Ictidomys tridecemlineatus (thirteen-lined ground squirrel): 101976548
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Entry
101976548 CDS
T10664
Symbol
Nos3
Name
(RefSeq) nitric oxide synthase, endothelial
KO
K13242
nitric-oxide synthase, endothelial [EC:
1.14.13.39
]
Organism
iti Ictidomys tridecemlineatus (thirteen-lined ground squirrel)
Pathway
iti00220
Arginine biosynthesis
iti00330
Arginine and proline metabolism
iti01100
Metabolic pathways
iti04020
Calcium signaling pathway
iti04022
cGMP-PKG signaling pathway
iti04066
HIF-1 signaling pathway
iti04071
Sphingolipid signaling pathway
iti04151
PI3K-Akt signaling pathway
iti04370
VEGF signaling pathway
iti04371
Apelin signaling pathway
iti04611
Platelet activation
iti04915
Estrogen signaling pathway
iti04921
Oxytocin signaling pathway
iti04926
Relaxin signaling pathway
iti04931
Insulin resistance
iti04933
AGE-RAGE signaling pathway in diabetic complications
iti05415
Diabetic cardiomyopathy
iti05417
Lipid and atherosclerosis
iti05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
iti00001
]
09100 Metabolism
09105 Amino acid metabolism
00220 Arginine biosynthesis
101976548 (Nos3)
00330 Arginine and proline metabolism
101976548 (Nos3)
09130 Environmental Information Processing
09132 Signal transduction
04370 VEGF signaling pathway
101976548 (Nos3)
04371 Apelin signaling pathway
101976548 (Nos3)
04066 HIF-1 signaling pathway
101976548 (Nos3)
04020 Calcium signaling pathway
101976548 (Nos3)
04071 Sphingolipid signaling pathway
101976548 (Nos3)
04022 cGMP-PKG signaling pathway
101976548 (Nos3)
04151 PI3K-Akt signaling pathway
101976548 (Nos3)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
101976548 (Nos3)
09152 Endocrine system
04915 Estrogen signaling pathway
101976548 (Nos3)
04921 Oxytocin signaling pathway
101976548 (Nos3)
04926 Relaxin signaling pathway
101976548 (Nos3)
09160 Human Diseases
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
101976548 (Nos3)
05418 Fluid shear stress and atherosclerosis
101976548 (Nos3)
05415 Diabetic cardiomyopathy
101976548 (Nos3)
09167 Endocrine and metabolic disease
04931 Insulin resistance
101976548 (Nos3)
04933 AGE-RAGE signaling pathway in diabetic complications
101976548 (Nos3)
Enzymes [BR:
iti01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
1.14.13.39 nitric-oxide synthase (NADPH)
101976548 (Nos3)
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Gene cluster
GFIT
Motif
Pfam:
NO_synthase
FAD_binding_1
Flavodoxin_1
NAD_binding_1
Motif
Other DBs
NCBI-GeneID:
101976548
NCBI-ProteinID:
XP_005326717
UniProt:
A0A287D6H1
LinkDB
All DBs
Position
Unknown
AA seq
1202 aa
AA seq
DB search
MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPVSEPSRAPASPPPPPPASDHSPPLTR
PPEGPKFPRVKNWEMGSITYDTLSAQAQQDGPCTPRRCLGSLVFPRKVQSRPSQSPPSTE
QLLGQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRNA
PRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATNKGNIRSAITVFPQRSPGRGDF
RIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNSRFDVLPLLLQAPDEPPE
LFTLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSSE
IGMRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDHH
AATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPWK
GSAAKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGRL
FRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSP
RPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFC
AFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQASCETFCVGEDAKAAAQ
DIFSPKRSWKRQRYRLSAQAEGLQLLPGLIHVHRRKMFQATVLSVENLQSSRSTRATILV
RLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPPPSEPVAVEQLEKGSPGGPP
PSWVRDPRLPPCTLRQALTYFLDITSPPSPRLLRLLSTLAEESSEQQELEALSQDPRRYE
EWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSTHPGEIHLTVAVLA
YRTQDGLGPLHYGVCSTWLSQLKAGDLVPCFIRGAPSFRLPPDPSLPCILVGPGTGIAPF
RGFWQERLHDIESKGLQPAPMTLVFGCRCSQLDHLYRDEVQDAQQRGVFGRVLTAFSREP
DSPKTYVQDVLRTELAAEVHRVLCLERGHMFVCGDVTMATSVLQTVQRILATEGDMELDE
AGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWAFDPPGSDTL
YP
NT seq
3609 nt
NT seq
+upstream
nt +downstream
nt
atgggcaacttgaagagcgtgggccaggagcctgggccaccctgcggcctgggactgggg
ctgggcctcgggctgtgcggcaaacagggcccagcctctccagtatcagagcccagccga
gcaccagcatccccacccccacccccaccggcatcagaccacagtcccccactaaccagg
cccccggagggacccaagttcccacgagtgaagaactgggagatgggcagcatcacctat
gacaccctcagtgcccaggcccagcaggatgggccctgcaccccaagacgctgcctgggc
tcccttgtatttccaaggaaagtacagagtcggccctcccagagccctccatccactgag
cagctgctgggtcaggccagggacttcatcaaccagtactacagctccatcaagaggagc
ggctcccaggcccatgagcagcggcttcaggaggtggaggctgaggtggcagccacgggc
acctaccagctccgggagagtgagctggtgttcggggccaagcaagcctggcgcaatgcc
ccccgctgtgtgggccggatccagtggggaaagctgcaggtgtttgatgcccgagattgt
aggtctgcccaggaaatgttcacctacatctgcaatcacatcaagtacgccaccaacaag
ggcaacatccgctcggccatcacagtgttcccccagcgctccccaggccgcggggacttc
cgaatctggaacagccagctggtgcgttatgctggctacaggcagcaggatggctctgtg
cggggggaccctgccaacgtggagatcactgagctctgcatccagcatggctggacccca
ggaaacagtcgcttcgatgtgctacccttgctgctccaggcccctgatgagcccccagaa
ctcttcactctgccccccgagctggtcctcgaggtgcccctagagcaccccacgctggag
tggttcgcagccctgggcctgcgctggtacgctcttcctgccgtgtccaacatgctgctg
gagataggaggactggagtttcccgcggcccctttcagcggctggtacatgagctctgag
atcggcatgaggaacctctgtgaccctcaccgctataacattctggaggacgtggccgtc
tgcatggacctggacacccgcaccacgtcatccctctggaaagacaaggcagcagtggaa
attaacgtggctgtgctgcacagttaccagctggccaaagtgaccattgtggaccaccat
gcggccacagcctccttcatgaagcacctggagaatgagcagaaggccaggggcgggtgc
cctgccgactgggcctggatcgtaccccccatctcaggcagcctcactcctgtcttccac
caagagatggtcaactatttcttatcccctgccttccgctaccagccagacccctggaag
gggagtgcagccaagggcactggcatcaccagaaagaagaccttcaaggaggtggccaac
gcggtgaagatctctgcctcgctcatgggcacggtgatggcgaagcgtgtgaaggcgacc
atcctgtatggctccgagaccggccgggcccagagctatgcacagcagctggggaggctc
ttccggaaggcgtttgacccccgggtcctgtgcatggatgaatatgacgtggtgtccctg
gagcacgagaccctggtgttggtggtgaccagcacatttgggaatggagatcccccagag
aatggagagagttttgcagcagccctgatggagatgtccggcccctacaacagctcccct
cggccagagcaacacaagagttacaaaatccgcttcaacagtgtctcctgctcagacccc
ctcgtgtcctcctggcggcggaagaggaaggagtctagcaacacagacagcgcaggggcc
ctgggcaccctcaggttctgtgtgttcgggctgggctccagggcatacccccacttctgt
gcctttgctcgggcggtggacacgaggctggaggagctgggtggggaacggctactgcag
ctgggccagggcgacgagctgtgtggccaggaggaggccttccgcggctgggcccaggct
gctttccaggcctcctgtgagaccttctgtgtgggggaggatgccaaggcagcagcccag
gatatattcagccccaagcgcagctggaagcgtcagcggtaccggctgagtgcccaggct
gagggcctgcagctgctgccaggcctgatccatgtgcacaggcggaaaatgttccaggcc
acagtcctctcagtggaaaacctgcaaagcagcagatccacccgggccaccatcctggtg
cgccttgacactggaggccaggaggggctgcagtaccagcctggggaccatataggtgtg
tgcccacccaaccggcctggcctcgtagaggcgctattgagccgcgtggaggacccgcca
ccacccagcgagcctgtggcagtggagcagctggagaagggcagccctggtggccctccc
ccgagctgggtgagggacccccggctgcccccgtgcacgctgcgccaggctctcacctac
ttcctggacatcacttctccacccagccctcgcctccttcgattgctcagcactctagcc
gaagagtccagcgaacagcaggaactggaggcccttagccaggacccccggcgctatgag
gagtggaagtggttccgctgtcccacactgctggaggtcttggagcagttcccatcagtg
gcactgcctgcgcccctgctcctcactcagctgcccctgctccagcctcggtactactcc
gtcagctcagcacccagcacccacccaggagagatccacctcaccgtagctgtgttggca
tacaggacccaggatgggctgggccccttacattatggagtctgctccacatggctgagc
caactcaaggctggagacctcgtgccctgcttcatcagaggggctccctctttccggcta
ccacctgatcccagtctgccctgcatcctggtgggcccaggcactggcattgcccccttc
aggggattctggcaggagcggcttcatgacattgagagcaaaggacttcagcccgccccc
atgactctggtattcggctgccgatgctcccaactcgaccatctctaccgcgacgaggtg
caagacgcccagcagcgcggggtgtttggccgcgtcctcaccgccttctcccgggaaccc
gacagccccaagacctacgtgcaggacgtcctgaggactgagctggctgctgaggtgcac
cgcgtgctgtgcctcgagaggggccatatgtttgtttgcggcgatgtcaccatggcaacc
agcgtcctgcaaactgtgcagcgaatcctagcgacagagggcgacatggagctggacgag
gcgggtgacgttatcggcgtgctgcgggatcagcaacgctaccacgaggacattttcggg
ctcactcttcgcactcaagaggtgacaagccgcatacgcacccagagcttttccctgcag
gagcgacagctgcggggcgcagtgccctgggcctttgacccaccaggctcagacaccctc
tacccttga
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