Klebsiella pneumoniae blaNDM-1: FH42_21270
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Entry
FH42_21270 CDS
T03440
Symbol
murF
Name
(GenBank) UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
KO
K01929
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:
6.3.2.10
]
Organism
kpb
Klebsiella pneumoniae blaNDM-1
Pathway
kpb00300
Lysine biosynthesis
kpb00550
Peptidoglycan biosynthesis
kpb01100
Metabolic pathways
kpb01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
kpb00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
FH42_21270 (murF)
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
FH42_21270 (murF)
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
FH42_21270 (murF)
Enzymes [BR:
kpb01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
FH42_21270 (murF)
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Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Mur_ligase
YAcAr
LpxD
Motif
Other DBs
NCBI-ProteinID:
AIJ43163
UniProt:
A0A081M2L4
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Position
4395975..4397333
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AA seq
452 aa
AA seq
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MIRFTLSQLAAIAHGERQGSDVAIDEVTTDTRKVTAGCLFVALKGERFDAHDFAEQAKAA
GAGALLVSRPLACDLPQVIVNDTRQAFGELAAWVRQHVPTRVVALTGSSGKTSVKEMTAA
ILSQCGNTLYTAGNLNNDIGVPMTLLRLTKEHQYAVIELGANHQGEIAWTVSLTRPEAAL
VNNLAAAHLEGFGSLAGVAKAKGEIYTGLPENGIAILNADNNDWLNWQAVIGDRKVWRFS
PNAANSDFTATNVQITSHGTEFTLQTPTGNVDVLLPLPGRHNIANALAATSLAMAVGADL
AAVKAGLAQLQAVPGRLFPIRLTESQLLLDDSYNANVGSMTAAVQVLSEMPGFRTMVVGD
MAELGAESAACHREVGEAAKAAGLDCVLSVGALSADISRASGVGEHFNDKAAVVARLREL
LAEHKIMTILVKGSRSAAMEEVVRALQETGTC
NT seq
1359 nt
NT seq
+upstream
nt +downstream
nt
atgattcgctttacgttaagtcaacttgccgcgatcgcccatggcgaacggcagggtagc
gatgtcgctatcgacgaggtgaccaccgatacccgtaaagtgacggcgggctgcctgttt
gtggcgctgaaaggggagcgtttcgacgcccatgattttgccgaacaggcgaaagcggcg
ggcgccggcgcgctgctggtgagtcgtccgctggcctgcgatctcccgcaggtgattgtg
aacgatacccggcaggctttcggtgagttagccgcctgggtgcgtcagcatgtgccgact
cgcgtcgtcgccctgaccggctcgtccggtaaaacctcggttaaagagatgaccgcggcg
atcctcagccagtgcggcaacacgctgtataccgccggcaacctgaacaacgatatcggc
gtcccgatgacgctactgcggctgaccaaagagcatcagtacgcggtgatcgaactcggc
gccaaccaccagggcgaaatcgcctggaccgtcagcctgacgcgtccggaagcggcgctg
gtcaacaaccttgctgcggcgcacctggaaggtttcggttcgctggcgggcgtggcgaag
gcgaagggcgaaatctataccggtctgccggaaaatggcatcgccatcctcaatgccgac
aataacgactggctgaactggcaggcggtgattggcgatcgcaaagtgtggcgcttctcg
ccgaacgcggcgaacagcgatttcacggcgaccaacgtgcagatcactagccacggcacc
gaatttacgctgcagaccccaaccggcaacgttgacgtactgctgccgctgccgggacgc
cacaacatcgctaatgcgctggccgccacttcgctggcgatggcggtaggcgccgatttg
gcggcggtgaaagccggactggcgcagctgcaggccgttccgggacgtctgttcccgatc
cggctgaccgagagccagctgctgctggatgattcctataacgctaacgttggttcgatg
accgcggcggtgcaggtgctgtcagagatgcccggctttcgcacgatggtggtcggcgat
atggcagagcttggcgcggagagcgcggcctgccatcgcgaagtcggcgaagcggcgaaa
gcggcgggtctggattgcgtcctcagcgtcggtgccttgagcgcggatatcagccgcgcc
agcggcgtgggcgaacattttaacgataaagccgccgtggtggctcgcctgcgcgagctg
ctggcggagcacaaaataatgaccattttagtgaagggttcacgtagtgccgccatggaa
gaggtagtacgcgcattacaggagactgggacatgttag
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