| Entry |
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| Symbol |
TOP2A
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| Name |
(RefSeq) DNA topoisomerase 2-alpha
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| KO |
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| Organism |
lalb Lagenorhynchus albirostris (white-beaked dolphin)
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| Pathway |
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| Brite |
KEGG Orthology (KO) [BR:lalb00001]
09160 Human Diseases
09176 Drug resistance: antineoplastic
01524 Platinum drug resistance
132511392 (TOP2A)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03032 DNA replication proteins [BR:lalb03032]
132511392 (TOP2A)
03036 Chromosome and associated proteins [BR:lalb03036]
132511392 (TOP2A)
Enzymes [BR:lalb01000]
5. Isomerases
5.6 Isomerases altering macromolecular conformation
5.6.2 Enzymes altering nucleic acid conformation
5.6.2.2 DNA topoisomerase (ATP-hydrolysing)
132511392 (TOP2A)
DNA replication proteins [BR:lalb03032]
Eukaryotic type
DNA Topoisomerases
132511392 (TOP2A)
Chromosome and associated proteins [BR:lalb03036]
Eukaryotic type
Chromosome condensation proteins
Other regulators of chromosome condensation
132511392 (TOP2A)
Centrosome formation proteins
Centriole proteins
132511392 (TOP2A)
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| Position |
20:complement(39773228..39798690)
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| AA seq |
1533 aa
MEMSPLQPVDDNMQVNKTKKNEDAKKRLSIERIYQKKTQLEHILLRPDTYIGSVESVTQQ
MWVYDEDIGINCREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWN
NGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDEEKKVTGGRNGYGAKLCNIFSTKFTVE
TASREYKKMFKQTWRDNMGRAGEMELKPFSGEDYTCITFHPDLSKFKMQSLDKDIVALMV
RRAYDIAGSTKDVKVFLNGNKLPIKGFRSYVDMYLKDKVDETGNALKIIHEQVNPRWEVC
LTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHM
WIFVNALIENPTFDSQTKENMTLQVKSFGSTCPLSEKFIKAAIGCGIVESILNWVKFKAQ
VQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDK
YGVFPLRGKMLNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMT
DQDQDGSHIKGLLINFIHHNWPSLLHHRFLEEFITPIVKVSKNKQEVAFYSLPEFEEWKN
STPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDD
RKEWLTHFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVD
GLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNN
LNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLLFPPKDDHTLRFLYDDNQRVEPEW
YIPIIPMVLINGAEGIGTGWSCKIPNFDVREVVNNIRRLMDGEEPLPMLPSYKNFKGTIE
ELAPNQYVISGEMSILNSTTIEISELPIRTWTQTYKEQVLEPMLNGTEKTPPLITDYREY
HTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILR
DFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQR
GYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEK
KDELCRLRNEKEQELETLKRKSPSDLWKEDLAAFVEELEAVEAKEKQDEQIGLPGKGGKA
KGKKTQRAEVLPSPCGKRVIPQVTIEMKAEAEKKIKKKIKNENTEGSSREDGMEIEGLKQ
RLEKKQKIEPGTKTKKQTTLPFKPVKKAKKRNPWSDSESDIDSNESNFDVPPREKEPRRA
ATKTKFTMDLDSDEDFSDFDENTQDEDRVPSDASPPRTTTSPKHTNKELKPQKSATSVTD
LNADDAKDNVPPPPSSPAADFPAVTKTTNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAP
KGTKKDPDLDSDVSKKPNPPKTKSHRKRKPSTSDDSDSNFEKMISKAVTSKKPKEDSDDF
HLDLDSAVASRAKSGRTKKPIKYLEESDEDDLF |
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| NT seq |
4602 nt +upstreamnt +downstreamnt
atggagatgtcaccactgcagcctgtagatgacaatatgcaagtcaacaaaacaaagaaa
aatgaagatgctaagaaaagactgtctattgaaagaatctatcagaagaaaacacaactg
gaacatattctgctccgcccagacacctacattggctctgtggaatcagtgacccagcaa
atgtgggtttacgatgaagatattggcattaactgtagggaagtcacttttgttcctggt
ttgtacaaaatctttgatgagattctagtcaatgctgcagacaacaaacaaagggacccc
aaaatgtcttgtattagagtcacaattgacccggagaataatttaattagtatatggaat
aatggaaaaggtattcctgttgttgaacacaaagttgagaagatgtatgtcccagctctc
atctttggacagctcctaacttctagtaactatgatgatgaagaaaagaaagtaacgggt
ggtcgaaatggctatggagccaaattgtgtaacatattcagtaccaaatttactgtggaa
acagccagtagagaatacaagaaaatgttcaaacagacatggagggataacatggggaga
gctggtgagatggaactcaagccctttagtggagaagattatacatgtattaccttccac
cctgatttgtctaagtttaaaatgcaaagcctagacaaagatattgttgcactgatggtt
agaagagcatatgatattgctggatccactaaagatgtcaaggtctttctcaatggaaat
aagcttccaataaaaggattccgtagctatgtagatatgtatctgaaggataaggtagat
gaaactggcaatgcactgaaaattatccatgaacaagtaaaccccaggtgggaagtgtgt
ttaacaatgagtgaaaaaggctttcagcaaatcagctttgtcaacagcattgctacttcc
aagggtggcagacatgttgattatgtagctgatcagattgtgactaaacttgttgatgtt
gtgaagaaaaagaacaagggtggtgttgcagtaaaagcacatcaggtaaaaaatcacatg
tggatttttgtgaacgccttaattgaaaacccaaccttcgactcccagacaaaagagaac
atgactttacaagtcaagagctttggatcaacgtgcccgttgagtgaaaaattcatcaaa
gctgcaattggctgtggtattgtagaaagcatactaaactgggtgaaatttaaggcccaa
gtccagttaaacaagaagtgttcagctgtaaaacataacagaatcaaaggaattcccaaa
cttgatgatgccaatgatgcaggaggccgaaactccactgagtgtacacttatcctgaca
gagggagactcagctaaaactttggctgtttcaggccttggtgtggttgggagagacaag
tacggggttttccctcttagaggaaaaatgcttaatgttcgagaagcttctcataaacag
ataatggaaaatgctgaaattaacaatataatcaagattgtgggtcttcagtacaagaaa
aactatgaagatgaagattcattgaagactctgcgttatgggaagataatgattatgaca
gatcaggaccaagacggttcccatatcaaaggcttgctgattaattttatccatcataac
tggccctctcttctgcaccatcgttttctggaggaatttatcactcccattgtaaaggtg
tctaaaaacaagcaagaagtggcattctatagccttcctgagtttgaagaatggaagaat
tctacgccaaatcataaaaaatggaaagtcaagtattacaaaggtttgggcaccagcaca
tcaaaagaagctaaagagtactttgcagatatgaaaagacatcgtatccaattcaaatat
tcaggtcctgaagatgatgctgcaatcagcctggcctttagcaaaaaacagatagatgat
cgaaaggaatggttaactcatttcatggaagatagaaggcaacgaaagttacttggcctt
cctgaggattacttatatgggcaaactaccacatatctgacatataatgacttcataaat
aaggaacttatcctgttctcaaattctgataatgagaggtctatcccatctatggtggat
ggtttgaagccaggtcagagaaaggttttgtttacatgtttcaaacggaatgacaagcga
gaggtgaaggttgcccagttagctgggtcagtagctgagatgtcctcttatcatcatggt
gagatgtcactaatgatgaccattatcaatttggctcagaactttgtgggtagcaataat
ctgaacctcttgcagcccattggtcagtttggtaccaggctgcatggtggcaaggattct
gctagtccccgatacatcttcacaatgctcagccctttggctcggttgttatttccacca
aaagatgatcacacgttaaggtttttatatgatgacaaccaacgtgttgagcctgaatgg
tacattcctattatacccatggtgctgataaatggcgctgaaggaattggtactgggtgg
tcctgcaaaatccccaacttcgatgttcgtgaagttgtgaataacatcagacgtttgatg
gatggagaagaacctttgccaatgcttccaagttacaagaacttcaagggtactattgaa
gagctggctccaaatcaatatgtgattagtggtgaaatgtctattcttaattctacaacc
attgaaatctcagagcttcccatcagaacatggacccagacatataaagaacaggttcta
gaacccatgttgaatggcactgagaagacaccccctctgataacagattatagggaatac
cacacagacaccactgtgaagtttgttgtgaagatgactgaagaaaaactggcagaggca
gagagagttggactacacaaagtcttcaaactccaaactagtctcacatgcaactctatg
gtgctttttgaccacgtaggctgtttaaagaaatacgacacagtgttggatattctaaga
gacttctttgaactcaggcttaaatattatggattaagaaaagaatggcttctaggaatg
cttggcgctgaatctgctaaactgaataatcaggctcgctttatcttagagaaaatagat
ggcaaaataatcattgaaaacaagcctaagaaagaattaattaaagttctgattcaaaga
ggttatgattcggatcctgtgaaggcttggaaagaagcccagcaaaaggttccagatgaa
gaagaaaatgaagagagtgacaatgaaaaggaaactgaaaagagtgactctgtaacagat
tctggaccaaccttcaactaccttcttgatatgcctctttggtatctaaccaaggaaaag
aaagatgaactgtgcagactaagaaatgaaaaagagcaagagctagaaacattaaagaga
aagagtccatcagatttgtggaaagaagacttggctgcttttgttgaagagctggaggct
gttgaagcaaaggagaaacaagatgaacaaataggacttcctgggaaaggtgggaaagca
aaggggaaaaaaacacaaagggcagaagttttgccttctccatgtggaaaaagagtcatc
ccccaagtgaccatagagatgaaagcagaggcagaaaagaaaattaaaaaaaaaattaag
aatgaaaatactgaaggaagctctcgagaggatgggatggaaatagaaggcctaaaacag
agattagaaaagaaacagaaaatagaaccaggtaccaagacaaagaaacaaactacattg
ccatttaaaccagtcaagaaagccaaaaagagaaacccctggtctgattcggaatcagat
atagacagtaacgaaagtaattttgatgtccctccccgagaaaaagagccacggagagca
gcaacaaaaaccaaattcacaatggatttggattcagatgaagatttctcagattttgat
gaaaacactcaagatgaagatcgtgtcccatcagatgctagtccacctaggaccacaact
tccccaaaacatactaacaaagaactgaagccacagaaaagtgccacatcagtaacggac
cttaacgctgatgatgccaaggataatgtaccacctcctccaagctctcctgctgctgat
ttcccagctgtaactaaaaccacaaaccctgttcctaaaaagaacgtgacagtgaagaag
acggcagcaaaaagtcagtcttccacctctactacaggggccaaaaaaagggctgcacca
aaaggaaccaaaaaggatccagacttggattctgatgtctctaaaaagcctaatcccccc
aaaaccaagagtcaccgcaaaaggaagccgtccacttctgatgattccgactctaatttt
gagaaaatgatttctaaagcagtcacaagcaagaaacccaaggaggacagtgatgacttc
cacctggacttagactcagctgtggcttctcgggcaaaatcgggacggacaaagaaacct
ataaagtacctcgaagaatcagatgaagatgatctgttttaa |
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