KEGG ORTHOLOGY: K16311

ORTHOLOGY: K16311

Entry

K16311                      KO

Symbol

SIK2

Name

serine/threonine-protein kinase SIK2 [EC:2.7.11.1]

Pathway

map04922

Glucagon signaling pathway

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09152 Endocrine system
   04922 Glucagon signaling pathway
    K16311  SIK2; serine/threonine-protein kinase SIK2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K16311  SIK2; serine/threonine-protein kinase SIK2
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K16311  SIK2; serine/threonine-protein kinase SIK2
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K16311  SIK2; serine/threonine-protein kinase SIK2
Protein kinases [BR:ko01001]
Serine/threonine kinases: CAMK group
  CAMKL family
   K16311  SIK2; serine/threonine-protein kinase SIK2
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Centrosome formation proteins
   Kinases and associated factors
    K16311  SIK2; serine/threonine-protein kinase SIK2

Genes

HSA:	23235(SIK2)

PTR:	451540(SIK2)

PPS:	100995431(SIK2)

GGO:	101133594(SIK2)

PON:	100171614(SIK2)

PPYG:

129008918(SIK2)

NLE:	100604913(SIK2)

HMH:	116476924(SIK2)

SSYN:

129479626(SIK2)

MCC:	711453(SIK2)

MCF:	102125528(SIK2)

MTHB:

126935782

MNI:	105493623(SIK2)

CSAB:

103248443(SIK2)

CATY:

105588700(SIK2)

PANU:

101003571(SIK2)

TGE:	112605717(SIK2)

MLEU:

105537398(SIK2)

RRO:	104677338(SIK2)

RBB:	108536464(SIK2)

PTEH:

111540118(SIK2)

CANG:

105501009(SIK2)

CJC:	100395360(SIK2)

SBQ:	101032802(SIK2)

CIMI:

108295459(SIK2)

ANAN:

105729620(SIK2)

CSYR:

103256339(SIK2)

MMUR:

105862926(SIK2)

LCAT:

123641706(SIK2)

PCOQ:

105822254(SIK2)

OGA:	100959358(SIK2)

MMU:	235344(Sik2)

MCAL:

110302128(Sik2)

MPAH:

110328278(Sik2)

RNO:	315649(Sik2)

MCOC:

116073309(Sik2)

ANU:	117699504(Sik2)

ASYL:

127689083(Sik2)

MUN:	110560603(Sik2)

CGE:	100754772(Sik2)

MAUA:

101837051(Sik2)

PROB:

127231726(Sik2)

PLEU:

114690257(Sik2)

MORG:

121438279(Sik2)

MFOT:

126510087

AAMP:

119810131(Sik2)

NGI:	103733890(Sik2)

HGL:	101724122(Sik2)

CPOC:

100718040(Sik2)

CCAN:

109687775(Sik2)

DORD:

105980606(Sik2)

DSP:	122110278(Sik2)

PLOP:

125349566(Sik2)

NCAR:

124958286

MMMA:

107145868(Sik2)

ITI:	101966350(Sik2)

OCU:

100350619

OPI:	101535765(SIK2)

TUP:	102476473(SIK2)

GVR:	103598632(SIK2)

CFA:	489410(SIK2)

CLUD:

112671355(SIK2)

VVP:	112925971(SIK2)

VLG:	121499586(SIK2)

NPO:	129497381(SIK2)

AML:	100481352(SIK2)

UMR:	103662532(SIK2)

UAH:	113260071(SIK2)

UAR:	123792555(SIK2)

ELK:

111153733

LLV:

125078653

MPUF:

101687778(SIK2)

MNP:	132028465(SIK2)

MLK:	131835743(SIK2)

NVS:	122912264(SIK2)

ORO:	101362583(SIK2)

EJU:	114211330(SIK2)

ZCA:	113913853(SIK2)

MLX:	118013219(SIK2)

NSU:	110586117(SIK2)

LWW:	102746795(SIK2)

FCA:	101091894(SIK2)

PYU:	121035372(SIK2)

PCOO:

112865440(SIK2)

PBG:	122482941(SIK2)

PVIV:

125176420(SIK2)

LRUF:

124504616

LGF:	123600641(SIK2)

AJU:

106984438

PTG:	102961815(SIK2)

PPAD:

109278669(SIK2)

PUC:

125909957

PLEZ:

122201055(SIK2)

HHV:	120229914(SIK2)

BTA:	539570(SIK2)

BOM:	102264410(SIK2)

BIU:	109569422(SIK2)

BBUB:

102410525(SIK2)

BBIS:

105005028(SIK2)

CHX:	102175697(SIK2)

OAS:	101107630(SIK2)

BTAX:

128060693(SIK2)

CSUM:

138092927(SIK2)

ODA:	120876224(SIK2)

CCAD:

122450319(SIK2)

MREE:

136174268(SIK2)

OVR:	110130344(SIK2)

MBEZ:

129554316(SIK2)

SSC:	100624404(SIK2)

CFR:	102507370(SIK2)

CBAI:

105080071(SIK2)

CDK:	105094221(SIK2)

VPC:	102545793(SIK2)

BACU:

103002622(SIK2)

BMUS:

118899951(SIK2)

LVE:	103069585(SIK2)

OOR:	101276597(SIK2)

LALB:

132526294(SIK2)

DLE:	111168061(SIK2)

PCAD:

102991842(SIK2)

PSIU:

116757414(SIK2)

NASI:

112405713(SIK2)

ECB:	100070391(SIK2)

EPZ:	103555596(SIK2)

EAI:	106840204(SIK2)

MYB:	102254216(SIK2)

MYD:	102758915(SIK2)

MMYO:

118664326(SIK2)

MLF:	102441528(SIK2)

MDT:	132240538(SIK2)

MYUM:

139017527(SIK2)

PKL:	118713298(SIK2)

EFUS:

103293768(SIK2)

MNA:	107531288(SIK2)

DRO:	112314294(SIK2)

SHON:

119000515(SIK2)

AJM:	119042442(SIK2)

PDIC:

114499531(SIK2)

PHAS:

123818216(SIK2)

MMF:	118627486(SIK2)

PPAM:

129086001(SIK2)

HAI:	109388693(SIK2)

RFQ:	117030067(SIK2)

PALE:

102888580(SIK2)

PGIG:

120621981(SIK2)

PVP:	105295646(SIK2)

RAY:	107521183(SIK2)

MJV:	108409552(SIK2)

TOD:	119240374(SIK2)

SARA:

101558225(SIK2)

SFUM:

130016874(SIK2)

SETR:

126016109(SIK2)

LAV:	100663250(SIK2)

TMU:

101343973

ETF:	101642690(SIK2)

DNM:	101415009(SIK2)

MDO:	100026530(SIK2)

GAS:	123241815(SIK2)

SHR:	100918623(SIK2)

AFZ:

127554974

PCW:	110210694(SIK2)

TVP:	118835823(SIK2)

PBRV:

138155189(SIK2)

OAA:	100090344(SIK2)

TACU:

119934568(SIK2)

GGA:	768557(SIK2)

PCOC:

116233016(SIK2)

MGP:	100542921(SIK2)

CJO:	107324108(SIK2)

TPAI:

128087632(SIK2)

LMUT:

125703599(SIK2)

NMEL:

110387580(SIK2)

APLA:

101794173(SIK2)

ACYG:

106039719(SIK2)

CATA:

118252446(SIK2)

AFUL:

116497901(SIK2)

TGU:	100229187(SIK2)

LSR:	110475966(SIK2)

SCAN:

103823031(SIK2)

PMOA:

120508375(SIK2)

OTC:	121340829(SIK2)

PRUF:

121355737(SIK2)

ATRC:

139600900(SIK2)

GFR:	102045593(SIK2)

FAB:	101812000(SIK2)

OMA:	130262493(SIK2)

PHI:	102114452(SIK2)

PMAJ:

107214348(SIK2)

CCAE:

111939236(SIK2)

CCW:	104692088(SIK2)

CBRC:

103618594(SIK2)

ACOE:

138098398(SIK2)

ETL:	114067817(SIK2)

ZAB:	102066878(SIK2)

ZLE:	135457404(SIK2)

ACHL:

103807758

SVG:	106858179(SIK2)

MMEA:

130586069(SIK2)

HRT:	120762572(SIK2)

SATI:

136371002(SIK2)

CCIC:

134053568(SIK2)

FPG:	101914007(SIK2)

FCH:	102059749(SIK2)

CCRI:

104162370(SIK2)

NNT:	104406792(SIK2)

SHAB:

115616306(SIK2)

ACUN:

113488540(SIK2)

TALA:

104366071(SIK2)

ACHC:

115344466(SIK2)

HALD:

104322578(SIK2)

HLE:	104840497(SIK2)

AGEN:

126038271

HHAR:

128141608(SIK2)

GCL:

127025730

CSTI:

104553833(SIK2)

LDI:	104350542(SIK2)

MNB:	103769798(SIK2)

DPUB:

104303152(SIK2)

PPUS:

135191200(SIK2)

AVIT:

104277247(SIK2)

BRHI:

104502026(SIK2)

EGZ:	104125941(SIK2)

NNI:	104008770(SIK2)

PCRI:

104032101(SIK2)

PCAO:

104049414(SIK2)

PADL:

103921575(SIK2)

AFOR:

103906134(SIK2)

FGA:	104080940(SIK2)

GSTE:

104257191(SIK2)

CBOY:

140661783(SIK2)

CLV:	102091067(SIK2)

MUI:	104543982(SIK2)

PGUU:

104465014(SIK2)

PLET:

104613639(SIK2)

EHS:	104511123(SIK2)

CMAC:

104478583(SIK2)

CUCA:

104067211(SIK2)

TEO:	104382374(SIK2)

BREG:

104637611(SIK2)

OHA:	104336447(SIK2)

ACAR:

104517501(SIK2)

CPEA:

104388552(SIK2)

CVF:	104284153(SIK2)

RTD:	128918705(SIK2)

CRID:

134524893(SIK2)

AAM:	106495795(SIK2)

AROW:

112967477(SIK2)

NPD:	112948712(SIK2)

TGT:	104572273(SIK2)

DNE:	112986523(SIK2)

SCAM:

104141117(SIK2)

ASN:	102374412(SIK2)

AMJ:	102562583(SIK2)

CPOO:

109317946(SIK2)

GGN:	109292835(SIK2)

PSS:	102452516(SIK2)

CMY:	102934919(SIK2)

CCAY:

125625412(SIK2)

DCC:	119846741(SIK2)

CPIC:

101942104(SIK2)

TST:	117868611(SIK2)

CABI:

116829301(SIK2)

MRV:	120375632(SIK2)

ACS:	100553206(sik2)

ASAO:

132782283(SIK2)

PVT:	110078624(SIK2)

SUND:

121934663(SIK2)

PBI:	103052181(SIK2)

PMUR:

107284504(SIK2)

CTIG:

120311271(SIK2)

TSR:	106554247(SIK2)

PGUT:

117670159(SIK2)

APRI:

131203766(SIK2)

PTEX:

113441945(SIK2)

NSS:	113420898(SIK2)

VKO:	123036824(SIK2)

PMUA:

114585767(SIK2)

PRAF:

128402941(SIK2)

ZVI:	118097419(SIK2)

HCG:	128333653(SIK2)

GJA:	107114147(SIK2)

STOW:

125441755(SIK2)

EMC:	129342032(SIK2)

XLA:	100502576(sik2.L) 108697582(sik2.S)

XTR:	100125196(sik2)

NPR:	108793092(SIK2)

RTEM:

120915137(SIK2)

BBUF:

120996516(SIK2)

BGAR:

122926297(SIK2) 122926298

PWL:	138285276(SIK2)

MUO:	115481533(SIK2)

GSH:	117347364(SIK2)

DRE:	567919(sik2b)

SRX:	107709128 107709983 107717286 107745129

SANH:

107657230 107663770 107670961(sik2) 107691747

SGH:	107586235 107600780 107601680 107603193

CCAR:

109081286 109085620 109090649(sik2a) 109103188

CAUA:

113049791(sik2) 113058423 113081906 113115098

CGIB:

127958612 127972777 127994500 128029236

PTET:

122345310(sik2a) 122358370(sik2b)

LROH:

127165439(sik2a) 127176844(sik2b)

OMC:	131541490(sik2a) 131554287(sik2b)

PPRM:

120472216(sik2a) 120478754(sik2b) 120483554

RKG:	130086754(sik2a) 130096715(sik2b)

MAMB:

125248356(sik2b) 125267947(sik2a)

CIDE:

127495001 127513381

CERY:

137005308(sik2b) 137034820(sik2a)

MASI:

127422091 127426823 127429726 127439846

TROS:

130546082(sik2a) 130564672(sik2b)

TDW:	130420166(sik2a) 130428103(sik2b)

MANU:

129437973(sik2b) 129440862(sik2a)

PDAB:

135771135(sik2b) 135774206(sik2a)

IPU:	108260121(sik2a) 108277697(sik2b)

IFU:	128603503(sik2a) 128621468(sik2b)

PHYP:

113531665(sik2) 113532509

SMEO:

124379025(sik2a) 124394496(sik2b)

TFD:	113660432(sik2b) 113663391(sik2a)

TVC:	132841118(sik2a) 132858052(sik2b)

CGAR:

128511792(sik2a) 128533066(sik2b)

NGRA:

132875481(sik2a) 132901445(sik2b)

TRN:	134303414(sik2a) 134334680(sik2b)

AMEX:

103031934(sik2b) 103032550(sik2a)

CMAO:

118800513(sik2b) 118814290(sik2a)

EEE:	113579600 113591350

CHAR:

105903767(sik2b)

SPIL:

134066147(sik2b)

TRU:	101075462(sik2)

TFS:	130535581(sik2b)

TNG:	GSTEN00014865G001

LCO:	104918017(sik2)

NCC:	104965970(sik2)

TBEN:

117470338(sik2b)

CGOB:

115017884(sik2)

PGEO:

117457384(sik2b)

GACU:

117552170(sik2b)

EMAC:

134879859(sik2b)

ELY:	117260142(sik2b)

EFO:	125888414(sik2b)

PLEP:

121943518(sik2b)

SLUC:

116047958(sik2b)

ECRA:

117942410(sik2b)

ESP:	116687131(sik2)

PFLV:

114552291(sik2)

GAT:	120817675(sik2b)

PPUG:

119216676(sik2b)

AFB:	129089804(sik2b)

CLUM:

117741996(sik2b)

PSWI:

130210476(sik2b)

CANA:

137790223(sik2b)

CVE:	137872621(sik2b)

MSAM:

119882310(sik2b)

SCHU:

122879562(sik2b)

CUD:	121521573(sik2b)

SPUL:

138596990(sik2b)

LMIX:

132980435(sik2b)

ALAT:

119030901(sik2b)

ASTR:

137596618(sik2b)

MZE:	101483918(sik2)

ONL:	100695941(sik2)

OAU:	116328171(sik2b)

OLA:	101167310(sik2)

OML:	112149489(sik2b)

CSAI:

133441748(sik2b)

XMA:	102225985(sik2)

XCO:	114161876(sik2)

XHE:	116707846(sik2)

PRET:

103474594(sik2)

PFOR:

103136232(sik2)

PLAI:

106960966(sik2)

PMEI:

106919979(sik2)

GAF:	122833210(sik2b)

PPRL:

129359402(sik2b)

CVG:	107086376(sik2)

CTUL:

119792088(sik2b)

GMU:	124883765(sik2b)

NFU:	107380331(sik2)

KMR:	108243523(sik2b)

ALIM:

106515439(sik2)

NWH:	119410614(sik2b)

AOCE:

111564950(sik2b)

EJA:	138197329(sik2b)

BFRE:

138616282(sik2b)

MCEP:

125013003(sik2b)

CSEM:

103378419(sik2)

POV:	109630352(sik2)

SSEN:

122773862(sik2b)

SSOE:

131462939(sik2b)

HHIP:

117773353(sik2b)

HSP:	118105926(sik2b)

PPLT:

128439878(sik2b)

SMAU:

118299654(sik2b)

LCF:	108886412(sik2b)

SDU:	111228028(sik2)

SLAL:

111655983(sik2)

XGL:	120791674(sik2b)

HCQ:	109526400(sik2)

SSCV:

125972772(sik2b)

SBIA:

133505156(sik2b)

PEE:	133404721(sik2b)

PTAO:

133481990(sik2b)

BPEC:

110154145(sik2)

ENY:	140377690(sik2b)

MALB:

109960186(sik2)

BSPL:

114867940(sik2b)

SJO:	128360182(sik2b)

SSCO:

133980937(sik2b)

GMH:	115560895(sik2)

SASA:

106612460(sik2)

STRU:

115162919 115205878

OTW:	112265055(sik2b) 112266710

OMY:	110503529 110507361(sik2b)

OGO:	123993116(sik2b) 124005622

ONE:	115137137 115141478

OKI:	109905371 109908855

OKE:	118386570 118397074(sik2b)

OMM:	135546048 135552518(sik2b)

OCLA:

139382263 139385646

SALP:

111949358 111960565

SNH:	120018433(sik2b) 120028324

CCLU:

121561148(sik2b) 121567337

ELS:	105011491(sik2)

OEP:	134029154(sik2b)

SFM:	108928736 108936192(sik2)

PKI:	111844795(sik2) 111851375

AANG:

118209777(sik2b) 118236418

AROT:

135235481(sik2b) 135263228

CCOG:

133107800(sik2b) 133133935(sik2a)

LOC:	102698176(sik2)

PSPA:

121303967

ARUT:

117397458 117966527

PSEX:

120535840

LCM:	102366218(SIK2)

CMK:	103187705(sik2b)

RTP:	109912894(sik2a)

CPLA:

122540645(sik2a)

HOC:	132829485(sik2a)

LERI:

129712340(sik2a)

PMRN:

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

DME:	Dmel_CG4290(Sik2)

DER:

6555562

DSE:

6616076

DSI:	Dsimw501_GD24618(Dsim_GD24618)

DYA:	Dyak_GE16985

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI15425

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:

MDE:

LCQ:

LSQ:

CVJ:	135958603(Sik2)

GFS:

ECOE:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

ACOS:

CBRI:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

TLN:

HST:

DQU:

CFO:

FEX:

PMEC:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

CINS:

VCAN:

CCIN:

AROA:

TCA:

TMOL:

DPA:

ESIM:

EFOR:

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_206646

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PXU:

BPHI:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

PHU:	Phum_PHUM287820

FOC:

TPAL:

ZNE:

CSEC:

PAME:

SGRE:

BROR:

IEL:

HAMR:

139688359(Sik2)

FCD:

DMK:

DPZ:

PJA:

PCHN:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

MRJ:

PORN:

EAF:

LSM:	121128474 121128997

DSV:

RSAN:

RMP:

CSCU:

CVS:	136975885 136981406

LPOL:

106464977 106467797 106478581

PMEO:

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

HMG:

HSY:

RES:

Reference

PMID:12624099

Authors

Horike N, Takemori H, Katoh Y, Doi J, Min L, Asano T, Sun XJ, Yamamoto H, Kasayama S, Muraoka M, Nonaka Y, Okamoto M

Title

Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2.

Journal

J Biol Chem 278:18440-7 (2003)
DOI:10.1074/jbc.M211770200

Sequence

[mmu:235344]

LinkDB

DBGET integrated database retrieval system