Klebsiella pneumoniae PMK1: PMK1_02321
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Entry
PMK1_02321 CDS
T03419
Symbol
thrA
Name
(GenBank) Aspartokinase I/homoserine dehydrogenase I
KO
K12524
bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:
2.7.2.4
1.1.1.3
]
Organism
kpx
Klebsiella pneumoniae PMK1
Pathway
kpx00260
Glycine, serine and threonine metabolism
kpx00261
Monobactam biosynthesis
kpx00270
Cysteine and methionine metabolism
kpx00300
Lysine biosynthesis
kpx01100
Metabolic pathways
kpx01110
Biosynthesis of secondary metabolites
kpx01120
Microbial metabolism in diverse environments
kpx01230
Biosynthesis of amino acids
Module
kpx_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
kpx_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
kpx_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
kpx00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
PMK1_02321 (thrA)
00270 Cysteine and methionine metabolism
PMK1_02321 (thrA)
00300 Lysine biosynthesis
PMK1_02321 (thrA)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
PMK1_02321 (thrA)
Enzymes [BR:
kpx01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
PMK1_02321 (thrA)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
PMK1_02321 (thrA)
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SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Homoserine_dh
AA_kinase
ACT_9
NAD_binding_3
ACT_7
ACT
DUF6247
Motif
Other DBs
NCBI-ProteinID:
AIT01786
UniProt:
A0A086IN02
LinkDB
All DBs
Position
2498188..2500650
Genome browser
AA seq
820 aa
AA seq
DB search
MRVLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNHLVAMIEKTIGGQDA
LPNIADAERIFAELLQGLADAQPAFPLAQLKAFVEQEFAQIKHVLHGISLLGQCPDSVNA
ALICRGEKLSIAIMAGLLEARGHKVSVINPVEKLLAVGHYLESTVDIAESTRRIAASQIP
ADHMILMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRQV
PDARLLKSMSYQEAMELSYFGAKVLHPRTIAPIAQFQIPCLIKNTGNPQAPGTLIGASRD
EDDLPVKGISNLNNMAMFNVSGPGMKGMVGMAARVFATMSRAGISVVLITQSSSEYSISF
CVPQSDCARAKRAMEDEFYLELKEGLLEPLAIMERLAIISVVGDGMRTLRGISAKFFAAL
ARANINIVAIAQGSSERSISVVVSNDDATTGVRVTHQMLFNTDQVIEVFVIGVGGVGGAL
LEQIKRQQGWLKNKHIDLRVCGVANSQALLTSVHGLNLENWSAELAEAKEPFNLGRLIRL
VKEYHLLNPVIVDCTSSQAVADQYADFLREGFHVVTPNKKANTSSLDYYHQLRHAASSSR
RKFLYDTNVGAGLPVIENLQNLLNAGDELRHFSGILSGSLSFIFGKLDEGVSFSAATAMA
REMGYTEPDPRDDLSGVDVARKLLILARETGRELELADIIVESALPPDFDASGDVETFMA
RLPSLDDGFASRVAKARDEGKVLRYVGNIEEDGTCRVKIAAVDGNDPLFKVKNGENALAF
YSHYYQPLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV
NT seq
2463 nt
NT seq
+upstream
nt +downstream
nt
atgcgagtgttgaagttcggcggtacatcagtggcaaatgcggaacggtttctgcgggtt
gccgatattctggagagtaatgccaggcaggggcaggtagcgacggtcctgtctgccccg
gcgaagatcactaaccatctggtagcaatgattgaaaagaccattggcggccaggatgcc
ctccccaatattgccgacgccgaacgcatttttgccgaacttcttcagggccttgccgac
gcccagcccgctttcccgcttgcccagttaaaagccttcgtggagcaggaatttgctcag
attaagcatgttctgcacggcatcagcctgctgggtcagtgcccggacagcgtcaatgcc
gcgctgatctgccgcggcgaaaagctctccatcgccatcatggcgggtctgctggaagcc
cgtggacataaagtcagtgtcattaacccggtcgaaaaactgctcgccgtgggccactat
ctggaatccaccgtcgatatcgccgaatccacccgccgcattgccgccagccagatcccg
gcagaccatatgatcctgatggccgggtttaccgccggcaatgagaaaggcgagctggtg
gtgctggggcgtaacggctccgactactcggctgcggtactggccgcctgcctgcgcgct
gactgctgcgaaatctggaccgatgtcgacggagtgtacacctgcgatccgcgtcaggtg
ccggatgcgcgcctgctgaaatcgatgtcttatcaggaggcgatggagctctcctacttt
ggcgcgaaagtgctgcacccgcgcaccatcgcccctatcgcccagttccaaatcccatgc
ctgattaaaaataccggcaacccacaggcgccgggaacgcttatcggcgccagccgcgac
gaggacgatttgccggtgaaaggcatctctaacctcaacaacatggcgatgttcaacgtc
tccgggccggggatgaaagggatggtcggcatggcggcccgcgtcttcgccaccatgtcc
cgcgccggcatctcagtggtgttgatcactcaatcttcttcggagtacagcatcagtttc
tgcgtgccgcagagcgactgcgcacgtgccaaacgggcgatggaagatgagttttatctg
gagctgaaagaggggctgctggagccgctggcgattatggagcgtctggcgatcatctcc
gtggtgggcgacggaatgcgtaccctgcgcggtatctcggcgaaattctttgcggcactg
gcccgcgccaatatcaatatcgtggcgattgcccagggctcttccgagcgctcaatttcg
gtagtggtcagcaatgacgacgccaccaccggcgtgcgcgtgacccatcagatgctgttc
aacaccgaccaggtgattgaagtgtttgtcatcggcgtcggcggcgtcggcggcgcgctg
ctagagcagatcaagcgccagcaggggtggctgaagaacaaacatatcgatctgcgcgtc
tgcggtgtagccaattctcaggcgctgctgaccagcgtgcatggcctgaatctggaaaac
tggagtgcggaactggcggaggcgaaagagccgtttaatcttggccgcctgatccgcctg
gtgaaagagtaccacctgctcaatccggtgatcgtcgactgtacctccagccaggcggtc
gccgatcagtatgccgacttcctgcgcgaaggtttccatgtggtgacgccgaacaaaaag
gccaatacctcttcgctggattactatcaccagctgcgccatgcggccagcagctcgcgg
cgtaagttcctctatgacactaacgttggcgcgggcctgccggtgattgagaacctgcag
aacctgctcaacgccggcgatgagctgcgccatttctccgggatcctgtccggctccctg
tcgtttatcttcggcaagctggacgagggggtgagtttctccgcggcgacggcgatggcc
cgtgagatggggtataccgagccggatccgcgcgacgatttatccggggtggatgtggcg
cgtaaactgctgattctggcccgtgagaccgggcgtgaactggagctggcggacattatc
gtcgagtcggcgctgccgccggacttcgacgccagcggcgatgtcgagacctttatggcc
cgcctgccgtcgctggacgatggttttgcctcgcgggttgctaaggcgcgcgatgaaggt
aaagtcttgcgctacgtcggtaacatcgaagaggatggtacctgccgggtaaaaatagcc
gcggttgacggcaacgatccgctgttcaaagttaagaatggtgagaacgcgctggctttt
tatagccattattatcagccattgccgctggtgctgcgcggctatggcgccgggaacgac
gtcacggcggccggcgtattcgccgacctgctgcgcaccctgtcctggaagttaggagtt
taa
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