KEGG   ORTHOLOGY: K25060
Entry
K25060                      KO                                     
Symbol
CYP87D18_20
Name
cucurbitadienol 11-hydroxylase / 11-oxocucurbitadienol 20-hydroxylase [EC:1.14.14.71 1.14.14.-]
Pathway
map00996  Biosynthesis of various alkaloids
map01110  Biosynthesis of secondary metabolites
Reaction
R12007  cucurbitadienol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (11-oxocucurbitadienol forming)
R12831  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00996 Biosynthesis of various alkaloids
    K25060  CYP87D18_20; cucurbitadienol 11-hydroxylase / 11-oxocucurbitadienol 20-hydroxylase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K25060  CYP87D18_20; cucurbitadienol 11-hydroxylase / 11-oxocucurbitadienol 20-hydroxylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.71  cucurbitadienol 11-hydroxylase
     K25060  CYP87D18_20; cucurbitadienol 11-hydroxylase / 11-oxocucurbitadienol 20-hydroxylase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, plant type
  CYP87 family
   K25060  CYP87D18_20; cucurbitadienol 11-hydroxylase / 11-oxocucurbitadienol 20-hydroxylase
Genes
CSV: 101213710
CMO: 103482802
BHJ: 120083895
CMAX: 111490271
CMOS: 111457186
CPEP: 111802347
AG: AEM42986(CYP87D18)
Reference
PMID:26903528 (CYP87D18)
  Authors
Zhang J, Dai L, Yang J, Liu C, Men Y, Zeng Y, Cai Y, Zhu Y, Sun Y
  Title
Oxidation of Cucurbitadienol Catalyzed by CYP87D18 in the Biosynthesis of Mogrosides from Siraitia grosvenorii.
  Journal
Plant Cell Physiol 57:1000-7 (2016)
DOI:10.1093/pcp/pcw038
  Sequence
Reference
PMID:27892922 (CYP87D20)
  Authors
Zhou Y, Ma Y, Zeng J, Duan L, Xue X, Wang H, Lin T, Liu Z, Zeng K, Zhong Y, Zhang S, Hu Q, Liu M, Zhang H, Reed J, Moses T, Liu X, Huang P, Qing Z, Liu X, Tu P, Kuang H, Zhang Z, Osbourn A, Ro DK, Shang Y, Huang S.
  Title
Convergence and divergence of bitterness biosynthesis and regulation in Cucurbitaceae.
  Journal
Nat Plants 2:16183 (2016)
DOI:10.1038/nplants.2016.183
  Sequence
[csv:101213710]
LinkDB

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