KEGG   Ictidomys tridecemlineatus (thirteen-lined ground squirrel): 101978560
Entry
101978560         CDS       T10664                                 
Symbol
Plcb4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
iti  Ictidomys tridecemlineatus (thirteen-lined ground squirrel)
Pathway
iti00562  Inositol phosphate metabolism
iti01100  Metabolic pathways
iti04015  Rap1 signaling pathway
iti04020  Calcium signaling pathway
iti04022  cGMP-PKG signaling pathway
iti04062  Chemokine signaling pathway
iti04070  Phosphatidylinositol signaling system
iti04071  Sphingolipid signaling pathway
iti04072  Phospholipase D signaling pathway
iti04081  Hormone signaling
iti04082  Neuroactive ligand signaling
iti04261  Adrenergic signaling in cardiomyocytes
iti04270  Vascular smooth muscle contraction
iti04310  Wnt signaling pathway
iti04371  Apelin signaling pathway
iti04540  Gap junction
iti04611  Platelet activation
iti04613  Neutrophil extracellular trap formation
iti04621  NOD-like receptor signaling pathway
iti04713  Circadian entrainment
iti04720  Long-term potentiation
iti04723  Retrograde endocannabinoid signaling
iti04724  Glutamatergic synapse
iti04725  Cholinergic synapse
iti04726  Serotonergic synapse
iti04728  Dopaminergic synapse
iti04730  Long-term depression
iti04742  Taste transduction
iti04750  Inflammatory mediator regulation of TRP channels
iti04911  Insulin secretion
iti04912  GnRH signaling pathway
iti04915  Estrogen signaling pathway
iti04916  Melanogenesis
iti04918  Thyroid hormone synthesis
iti04919  Thyroid hormone signaling pathway
iti04921  Oxytocin signaling pathway
iti04922  Glucagon signaling pathway
iti04924  Renin secretion
iti04925  Aldosterone synthesis and secretion
iti04926  Relaxin signaling pathway
iti04927  Cortisol synthesis and secretion
iti04928  Parathyroid hormone synthesis, secretion and action
iti04929  GnRH secretion
iti04933  AGE-RAGE signaling pathway in diabetic complications
iti04934  Cushing syndrome
iti04935  Growth hormone synthesis, secretion and action
iti04961  Endocrine and other factor-regulated calcium reabsorption
iti04970  Salivary secretion
iti04971  Gastric acid secretion
iti04972  Pancreatic secretion
iti04973  Carbohydrate digestion and absorption
iti05010  Alzheimer disease
iti05016  Huntington disease
iti05017  Spinocerebellar ataxia
iti05022  Pathways of neurodegeneration - multiple diseases
iti05142  Chagas disease
iti05143  African trypanosomiasis
iti05146  Amoebiasis
iti05163  Human cytomegalovirus infection
iti05200  Pathways in cancer
iti05415  Diabetic cardiomyopathy
iti05417  Lipid and atherosclerosis
Module
iti_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:iti00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101978560 (Plcb4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    101978560 (Plcb4)
   04310 Wnt signaling pathway
    101978560 (Plcb4)
   04371 Apelin signaling pathway
    101978560 (Plcb4)
   04020 Calcium signaling pathway
    101978560 (Plcb4)
   04070 Phosphatidylinositol signaling system
    101978560 (Plcb4)
   04072 Phospholipase D signaling pathway
    101978560 (Plcb4)
   04071 Sphingolipid signaling pathway
    101978560 (Plcb4)
   04022 cGMP-PKG signaling pathway
    101978560 (Plcb4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    101978560 (Plcb4)
   04081 Hormone signaling
    101978560 (Plcb4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    101978560 (Plcb4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101978560 (Plcb4)
   04613 Neutrophil extracellular trap formation
    101978560 (Plcb4)
   04621 NOD-like receptor signaling pathway
    101978560 (Plcb4)
   04062 Chemokine signaling pathway
    101978560 (Plcb4)
  09152 Endocrine system
   04911 Insulin secretion
    101978560 (Plcb4)
   04922 Glucagon signaling pathway
    101978560 (Plcb4)
   04929 GnRH secretion
    101978560 (Plcb4)
   04912 GnRH signaling pathway
    101978560 (Plcb4)
   04915 Estrogen signaling pathway
    101978560 (Plcb4)
   04921 Oxytocin signaling pathway
    101978560 (Plcb4)
   04926 Relaxin signaling pathway
    101978560 (Plcb4)
   04935 Growth hormone synthesis, secretion and action
    101978560 (Plcb4)
   04918 Thyroid hormone synthesis
    101978560 (Plcb4)
   04919 Thyroid hormone signaling pathway
    101978560 (Plcb4)
   04928 Parathyroid hormone synthesis, secretion and action
    101978560 (Plcb4)
   04916 Melanogenesis
    101978560 (Plcb4)
   04924 Renin secretion
    101978560 (Plcb4)
   04925 Aldosterone synthesis and secretion
    101978560 (Plcb4)
   04927 Cortisol synthesis and secretion
    101978560 (Plcb4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101978560 (Plcb4)
   04270 Vascular smooth muscle contraction
    101978560 (Plcb4)
  09154 Digestive system
   04970 Salivary secretion
    101978560 (Plcb4)
   04971 Gastric acid secretion
    101978560 (Plcb4)
   04972 Pancreatic secretion
    101978560 (Plcb4)
   04973 Carbohydrate digestion and absorption
    101978560 (Plcb4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    101978560 (Plcb4)
  09156 Nervous system
   04724 Glutamatergic synapse
    101978560 (Plcb4)
   04725 Cholinergic synapse
    101978560 (Plcb4)
   04728 Dopaminergic synapse
    101978560 (Plcb4)
   04726 Serotonergic synapse
    101978560 (Plcb4)
   04720 Long-term potentiation
    101978560 (Plcb4)
   04730 Long-term depression
    101978560 (Plcb4)
   04723 Retrograde endocannabinoid signaling
    101978560 (Plcb4)
  09157 Sensory system
   04742 Taste transduction
    101978560 (Plcb4)
   04750 Inflammatory mediator regulation of TRP channels
    101978560 (Plcb4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    101978560 (Plcb4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101978560 (Plcb4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    101978560 (Plcb4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    101978560 (Plcb4)
   05142 Chagas disease
    101978560 (Plcb4)
   05143 African trypanosomiasis
    101978560 (Plcb4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101978560 (Plcb4)
   05016 Huntington disease
    101978560 (Plcb4)
   05017 Spinocerebellar ataxia
    101978560 (Plcb4)
   05022 Pathways of neurodegeneration - multiple diseases
    101978560 (Plcb4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101978560 (Plcb4)
   05415 Diabetic cardiomyopathy
    101978560 (Plcb4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    101978560 (Plcb4)
   04934 Cushing syndrome
    101978560 (Plcb4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:iti04131]
    101978560 (Plcb4)
Enzymes [BR:iti01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     101978560 (Plcb4)
Membrane trafficking [BR:iti04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    101978560 (Plcb4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    101978560 (Plcb4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 101978560
NCBI-ProteinID: XP_021578840
LinkDB
Position
Unknown
AA seq 1206 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVL
ECSLINSIRLGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTTGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDVKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESAAPASILEDDNEEEIESADQEEEAHPEFKFGSELSADDLGHKEAVANSVKKTSD
DLEHENNKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANPAKANVTPQ
SSSELRPTTTAALGPGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKRGGNNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLNQQCELLRKLLINAHEQQTQQLKLS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSSV
KLQNAN
NT seq 3621 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaactggcagaaggaagtcccttcctttttgcaagaagga
gcagtttttgacagatatgaagaggaatcattcgtctttgaacccaactgcctcttcaaa
gtggatgaatttggcttctttctgacttggaaaagtgaaggcaaggaaggacaagtgctg
gaatgttccctcatcaacagtattcggctgggagccataccaaaggatcccaaaatcctg
gctgctctcgaagctgttggaaaatcagaaaatgatctggaagggcggatagtttgcgtc
tgcagtggcacagatcttgtgaacattagtttcacgtacatggtggctgaaaacccagaa
gtaacaaagcaatgggtagaaggcctgagatcaatcatacacaacttcagggccaacaac
gtcagtccaatgacctgcctcaagaaacactggatgaaattggcgtttatgaccaacaca
actggtaaaattccagttaggagtatcactagaacctttgcatcggggaaaacagagaag
gtgatctttcaagcactcaaggagttaggtcttcccagtggaaagaatgatgaaattgaa
cctgctgcctttacttatgaaaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaagatctttttaagaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagatcctcgactgaatgaaattttattc
ccattttatgatgttaaaagggcaatgcagatcattgagatgtatgagcctgatgaagat
ttgaagaaaaaaggactcatatcaagtgatgggttttgcagatatctgatgtcagatgaa
aatgccccagtcttcctagatcgtttagagctttaccaagaaatggaccatcctctggct
cactacttcatcagttcttcccataacacctatctcactggccgacagtttggtgggaag
tcttcagtagaaatgtacagacaagttctcctggctggttgcaggtgtgttgaacttgac
tgttgggatggaaaaggtgaagatcaagaaccaataataactcatgggaaagcaatgtgt
acagatatactttttaaggatgtaattcaagccatcaaggaaactgcatttgtcacatcc
gaatatcctgtaattctctcctttgaaaaccactgcagcaaatatcaacagtacaagatg
tccaaatattgtgaagatctatttggggatctcctgttgaaacaagcacttgaatcacat
ccactcgaaccaggaagacctctgccatcccccaatgacctcaaaagaaaaatactcatc
aaaaataagcgcctaaaacctgaagttgaaaagaaacagcttgaagctttgaaaagcatg
atggaagctggggagtctgcagctccagctagcatcttagaggatgataatgaagaggaa
atagaaagtgctgaccaagaggaggaagctcaccctgagttcaaatttggaagtgaactt
tctgctgatgacttgggtcataaggaagctgttgcaaatagtgtcaagaagacttcagat
gaccttgaacatgaaaacaacaaaaagggcctggttactgtagaggatgagcaggcatgg
atggcatcttataaatatgtaggtgctaccactaatatccatccctatttgtccaccatg
atcaattatgcacagccagtgaagtttcaaggtttccatgtggctgaagaacgcaacatt
cattataacatgtcttcttttaatgaatcagttggccttggctacttgaagacacatgcg
attgaattcgtgaattacaacaaacggcaaatgagtcgcatttaccccaagggaggcaga
gtcgattctagtaattacatgcctcagatattctggaacgctggatgccagatggtttca
ctgaactatcaaaccccagatttagcaatgcaattgaaccaggggaaatttgagtataat
ggatcttgcgggtacctgctcaaaccagatttcatgaggcggcctgaccgaacatttgat
cccttctctgaaacccctgtggatggggttattgcagccacatgctcggtgcaggtcata
tcagggcagttcttatcagataagaagattggcacatacgttgaagtggacatgtatggg
ctgcccactgacaccatacgaaaggaattccgaactcgtatggttatgaacaacgggctc
aatccagtttacaatgaagaatcgtttgtgtttcggaaggtgatcctgccagacctggct
gtcttgagaatagcagtatatgatgacaacaacaagctgattggccagaggatccttcca
ctggatggcctccaagcaggctatcgacacatttcccttcggaatgagggaaacaaacca
ttatcactgccaacaattttctgcaatattgttcttaaaacatatgtgcctgatgggttt
ggagatattgtggatgctttatcagatccaaagaaatttctctcaattacagaaaagaga
gcagaccaaatgagagctatgggcattgaaactagtgacatagccgatgtgcccagcgac
acttccaagaatgacaagaaaggaaaggccaacccagccaaagccaacgtgacccctcag
agtagctccgagctcagacccaccactacagccgccctgggccccggcgtggaagccaag
aaaggcattgaacttatccctcaagtgaggatagaagatttaaagcagatgaaggcttac
ttgaagcatttaaagaaacaacagaaagagctaaattctttaaagaagaaacatgcaaag
gagcacagtaccatgcagaagttacattgcacgcaagttgacaaaattgtggctcagtac
gacaaagagaagtccactcatgagaaaatcctggagaaggcaatgaagaagaggggggga
aataattgtcttgaaatgaaaaaagaaacagaaattaaaattcagaccctgacatcagat
cacaaatcaaaggtcaaagagattgtagcacagcacacaaaggagtggtcagaaatgatc
aacacccacagtgctgaggagcaagaaatacgggacctgcaccttaaccagcagtgtgaa
ctactgagaaagctactaatcaatgctcacgagcagcaaacccagcagctgaaactgtcc
catgacagggaaagcaaggaaatgagagcccaccaggccaagatctctatggaaaacagc
aaagccatcagccaagacaaatctatcaagaataaagcagaacgggaaaggcgagtcaga
gaactaaacagcagcaacactaaaaaatttctagaagaaagaaagagacttgcaatgaag
caatccaaagaaatggatcaattgaaaaaagtccaacttgaacacctagaatttctagag
aagcagaatgagcagcttttgaaatcctgtcatgcagtgtcccaaacgcaaggcgaagga
gatgcagcagatggtgaaattggaagccgagatggaccgcagaccagcaacagtagtgtg
aaactccaaaatgcaaactga

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