Loxodonta africana (African savanna elephant): 100655087
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Entry
100655087 CDS
T04351
Symbol
IGF1R
Name
(RefSeq) insulin-like growth factor 1 receptor
KO
K05087
insulin-like growth factor 1 receptor [EC:
2.7.10.1
]
Organism
lav
Loxodonta africana (African savanna elephant)
Pathway
lav01521
EGFR tyrosine kinase inhibitor resistance
lav01522
Endocrine resistance
lav04010
MAPK signaling pathway
lav04014
Ras signaling pathway
lav04015
Rap1 signaling pathway
lav04066
HIF-1 signaling pathway
lav04068
FoxO signaling pathway
lav04081
Hormone signaling
lav04114
Oocyte meiosis
lav04140
Autophagy - animal
lav04144
Endocytosis
lav04150
mTOR signaling pathway
lav04151
PI3K-Akt signaling pathway
lav04152
AMPK signaling pathway
lav04211
Longevity regulating pathway
lav04213
Longevity regulating pathway - multiple species
lav04510
Focal adhesion
lav04520
Adherens junction
lav04550
Signaling pathways regulating pluripotency of stem cells
lav04730
Long-term depression
lav04913
Ovarian steroidogenesis
lav04914
Progesterone-mediated oocyte maturation
lav05200
Pathways in cancer
lav05202
Transcriptional misregulation in cancer
lav05205
Proteoglycans in cancer
lav05214
Glioma
lav05215
Prostate cancer
lav05218
Melanoma
lav05224
Breast cancer
lav05225
Hepatocellular carcinoma
Brite
KEGG Orthology (KO) [BR:
lav00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
100655087 (IGF1R)
04014 Ras signaling pathway
100655087 (IGF1R)
04015 Rap1 signaling pathway
100655087 (IGF1R)
04066 HIF-1 signaling pathway
100655087 (IGF1R)
04068 FoxO signaling pathway
100655087 (IGF1R)
04151 PI3K-Akt signaling pathway
100655087 (IGF1R)
04152 AMPK signaling pathway
100655087 (IGF1R)
04150 mTOR signaling pathway
100655087 (IGF1R)
09133 Signaling molecules and interaction
04081 Hormone signaling
100655087 (IGF1R)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
100655087 (IGF1R)
04140 Autophagy - animal
100655087 (IGF1R)
09143 Cell growth and death
04114 Oocyte meiosis
100655087 (IGF1R)
09144 Cellular community - eukaryotes
04510 Focal adhesion
100655087 (IGF1R)
04520 Adherens junction
100655087 (IGF1R)
04550 Signaling pathways regulating pluripotency of stem cells
100655087 (IGF1R)
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
100655087 (IGF1R)
04914 Progesterone-mediated oocyte maturation
100655087 (IGF1R)
09156 Nervous system
04730 Long-term depression
100655087 (IGF1R)
09149 Aging
04211 Longevity regulating pathway
100655087 (IGF1R)
04213 Longevity regulating pathway - multiple species
100655087 (IGF1R)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100655087 (IGF1R)
05202 Transcriptional misregulation in cancer
100655087 (IGF1R)
05205 Proteoglycans in cancer
100655087 (IGF1R)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
100655087 (IGF1R)
05214 Glioma
100655087 (IGF1R)
05218 Melanoma
100655087 (IGF1R)
05215 Prostate cancer
100655087 (IGF1R)
05224 Breast cancer
100655087 (IGF1R)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100655087 (IGF1R)
01522 Endocrine resistance
100655087 (IGF1R)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
lav01001
]
100655087 (IGF1R)
09183 Protein families: signaling and cellular processes
04090 CD molecules [BR:
lav04090
]
100655087 (IGF1R)
Enzymes [BR:
lav01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
100655087 (IGF1R)
Protein kinases [BR:
lav01001
]
Receptor tyrosine kinases (RTK)
INSR family [OT]
100655087 (IGF1R)
CD molecules [BR:
lav04090
]
Proteins
100655087 (IGF1R)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Recep_L_domain
Pkinase
Furin-like
fn3
Kinase-like
Insulin_TMD
Motif
Other DBs
NCBI-GeneID:
100655087
NCBI-ProteinID:
XP_010592155
LinkDB
All DBs
Position
Unknown
AA seq
1368 aa
AA seq
DB search
MKSGSGEGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLRRLENCTVIEGYLH
ILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIF
EMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGD
LCPGTMEEKPLCEKTTINNEYNYRCWTTNRCQKMCPSACGKRACTENNECCHAECLGSCS
APDNATACVACRHYYYAGICVPTCPPNTYKFEGWRCVDRDFCANIPNAESNDAEGFVIHD
GECMQECPSGFIRNGTQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNL
LINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRQILGEEQLEGNYSF
YVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTR
NNGERASCESDVLHFTSTTTWKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDG
QDACGSNSWNMVDVDLPTNKDIEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSE
ILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDSYLYRH
NYCSKDKIPIRKYADGTIDVEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRK
VFENFLHNSIFVPRPERKRRDVMQVANPTMSSRSRNTTMADTYNVTDPEELETEFPFFES
RVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTW
ESRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGN
YTARIQATSLSGNGSWTEPVFFYVPTKIRPYENFIHLIISVPVAALLIVGGLVIMLYVFH
RKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAK
GVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIM
ELMTRGDLKSYLRSLRPEMENNPALAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAAR
NCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFG
VVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSF
LEIIGSVKDEMEPGFREVSFYYSEENKPPEPEELDLEPENMESVPLDPSASSSSLPLPDR
HSGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSSTC
NT seq
4107 nt
NT seq
+upstream
nt +downstream
nt
atgaagtctggctccggagaagggtccccgacctcgctgtgggggctcttgttcctctcc
gcggcgctctcgctctggccgacgagtggagaaatctgcgggccaggcatcgacatccgc
aatgactaccagcagctgaggcgcctggagaactgcacggtgatcgagggctacctgcac
atcctgctcatctccaaggcggaggactaccgcagctaccgcttccccaagctcaccgtc
atcactgagtacttgctgctcttccgcgtggccggcctcgagagtctcggcgacctcttc
ccgaacctcacggtcatccgcggctggaagctcttctacaactatgccctggtcatcttc
gagatgaccaacctcaaggatattgggctttacaacctgaggaacattactcggggggcc
atcaggattgaaaagaatgctgacctctgctacctctccactgtggactggtccctgatc
ctggatgctgtgtccaataactacatcgtgggcaacaaacccccgaaggagtgtggggac
ctgtgtccgggaacgatggaggagaagccattgtgtgagaagaccaccattaacaatgag
tacaactaccgctgctggaccaccaaccgctgccagaaaatgtgcccgagtgcctgcgga
aagcgagcgtgcaccgagaacaacgagtgctgccatgccgagtgcctgggcagctgcagc
gcacccgacaacgccacggcctgcgtcgcctgccgccactactactacgcaggcatctgc
gtgcccacctgcccacccaacacctacaagtttgagggctggcgctgcgtggaccgggac
ttctgcgccaacatccccaatgctgagagcaacgacgccgagggcttcgtcatccacgat
ggggagtgcatgcaggagtgcccatcggggttcatccggaacgggacccagagcatgtac
tgtatcccttgcgaaggtccttgccccaaagtctgtgaggaagagaagaaaacaaagacc
attgattctgtgacttctgcacaaatgctgcaaggatgcaccatcttcaagggcaacttg
ctcatcaatattcgacgaggcaataacattgcctcggagctggagaacttcatgggtctc
atcgaggttgtgacgggctacgtgaagatccgccattcccacgccttggtctccctgtct
ttcctgaaaaatctccgccagattttaggggaggagcagctagaagggaattactccttc
tacgtcctggacaaccagaacctgcagcagctgtgggactgggaccaccgcaacctgaca
atcaaagcagggaaaatgtactttgcttttaatcccaagttgtgcgtttccgaaatttac
cgcatggaggaagtgacagggactaaagggcgccagagcaaaggggacataaacacaagg
aacaacggagaaagagcctcttgtgaaagcgatgtgctgcatttcacctccaccaccacg
tggaagaatcggattatcatcacctggcaccgctaccggccccctgactacagggatctc
atcagcttcactgtgtactataaggaagccccctttaaaaacgtgacggagtatgacggg
caggacgcctgtggctccaacagctggaacatggtggacgtggacctccccaccaacaag
gacatcgagccaggcattttactgcacggactgaagccctggactcagtacgccgtttac
gtcaaggcagtgactctcaccatggtggagaacgaccacatccgcggggccaagagtgaa
atcttatacattcgcaccaatgcatcagttccttccatccccctggatgttctttcagca
tcaaactcctcttctcaattgattgtgaagtggaacccaccctccctgccaaacggtaac
ctgagctactacatagtgaggtggcagcggcagcctcaggacagctacctttaccggcac
aattactgctccaaagacaaaatccctatcaggaagtacgccgacggcaccatcgatgtt
gaggaggtgacagagaatcccaagaccgaggtgtgtggtggagagaaagggccttgctgc
gcctgccccaaaactgaggctgagaagcaggccgagaaggaggaggccgagtaccggaag
gtctttgagaatttcctgcacaactccatcttcgtgcccagacctgagaggaagcggagg
gatgtcatgcaagttgccaaccccaccatgtccagccggagcaggaacactacgatggca
gatacctacaacgtcacagacccagaagagctcgagacggagttcccattctttgagagc
agagtggataacaaggagagaaccgtcatttccaacctgcgacctttcacactgtaccgc
atcgatattcacagctgcaatcacgaggctgagaagctgggctgcagcgcctccaacttc
gtctttgcaaggaccatgccagcagaaggagcagatgacattcctgggccagtgacctgg
gagtcaaggcctgaaaactccatctttctaaagtggccagaaccagagaatcccaatgga
ttgatcctaatgtatgaaataaaatatggatcacaagtcgaggatcagcgggagtgtgtt
tccagacaggagtaccggaagtatggaggggccaagcttaaccggctaaacccagggaac
tacacagcccggattcaggccacttccctttctgggaacgggtcgtggacagagcctgtg
ttcttctacgtaccgaccaaaataagaccgtatgaaaacttcatccatctgatcatctcc
gtgcccgtggctgccctgttgatagtgggagggctggttataatgctatacgtcttccac
aggaagagaaataacagcaggctggggaatggagtgctgtacgcctctgtgaacccagaa
tacttcagcgcagctgacgtgtatgtcccagatgagtgggaagtggcccgagagaagatc
actatgagccgagagcttgggcaggggtcgtttggaatggtgtatgaaggagttgccaag
ggtgtcgtcaaagatgagcctgaaaccagggtggccattaaaacggtgaatgaggctgcg
agcatgcgagaaaggattgaatttctcaacgaggcttcagtgatgaaggagttcaattgt
caccatgtggtgcggttgttgggcgtggtgtcccagggccagccaacgctggtcatcatg
gaactgatgacacggggggatctcaaaagttacctcaggtctctgaggccagaaatggag
aataatccagccctagcacctccaagcctaagcaagatgattcagatggcgggcgagatt
gcggatggcatggcatacctcaacgctaacaagttcgttcacagagacctggccgcccgg
aactgcatggtggctgaagacttcacagtcaaaatcggagattttggcatgacgagagat
atttatgagacagactattaccggaaaggagggaaagggctgctgcctgtgcgctggatg
tctcccgagtcgctcaaggatggagtcttcaccacgcattctgacgtctggtccttcggg
gtggtcctctgggagatcgccacattggccgagcagccataccagggcttatccaacgag
caagtccttcgctttgtcatggaaggcggacttctggacaagccagacaactgcccagac
atgctgtttgagctgatgcgcatgtgctggcagtacaaccccaagatgaggccctccttc
ctggagatcatcggcagcgtcaaggacgagatggagcccggcttccgggaggtctccttc
tactacagcgaggagaacaagccgcccgagccggaggagctggacctggagccggagaac
atggagagtgtccccctggacccctccgcctcctcgtcctccctgccgctgcccgacaga
cactcgggacacaaggctgagaacggcccgggtcccggtgtgctggttctccgagccagc
ttcgacgagagacagccttacgcgcacatgaacgggggacgcaagaacgagagggccttg
cccctgccccagtcttcaacctgctga
DBGET
integrated database retrieval system
