Streptomyces sp. NL15-2K: Q4V64_46375
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Entry
Q4V64_46375 CDS
T09250
Symbol
murF
Name
(GenBank) UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
KO
K01929
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:
6.3.2.10
]
Organism
kbu
Streptomyces sp. NL15-2K
Pathway
kbu00300
Lysine biosynthesis
kbu00550
Peptidoglycan biosynthesis
kbu01100
Metabolic pathways
kbu01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
kbu00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
Q4V64_46375 (murF)
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
Q4V64_46375 (murF)
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
Q4V64_46375 (murF)
Enzymes [BR:
kbu01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
Q4V64_46375 (murF)
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Mur_ligase
Motif
Other DBs
NCBI-ProteinID:
WKX14541
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Position
10620762..10622105
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AA seq
447 aa
AA seq
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MIPLSLGEIAEVVGGKAEGDSSVTVTAPAVLDGRQAEPGGLFVAFTGEHVDGHDYAGQAG
RAGAVAVLGSRPTPLPTVVVEDAQAALQALAAHVVARLRDGLTVVGLTGSQGKTSTKDLL
AAVLSSAAPTIATIGSLNNELGVPLTMLRADAATRFLVLEMGARHVGDIAELTGLVAPDI
AVVLNVGQAHLGEFGSRAAIARAKGELVQGLAPGGAAVLNADDPRVVAMRSLTDGPVLTF
GRAAHADVRALGLALDRLGRPSFTLRTAEASVPLTLPLVGAHQALNASAAAAAGLAADVP
LDMATAALATASLSKWRLELRDLAGGATLLNDSYNANPDSTRAALDALAAIEGGRRIAVL
GEMLELGDDSEAEHRAVGEYAASRADVVAAVGEAARSIADGAGERAMVLADNDAAVDWLR
GHIAAGDVVLVKASRGARLDEVAAALA
NT seq
1344 nt
NT seq
+upstream
nt +downstream
nt
atgatcccgctcagcctcggcgagatcgccgaggtcgtcggcgggaaggccgagggcgac
agctccgtgacagtgaccgcgccggccgtgctcgacggccggcaggccgagccgggcggc
ctcttcgtcgccttcaccggcgagcacgtcgacggccatgactacgccggccaggccggc
cgggccggcgccgtggccgtgctcggctcccggcccacgccgctgcccaccgtcgtcgtc
gaggacgcccaggccgcgctgcaggcgctcgccgcccacgttgtggcccggctgcgcgac
gggctgaccgttgtcgggctgaccggctcccagggcaagaccagtaccaaggacctgctg
gcggccgtgctttcgagcgccgcgccgacgatcgccacgatcggctcgctcaacaacgaa
ctcggtgtgccgctcaccatgctgcgcgccgacgcggccacccggttcctcgtcctggag
atgggagcccgccatgtcggcgacatcgccgagctcaccggcctggtcgcgcccgacatc
gccgtcgtcctcaatgtcggccaggcccacctcggcgagttcgggtcgcgcgcggccatc
gccagggccaagggcgagctggtgcaggggctggcgccaggtggcgccgccgtcctcaac
gccgacgatccccgggtggtcgcgatgcgctcgctcaccgacggtccggtgctgacgttc
ggccgggcggcccacgccgatgtacgggcgctcggcctggcccttgaccggctcggccgg
ccgtccttcacgctgcggaccgccgaggcctcggttcccctcacgctgccactcgtgggt
gcccaccaggcgctcaacgcgtcggctgccgcggcggcggggctggcggccgacgtaccc
ctcgacatggccacggcggcgctggccaccgcttcgctgtcgaagtggcggctggagctg
cgcgatctcgccggtggcgcgacgctgctcaacgactcctacaacgccaaccccgactcg
acccgcgccgccctggacgcgctggcggcgatcgagggcgggcgccgcatcgccgtcctc
ggcgaaatgctggagctcggcgacgacagcgaggctgagcaccgcgccgtcggggagtac
gccgcctcccgggccgacgtggtggccgctgtcggcgaggccgcccggtcgatcgccgac
ggcgcgggagagcgggcgatggtgctggccgacaacgacgcggccgtcgactggctgcgc
ggccacatcgccgccggcgatgtggtgctcgtcaaggcctcccgcggggcgcgcctcgac
gaggtcgccgccgcgctcgcctga
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