Klebsiella pneumoniae subsp. rhinoscleromatis SB3432: KPR_0936
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Entry
KPR_0936 CDS
T02793
Symbol
thrA
Name
(GenBank) highly similar to bifunctional aspartokinase I-homeserine dehydrogenase I from Escherichia coli O1:K1 - APEC (tr|A1A755)
KO
K12524
bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:
2.7.2.4
1.1.1.3
]
Organism
kpr
Klebsiella pneumoniae subsp. rhinoscleromatis SB3432
Pathway
kpr00260
Glycine, serine and threonine metabolism
kpr00261
Monobactam biosynthesis
kpr00270
Cysteine and methionine metabolism
kpr00300
Lysine biosynthesis
kpr01100
Metabolic pathways
kpr01110
Biosynthesis of secondary metabolites
kpr01120
Microbial metabolism in diverse environments
kpr01230
Biosynthesis of amino acids
Module
kpr_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
kpr_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
kpr_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
kpr00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
KPR_0936 (thrA)
00270 Cysteine and methionine metabolism
KPR_0936 (thrA)
00300 Lysine biosynthesis
KPR_0936 (thrA)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
KPR_0936 (thrA)
Enzymes [BR:
kpr01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
KPR_0936 (thrA)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
KPR_0936 (thrA)
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GFIT
Motif
Pfam:
Homoserine_dh
AA_kinase
ACT_9
NAD_binding_3
ACT_7
ACT
Motif
Other DBs
NCBI-ProteinID:
CCI75166
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All DBs
Position
971178..973682
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AA seq
834 aa
AA seq
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MRAFFLTRDQGVRTMRVLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNH
LVAMIEKTIGGQDALPNIADAERIFAELLQGLADAQPAFPLAQLKAFVEQEFAQIKHVLH
GISLLGQCPDSVNAALICRGEKLSIAIMAGLLEARGHKVSVINPVEKLLAVGHYLESTVD
IAESTRRIAASQIPADHMILMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIW
TDVDGVYTCDPRQVPDARLLKSMSYQEAMELSYFGAKVLHPRTIAPIAQFQIPCLIKNTG
NPQAPGTLIGASRDEDDLPVKGISNLNNMAMFNVSGPGMKGMVGMAARVFATMSRAGISV
VLITQSSSEYSISFCVPQSDCARAKRAMEDEFHLELKEGLLEPLAIMERLAIISVVGDGM
RTLRGISAKFFAALARANINIVAIAQGSSERSISVVVSNDDATTGVRVTHQMLFNTDQVI
EVFVIGVGGVGGALLEQIKRQQGWLKNKHIDLRVCGVANSQALLTSVHGLNLENWSAELA
EAKEPFNLGRLIRLVKEYHLLNPVIVDCTSSQAVADQYTDFLREGFHVVTPNKKANTSSL
DYYHQLRHAASSSRRKFLYDTNVGAGLPVIENLQNLLNAGDELRHFSGILSGSLSFIFGK
LDEGVSFSAATAMAREMGYTEPDPRDDLSGVDVARKLLILARETGRELELADIIVESALP
PDFDASGDVETFMARLPSLDDGFASRVAKARDEGKVLRYVGNIEEDGTCRVKIAAVDGND
PLFKVKNGENALAFYSHYYQPLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV
NT seq
2505 nt
NT seq
+upstream
nt +downstream
nt
gtgcgggctttttttttgacaagagatcaaggggtaagaaccatgcgagtgttgaagttc
ggcggtacatcagtggcaaatgcggaacggtttctgcgggttgccgatattctggagagt
aatgccaggcaggggcaggtagcgacggtcctgtctgccccggcgaagatcactaaccac
ctggtagcgatgattgaaaagaccattggcggccaggatgccctccccaatattgccgac
gccgaacgcatttttgccgaacttcttcagggccttgccgacgcccagcccgctttcccg
cttgcccagttaaaagccttcgtggagcaggaatttgctcagattaagcatgttctgcac
ggcatcagcctgctgggtcagtgcccggacagcgtcaatgccgcgctgatctgccgcggc
gaaaagctctccatcgccatcatggcgggtctgctggaagcccgtggacataaagtcagt
gtcattaacccggtcgaaaaactgctcgccgtgggccactatctggaatccaccgtcgat
atcgccgaatccacccgccgcattgccgccagccagatcccggcagaccatatgatcctg
atggccgggtttaccgccggcaatgagaaaggcgagctggtggtgctggggcgtaacggc
tccgactactcggctgcggtactggccgcctgcctgcgcgctgactgctgcgaaatctgg
accgatgtcgacggagtgtacacctgcgatccgcgtcaggtgccggatgcgcgcctgctg
aaatcgatgtcttatcaggaggcgatggagctctcctactttggcgcgaaagtgctgcac
ccgcgcaccatcgcccctatcgcccagttccaaatcccatgcctgattaaaaataccggc
aacccacaggcgccgggaacgcttatcggcgccagccgcgacgaggacgatttgccggtg
aaaggcatctctaacctcaacaacatggcgatgttcaacgtctccgggccggggatgaaa
gggatggtcggcatggcggcccgcgtcttcgccaccatgtcccgcgccggcatctcggtg
gtgttgatcactcaatcttcttcggagtacagcatcagtttctgcgtgccgcagagcgac
tgcgcacgtgctaaacgggcgatggaagatgagtttcatctggagctgaaagaggggctg
ctggagccgctggcgattatggagcgtctggcgatcatctccgtggtgggcgacggaatg
cgtaccctgcgcggtatctcggcgaaattctttgcggcactggcccgcgccaatatcaat
atcgtggcgattgcccagggctcttccgagcgctcaatttcggtagtggtcagcaatgac
gacgccaccaccggcgtgcgcgtgacccatcagatgctgttcaacaccgaccaggtgatt
gaagtgtttgtcatcggcgtcggcggcgtcggcggcgcgctgctagagcagatcaagcgc
cagcaggggtggctgaagaacaaacatatcgatctgcgcgtctgtggtgtagccaattct
caggcgctgctgaccagcgtgcatggcctgaatctggaaaactggagtgcggaactggcg
gaggcgaaagagccgtttaatcttggccgcctgatccgcctggtgaaagagtaccacctg
ctcaatccggtgatcgtcgactgtacctccagccaggcggtcgccgatcagtataccgac
ttcctgcgcgaaggtttccatgtggtgacgccgaacaaaaaggccaatacctcttcgctg
gattactatcaccagctgcgccatgcggccagcagctcgcggcgtaagttcctctatgac
actaacgttggcgctggcctgccggtgattgagaacctgcagaacctgctcaacgccggc
gatgagctgcgccacttctcagggatcctgtccggctccctgtcgtttatcttcggcaag
ctggacgagggggtgagtttctccgcggcgacggcgatggcccgtgagatggggtatacc
gagccggatccgcgcgacgatttatccggggtggatgtggcgcgtaaactgctgattctg
gcccgtgagaccgggcgtgaactggagctggcggacattatcgtcgagtcggcgctgccg
ccggacttcgacgccagcggcgatgtcgagacctttatggcccgcctgccgtcgctggac
gatggttttgcctcgcgggttgctaaggcgcgcgatgaaggtaaagtcttgcgctacgtc
ggtaacatcgaagaggatggtacctgccgggtaaaaatagccgcggttgacggcaacgat
ccgctgttcaaagttaagaatggtgagaacgcgctggctttttatagccattattatcag
ccattgccgctggtgctgcgcggctatggcgccgggaacgacgtcacggcggccggcgta
ttcgccgacctgctgcgcaccctgtcctggaagttaggagtttaa
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