Entry Name Protein export
Description The protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role.
Class Genetic Information Processing; Folding, sorting and degradationBRITE hierarchy
Pathway map Other DBs Orthology K01551 arsA, ASNA1, GET3; arsenite/tail-anchored protein-transporting ATPase [EC:7.3.2.7 7.3.-.-]
K01983 ffs; signal recognition particle 4.5S RNA
K03071 secB; preprotein translocase subunit SecB
K03072 secD; preprotein translocase subunit SecD
K03073 secE; preprotein translocase subunit SecE
K03074 secF; preprotein translocase subunit SecF
K03075 secG; preprotein translocase subunit SecG
K03076 secY; preprotein translocase subunit SecY
K03104 SRP14; signal recognition particle subunit SRP14
K03105 SRP19; signal recognition particle subunit SRP19
K03106 SRP54, ffh; signal recognition particle subunit SRP54 [EC:3.6.5.4 ]
K03107 SRP68; signal recognition particle subunit SRP68
K03108 SRP72; signal recognition particle subunit SRP72
K03109 SRP9; signal recognition particle subunit SRP9
K03110 ftsY; fused signal recognition particle receptor
K03116 tatA; sec-independent protein translocase protein TatA
K03117 tatB; sec-independent protein translocase protein TatB
K03118 tatC; sec-independent protein translocase protein TatC
K03210 yajC; preprotein translocase subunit YajC
K03217 yidC, spoIIIJ, OXA1, ccfA; YidC/Oxa1 family membrane protein insertase
K03425 tatE; sec-independent protein translocase protein TatE
K07342 SEC61G, SSS1, secE; protein transport protein SEC61 subunit gamma and related proteins
K09481 SEC61B, SBH2; protein transport protein SEC61 subunit beta
K09540 SEC63, DNAJC23; translocation protein SEC63
K09647 IMP1; mitochondrial inner membrane protease subunit 1 [EC:3.4.21.-]
K09648 IMP2; mitochondrial inner membrane protease subunit 2 [EC:3.4.21.-]
K10956 SEC61A; protein transport protein SEC61 subunit alpha
K12257 secDF; SecD/SecF fusion protein
K12272 SRPRB, SRP102; signal recognition particle receptor subunit beta
K12275 SEC62; translocation protein SEC62
K12946 SPCS1; signal peptidase complex subunit 1 [EC:3.4.-.-]
K12947 SPCS2, SPC2; signal peptidase complex subunit 2 [EC:3.4.-.-]
K12948 SPCS3, SPC3; signal peptidase complex subunit 3 [EC:3.4.-.-]
K13301 secM; secretion monitor
K13431 SRPR; signal recognition particle receptor subunit alpha
K16365 SGTA; small glutamine-rich tetratricopeptide repeat-containing protein alpha
K22384 GET1, WRB; tail-anchored protein insertion receptor
K22386 GET2; GET complex subunit GET2
K23387 GET4; golgi to ER traffic protein 4
K23388 UBL4; ubiquitin-like protein 4
K23390 BAG6; large proline-rich protein BAG6
K27163 SND1; SRP-independent targeting protein 1
K27164 SND2, TMEM208; SRP-independent targeting protein 2
K27165 SND3, PHO88; SRP-independent targeting protein 3
Reference Authors Dalbey RE, Robinson C.
Title Protein translocation into and across the bacterial plasma membrane and the plant thylakoid membrane.
Journal Reference Authors Berks BC, Sargent F, Palmer T.
Title The Tat protein export pathway.
Journal Reference Authors Wexler M, Sargent F, Jack RL, Stanley NR, Bogsch EG, Robinson C, Berks BC, Palmer T.
Title TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export.
Journal Reference Authors Jongbloed JD, Martin U, Antelmann H, Hecker M, Tjalsma H, Venema G, Bron S, van Dijl JM, Muller J.
Title TatC is a specificity determinant for protein secretion via the twin-arginine translocation pathway.
Journal Reference Authors Rapoport TA
Title Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
Journal Reference Authors Flower AM
Title The SecY translocation complex: convergence of genetics and structure.
Journal Reference Authors Osborne AR, Rapoport TA, van den Berg B
Title Protein translocation by the Sec61/SecY channel.
Journal Reference Authors Paetzel M, Karla A, Strynadka NC, Dalbey RE
Title Signal peptidases.
Journal Reference Authors Paetzel M, Dalbey RE, Strynadka NC
Title The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target.
Journal Reference Authors Ng SY, Chaban B, VanDyke DJ, Jarrell KF
Title Archaeal signal peptidases.
Journal Reference Authors Desvaux M, Hebraud M, Talon R, Henderson IR
Title Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
Journal Reference Authors Nakatogawa H, Murakami A, Ito K
Title Control of SecA and SecM translation by protein secretion.
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