KEGG ORTHOLOGY: K18182

ORTHOLOGY: K18182

Entry

K18182                      KO

Symbol

COX16

Name

cytochrome c oxidase assembly protein subunit 16

Pathway

map04714

Thermogenesis

Disease

H01368

Cytochrome c oxidase (COX) deficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09159 Environmental adaptation
   04714 Thermogenesis
    K18182  COX16; cytochrome c oxidase assembly protein subunit 16
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis
    K18182  COX16; cytochrome c oxidase assembly protein subunit 16
Mitochondrial biogenesis [BR:ko03029]
Mitochondrial quality control factors
  Mitochondrial respiratory chain complex assembly factors
   Complex-IV assembly factors
    K18182  COX16; cytochrome c oxidase assembly protein subunit 16

Genes

HSA:	51241(COX16)

PTR:	101057907(COX16)

PPS:

103787041

GGO:

101152596

PON:	100172069(COX16)

PPYG:

129012084

NLE:

100605313

HMH:	116456346 116478797

SSYN:

129487716

MCC:	100428036(COX16)

MCF:

102115550

MTHB:

126958789

MNI:

105472917

CSAB:

103229262(COX16)

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:

CIMI:

ANAN:

CSYR:

MMUR:

LCAT:

OGA:

MMU:	66272(Cox16)

MCAL:

110307056

MPAH:

110324383

RNO:	100302447(Cox16)

MCOC:

ANU:

ASYL:

MUN:

CGE:

MAUA:

PLEU:

MORG:

MFOT:

AAMP:

NGI:

HGL:

CPOC:

CCAN:

DORD:

DSP:

PLOP:

NCAR:

MMMA:

ITI:

OCU:

OPI:

TUP:

GVR:

CFA:

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:	113908961 113923878

MLX:	118017768 118018528

NSU:

110571618

LWW:

102733173

FCA:	101081902(COX16)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

LGF:

AJU:

PTG:

PPAD:

PUC:

PLEZ:

HHV:

BTA:	615979(COX16)

BOM:	102269677(COX16)

BIU:

BBUB:

BBIS:

CHX:

OAS:

BTAX:

CSUM:

138073996(COX16)

ODA:	120852761 120874322

CCAD:

122443808

MREE:

136171709(COX16)

OVR:	110125581 110130477(COX16)

MBEZ:

SSC:

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

LALB:

DLE:

PCAD:

PSIU:

NASI:

ECB:

EPZ:	103562247(COX16)

EAI:

MYB:

MYD:

MMYO:

MLF:

MDT:

MYUM:

139012029(COX16)

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

TOD:

SARA:

SFUM:

SETR:

LAV:

TMU:

ETF:

DNM:

MDO:

GAS:

SHR:

AFZ:

PCW:

TVP:

PBRV:

138164191(COX16)

OAA:

100090298

TACU:

119944515

GGA:	423257(COX16)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

106042267(COX16)

CATA:

118244500

AFUL:

116489554

TGU:

100224867

LSR:	110476078(COX16)

SCAN:

PMOA:

OTC:

PRUF:

FAB:

OMA:

PHI:

PMAJ:

CCAE:

CCW:

CBRC:

ACOE:

138111551(COX16)

ETL:

ZAB:

ZLE:

ACHL:

SVG:

MMEA:

HRT:

SATI:

136362623(COX16)

CCIC:

FPG:

FCH:

CCRI:

SHAB:

ACUN:

TALA:

ACHC:

HALD:

HLE:

AGEN:

HHAR:

GCL:

CSTI:

LDI:

MNB:

PPUS:

AVIT:

BRHI:

EGZ:

PADL:

AFOR:

FGA:

GSTE:

CLV:

MUI:

PLET:

EHS:

CMAC:

TEO:

BREG:

RTD:

CRID:

AAM:

AROW:

NPD:

TGT:

DNE:

SCAM:

ASN:

AMJ:	102576688(COX16)

CPOO:

GGN:

PSS:

CMY:

CCAY:

DCC:

CPIC:

TST:

CABI:

MRV:

ACS:

ASAO:

PVT:

PBI:

PMUR:

CTIG:

PGUT:

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:

STOW:

EMC:

XLA:	733273(cox16.L)

XTR:	100379706(cox16)

RTEM:

120921201

BBUF:

120982458

BGAR:

122921470

PWL:	138299115(COX16)

MUO:

115477628

GSH:

117363412

DRE:	550257(cox16)

SRX:	107705430 107739882

SANH:

107654922 107683441

SGH:	107553204 107577367 107602960

CCAR:

CAUA:

CGIB:

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

CIDE:

CERY:

137020169(cox16)

MASI:

TROS:

TDW:

MANU:

PDAB:

IPU:

PHYP:

SMEO:

TFD:

TVC:

CGAR:

NGRA:

TRN:

AMEX:

CMAO:

EEE:

CHAR:

SPIL:

TRU:

TFS:

TNG:	GSTEN00035803G001

LCO:

104929781

TBEN:

117481421

CGOB:

115027795

PGEO:

117467308(cox16)

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

GAT:

PPUG:

AFB:

CLUM:

PSWI:

CANA:

137788190(cox16)

CVE:	137880370(cox16)

MSAM:

119910255

SCHU:

122862163

SPUL:

138591744(cox16)

LMIX:

132960303

ALAT:

119034502

ASTR:

137611020(cox16)

MZE:

ONL:

OAU:

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:

ALIM:

NWH:

AOCE:

EJA:	138204945(cox16)

BFRE:

138632258(cox16)

MCEP:

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

125981126(cox16)

SBIA:

133513545

PEE:

133413111

PTAO:

133487479

ENY:	140370301(cox16)

MALB:

BSPL:

SJO:

SSCO:

GMH:

SASA:

106611490(CN112)

STRU:

115191292

OTW:

121846878

OMY:	100305264(cn112)

OGO:

OKI:

OKE:

OMM:

OCLA:

CCLU:

ELS:

OEP:

SFM:

PKI:

AANG:

AROT:

CCOG:

LOC:

PSPA:

ARUT:

PSEX:

LCM:

CPLA:

HOC:

LERI:

PMRN:

LRJ:

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

DME:	Dmel_CG14865(l(3)neo43)

DER:

6553168

DSE:

6606288

DSI:	Dsimw501_GD20364(Dsim_GD20364)

DYA:	Dyak_GE26392

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI24662

DAZ:

108610989

DNV:

108650994

DHE:

111603029

DVI:	6630102(l(3)neo43)

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:	119664183 119683287

MDE:

SCAC:

LCQ:

LSQ:

CVJ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ003566

CPII:

CNS:

BCOO:

LLL:

PPAP:

AME:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

139105844(L(3)neo43)

TLN:	139816115(L(3)neo43)

HST:

DQU:

CFO:

FEX:

PMEC:

138941529(L(3)neo43)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

CSOL:

TPRE:

LHT:

LBD:

MDL:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:	124220959(l(3)neo43)

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

138128633(l(3)neo43)

DPA:

109539732

ESIM:

136411992(l(3)neo43)

EFOR:

136341215(l(3)neo43)

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:	108906532 111692790

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_202510

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

BPHI:

137923391(l(3)neo43)

PRAP:

PBX:

PNAP:

CCRC:

LSIN:

AAGE:

HAW:	110384320(L(3)neo43)

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PGW:

LGLY:

CSTB:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106684087(l(3)neo43)

NLU:	111055603 120353088

HVI:

MQU:

FOC:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

HAMR:

139695020(l(3)neo43)

FCD:

110846081

DPX:	DAPPUDRAFT_39440

DMK:

116919755

DPZ:

124341919

PVM:	113825965(l(3)neo43)

PJA:

122267236

PCHN:

125032133

HAME:

121869572

PCLA:

123769841(l(3)neo43)

PTRU:

123501655

MNZ:

135213371

MRJ:	136836362(l(3)neo43)

PORN:

139761091(l(3)neo43)

TCF:

PPOI:

DSV:

RMP:

VDE:

VJA:

DPTE:

DFR:

CVS:	136984615(l(3)neo43)

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

LOA:	LOAG_06049

LGI:	LOTGIDRAFT_233255

PCAN:

BGT:

GAE:

HRF:

HASI:

HCRA:

CRG:

CANU:

PMAX:

AIRR:

OBI:

OSN:

LJP:

LLON:

NVE:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

DGT:

XEN:

HSY:

RES:

ATH:

ALY:

CRB:

CSAT:

104719041 104723813 104732263 104774868

EUS:	EUTSA_v10026557mg

BRP:	103833792 103835187

BNA:	106361553 106389751 106397589 106415793

BOE:	106308018 106332608

RSZ:	108821081 108822248 108838287

THJ:

104808680

CIT:

102609682

CIC:	CICLE_v10033053mg

PVY:

MINC:

TCC:

GRA:

GHI:

GAB:

HSYR:

120119293 120147121 120196144

DZI:	111293688 111310319

EGR:

104421785

RARG:

115755320

GMX:	100814113 100817712

GSJ:	114370436 114402601

PVU:

137827681

VRA:

106771439

VAR:

108325304

VUN:	114163380 114184927 114191761

VUM:

CCAJ:

APRC:

MTR:

TPRA:

CAM:

PSAT:

VVO:	131641076 131643743

LJA:

130721286

ADU:

107467939

AIP:	107607127 107613295 107619449

AHF:	112703008 112712610 112763138 112770638 112776413

LANG:

109363272

PCIN:

129311086

QSA:	O6P43_005028

FVE:

AANS:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:

MSYL:

PXB:

PCOX:

ZJU:

MNT:

CSAV:

CSV:

CMO:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

MEAN:

JCU:

HBR:

MESC:

POP:

PEU:

PALZ:

PNZ:

JRE:

CILL:

CAVE:

AGLU:

QSU:

QLO:	115955606 115984349

TWL:

VVI:

VRI:

SLY:

SPEN:

SOT:

SSTN:

SDUL:

CANN:

LBB:

NTA:

NSY:	104215297 104225720

NTO:

104114221

NAU:	109215178 109234391

INI:	109156762 109190555

ITR:	116021918 116024041

SIND:

105161328

OEU:	111372196 111402179

EGT:	105955400 105973443

SSPL:

SMIL:

SHIS:

APAN:

HAN:	110873312 110878722

ECAD:

122582345

LSV:	111884693 111899397

CCAV:

DCR:

CSIN:

RVL:

AEW:	130752808 130760083

BVG:

104899659

SOE:

110787183

CQI:	110688002 110726684

ATRI:

MOF:

NNU:

MING:

TSS:

PSOM:

OSA:

DOSA:

OBR:

OGL:

BDI:

TDC:

TAES:

123085555 123092489 123097801

TUA:

LPER:

LRD:

SBI:

ZMA:

MFLO:

136496597 136500949 136535885 136540143

SITA:

101766634 101767183

SVS:	117839018 117852574

PVIR:

PHAI:

PAUA:

PDA:

EGU:

ZOF:	121989549 121998484

DCT:

PEQ:

MSIN:

ACAK:

ATR:

CJF:

SMO:	SELMODRAFT_117345 SELMODRAFT_132552 SELMODRAFT_132707

PPP:

112282419

CVR:	CHLNCDRAFT_143713

APRO:

F751_3445

OLU:	OSTLU_28728

OTA:	OT_ostta01g01190

BPG:	Bathy01g01070

MIS:	MICPUN_57285

MPP:	MICPUCDRAFT_54273

CME:	CYME_CMQ318C

GSL:	Gasu_20000

CCP:	CHC_T00002524001

SCE:	YJL003W(COX16)

SEUB:

DI49_3014

SPAO:

SPAR_J01870

AGO:	AGOS_AAL168C

ERC:

Ecym_8280

KLA:	KLLA0_F13024g

KMX:	KLMA_20116(COX16)

LTH:	KLTH0B03190g

VPO:	Kpol_534p54

ZRO:	ZYRO0B10230g

CGR:	2886982(GVI51_D03047)

NCS:	NCAS_0D02790(NCAS0D02790)

NDI:	NDAI_0I02110(NDAI0I02110)

TPF:	TPHA_0N00710(TPHA0N00710)

TBL:	TBLA_0C06170(TBLA0C06170)

TGB:	HG536_0E04270

TDL:	TDEL_0E04170(TDEL0E04170)

KAF:	KAFR_0J01040(KAFR0J01040)

KNG:	KNAG_0M01690(KNAG0M01690)

ZMK:	HG535_0A05310

SLUD:

SCDLUD_002130

DHA:	DEHA2A13442g

PIC:	PICST_53528(COX16)

PGU:	PGUG_01097

SPAA:

SPAPADRAFT_133396

LEL:	PVL30_002322(COX16)

LBG:	92207236(LODBEIA_P20400)

CAL:	CAALFM_CR10760CA(CaO19.7665)

CTP:	CTRG_02351

COT:	CORT_0D00110

CDU:	CD36_35526

CTEN:

18247399(COX16)

CLU:	CLUG_03456

CLUS:

A9F13_01g07260

CAUR:

CJI96_0003108

ASAU:

88175842(PUMCH_004782)

PKZ:	C5L36_0A04850

BNN:	FOA43_003273

BBRX:

BRETT_004116

OPA:	HPODL_02259

YLI:	2909796(YALI2_C00185g)

NCR:

NCU00641

NTE:	NEUTE1DRAFT126882(NEUTE1DRAFT_126882)

SMP:	10810120(SMAC4_01323)

PAN:	PODANSg3903

PBEL:

QC761_114380(COX16)

PPSD:

QC762_114380(COX16)

PPSP:

QC763_114380(COX16)

PPSA:

QC764_114380(COX16)

TTT:	THITE_2170062

MTM:	MYCTH_2313902

CTHR:

CTHT_0014460

RTHE:

98124967(VTJ83DRAFT_3895)

MGR:

PPEI:

PGRI:

SSCK:

FGR:	FGSG_06413

FPU:	FPSE_12317

FPOA:

FPOAC1_009412(COX16)

FVN:	FVRRES_10049

FVR:	FVEG_06467

FOX:	FOXG_08201

NHE:	NECHADRAFT_41129

FFC:	NCS54_00730000

FKR:	NCS57_00770300

FMU:	J7337_004325(COX16)

TRE:	TRIREDRAFT_4901

TRR:	M419DRAFT_131634

TATV:

25776481(TrAtP1_012953)

TASP:

36608353(COX16)

MAW:	19251198(COX16_2)

MAJ:

MAA_01051

MBRN:

26244324(COX16)

PCHM:

VFPPC_09996

AMUS:

LMH87_011204

PLJ:	28888250(PLICBS_003453)

PTKZ:

JDV02_000390(COX16)

VAL:	VDBG_02212

VDA:	VDAG_02683

CFJ:	CFIO01_12524

CLUP:

CLUP02_08946

CHIG:

CH63R_07351

CDET:

87944540(CDEST_08037)

SAPO:

SAPIO_CDS10104

PFY:	PFICI_02338

SSL:	SS1G_11598

BFU:	BCIN_08g06260

MBE:

MBM_07508

PSCO:

LY89DRAFT_701352

GLZ:	GLAREA_02828

ANI:	ANIA_10871 ANIA_10881

ACT:	ACLA_053630

NFI:	NFIA_028620

AOR:	AO090206000015

AFV:	AFLA_013010

ALUC:

AKAW2_40700S(COX16)

ACHE:

ACHE_31028S(COX16)

APUU:

APUU_80642S(COX16)

PDP:	PDIP_14840

POU:	POX_b02156

TMF:	EYB26_004654

TRG:	TRUGW13939_02018

CIM:	CIMG_08520

CPW:	9695949(COX16)

URE:	UREG_02586

ABE:

ARB_06010

PBL:	PAAG_01488

PBN:	PADG_00294

AJE:	HCAG_07668

BGH:	BDBG_09152

PNO:	SNOG_08351

PTE:

PTT_05760

PTRR:

6346442(PtrM4_151080)

BZE:	COCCADRAFT_86727

BSC:	COCSADRAFT_174147

BOR:	COCMIDRAFT_82336

AALT:

CC77DRAFT_1017728

ADAC:

96081546(ACET3X_001224)

ARAB:

EKO05_0004834

ZTR:	MYCGRDRAFT_56211

PFJ:	MYCFIDRAFT_87555

FFU:	CLAFUR5_10582

CBET:

CB0940_06201

TML:	GSTUM_00012055001

SPO:	2541594(cox16)

SOM:	SOMG_00342(cox16)

CNE:

CNI00260

CNB:

CNBH0260

CNG:	CNAG_04529

CGI:	CGB_H0650W

CDEU:

CNBG_2541

CDEP:

91087136(L203_102925)

KMG:	30163905(I203_103815)

KNE:	92179208(IAR55_001949)

TMS:	TREMEDRAFT_41164

TASA:

A1Q1_00462

CCAC:

CcaHIS019_0107800(COX16)

PPL:	POSPLDRAFT_38139

TVS:	TRAVEDRAFT_156938

PCO:	PHACADRAFT_194964

SHS:	STEHIDRAFT_128538

HIR:	HETIRDRAFT_44056(lep8)

PSQ:	PUNSTDRAFT_71377

ADL:	AURDEDRAFT_54831

GTR:	GLOTRDRAFT_71677

RSX:	RhiXN_02650

CCI:	CC1G_10073

ABP:	AGABI1DRAFT16423(AGABI1DRAFT_16423)

ABV:	AGABI2DRAFT205247(AGABI2DRAFT_205247)

PCUB:

JR316_0003991

MPR:	MPER_09212

MRR:	Moror_11741

E1B28_003305

CPUT:

CONPUDRAFT_114275

SLA:	SERLADRAFT_476383

WSE:	WALSEDRAFT_68788

UMA:	UMAG_05870

PFP:	PFL1_02460

PGR:	PGTG_07857 PGTG_20169

PTRC:

PtA15_3A844

PSTR:

Pst134EA_006824 Pst134EA_032004

MLR:	MELLADRAFT_36450

RIE:	OCT59_018418

SRE:	PTSG_00364

DDI:	DDB_G0280129

ACAN:

ACA1_287230

PIF:	PITG_00724

SPAR:

SPRG_03338

EHX:	EMIHUDRAFT_232823

GTT:	GUITHDRAFT_149818

» show all

Reference

PMID:12446688

Authors

Carlson CG, Barrientos A, Tzagoloff A, Glerum DM

Title

COX16 encodes a novel protein required for the assembly of cytochrome oxidase in Saccharomyces cerevisiae.

Journal

J Biol Chem 278:3770-5 (2003)
DOI:10.1074/jbc.M209893200

Sequence

[sce:YJL003W]

LinkDB

DBGET integrated database retrieval system