Klebsiella pneumoniae subsp. pneumoniae MGH 78578 (serotype K52): KPN_00080
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Entry
KPN_00080 CDS
T00566
Symbol
leuA
Name
(GenBank) 2-isopropylmalate synthase
KO
K01649
2-isopropylmalate synthase [EC:
2.3.3.13
]
Organism
kpn
Klebsiella pneumoniae subsp. pneumoniae MGH 78578 (serotype K52)
Pathway
kpn00290
Valine, leucine and isoleucine biosynthesis
kpn00620
Pyruvate metabolism
kpn01100
Metabolic pathways
kpn01110
Biosynthesis of secondary metabolites
kpn01210
2-Oxocarboxylic acid metabolism
kpn01230
Biosynthesis of amino acids
Module
kpn_M00432
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:
kpn00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00620 Pyruvate metabolism
KPN_00080 (leuA)
09105 Amino acid metabolism
00290 Valine, leucine and isoleucine biosynthesis
KPN_00080 (leuA)
Enzymes [BR:
kpn01000
]
2. Transferases
2.3 Acyltransferases
2.3.3 Acyl groups converted into alkyl groups on transfer
2.3.3.13 2-isopropylmalate synthase
KPN_00080 (leuA)
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Motif
Pfam:
HMGL-like
LeuA_dimer
HCS_D2
IPMS_D2
Trp_syntA
Motif
Other DBs
NCBI-ProteinID:
ABR75540
UniProt:
A6T4L9
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Position
complement(93598..95169)
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AA seq
523 aa
AA seq
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MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT
IARTIKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE
RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEY
ANIISGLYDRVPNIDKAIISVHTHDDLGIAVGNALAAVHAGARQVEGAMNGIGERAGNCA
LEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGTGAFAHSSGIH
QDGVLKNRENYEIMTPESIGLNQVQLNLTSRSGRAAVKHRMEEMGYQESDYNLDHLYDAF
LKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFNVQSGSSDIATASIKLVCGDEIKT
EAANGNGPVDAIYQAINRVTDYNIELVKYGLSAKGHGKDALGQVDIVVDYNGRRFHGVGL
ATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQNKENNKETV
NT seq
1572 nt
NT seq
+upstream
nt +downstream
nt
atgagccagcaagtcattattttcgatacgaccttacgtgatggcgaacaagcgttacag
gcaagcctgagtgtcaaagagaagctgcagatcgcactggcccttgagcgaatgggggtc
gacgtaatggaagtcggtttcccggtatcctcgccgggcgattttgaatcggtgcaaacc
atcgcgcgcaccattaaaaacagccgcgtgtgcgctctggcgcgctgcgttgagaaagat
atcgacgtggcggcggaatcgttaaaagtggccgaggctttccgtattcatacctttatt
gccacctcgccgatgcatatcgccaccaaactgcgcagtacgctggatgaggttattgag
cgcgcgatctatatggtgaagcgggcacgcaactacactgacgacgttgagttctcctgt
gaagacgccggccgtacgccgattgccgatctggctcgcgtcgtggaagcggcgatcaac
gccggtgccaccaccattaatatcccggataccgtcggctataccatgccgttcgaatat
gccaacatcatcagcggcctgtatgatcgcgtgccgaatatcgacaaagcaattatttcc
gtccacacccatgatgatctgggcatcgctgtcggtaacgccctcgccgcggtccacgcc
ggtgcgcgccaggtagaaggtgcgatgaacggtatcggcgaacgcgccggcaactgcgcg
ctggaagaagtgatcatggcgatcaaagtgcgcaaagacatcatgaacgtgcacaccaac
attaatcatcatgaaatctggcgcaccagccagaccgtcagccagatctgcaatatgccg
atcccggcgaacaaggccatcgtcggcaccggcgccttcgcccactcctccggcattcac
caggacggcgtgctgaagaaccgcgaaaactacgagatcatgaccccggaatctatcggc
ctgaaccaggtgcaactgaacctgacttcccgctccggccgcgcggcggtgaaacaccgg
atggaagagatgggctaccaggagagcgattacaacctggatcatctgtacgacgcattc
ctgaagctggcggacaaaaaaggccaggtcttcgattacgatctggaagcgctggccttt
atcaacaagcagcaggaagagccagagcatttccgcctggattacttcaacgtccaatcc
ggatccagcgatatcgccaccgcctcgatcaaactggtctgcggggatgagatcaaaacc
gaagccgccaacggcaacggtccggtcgatgctatctaccaggcgattaatcgcgtcacc
gactacaacattgaattagtgaagtatggcttaagcgcgaaaggccacggcaaagacgcc
ctgggccaggtggatatcgtcgttgactacaatggccgccgcttccatggcgttggtctg
gcaacggatatcgtagagtcgtcagccaaagcgatggttcacgtgctgaacaacatctgg
cgcgccgccgaagtcgaaaaagaattgcaacgcaaagctcagaataaagagaacaataag
gaaaccgtgtaa
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