KEGG   Lagenorhynchus albirostris (white-beaked dolphin): 132505000
Entry
132505000         CDS       T10760                                 
Symbol
PLCB1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
lalb  Lagenorhynchus albirostris (white-beaked dolphin)
Pathway
lalb00562  Inositol phosphate metabolism
lalb01100  Metabolic pathways
lalb04015  Rap1 signaling pathway
lalb04020  Calcium signaling pathway
lalb04022  cGMP-PKG signaling pathway
lalb04062  Chemokine signaling pathway
lalb04070  Phosphatidylinositol signaling system
lalb04071  Sphingolipid signaling pathway
lalb04072  Phospholipase D signaling pathway
lalb04081  Hormone signaling
lalb04082  Neuroactive ligand signaling
lalb04261  Adrenergic signaling in cardiomyocytes
lalb04270  Vascular smooth muscle contraction
lalb04310  Wnt signaling pathway
lalb04371  Apelin signaling pathway
lalb04540  Gap junction
lalb04611  Platelet activation
lalb04613  Neutrophil extracellular trap formation
lalb04621  NOD-like receptor signaling pathway
lalb04713  Circadian entrainment
lalb04720  Long-term potentiation
lalb04723  Retrograde endocannabinoid signaling
lalb04724  Glutamatergic synapse
lalb04725  Cholinergic synapse
lalb04726  Serotonergic synapse
lalb04728  Dopaminergic synapse
lalb04730  Long-term depression
lalb04742  Taste transduction
lalb04750  Inflammatory mediator regulation of TRP channels
lalb04911  Insulin secretion
lalb04912  GnRH signaling pathway
lalb04915  Estrogen signaling pathway
lalb04916  Melanogenesis
lalb04918  Thyroid hormone synthesis
lalb04919  Thyroid hormone signaling pathway
lalb04921  Oxytocin signaling pathway
lalb04922  Glucagon signaling pathway
lalb04924  Renin secretion
lalb04925  Aldosterone synthesis and secretion
lalb04926  Relaxin signaling pathway
lalb04927  Cortisol synthesis and secretion
lalb04928  Parathyroid hormone synthesis, secretion and action
lalb04929  GnRH secretion
lalb04933  AGE-RAGE signaling pathway in diabetic complications
lalb04934  Cushing syndrome
lalb04935  Growth hormone synthesis, secretion and action
lalb04961  Endocrine and other factor-regulated calcium reabsorption
lalb04970  Salivary secretion
lalb04971  Gastric acid secretion
lalb04972  Pancreatic secretion
lalb04973  Carbohydrate digestion and absorption
lalb05010  Alzheimer disease
lalb05016  Huntington disease
lalb05017  Spinocerebellar ataxia
lalb05022  Pathways of neurodegeneration - multiple diseases
lalb05142  Chagas disease
lalb05143  African trypanosomiasis
lalb05146  Amoebiasis
lalb05163  Human cytomegalovirus infection
lalb05200  Pathways in cancer
lalb05415  Diabetic cardiomyopathy
lalb05417  Lipid and atherosclerosis
Module
lalb_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:lalb00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    132505000 (PLCB1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    132505000 (PLCB1)
   04310 Wnt signaling pathway
    132505000 (PLCB1)
   04371 Apelin signaling pathway
    132505000 (PLCB1)
   04020 Calcium signaling pathway
    132505000 (PLCB1)
   04070 Phosphatidylinositol signaling system
    132505000 (PLCB1)
   04072 Phospholipase D signaling pathway
    132505000 (PLCB1)
   04071 Sphingolipid signaling pathway
    132505000 (PLCB1)
   04022 cGMP-PKG signaling pathway
    132505000 (PLCB1)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    132505000 (PLCB1)
   04081 Hormone signaling
    132505000 (PLCB1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    132505000 (PLCB1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    132505000 (PLCB1)
   04613 Neutrophil extracellular trap formation
    132505000 (PLCB1)
   04621 NOD-like receptor signaling pathway
    132505000 (PLCB1)
   04062 Chemokine signaling pathway
    132505000 (PLCB1)
  09152 Endocrine system
   04911 Insulin secretion
    132505000 (PLCB1)
   04922 Glucagon signaling pathway
    132505000 (PLCB1)
   04929 GnRH secretion
    132505000 (PLCB1)
   04912 GnRH signaling pathway
    132505000 (PLCB1)
   04915 Estrogen signaling pathway
    132505000 (PLCB1)
   04921 Oxytocin signaling pathway
    132505000 (PLCB1)
   04926 Relaxin signaling pathway
    132505000 (PLCB1)
   04935 Growth hormone synthesis, secretion and action
    132505000 (PLCB1)
   04918 Thyroid hormone synthesis
    132505000 (PLCB1)
   04919 Thyroid hormone signaling pathway
    132505000 (PLCB1)
   04928 Parathyroid hormone synthesis, secretion and action
    132505000 (PLCB1)
   04916 Melanogenesis
    132505000 (PLCB1)
   04924 Renin secretion
    132505000 (PLCB1)
   04925 Aldosterone synthesis and secretion
    132505000 (PLCB1)
   04927 Cortisol synthesis and secretion
    132505000 (PLCB1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    132505000 (PLCB1)
   04270 Vascular smooth muscle contraction
    132505000 (PLCB1)
  09154 Digestive system
   04970 Salivary secretion
    132505000 (PLCB1)
   04971 Gastric acid secretion
    132505000 (PLCB1)
   04972 Pancreatic secretion
    132505000 (PLCB1)
   04973 Carbohydrate digestion and absorption
    132505000 (PLCB1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    132505000 (PLCB1)
  09156 Nervous system
   04724 Glutamatergic synapse
    132505000 (PLCB1)
   04725 Cholinergic synapse
    132505000 (PLCB1)
   04728 Dopaminergic synapse
    132505000 (PLCB1)
   04726 Serotonergic synapse
    132505000 (PLCB1)
   04720 Long-term potentiation
    132505000 (PLCB1)
   04730 Long-term depression
    132505000 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    132505000 (PLCB1)
  09157 Sensory system
   04742 Taste transduction
    132505000 (PLCB1)
   04750 Inflammatory mediator regulation of TRP channels
    132505000 (PLCB1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    132505000 (PLCB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    132505000 (PLCB1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    132505000 (PLCB1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    132505000 (PLCB1)
   05142 Chagas disease
    132505000 (PLCB1)
   05143 African trypanosomiasis
    132505000 (PLCB1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    132505000 (PLCB1)
   05016 Huntington disease
    132505000 (PLCB1)
   05017 Spinocerebellar ataxia
    132505000 (PLCB1)
   05022 Pathways of neurodegeneration - multiple diseases
    132505000 (PLCB1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    132505000 (PLCB1)
   05415 Diabetic cardiomyopathy
    132505000 (PLCB1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    132505000 (PLCB1)
   04934 Cushing syndrome
    132505000 (PLCB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:lalb04131]
    132505000 (PLCB1)
Enzymes [BR:lalb01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     132505000 (PLCB1)
Membrane trafficking [BR:lalb04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    132505000 (PLCB1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    132505000 (PLCB1)
SSDB
Motif
Pfam: PI-PLC-X PLC-beta_C PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like
Other DBs
NCBI-GeneID: 132505000
NCBI-ProteinID: XP_059978812
LinkDB
Position
15:35470211..36223721
AA seq 1216 aa
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQSKE
TELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGRLEHRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDLIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLS
GEENGVVPPEKLDLNEDMSQPLTHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPLDLMYKILVKNKKKSHKSSEGSGKK
KLSEQTSNTYSDSSSVFEPSSPGAGEADTESDDDDDEDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFEISKKRNRSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPVWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLMLPALFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETQSEAPSEARTTPAENGMNHTTSLTPKPPSQALHSQPAPGSVKAPAKTEDLIQS
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL
RRRAALEKTAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP
KLQVELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHSSVPPLLTSDPGKLNHKPPSS
EKLEGENPGKEFDTPL
NT seq 3651 nt   +upstreamnt  +downstreamnt
atggccggggctcagcccggagtacacgctctgcaactcaagcccgtgtgcgtgtccgac
agcctcaagaagggcaccaaattcgtcaagtgggatgatgactccactattgtcactcca
attattttgaggaccgaccctcagggatttttcttttactggacagatcaaagcaaggag
acggagctgttagatctcagccttgtcaaagatgccagatgtgggaaacacgccaaggct
cccaaggaccccaaattacgtgaacttctggatgtggggaacatcgggcgcctggaacat
cgcatgataacagtggtgtatgggcctgacttagttaacatctcccatttgaacctcgtg
gctttccaagaagaagtggccaaggaatggacaaatgaagttttcagtctggcaacgaac
ctgctggcccaaaacatgtctagggatgcatttctggaaaaagcctatactaaacttaag
ctgcaagtcactccagaaggacgcattcctctcaaaaacatataccgcttgttctcagca
gatcggaagcgagttgaaactgctttagaggcttgtagtcttccatcttcaaggaatgat
ttgatacctcaagaagatttcactccagaagtgtacagagttttcctgaacaacctttgt
cctcggcctgaaattgataacatcttttccgaatttggtgccaaaagcaaaccatacctt
acggttgatcagatgatggattttatcaacctcaagcagcgagatcccaggctaaatgaa
attctttacccacctttaaagcaagagcaagtccaggtgttgattgagaagtatgaaccc
aacaacagtcttgccagaaaaggacagatatcagtggatggatttatgcgctatctgagt
ggagaggaaaatggagtcgttccacctgagaaactggatttgaatgaagatatgtctcag
ccacttactcactatttcattaattcctcacacaacacctacctcacagctggccagctg
gctggaaactcctctgtcgagatgtatcgccaagtgctcctgtctggttgtcgctgtgtg
gagttggactgctggaagggacggaccgcagaagaggagccagtcatcacccatgggttc
accatgaccacggagatatccttcaaggaagtgatagaagccattgctgagtgtgcattt
aagacttcaccttttccaattctgctttcatttgagaaccacgtggattccccaaagcag
caggccaagatggcagagtattgccgactgatcttcggggacgcccttctcatggagccc
ctggaaaagtacccactggaatctggagttcctcttccaagccctctggacttaatgtac
aaaattttggtgaaaaataagaagaaatcccacaaatcgtcagaaggaagtggcaaaaag
aagctctcagaacagacttccaacacgtacagcgactcctccagtgtgtttgagccctcg
tccccaggagctggagaagctgatacggagagtgacgatgatgacgatgaggatgactgt
aaaaagtcctcgatggatgaggggactgctgggagcgaggccatggccacagaagagatg
tctaatctggtgaactatattcagccagtaaagttcgagtcattcgaaatttcaaaaaaa
agaaacagaagcttcgaaatgtcttcctttgtggaaaccaaaggacttgagcaacttaca
aagtctccagtggaatttgtagaatataacaaaatgcagcttagcaggatatatccaaaa
ggaacacgtgtggattcatccaactacatgccccagctcttctggaatgcaggctgccaa
atggttgcacttaatttccaaacagtggacctggctatgcaaataaacatggggatgtat
gaatacaatgggaaaagtggctacagactgaagccagagttcatgaggagacctgacaag
cactttgatccattcaccgaaggcattgtggatgggatcgtggccaacactttatctgtt
aagattatttcaggtcagtttctctctgataagaaagtcgggacttatgtggaagtggat
atgtttggtttgcctgtggacacaaggaggaaggcatttaagacaaagacatcacaagga
aatgctgtaaatcctgtctgggaagaagaacccattgtgttcaaaaaggttgttcttcct
tctctggcctgtttgaggatagcagtttatgaagaaggaggtaaatttattggtcaccga
atcttgccagtacaagcaattcgaccaggctatcactacatctgtctgaggaatgaaagg
aaccagcctctgatgctgccagctctctttgtctacatagaggtgaaggactatgtccca
gatacatatgcagatgtgattgaagctttgtcaaatccaatccgatatgtgaatctgatg
gagcagagagctaaacaactggcagctttgacgctggaagatgaagaagaagtaaagaaa
gaggctgatcctggggaaacacagtcagaagctccaagtgaagccaggacaactccagca
gaaaacgggatgaatcacactacatccctgacacccaaaccaccctcccaggctctccac
agccaaccagctccaggctctgtaaaggcacctgccaaaacagaagatcttattcagagt
gttttaacagaagtagaagcgcagacaattgaagagctgaagcaacagaagtcgtttgtg
aaacttcaaaagaagcactacaaagaaatgaaagacctggtgaagagacaccacaagaaa
accaccgaccttatcaaagaacacactacaaaatataatgaaatccagaatgactacttg
cgaaggagggcagctttggaaaagacagccaaaaaggatagtaagaaaaaatcggaaccc
agcagccctgaccatggttcgtcaacaattgagcaagaccttgctgccctggatgccgaa
atgacccaaaagttaatagacttgaaggacaaacaacagcagcagctgcttaatcttcga
caagaacagtattacagcgaaaaataccagaagcgagaacatattaaactgcttattcaa
aaattgacagatgttgctgaagaatgtcagaataatcagttaaagaagcttaaagaaatt
tgtgagaaagagaagaaggaattaaagaagaaaatggataaaaagaggcaggagaagata
acagaagctaaatccaaagacaaaagccagatggaagaggaaaagacagagatgatccgg
tcatacatccaggaggtggtgcagtacatcaagaggttagaagaggcacaaagtaaacgg
caagaaaaactcgtagagaaacacaaagagatacgtcagcagatcctggacgaaaagccc
aagctgcaggtggagctagagcaggagtaccaagacaagttcaaaaggctgcccctggag
attttggaattcgtgcaggaagccatgaaagggaagatcagtgaagacagcaatcacagc
tctgtccctcccctgctgacctcagaccctggaaaactgaaccacaagcctccttccagt
gagaagctggaaggagaaaacccaggaaaagaatttgatactcccctgtga

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