrophin signaling pathway
    101965906
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101965906
  09158 Development and regeneration
   04360 Axon guidance
    101965906
   04380 Osteoclast differentiation
    101965906
  09149 Aging
   04211 Longevity regulating pathway
    101965906
   04213 Longevity regulating pathway - multiple species
    101965906
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101965906
   05206 MicroRNAs in cancer
    101965906
   05205 Proteoglycans in cancer
    101965906
   05207 Chemical carcinogenesis - receptor activation
    101965906
   05208 Chemical carcinogenesis - reactive oxygen species
    101965906
   05203 Viral carcinogenesis
    101965906
   05230 Central carbon metabolism in cancer
    101965906
   05231 Choline metabolism in cancer
    101965906
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101965906
  09162 Cancer: specific types
   05210 Colorectal cancer
    101965906
   05212 Pancreatic cancer
    101965906
   05225 Hepatocellular carcinoma
    101965906
   05226 Gastric cancer
    101965906
   05214 Glioma
    101965906
   05221 Acute myeloid leukemia
    101965906
   05220 Chronic myeloid leukemia
    101965906
   05218 Melanoma
    101965906
   05211 Renal cell carcinoma
    101965906
   05215 Prostate cancer
    101965906
   05213 Endometrial cancer
    101965906
   05224 Breast cancer
    101965906
   05222 Small cell lung cancer
    101965906
   05223 Non-small cell lung cancer
    101965906
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101965906
   05170 Human immunodeficiency virus 1 infection
    101965906
   05161 Hepatitis B
    101965906
   05160 Hepatitis C
    101965906
   05171 Coronavirus disease - COVID-19
    101965906
   05164 Influenza A
    101965906
   05162 Measles
    101965906
   05168 Herpes simplex virus 1 infection
    101965906
   05163 Human cytomegalovirus infection
    101965906
   05167 Kaposi sarcoma-associated herpesvirus infection
    101965906
   05169 Epstein-Barr virus infection
    101965906
   05165 Human papillomavirus infection
    101965906
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    101965906
   05135 Yersinia infection
    101965906
   05100 Bacterial invasion of epithelial cells
    101965906
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    101965906
   05142 Chagas disease
    101965906
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101965906
   05017 Spinocerebellar ataxia
    101965906
   05020 Prion disease
    101965906
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101965906
   05418 Fluid shear stress and atherosclerosis
    101965906
   05415 Diabetic cardiomyopathy
    101965906
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    101965906
   04932 Non-alcoholic fatty liver disease
    101965906
   04931 Insulin resistance
    101965906
   04933 AGE-RAGE signaling pathway in diabetic complications
    101965906
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101965906
   01524 Platinum drug resistance
    101965906
   01522 Endocrine resistance
    101965906
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:iti04131]
    101965906
Enzymes [BR:iti01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     101965906
Membrane trafficking [BR:iti04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    101965906
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_p85B PI3K_rbd PI3K_C2
Other DBs
NCBI-GeneID: 101965906
NCBI-ProteinID: XP_013220975
LinkDB
Position
Unknown
AA seq 1050 aa
MVIPLGIDCLMEFWTEEEKNHSVVVDFLLPTGIYLSFPVSYNANLSTIKQMLWHEAQNEP
LFHMLSDPKAYVFTCVNQTAEQQELEDEEQRLCDVRPFLPMLRLVTREGDHMEKLINSQI
SLLIGKGLHEFDSLQDPEVNDFCTKMRQFSEETAARRQQLGLEAWLQYSFFLQLEPSTRS
WGDSNTSQIFNPDLLVNVKFEGSRESFTIQLSTKNVPIALIACALQKKTKVYQNLTMEQP
EDYVLQVNGWHEYLYGSYLLCQFKYICSCXHSGLTPHLTMVHSSSILAMRDEQSKXAPQV
QKPHTKLPPVPIKKPSSVSQWSLGQPFCIELIQGSKINADEQMKLVVQAGLFHGNEMLCK
TISSLEVSVCSEPMWKQHLEFDINIXDLQRMARLCFALYAVIEKAKKAHSSNKKSKKDCP
IAWANLMLFDYKDQLKTGELCLYMWPSVPDEKGDLLNPMGTVHSNPNTESAVTLVIYLPE
VAPHPVYYPALEKILELGHHRERGPTTKEQLQLQGILEQRGSGELYEHEKDLVWKMQHEV
QEHFPEALAHLLLVTKWNKHEDVAQMLYLLCSWSELPVLNALELLEFSFPDFHVGSFAIR
SLQKLTDDELFQCLLQLVQVLKYKSYLDCELTQFLLDRALANQKIGHFLFWHHRTEMHVP
SVALRFGLIMEAYFRGSTYHMKVLMKQVEALSKLKALSGFVKVSSQKTTKPQTKELMHLY
MRQDTYLEALLHLQSPLDPSTMLAEVCVERCTFMDSKMKPLWFLYSSEEAGSAGSIGIIF
KNRDDLCQDMLTLKMIQLMDALWKQEGLDLRMTSYGCLSXGDCMGLIEAVQHSDTIANIQ
LNQSNLAATAAFNKDTLLNWLKSKNPGEALDRAIESSPSEFTLSCAGYCVATYVQGIGDR
HSDNIMIRENGQLFHIDFGHILGNFKTKFGINREXVPFILTHDFVHVIQQGNTSNNEKFE
RFRGYCEQAYRILRRHGLLFLQLFALMRAAGLPELSSSKDIHYLKDTLALGKTEEEGLKH
FWVKFNEALSESWKTKVNWLAHNLTKDNRQ
NT seq 3153 nt   +upstreamnt  +downstreamnt
atggtaatacccctggggattgactgtctcatggaattctggaccgaggaggagaagaat
catagtgtggtggttgacttccttctacccacagggatctacctgagcttccctgtgtcc
tacaatgccaacctcagcaccatcaagcagatgctgtggcacgaagcccagaatgagccc
ctcttccacatgctcagtgaccccaaggcctacgtgttcacctgtgtcaaccagaccgca
gagcagcaggagctagaggatgaagagcagcggctgtgtgatgtccggcccttcctgccc
atgctgcgcctggtgacccgcgagggtgatcacatggagaagctcatcaactcacagata
agcctcctcatcggcaaaggcctccacgagtttgactccctgcaagacccagaagtgaat
gacttctgcactaagatgcgccagttcagcgaggagacggctgcccgccggcagcagctg
ggcttggaggcctggctacaatacagttttttccttcagctggagccctccaccaggagc
tggggagacagcaacacctctcaaatcttcaacccagacctgcttgtcaatgtcaaattt
gagggcagcagggagagcttcaccatccagttgtccaccaagaatgtgcccatagcgctg
attgcctgcgccctccagaagaagaccaaggtgtaccaaaacctcacaatggagcagcct
gaggactatgtgctgcaggtgaatgggtggcatgagtacctctatggcagctacctgctc
tgtcagttcaaatacatatgcagctgcntgcacagtggactgaccccccacctgaccatg
gtgcactcctcttctatccttgccatgcgggatgagcagagcaaancggcccctcaggtc
cagaaaccacacaccaaactgccccccgttcccatcaaaaagccctcctctgtgtcccag
tggtcgctggggcagcctttctgcattgagctgatccagggcagcaaaatcaatgctgat
gagcagatgaagctggtggtacaggccgggctcttccatggcaatgagatgctgtgcaag
acgatttccagcttggaggtgagcgtgtgttcagagcccatgtggaagcagcatctggag
tttgacatcaacatcnntgacctgcagcgcatggcccggctctgctttgcactctatgcc
gtgattgagaaggccaagaaggcgcactctagcaataaaaagtccaagaaggactgccca
attgcctgggccaacctcatgctgtttgactacaaggatcagctcaagactggggagctc
tgcctctacatgtggccctctgtcccagatgagaaaggagacctgctgaaccccatgggt
actgtgcatagcaatcccaacacagagagtgctgtcaccctggttatctacctgcccgag
gtggcccctcaccctgtgtactaccctgccctggagaagatcctggagctgggacatcac
agggaacgtggccctaccaccaaggagcagctgcagctgcagggaatcttggagcagcgg
gggtcgggagagctgtatgagcatgagaaggacctggtgtggaagatgcagcatgaagtg
caggagcacttcccagaggctctggcccacctgctgctcgtgaccaagtggaacaagcac
gaggatgtggcccagatgctgtacctactgtgctcctggtccgagcttcctgtcctgaat
gccctggagctgctggaattcagcttccctgacttccacgtgggctcctttgccatcagg
tccctgcagaaactaacggacgacgagcttttccagtgcttgctgcagctggtgcaggtc
ctcaagtacaagtcctacctggactgcgaactgacccaattcttgttggaccgggctctg
gccaaccaaaaaattggccacttcctcttctggcatcatcgcactgagatgcatgtgccg
tccgtggccttgcgttttggcctcataatggaggcctacttcaggggcagcacctaccac
atgaaggtgctgatgaagcaggtggaagcactgagcaagctgaaggccctgagcggcttt
gtgaaggtgagctcacagaagaccaccaagccccaaactaaggagctgatgcacttgtac
atgcgccaggacacctacctagaggcccttttacacttgcagtccccattggaccccagc
acgatgctggcagaagtctgtgtggaaaggtgcaccttcatggactccaagatgaaacct
ctgtggttcctgtacagcagtgaggaggcaggcagtgctggcagcattggcatcatcttt
aagaacagggatgacctctgccaggacatgctgactctgaagatgatccagctcatggac
gccctgtggaagcaggagggcctggacctaaggatgacctcctatggctgcctatccnac
ggtgactgcatgggcctcattgaggcagtgcagcactcggacaccattgccaacatccag
ctgaaccagagcaacctggctgccacggctgccttcaacaaggataccctgctcaactgg
ctcaagtccaagaaccctggagaagccctggatcgagccattgagagttcaccctctgag
ttcaccctctcctgtgctggctactgtgtggccacatatgtgcagggcatcggtgaccgg
cacagtgacaacatcatgatccgtgagaatgggcagctatttcacattgactttggccac
attctggggaattttaagaccaagtttggaatcaaccgtgagtgagtcccattcatcctc
acccatgactttgtccacgtgattcagcagggcaatactagtaataatgagaaatttgaa
aggtttcgaggctactgtgaacaggcctacagaattctgcggcgccatgggctcctcttc
ctccaactctttgctctgatgcgagcagcaggcctgcctgagctcagctcctccaaagac
atccactatttgaaggacaccctggcgctggggaagacggaggaggaggggctgaagcac
ttctgggtgaagttcaatgaagccctgagcgagagctggaagaccaaagtgaactggctg
gcacacaacctgaccaaagacaaccggcaatag

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