KEGG   Ictidomys tridecemlineatus (thirteen-lined ground squirrel): 101969987
Entry
101969987         CDS       T10664                                 
Symbol
Akt1
Name
(RefSeq) RAC-alpha serine/threonine-protein kinase isoform X1
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
iti  Ictidomys tridecemlineatus (thirteen-lined ground squirrel)
Pathway
iti01521  EGFR tyrosine kinase inhibitor resistance
iti01522  Endocrine resistance
iti01524  Platinum drug resistance
iti04010  MAPK signaling pathway
iti04012  ErbB signaling pathway
iti04014  Ras signaling pathway
iti04015  Rap1 signaling pathway
iti04022  cGMP-PKG signaling pathway
iti04024  cAMP signaling pathway
iti04062  Chemokine signaling pathway
iti04066  HIF-1 signaling pathway
iti04068  FoxO signaling pathway
iti04071  Sphingolipid signaling pathway
iti04072  Phospholipase D signaling pathway
iti04140  Autophagy - animal
iti04150  mTOR signaling pathway
iti04151  PI3K-Akt signaling pathway
iti04152  AMPK signaling pathway
iti04210  Apoptosis
iti04211  Longevity regulating pathway
iti04213  Longevity regulating pathway - multiple species
iti04218  Cellular senescence
iti04261  Adrenergic signaling in cardiomyocytes
iti04370  VEGF signaling pathway
iti04371  Apelin signaling pathway
iti04380  Osteoclast differentiation
iti04510  Focal adhesion
iti04550  Signaling pathways regulating pluripotency of stem cells
iti04611  Platelet activation
iti04613  Neutrophil extracellular trap formation
iti04620  Toll-like receptor signaling pathway
iti04625  C-type lectin receptor signaling pathway
iti04630  JAK-STAT signaling pathway
iti04660  T cell receptor signaling pathway
iti04662  B cell receptor signaling pathway
iti04664  Fc epsilon RI signaling pathway
iti04666  Fc gamma R-mediated phagocytosis
iti04668  TNF signaling pathway
iti04722  Neurotrophin signaling pathway
iti04725  Cholinergic synapse
iti04728  Dopaminergic synapse
iti04810  Regulation of actin cytoskeleton
iti04910  Insulin signaling pathway
iti04914  Progesterone-mediated oocyte maturation
iti04915  Estrogen signaling pathway
iti04917  Prolactin signaling pathway
iti04919  Thyroid hormone signaling pathway
iti04920  Adipocytokine signaling pathway
iti04922  Glucagon signaling pathway
iti04923  Regulation of lipolysis in adipocytes
iti04926  Relaxin signaling pathway
iti04929  GnRH secretion
iti04931  Insulin resistance
iti04932  Non-alcoholic fatty liver disease
iti04933  AGE-RAGE signaling pathway in diabetic complications
iti04935  Growth hormone synthesis, secretion and action
iti04936  Alcoholic liver disease
iti04973  Carbohydrate digestion and absorption
iti05010  Alzheimer disease
iti05017  Spinocerebellar ataxia
iti05132  Salmonella infection
iti05135  Yersinia infection
iti05142  Chagas disease
iti05145  Toxoplasmosis
iti05152  Tuberculosis
iti05160  Hepatitis C
iti05161  Hepatitis B
iti05162  Measles
iti05163  Human cytomegalovirus infection
iti05164  Influenza A
iti05165  Human papillomavirus infection
iti05166  Human T-cell leukemia virus 1 infection
iti05167  Kaposi sarcoma-associated herpesvirus infection
iti05168  Herpes simplex virus 1 infection
iti05169  Epstein-Barr virus infection
iti05170  Human immunodeficiency virus 1 infection
iti05200  Pathways in cancer
iti05205  Proteoglycans in cancer
iti05207  Chemical carcinogenesis - receptor activation
iti05208  Chemical carcinogenesis - reactive oxygen species
iti05210  Colorectal cancer
iti05211  Renal cell carcinoma
iti05212  Pancreatic cancer
iti05213  Endometrial cancer
iti05214  Glioma
iti05215  Prostate cancer
iti05218  Melanoma
iti05220  Chronic myeloid leukemia
iti05221  Acute myeloid leukemia
iti05222  Small cell lung cancer
iti05223  Non-small cell lung cancer
iti05224  Breast cancer
iti05225  Hepatocellular carcinoma
iti05226  Gastric cancer
iti05230  Central carbon metabolism in cancer
iti05231  Choline metabolism in cancer
iti05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
iti05415  Diabetic cardiomyopathy
iti05417  Lipid and atherosclerosis
iti05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:iti00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101969987 (Akt1)
   04012 ErbB signaling pathway
    101969987 (Akt1)
   04014 Ras signaling pathway
    101969987 (Akt1)
   04015 Rap1 signaling pathway
    101969987 (Akt1)
   04370 VEGF signaling pathway
    101969987 (Akt1)
   04371 Apelin signaling pathway
    101969987 (Akt1)
   04630 JAK-STAT signaling pathway
    101969987 (Akt1)
   04668 TNF signaling pathway
    101969987 (Akt1)
   04066 HIF-1 signaling pathway
    101969987 (Akt1)
   04068 FoxO signaling pathway
    101969987 (Akt1)
   04072 Phospholipase D signaling pathway
    101969987 (Akt1)
   04071 Sphingolipid signaling pathway
    101969987 (Akt1)
   04024 cAMP signaling pathway
    101969987 (Akt1)
   04022 cGMP-PKG signaling pathway
    101969987 (Akt1)
   04151 PI3K-Akt signaling pathway
    101969987 (Akt1)
   04152 AMPK signaling pathway
    101969987 (Akt1)
   04150 mTOR signaling pathway
    101969987 (Akt1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    101969987 (Akt1)
  09143 Cell growth and death
   04210 Apoptosis
    101969987 (Akt1)
   04218 Cellular senescence
    101969987 (Akt1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101969987 (Akt1)
   04550 Signaling pathways regulating pluripotency of stem cells
    101969987 (Akt1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101969987 (Akt1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101969987 (Akt1)
   04613 Neutrophil extracellular trap formation
    101969987 (Akt1)
   04620 Toll-like receptor signaling pathway
    101969987 (Akt1)
   04625 C-type lectin receptor signaling pathway
    101969987 (Akt1)
   04660 T cell receptor signaling pathway
    101969987 (Akt1)
   04662 B cell receptor signaling pathway
    101969987 (Akt1)
   04664 Fc epsilon RI signaling pathway
    101969987 (Akt1)
   04666 Fc gamma R-mediated phagocytosis
    101969987 (Akt1)
   04062 Chemokine signaling pathway
    101969987 (Akt1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101969987 (Akt1)
   04922 Glucagon signaling pathway
    101969987 (Akt1)
   04923 Regulation of lipolysis in adipocytes
    101969987 (Akt1)
   04920 Adipocytokine signaling pathway
    101969987 (Akt1)
   04929 GnRH secretion
    101969987 (Akt1)
   04915 Estrogen signaling pathway
    101969987 (Akt1)
   04914 Progesterone-mediated oocyte maturation
    101969987 (Akt1)
   04917 Prolactin signaling pathway
    101969987 (Akt1)
   04926 Relaxin signaling pathway
    101969987 (Akt1)
   04935 Growth hormone synthesis, secretion and action
    101969987 (Akt1)
   04919 Thyroid hormone signaling pathway
    101969987 (Akt1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101969987 (Akt1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    101969987 (Akt1)
  09156 Nervous system
   04725 Cholinergic synapse
    101969987 (Akt1)
   04728 Dopaminergic synapse
    101969987 (Akt1)
   04722 Neurotrophin signaling pathway
    101969987 (Akt1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    101969987 (Akt1)
  09149 Aging
   04211 Longevity regulating pathway
    101969987 (Akt1)
   04213 Longevity regulating pathway - multiple species
    101969987 (Akt1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101969987 (Akt1)
   05205 Proteoglycans in cancer
    101969987 (Akt1)
   05207 Chemical carcinogenesis - receptor activation
    101969987 (Akt1)
   05208 Chemical carcinogenesis - reactive oxygen species
    101969987 (Akt1)
   05230 Central carbon metabolism in cancer
    101969987 (Akt1)
   05231 Choline metabolism in cancer
    101969987 (Akt1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101969987 (Akt1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101969987 (Akt1)
   05212 Pancreatic cancer
    101969987 (Akt1)
   05225 Hepatocellular carcinoma
    101969987 (Akt1)
   05226 Gastric cancer
    101969987 (Akt1)
   05214 Glioma
    101969987 (Akt1)
   05221 Acute myeloid leukemia
    101969987 (Akt1)
   05220 Chronic myeloid leukemia
    101969987 (Akt1)
   05218 Melanoma
    101969987 (Akt1)
   05211 Renal cell carcinoma
    101969987 (Akt1)
   05215 Prostate cancer
    101969987 (Akt1)
   05213 Endometrial cancer
    101969987 (Akt1)
   05224 Breast cancer
    101969987 (Akt1)
   05222 Small cell lung cancer
    101969987 (Akt1)
   05223 Non-small cell lung cancer
    101969987 (Akt1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101969987 (Akt1)
   05170 Human immunodeficiency virus 1 infection
    101969987 (Akt1)
   05161 Hepatitis B
    101969987 (Akt1)
   05160 Hepatitis C
    101969987 (Akt1)
   05164 Influenza A
    101969987 (Akt1)
   05162 Measles
    101969987 (Akt1)
   05168 Herpes simplex virus 1 infection
    101969987 (Akt1)
   05163 Human cytomegalovirus infection
    101969987 (Akt1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101969987 (Akt1)
   05169 Epstein-Barr virus infection
    101969987 (Akt1)
   05165 Human papillomavirus infection
    101969987 (Akt1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    101969987 (Akt1)
   05135 Yersinia infection
    101969987 (Akt1)
   05152 Tuberculosis
    101969987 (Akt1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    101969987 (Akt1)
   05142 Chagas disease
    101969987 (Akt1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101969987 (Akt1)
   05017 Spinocerebellar ataxia
    101969987 (Akt1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101969987 (Akt1)
   05418 Fluid shear stress and atherosclerosis
    101969987 (Akt1)
   05415 Diabetic cardiomyopathy
    101969987 (Akt1)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    101969987 (Akt1)
   04932 Non-alcoholic fatty liver disease
    101969987 (Akt1)
   04931 Insulin resistance
    101969987 (Akt1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    101969987 (Akt1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101969987 (Akt1)
   01524 Platinum drug resistance
    101969987 (Akt1)
   01522 Endocrine resistance
    101969987 (Akt1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:iti01001]
    101969987 (Akt1)
Enzymes [BR:iti01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     101969987 (Akt1)
Protein kinases [BR:iti01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   101969987 (Akt1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_11 PH_20 Seadorna_VP7
Other DBs
NCBI-GeneID: 101969987
NCBI-ProteinID: XP_013218034
UniProt: A0A287D4L0
LinkDB
Position
Unknown
AA seq 480 aa
MNDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQRESPLNNFSVAQC
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKRQEEEMMDF
RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMLCGRLPFYNQDHEKLFEL
ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFASIVWQDVYEKK
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDNMECVDSERRPHFPQFSYSASGTA
NT seq 1443 nt   +upstreamnt  +downstreamnt
atgaacgacgtggccatcgtgaaagaggggtggctacacaaacgaggggagtacatcaag
acttggcggccacgatacttcctcctcaagaatgacggaaccttcatcggctacaaggag
cggccccaggatgttgaccagagggagtcccccctcaataacttctctgtggcacaatgc
cagctgatgaagacagagcggcccaggcccaacaccttcatcatccgctgcctgcagtgg
actacggtcatcgaacgcaccttccatgtggagacgcctgaggagcgggaggagtggaca
acagccattcagaccgtggctgatggactcaagaggcaagaggaagagatgatggacttc
cgttcgggctcacccagtgataactcgggagcagaggagatggaggtgtccctggctaag
cccaagcaccgcgtgaccatgaatgagtttgagtacctgaagctactgggcaagggcacc
tttgggaaggtgatcctggtgaaggagaaggccacaggccgctactacgctatgaagatc
ctgaagaaggaggtcatcgtggccaaggacgaggtggcccacacactcactgagaaccgc
gtcctgcagaactccaggcaccccttcctcacagccttgaagtattccttccagacccac
gaccgcctctgcttcgtcatggagtacgccaatgggggcgagctcttcttccacctgtcc
cgcgagcgtgtgttctccgaggaccgggctcgtttctacggcgcagagatcgtgtccgct
ctggactacctgcactccgagaagaatgtcgtgtaccgcgacctcaagctggagaacctc
atgctggacaaggacgggcacattaagatcacggacttcgggctgtgcaaggagggcatt
aaggacggcgccaccatgaagaccttctgtgggacacctgagtacctggcccctgaggtg
ctggaggacaatgactatggccgggccgtggactggtgggggctgggtgtggtcatgtac
gagatgctgtgcggccgcctgcccttctacaaccaggaccacgagaagttgtttgagctc
atactgatggaggagatccgcttccctcgcacgctgggcccagaggccaagtccctgctc
tccgggctgctgaagaaggaccccaagcagaggctcggcgggggctccgaggatgccaag
gagatcatgcagcaccgcttctttgccagcatcgtgtggcaggatgtgtatgagaagaag
ctcagcccacccttcaagccccaggtcacatcagagacagataccaggtattttgatgag
gagttcacggcgcagatgatcaccatcacaccgcctgaccaagatgacaacatggagtgc
gtggacagcgagcgcaggccacacttcccccagttctcctactcggccagcggcacagcc
tga

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