KEGG ORTHOLOGY: K15616

ORTHOLOGY: K15616

Entry

K15616                      KO

Symbol

EYA1

Name

eyes absent homolog 1 [EC:3.1.3.48]

Pathway

map05202

Transcriptional misregulation in cancer

Disease

H00453

Branchio-oto-renal syndrome

H02046

OFC syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K15616  EYA1; eyes absent homolog 1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K15616  EYA1; eyes absent homolog 1
Enzymes [BR:ko01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     K15616  EYA1; eyes absent homolog 1
Protein phosphatases and associated proteins [BR:ko01009]
HAD phosphatases
  EYAs
   K15616  EYA1; eyes absent homolog 1

Other DBs

GO:

0004725

Genes

HSA:	2138(EYA1)

PTR:	472789(EYA1)

PPS:	100974210(EYA1)

GGO:	101147738(EYA1)

PON:	100459661(EYA1)

PPYG:

129042752(EYA1)

NLE:	100596234(EYA1)

HMH:	116813197(EYA1)

SSYN:

129492751(EYA1)

MCC:	694364(EYA1)

MCF:	101926297(EYA1)

MTHB:

126961470

MNI:	105483597(EYA1)

CSAB:

103236953(EYA1)

CATY:

105585257(EYA1)

PANU:

101015387(EYA1)

TGE:	112629946(EYA1)

MLEU:

105553909(EYA1)

RRO:	104660503(EYA1)

RBB:	108530075(EYA1)

TFN:	117079161(EYA1)

PTEH:

111520948(EYA1)

CANG:

105510935(EYA1)

CJC:	100402657(EYA1)

SBQ:	101033362(EYA1)

CIMI:

108315280(EYA1)

ANAN:

105724825(EYA1)

CSYR:

103256168(EYA1)

MMUR:

105874687(EYA1)

LCAT:

123644667(EYA1)

PCOQ:

105825363(EYA1)

OGA:	100944006(EYA1)

MMU:	14048(Eya1)

MCAL:

110289326(Eya1)

MPAH:

110338633(Eya1)

RNO:	502935(Eya1)

MCOC:

116088187(Eya1)

ANU:	117698700(Eya1)

ASYL:

127680474(Eya1)

MUN:	110561040(Eya1)

CGE:	100772860(Eya1)

MAUA:

101833131(Eya1)

PROB:

127231374(Eya1)

PLEU:

114690112(Eya1)

MORG:

121458305(Eya1)

MFOT:

126501468

AAMP:

119826338(Eya1)

NGI:	103746608(Eya1)

HGL:	101697803(Eya1)

CPOC:

100714546(Eya1)

CCAN:

109674940 109674951

DORD:

105994781(Eya1)

DSP:	122095860(Eya1)

DMER:

138805788(Eya1)

PLOP:

125360838(Eya1)

NCAR:

124984517

MMMA:

107142443(Eya1)

ITI:	101961575(Eya1)

OCU:

100338386

OPI:	101534629(EYA1)

TUP:	102492448(EYA1)

GVR:	103585498(EYA1)

CFA:	477910(EYA1)

CLUD:

112678597(EYA1)

VVP:	112930175(EYA1)

VLG:	121498952(EYA1)

NPO:	129505298(EYA1)

AML:	100468043(EYA1)

UMR:	103681252(EYA1)

UAH:	113253061(EYA1)

UAR:	123800475(EYA1)

ELK:

111156802

LLV:

125098630

MPUF:

101694532(EYA1)

MNP:	132014078(EYA1)

MLK:	131826721(EYA1)

NVS:	122904523(EYA1)

ORO:	101372112(EYA1)

EJU:	114214993(EYA1)

ZCA:	113916336(EYA1)

MLX:	118014916(EYA1)

NSU:	110578647(EYA1)

LWW:	102741017(EYA1)

FCA:	101098114(EYA1)

PYU:	121038134(EYA1)

PCOO:

112859764(EYA1)

PBG:	122495479(EYA1)

PVIV:

125156363(EYA1)

LRUF:

124507421

LGF:	123586076(EYA1)

AJU:

106968355

PTG:	102956287(EYA1)

PPAD:

109269332(EYA1)

PUC:

125924627

PLEZ:

122211093(EYA1)

HHV:	120235866(EYA1)

BTA:	511188(EYA1)

BOM:	102267455(EYA1)

BIU:	109568589(EYA1)

BBUB:

102393277(EYA1)

BBIS:

104993644(EYA1)

CHX:	102178462(EYA1)

OAS:	101105259(EYA1)

BTAX:

128059090(EYA1)

CSUM:

138088815(EYA1)

ODA:	120878660(EYA1)

CCAD:

122451313(EYA1)

MREE:

136145056(EYA1)

OVR:	110147353(EYA1)

MBEZ:

129559844(EYA1)

SSC:	100737938(EYA1)

CFR:	102519487(EYA1)

CBAI:

105078559(EYA1)

CDK:	105088488(EYA1)

VPC:	102532170(EYA1)

BACU:

103013469(EYA1)

BMUS:

118883233(EYA1)

LVE:	103076381(EYA1)

OOR:	101272131(EYA1)

LALB:

132508068(EYA1)

GMF:	115854940(EYA1)

DDP:	132440199(EYA1)

DLE:	111185632(EYA1)

PCAD:

102988901(EYA1)

PSIU:

116742356(EYA1)

PPHC:

136137105(EYA1)

NASI:

112395682(EYA1)

ECB:	100051446(EYA1)

EPZ:	103550203(EYA1)

EAI:	106844924(EYA1)

MYB:	102240922(EYA1)

MYD:	102758668(EYA1)

MMYO:

118670932(EYA1)

MLF:	102438382(EYA1)

MDT:	132220025(EYA1)

MYUM:

138993060(EYA1)

PKL:	118718355(EYA1)

EFUS:

103293946(EYA1)

MNA:	107539538(EYA1)

DRO:	112315710(EYA1)

SHON:

118995548(EYA1)

AJM:	119045620(EYA1)

PDIC:

114514491(EYA1)

PHAS:

123833330(EYA1)

MMF:	118631603(EYA1)

PPAM:

129084199(EYA1)

HAI:	109372618 109383290

RFQ:	117034028(EYA1)

PALE:

102893048(EYA1)

PGIG:

120585482(EYA1)

PVP:	105296706(EYA1)

RAY:	107515190(EYA1)

MJV:	108388099(EYA1)

TOD:	119249688(EYA1)

SARA:

101557584(EYA1)

SFUM:

130044015(EYA1)

SETR:

126020358(EYA1)

LAV:	100676029(EYA1)

TMU:

101340277

ETF:	101648717(EYA1)

DNM:	101414136(EYA1)

MDO:	100028441(EYA1)

GAS:	123231670(EYA1)

SHR:	100932322(EYA1)

AFZ:

127543776

PCW:	110219048(EYA1)

TVP:	118855836(EYA1)

PBRV:

138170634(EYA1)

MLAO:

141502382(EYA1)

OAA:	100090225(EYA1)

TACU:

119945493(EYA1)

GGA:	395718(EYA1)

PCOC:

116236270(EYA1)

MGP:	100545319 104909293

CJO:	107310265(EYA1)

TPAI:

128091590(EYA1)

LMUT:

125690530(EYA1)

NMEL:

110394535(EYA1)

APLA:

101791853(EYA1)

ACYG:

106030601(EYA1)

CATA:

118256301(EYA1)

AFUL:

116486728(EYA1)

TGU:	100226956(EYA1)

LSR:	110477534(EYA1)

SCAN:

103812805(EYA1)

PMOA:

120499273(EYA1)

OTC:	121340161(EYA1)

PRUF:

121351964(EYA1)

ATRC:

139587078(EYA1)

GFR:	102034731(EYA1)

FAB:	101817323(EYA1)

OMA:	130250184(EYA1)

PHI:	102111008(EYA1)

PMAJ:

107214148(EYA1)

CCAE:

111924654(EYA1)

CCW:	104692820(EYA1)

CBRC:

103613571(EYA1)

ACOE:

138105946(EYA1)

ETL:	114068234(EYA1)

ZAB:	102066232(EYA1)

ZLE:	135443331(EYA1)

ACHL:

103797943(EYA1)

SVG:	106857446(EYA1)

MMEA:

130572313(EYA1)

HRT:	120751296(EYA1)

SATI:

136369429(EYA1)

CCIC:

134049717(EYA1)

FPG:	101924541(EYA1)

FCH:	102057873(EYA1)

CCRI:

104157906(EYA1)

NNT:	104409822(EYA1)

SHAB:

115617060(EYA1)

ACUN:

113476902(EYA1)

TALA:

104363960(EYA1)

ACHC:

115340628(EYA1)

HALD:

104319074(EYA1)

HLE:	104837030(EYA1)

AGEN:

126048846

HHAR:

128142147(EYA1)

GCL:

127012538

CSTI:

104550831(EYA1)

LDI:	104348018(EYA1)

MNB:	103781965(EYA1)

DPUB:

104303460(EYA1)

PPUS:

135189957(EYA1)

AVIT:

104278475(EYA1)

BRHI:

104492739

EGZ:	104122384(EYA1)

NNI:	104016177(EYA1)

PCRI:

104031068

PCAO:

104051473(EYA1)

PADL:

103926194(EYA1)

AFOR:

103893515(EYA1)

FGA:	104070278(EYA1)

GSTE:

104261860

CBOY:

140646890(EYA1)

CLV:	102087417(EYA1)

CNIC:

135984724(EYA1)

MUI:	104538034(EYA1)

PGUU:

104466922(EYA1)

PLET:

104625138(EYA1)

EHS:	104511043(EYA1)

CMAC:

104478505

CUCA:

104068068(EYA1)

TEO:

104377836

BREG:

104638920(EYA1)

OHA:	104334837(EYA1)

ACAR:

104526317(EYA1)

CPEA:

104386890(EYA1)

CVF:	104294914(EYA1)

RTD:	128905618(EYA1)

CRID:

134512048(EYA1)

LMIC:

141739611(EYA1)

AAM:	106484589(EYA1)

AROW:

112961284(EYA1)

NPD:	112942822(EYA1)

TGT:	104577922(EYA1)

DNE:	112992257(EYA1)

SCAM:

104150810(EYA1)

ASN:	102387135(EYA1)

AMJ:	106736833(EYA1)

CPOO:

109319499(EYA1)

GGN:	109304951(EYA1)

PSS:	102458552(EYA1)

CMY:	102935946(EYA1)

CCAY:

125632553(EYA1)

DCC:	119852049(EYA1)

CPIC:

101941902(EYA1)

TST:	117873569(EYA1)

CABI:

116833152(EYA1)

MRV:	120398841(EYA1)

ACS:	100555989(eya1)

ASAO:

132774909(EYA1)

PVT:	110089521(EYA1)

SUND:

121928925(EYA1)

PBI:	103058071(EYA1)

PMUR:

107290244(EYA1)

CTIG:

120308850(EYA1)

TSR:	106554079(EYA1)

PGUT:

117672880(EYA1)

PCAE:

139315764(EYA1)

APRI:

131195164(EYA1)

PTEX:

113439980(EYA1)

NSS:	113429211(EYA1)

VKO:	123020454(EYA1)

PMUA:

114600520(EYA1)

PRAF:

128417362(EYA1)

ZVI:	118089934(EYA1)

HCG:	128323792(EYA1)

GJA:	107121050(EYA1)

STOW:

125438971(EYA1)

EMC:	129333382(EYA1)

XLA:	108695338(eya1.S) 399175(eya1.L)

XTR:	779594(eya1)

NPR:	108791759(EYA1)

RTEM:

120941122(EYA1)

ACAT:

141145259(EYA1)

BBUF:

121001768(EYA1)

BGAR:

122938764(EYA1)

DTC:	141096934(EYA1)

PWL:	138282584(EYA1)

MUO:	115478176(EYA1)

GSH:	117355457(EYA1)

DRE:	30436(eya1)

SRX:	107724417 107758809

SANH:

107657823 107667589

SGH:	107589965 107589966 107596047

CCAR:

109051238(eya1) 109052752

CAUA:

113042313(eya1) 113066080

CGIB:

127946608 128013683

PTET:

122330128(eya1)

LROH:

127156000(eya1)

OMC:	131533474(eya1)

PPRM:

120475903(eya1)

RKG:	130087683(eya1)

MAMB:

125257641(eya1)

CIDE:

127506371

CERY:

137013644(eya1)

MASI:

127432198 127434302

TROS:

130547298(eya1)

TDW:	130413549(eya1)

MANU:

129426084(eya1)

PDAB:

135785486(eya1)

IPU:

108256687

IFU:	128599604(eya1)

PHYP:

113541307(eya1)

SMEO:

124375516(eya1)

TFD:	113662184(eya1)

TVC:	132840385(eya1)

CGAR:

128514477(eya1)

NGRA:

132867182(eya1)

TRN:	134300848(eya1)

AMEX:

103037134(eya1)

CMAO:

118798892(eya1)

EEE:	113592254(eya1)

CHAR:

105890232(eya1)

SPIL:

134066116(eya1)

ASAD:

121688562(eya1)

TRU:	101066202(eya1)

TFS:	130513941(eya1)

TNG:	GSTEN00015582G001 GSTEN00015583G001

LCO:	104921395(eya1)

TBEN:

117484030(eya1)

CGOB:

115025552(eya1)

PGEO:

117442787(eya1)

GACU:

117548911(eya1)

EMAC:

134858110(eya1)

ELY:	117264774(eya1)

EFO:	125881916(eya1)

PLEP:

121960695(eya1)

SLUC:

116037983(eya1)

ECRA:

117937969(eya1)

ESP:	116672324(eya1)

PFLV:

114549060(eya1)

GAT:	120811877(eya1)

PPUG:

119198852(eya1)

AFB:	129110505(eya1)

CLUM:

117749492(eya1)

PSWI:

130206271(eya1)

CANA:

137788730(eya1)

CVE:	137871842(eya1)

MSAM:

119909246(eya1)

SCHU:

122866811(eya1)

CUD:	121527738(eya1)

SPUL:

138595884(eya1)

LMIX:

132994099(eya1)

ALAT:

119008981(eya1)

ASTR:

137587814(eya1)

MZE:	101466788(eya1)

ONL:	100700360(eya1)

OAU:	116328319(eya1)

OLA:	100049367(eya1)

OML:	112151371(eya1)

CSAI:

133423040(eya1)

XMA:	102223280(eya1)

XCO:	114137174(eya1)

XHE:	116712040(eya1)

PRET:

103456666(eya1)

PFOR:

103139776(eya1)

PLAI:

106958983

PMEI:

106931631

GAF:	122824285(eya1)

PPRL:

129364564(eya1)

CVG:	107093224(eya1)

CTUL:

119785238(eya1)

GMU:	124858276(eya1)

NFU:	107382911(eya1)

KMR:	108230430(eya1)

ALIM:

106513473(eya1)

NWH:	119426569(eya1)

AOCE:

111587688(eya1)

EJA:	138199518(eya1)

BFRE:

138623895(eya1)

MCEP:

124995829(eya1)

CSEM:

103377012(eya1)

POV:	109629823(eya1)

SSEN:

122773664(eya1)

SSOE:

131457914(eya1)

HHIP:

117753932(eya1)

HSP:	118098549(eya1)

PPLT:

128425687(eya1)

SMAU:

118291324(eya1)

LCF:	108881810 108902297

SDU:	111220954(eya1)

SLAL:

111662890(eya1)

XGL:	120789805(eya1)

HCQ:	109513696(eya1)

SSCV:

125985869(eya1)

SBIA:

133493084(eya1)

PEE:	133396328(eya1)

PTAO:

133470368(eya1)

BPEC:

110160926(eya1)

ENY:	140364554(eya1)

MALB:

109960133(eya1)

BSPL:

114853874(eya1)

SJO:	128382193(eya1)

SSCO:

134001969(eya1)

GMH:

115538989

SASA:

106579715 106579723(eya1) 106590661

STRU:

115149114(eya1) 115182848

OTW:	112227456 112238482(eya1)

OMY:	110489530 110536533(eya1)

OGO:	123991433 124039451(eya1)

OKI:	109881801 109884524(eya1)

OKE:	118381140(eya1) 127912937

OMM:

135538565

OCLA:

139366880 139420131

SALP:

112071317

SNH:	120027924 120050297(eya1)

SFON:

129823253(eya1)

CCLU:

121549745 121569970

ELS:	105019643(eya1)

OEP:	134035367(eya1)

SFM:	108935550(eya1)

PKI:	111834907(eya1)

AANG:

118226176(eya1) 118232786

AROT:

135253589(eya1) 135260821

CCOG:

133126320(eya1) 133136564

LOC:	102687358(eya1)

PSPA:

121313404 121314349 121320195

ARUT:

117399737 117435640

PSEX:

120530285(eya1)

LCM:	102363391(EYA1)

CMK:	103174561(eya1) 103186265

RTP:	109927926 109935206(eya1)

CPLA:

122549420(eya1) 122560227

HOC:	132810948(eya1) 132822978

LERI:

129696497(eya1) 129707254

HAKA:

140725322(eya1) 140736154

PMRN:

116945244 116950990

LRJ:	133347438 133349261 133353392

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:	100372975(Eya1)

PFLL:

139133546

DME:	Dmel_CG9554(eya)

DER:

6540880

DSE:

6611399

DSI:	Dsimw501_GD22568(Dsim_GD22568)

DYA:	Dyak_GE18433

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI18181

DAZ:

108611902

DNV:

108649514

DHE:

111592639

DVI:	6628226(eya)

CCAT:

101455971

BOD:

106621129

BDR:

105232365

RZE:	108355713 108361049

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:	119611046 119613017

CVJ:	135951932(eya)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ004824 CpipJ_CPIJ004825

CPII:

CBRI:

CNS:

BCOO:

LLL:

PPAP:

TCA:	663237(Eya)

TMOL:

138122738(eya)

DPA:

109542661

ESIM:

136414649(eya)

EFOR:

136342293(eya)

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

DCOR:

135798180(eya)

APLN:

PPYR:

OTU:

CCRN:

API:

DNX:

RMD:

ACOO:

DVT:

BTAB:

DCI:	103510340 103514033

CLEC:

106672869

HHAL:

106683125(eya) 106684002

NLU:

111060571

HVI:

124367822

MQU:	128994506 129004781

PHU:	Phum_PHUM433110

FOC:

TPAL:

ZNE:

CSEC:

PAME:

138696832(eya)

SGRE:

126278064

BROR:

134528587

IEL:

124156504

HAMR:

139694177(eya)

FCD:

110842376

DPX:	DAPPUDRAFT_204955(EYA)

DMK:

116919388

DPZ:

124343958

AFRA:

136033093

PVM:	113804893(eya)

PJA:

122249841

PCHN:

125042370

HAME:

121867102

PCLA:

123749896(eya)

CQD:	128702328(eya)

PTRU:

123504273

ESN:

127007408

MNZ:

135205047

MRJ:	136856149(eya)

PORN:

139765169(eya)

HAZT:

EAF:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

CVS:	136975519 136986458

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_C49A1.4(eya-1)

CBR:	CBG_18807(Cbr-eya-1)

CRQ:	GCK72_001758

NAI:	NECAME_03438

TSP:

Tsp_11674

HRO:	HELRODRAFT_106264

LGI:	LOTGIDRAFT_124788

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OSN:

LJP:

LAK:

SMM:	Smp_173090

OVI:	T265_06655

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_58093

ATH:	AT2G35320(EYA)

ALY:	9298537 9315613

CRB:

17888593

CSAT:

104781932 104786023 104792287

EUS:	EUTSA_v10016981mg

BRP:

103857565

BNA:	106402538 106437850

BOE:

106331612

RSZ:	108830416 130509512

THJ:

104814437

CIT:

102617879

CIC:	CICLE_v10032247mg

PVY:	116146788 116146858

MINC:

123222445

TCC:

18606065

GRA:

105765017

GHI:	107946739 121224299

GAB:

HSYR:

DZI:

EGR:

RARG:

GMX:	100791661 100799315

GSJ:

PVU:

VRA:

VAR:

VUN:

VUM:

CCAJ:

APRC:

MTR:

TPRA:

CAM:

PSAT:

VVO:

LJA:

ADU:

AIP:

AHF:	112707454 112773118

LANG:

109349577

PCIN:

129310576

QSA:	O6P43_033980

FVE:

AANS:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:

MSYL:

PCOX:

ZJU:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

JCU:

HBR:

MESC:

POP:

PEU:	105118019 105121585

PALZ:

PNZ:

JRE:

CILL:

CAVE:

AGLU:

QSU:

QLO:

TWL:

VVI:

VRI:

SLY:

SPEN:

SOT:

SSTN:

SDUL:

CANN:

LBB:

NTA:	107797114 107821111

NSY:

NTO:

NAU:

INI:

ITR:

OEU:

EGT:

SSPL:

SMIL:

SHIS:

APAN:

PEBU:

HAN:

ECAD:

LSV:

CCAV:

DCR:

CSIN:

RVL:

DLT:

BVG:

SOE:

CQI:	110730203 110732520

ATRI:

SLAF:

MOF:

NNU:

MING:

TSS:	122646153 122663716

PSOM:

113302047

OSA:	4339886(OSEYA1)

DOSA:

OBR:

OGL:

BDI:

ATS:

TDC:

TAES:

123088430 123150196 123167450

TUA:

125529770

LPER:

127311638

LRD:	124667532 124684949

SBI:

8068174

ZMA:

100283254

MFLO:

136512710 136516932 136516933

SITA:

SVS:

PVIR:

PHAI:

PAUA:

TANG:

PDA:

EGU:

MUS:

ZOF:	121980612 121987481 122021750 122025483 122051601 122056124

DCT:

PEQ:

AOF:

MSIN:

ACAK:

NCOL:

ATR:

PPP:	112278975 112294285 112294730

VCN:	VOLCADRAFT_96122

SPAR:

SPRG_00515

» show all

Reference

PMID:19055944

Authors

Christensen KL, Patrick AN, McCoy EL, Ford HL

Title

The six family of homeobox genes in development and cancer.

Journal

Adv Cancer Res 101:93-126 (2008)
DOI:10.1016/S0065-230X(08)00405-3

Reference

PMID:10471511

Authors

Xu PX, Adams J, Peters H, Brown MC, Heaney S, Maas R

Title

Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia.

Journal

Nat Genet 23:113-7 (1999)
DOI:10.1038/12722

Sequence

[mmu:14048]

LinkDB

DBGET integrated database retrieval system