KEGG   Loxodonta africana (African savanna elephant): 100655007
Entry
100655007         CDS       T04351                                 
Symbol
MAP2K4
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 4
  KO
K04430  mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
Organism
lav  Loxodonta africana (African savanna elephant)
Pathway
lav04010  MAPK signaling pathway
lav04012  ErbB signaling pathway
lav04620  Toll-like receptor signaling pathway
lav04664  Fc epsilon RI signaling pathway
lav04668  TNF signaling pathway
lav04912  GnRH signaling pathway
lav04926  Relaxin signaling pathway
lav04935  Growth hormone synthesis, secretion and action
lav04936  Alcoholic liver disease
lav05132  Salmonella infection
lav05135  Yersinia infection
lav05142  Chagas disease
lav05161  Hepatitis B
lav05166  Human T-cell leukemia virus 1 infection
lav05167  Kaposi sarcoma-associated herpesvirus infection
lav05169  Epstein-Barr virus infection
lav05208  Chemical carcinogenesis - reactive oxygen species
lav05417  Lipid and atherosclerosis
lav05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:lav00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100655007 (MAP2K4)
   04012 ErbB signaling pathway
    100655007 (MAP2K4)
   04668 TNF signaling pathway
    100655007 (MAP2K4)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    100655007 (MAP2K4)
   04664 Fc epsilon RI signaling pathway
    100655007 (MAP2K4)
  09152 Endocrine system
   04912 GnRH signaling pathway
    100655007 (MAP2K4)
   04926 Relaxin signaling pathway
    100655007 (MAP2K4)
   04935 Growth hormone synthesis, secretion and action
    100655007 (MAP2K4)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    100655007 (MAP2K4)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100655007 (MAP2K4)
   05161 Hepatitis B
    100655007 (MAP2K4)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100655007 (MAP2K4)
   05169 Epstein-Barr virus infection
    100655007 (MAP2K4)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100655007 (MAP2K4)
   05135 Yersinia infection
    100655007 (MAP2K4)
  09174 Infectious disease: parasitic
   05142 Chagas disease
    100655007 (MAP2K4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100655007 (MAP2K4)
   05418 Fluid shear stress and atherosclerosis
    100655007 (MAP2K4)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    100655007 (MAP2K4)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:lav01001]
    100655007 (MAP2K4)
Enzymes [BR:lav01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     100655007 (MAP2K4)
Protein kinases [BR:lav01001]
 Serine/threonine kinases: STE group
  STE7 family
   100655007 (MAP2K4)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kinase-like ABC1 Pkinase_fungal Seadorna_VP7 Haspin_kinase Choline_kinase APH DUF7443
Other DBs
NCBI-GeneID: 100655007
NCBI-ProteinID: XP_023412247
LinkDB
Position
Unknown
AA seq 338 aa
MDTEEQLQWCAGERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVH
KPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELM
STSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSG
NIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELA
TGRFPYPKWNSVFDQLTQVVKGDPPQLTNSEEREFSPSFINFVNLCLTKDESKRPKYKEL
LKHPFILMYEERTVEVACYVCKILDQMPATPSSPMYVD
NT seq 1017 nt   +upstreamnt  +downstreamnt
atggacacagaagaacagttgcagtggtgtgcaggagagagactgagaacacacagcatt
gaatcgtcaggaaaactgaagatctcccctgaacaacactgggatttcactgcagaggac
ttgaaagaccttggagaaattggacgcggagcttatggttctgtcaacaaaatggtccac
aaaccaagtgggcaaataatggcagttaaaagaattcggtcaacagtggatgaaaaagaa
caaaaacaacttcttatggatttggatgtagtaatgcggagtagtgattgcccatatatt
gttcagttttatggtgcactcttcagagagggtgactgttggatctgtatggagctcatg
tctacctcgtttgataagttttacaaatatgtatatagtgtattagatgatgttattccc
gaagagattttaggaaaaatcactttagcaactgtgaaagcactaaaccacttaaaagaa
aacttgaaaatcattcacagagatatcaaaccttccaatattcttctggacagaagtgga
aatattaaactctgtgacttcggcatcagtggacagcttgtggattccattgccaagaca
agagatgcagggtgtaggccatacatggcgcctgaaagaatagacccaagtgcatcacga
caaggatatgatgtccgctctgatgtctggagtttggggatcacattgtacgagttggcc
acaggccgatttccttatccaaagtggaatagtgtatttgatcaactaacacaagtcgtg
aaaggagatcctccacagctgactaattctgaggaaagggaattctccccaagtttcatc
aactttgtcaacttgtgccttacgaaggatgaatccaaaaggccaaagtataaagaactt
ctgaaacatccctttatcttgatgtatgaagaacgtaccgtagaggtcgcatgctatgtt
tgtaaaatcctggatcaaatgccggctactcccagctctcccatgtatgtcgattga

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