Entry Name Protein export
Description The protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role.
Class Genetic Information Processing; Folding, sorting and degradationBRITE hierarchy
Pathway map Ortholog table Other DBs Orthology K03076 preprotein translocase subunit SecY
K03073 preprotein translocase subunit SecE
K03075 preprotein translocase subunit SecG
K03072 preprotein translocase subunit SecD
K03074 preprotein translocase subunit SecF
K12257 SecD/SecF fusion protein
K03210 preprotein translocase subunit YajC
K03217 YidC/Oxa1 family membrane protein insertase
K03071 preprotein translocase subunit SecB
K03110 fused signal recognition particle receptor
K10956 protein transport protein SEC61 subunit alpha
K09481 protein transport protein SEC61 subunit beta
K07342 protein transport protein SEC61 subunit gamma and related proteins
K12275 translocation protein SEC62
K09540 translocation protein SEC63
K03109 signal recognition particle subunit SRP9
K03104 signal recognition particle subunit SRP14
K03108 signal recognition particle subunit SRP72
K03107 signal recognition particle subunit SRP68
K03105 signal recognition particle subunit SRP19
K13431 signal recognition particle receptor subunit alpha
K12272 signal recognition particle receptor subunit beta
K01551 arsenite/tail-anchored protein-transporting ATPase [EC:7.3.2.7 7.3.-.-]
K23387 golgi to ER traffic protein 4
K23388 ubiquitin-like protein 4
K23390 large proline-rich protein BAG6
K16365 small glutamine-rich tetratricopeptide repeat-containing protein alpha
K22384 tail-anchored protein insertion receptor
K22386 GET complex subunit GET2
K27163 SRP-independent targeting protein 1
K27164 SRP-independent targeting protein 2
K27165 SRP-independent targeting protein 3
K03116 sec-independent protein translocase protein TatA
K03117 sec-independent protein translocase protein TatB
K03118 sec-independent protein translocase protein TatC
K03425 sec-independent protein translocase protein TatE
K12946 signal peptidase complex subunit 1 [EC:3.4.-.-]
K12947 signal peptidase complex subunit 2 [EC:3.4.-.-]
K12948 signal peptidase complex subunit 3 [EC:3.4.-.-]
K09647 mitochondrial inner membrane protease subunit 1 [EC:3.4.21.-]
K09648 mitochondrial inner membrane protease subunit 2 [EC:3.4.21.-]
Reference Authors Dalbey RE, Robinson C.
Title Protein translocation into and across the bacterial plasma membrane and the plant thylakoid membrane.
Journal Reference Authors Berks BC, Sargent F, Palmer T.
Title The Tat protein export pathway.
Journal Reference Authors Wexler M, Sargent F, Jack RL, Stanley NR, Bogsch EG, Robinson C, Berks BC, Palmer T.
Title TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export.
Journal Reference Authors Jongbloed JD, Martin U, Antelmann H, Hecker M, Tjalsma H, Venema G, Bron S, van Dijl JM, Muller J.
Title TatC is a specificity determinant for protein secretion via the twin-arginine translocation pathway.
Journal Reference Authors Rapoport TA
Title Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
Journal Reference Authors Flower AM
Title The SecY translocation complex: convergence of genetics and structure.
Journal Reference Authors Osborne AR, Rapoport TA, van den Berg B
Title Protein translocation by the Sec61/SecY channel.
Journal Reference Authors Paetzel M, Karla A, Strynadka NC, Dalbey RE
Title Signal peptidases.
Journal Reference Authors Paetzel M, Dalbey RE, Strynadka NC
Title The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target.
Journal Reference Authors Ng SY, Chaban B, VanDyke DJ, Jarrell KF
Title Archaeal signal peptidases.
Journal Reference Authors Desvaux M, Hebraud M, Talon R, Henderson IR
Title Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
Journal Reference Authors Nakatogawa H, Murakami A, Ito K
Title Control of SecA and SecM translation by protein secretion.
Journal LinkDB All DBs
