Klebsiella pneumoniae subsp. pneumoniae KPNIH24: KPNIH24_03640
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Entry
KPNIH24_03640 CDS
T03369
Symbol
thrA
Name
(GenBank) aspartate kinase
KO
K12524
bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:
2.7.2.4
1.1.1.3
]
Organism
kph
Klebsiella pneumoniae subsp. pneumoniae KPNIH24
Pathway
kph00260
Glycine, serine and threonine metabolism
kph00261
Monobactam biosynthesis
kph00270
Cysteine and methionine metabolism
kph00300
Lysine biosynthesis
kph01100
Metabolic pathways
kph01110
Biosynthesis of secondary metabolites
kph01120
Microbial metabolism in diverse environments
kph01230
Biosynthesis of amino acids
Module
kph_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
kph_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
kph_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
kph00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
KPNIH24_03640 (thrA)
00270 Cysteine and methionine metabolism
KPNIH24_03640 (thrA)
00300 Lysine biosynthesis
KPNIH24_03640 (thrA)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
KPNIH24_03640 (thrA)
Enzymes [BR:
kph01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
KPNIH24_03640 (thrA)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
KPNIH24_03640 (thrA)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Homoserine_dh
AA_kinase
ACT_9
NAD_binding_3
ACT_7
ACT
DUF6247
Motif
Other DBs
NCBI-ProteinID:
AID94337
LinkDB
All DBs
Position
752482..754944
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AA seq
820 aa
AA seq
DB search
MRVLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNHLVAMIEKTIGGQDA
LPNIADAERIFAELLQGLADAQPAFPLAQLKAFVEQEFAQIKHVLHGISLLGQCPDSVNA
ALICRGEKLSIAIMAGLLEARGHKVSVINPVEKLLAVGHYLESTVDIAESTRRIAASQIP
ADHMILMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRQV
PDARLLKSMSYQEAMELSYFGAKVLHPRTIAPIAQFQIPCLIKNTGNPQAPGTLIGASRD
EDDLPVKGISNLNNMAMFNVSGPGMKGMVGMAARVFATMSRAGISVVLITQSSSEYSISF
CVPQSDCARAKRAMEDEFYLELKEGLLEPLAIMERLAIISVVGDGMRTLRGISAKFFAAL
ARANINIVAIAQGSSERSISVVVSNDDATTGVRVTHQMLFNTDQVIEVFVIGVGGVGGAL
LEQIKRQQGWLKNKHIDLRVCGVANSQALLTSVHGLNLENWSAELAEAKEPFNLGRLIRL
VKEYHLLNPVIVDCTSSQAVADQYADFLREGFHVVTPNKKANTSSLDYYHQLRHAASSSR
RKFLYDTNVGAGLPVIENLQNLLNAGDELRHFSGILSGSLSFIFGKLDEGVSFSAATAMA
REMGYTEPDPRDDLSGVDVARKLLILARETGRELELADIIVESALPPDFDASGDVETFMA
RLPSLDDGFASRVAKARDEGKVLRYVGNIEEDGTCRVKIAAVDGNDPLFKVKNGENALAF
YSHYYQPLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV
NT seq
2463 nt
NT seq
+upstream
nt +downstream
nt
atgcgagtgttgaagttcggcggtacatcagtggcaaatgcggaacggtttctgcgggtt
gccgatattctggagagtaatgccaggcaggggcaggtagcgacggtcctgtctgccccg
gcgaagatcactaaccacctggtagcgatgattgaaaagaccattggcggccaggatgcc
ctccccaatattgccgacgccgaacgcatttttgccgaacttcttcagggccttgccgac
gcccagcccgctttcccgcttgcccagttaaaagccttcgtggagcaggaatttgctcag
attaagcatgttctgcacggcatcagcctgctgggtcagtgcccggacagcgtcaatgcc
gcgctgatctgccgcggcgaaaagctctccatcgccatcatggcgggtctgctggaagcc
cgtggacataaagtcagtgtcattaacccggtcgaaaaactgctcgccgtgggtcactat
ctggaatccaccgtcgatatcgccgaatccacccgccgcattgccgccagccagatcccg
gcagaccatatgatcctgatggccgggtttaccgccggcaatgagaaaggcgagctggtg
gtgctgggacgtaacggctccgactactcggctgcggtactggccgcctgcctgcgcgct
gactgctgcgaaatctggaccgatgtcgacggagtgtacacctgcgatccgcgtcaggtg
ccggatgcgcgcctgctgaaatcgatgtcttatcaggaggcgatggagctctcctacttt
ggcgcgaaagtgctgcacccgcgcaccatcgcccctatcgcccagttccaaatcccatgc
ctgattaaaaataccggcaacccacaggcgccgggaacgcttatcggcgccagccgcgac
gaggacgatttgccggtgaaaggcatctctaacctcaacaacatggcgatgttcaacgtc
tccgggccggggatgaaagggatggtcggcatggcggcccgcgtcttcgccaccatgtcc
cgcgccggcatctcggtggtgttgatcactcaatcttcttcggagtacagcatcagtttc
tgcgtgccgcagagcgactgcgcacgtgccaaacgggcgatggaagatgagttttatctg
gagctgaaagaggggctgctggagccgctggcgattatggagcgtctggcgatcatctcc
gtggtgggcgacggaatgcgtaccctgcgcggtatctcggcgaaattctttgcggcactg
gcccgcgccaatatcaatatcgtggcgattgcccagggctcttccgagcgctcaatttcg
gtagtggtcagcaatgacgacgccaccaccggcgtgcgcgtgacccatcagatgctgttc
aacaccgaccaggtgattgaagtgtttgtcatcggcgtcggcggcgtcggcggcgcgctg
ctagagcagatcaagcgccagcaggggtggctgaagaacaaacatatcgatctgcgcgtc
tgcggtgtagccaattctcaggcgctgctgaccagcgtgcatggcctgaatctggaaaac
tggagtgcggaactggcggaggcgaaagagccgtttaatcttggccgcctgatccgcctg
gtgaaagagtaccacctgctcaatccggtgatcgtcgactgtacctccagccaggcggtc
gccgatcagtatgccgacttcctgcgcgaaggtttccatgtggtgacgccgaacaaaaag
gccaatacctcttcgctggattactatcaccagctgcgccatgcggccagcagctcgcgg
cgtaagttcctctatgacactaacgttggcgcgggcctgccggtgattgagaacctgcag
aacctgctcaacgccggcgatgagctgcgccatttctccgggatcctgtccggctccctg
tcgtttatcttcggcaagctggacgagggggtgagtttctccgcggcgacggcgatggcc
cgtgagatggggtataccgagccggatccgcgcgacgatttatccggggtggatgtggcg
cgtaaactgctgattctggcccgcgagaccgggcgtgaactggagctggcggacattatc
gtcgagtcggcgctgccgccggacttcgacgccagcggcgatgtcgagacctttatggcc
cgcctgccgtcgctggatgatggttttgcctcgcgggttgctaaggcgcgcgatgaaggt
aaagtcttgcgctacgtcggtaacatcgaagaggatggtacctgccgggtaaaaatagcc
gcggttgacggcaacgatccgctgttcaaagttaagaatggtgagaacgcgctggctttt
tatagccattattatcagccattgccgctggtgctgcgcggctatggcgccgggaacgac
gtcacggcggccggcgtattcgccgacctgctgcgcaccctgtcctggaagttaggagtt
taa
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