KEGG   Loxodonta africana (African savanna elephant): 100657948
Entry
100657948         CDS       T04351                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
lav  Loxodonta africana (African savanna elephant)
Pathway
lav00562  Inositol phosphate metabolism
lav01100  Metabolic pathways
lav01521  EGFR tyrosine kinase inhibitor resistance
lav01522  Endocrine resistance
lav01524  Platinum drug resistance
lav04012  ErbB signaling pathway
lav04014  Ras signaling pathway
lav04015  Rap1 signaling pathway
lav04024  cAMP signaling pathway
lav04062  Chemokine signaling pathway
lav04066  HIF-1 signaling pathway
lav04068  FoxO signaling pathway
lav04070  Phosphatidylinositol signaling system
lav04071  Sphingolipid signaling pathway
lav04072  Phospholipase D signaling pathway
lav04081  Hormone signaling
lav04140  Autophagy - animal
lav04150  mTOR signaling pathway
lav04151  PI3K-Akt signaling pathway
lav04152  AMPK signaling pathway
lav04210  Apoptosis
lav04211  Longevity regulating pathway
lav04213  Longevity regulating pathway - multiple species
lav04218  Cellular senescence
lav04360  Axon guidance
lav04370  VEGF signaling pathway
lav04380  Osteoclast differentiation
lav04510  Focal adhesion
lav04550  Signaling pathways regulating pluripotency of stem cells
lav04611  Platelet activation
lav04613  Neutrophil extracellular trap formation
lav04620  Toll-like receptor signaling pathway
lav04625  C-type lectin receptor signaling pathway
lav04630  JAK-STAT signaling pathway
lav04650  Natural killer cell mediated cytotoxicity
lav04660  T cell receptor signaling pathway
lav04662  B cell receptor signaling pathway
lav04664  Fc epsilon RI signaling pathway
lav04666  Fc gamma R-mediated phagocytosis
lav04668  TNF signaling pathway
lav04670  Leukocyte transendothelial migration
lav04722  Neurotrophin signaling pathway
lav04725  Cholinergic synapse
lav04750  Inflammatory mediator regulation of TRP channels
lav04810  Regulation of actin cytoskeleton
lav04910  Insulin signaling pathway
lav04914  Progesterone-mediated oocyte maturation
lav04915  Estrogen signaling pathway
lav04917  Prolactin signaling pathway
lav04919  Thyroid hormone signaling pathway
lav04923  Regulation of lipolysis in adipocytes
lav04926  Relaxin signaling pathway
lav04929  GnRH secretion
lav04930  Type II diabetes mellitus
lav04931  Insulin resistance
lav04932  Non-alcoholic fatty liver disease
lav04933  AGE-RAGE signaling pathway in diabetic complications
lav04935  Growth hormone synthesis, secretion and action
lav04960  Aldosterone-regulated sodium reabsorption
lav04973  Carbohydrate digestion and absorption
lav05010  Alzheimer disease
lav05017  Spinocerebellar ataxia
lav05020  Prion disease
lav05100  Bacterial invasion of epithelial cells
lav05132  Salmonella infection
lav05135  Yersinia infection
lav05142  Chagas disease
lav05146  Amoebiasis
lav05160  Hepatitis C
lav05161  Hepatitis B
lav05162  Measles
lav05163  Human cytomegalovirus infection
lav05164  Influenza A
lav05165  Human papillomavirus infection
lav05166  Human T-cell leukemia virus 1 infection
lav05167  Kaposi sarcoma-associated herpesvirus infection
lav05168  Herpes simplex virus 1 infection
lav05169  Epstein-Barr virus infection
lav05170  Human immunodeficiency virus 1 infection
lav05171  Coronavirus disease - COVID-19
lav05200  Pathways in cancer
lav05203  Viral carcinogenesis
lav05205  Proteoglycans in cancer
lav05206  MicroRNAs in cancer
lav05207  Chemical carcinogenesis - receptor activation
lav05208  Chemical carcinogenesis - reactive oxygen species
lav05210  Colorectal cancer
lav05211  Renal cell carcinoma
lav05212  Pancreatic cancer
lav05213  Endometrial cancer
lav05214  Glioma
lav05215  Prostate cancer
lav05218  Melanoma
lav05220  Chronic myeloid leukemia
lav05221  Acute myeloid leukemia
lav05222  Small cell lung cancer
lav05223  Non-small cell lung cancer
lav05224  Breast cancer
lav05225  Hepatocellular carcinoma
lav05226  Gastric cancer
lav05230  Central carbon metabolism in cancer
lav05231  Choline metabolism in cancer
lav05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
lav05415  Diabetic cardiomyopathy
lav05417  Lipid and atherosclerosis
lav05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:lav00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100657948 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100657948 (PIK3CA)
   04014 Ras signaling pathway
    100657948 (PIK3CA)
   04015 Rap1 signaling pathway
    100657948 (PIK3CA)
   04370 VEGF signaling pathway
    100657948 (PIK3CA)
   04630 JAK-STAT signaling pathway
    100657948 (PIK3CA)
   04668 TNF signaling pathway
    100657948 (PIK3CA)
   04066 HIF-1 signaling pathway
    100657948 (PIK3CA)
   04068 FoxO signaling pathway
    100657948 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    100657948 (PIK3CA)
   04072 Phospholipase D signaling pathway
    100657948 (PIK3CA)
   04071 Sphingolipid signaling pathway
    100657948 (PIK3CA)
   04024 cAMP signaling pathway
    100657948 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    100657948 (PIK3CA)
   04152 AMPK signaling pathway
    100657948 (PIK3CA)
   04150 mTOR signaling pathway
    100657948 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    100657948 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100657948 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    100657948 (PIK3CA)
   04218 Cellular senescence
    100657948 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100657948 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    100657948 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100657948 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100657948 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    100657948 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    100657948 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    100657948 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    100657948 (PIK3CA)
   04660 T cell receptor signaling pathway
    100657948 (PIK3CA)
   04662 B cell receptor signaling pathway
    100657948 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    100657948 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    100657948 (PIK3CA)
   04670 Leukocyte transendothelial migration
    100657948 (PIK3CA)
   04062 Chemokine signaling pathway
    100657948 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100657948 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    100657948 (PIK3CA)
   04929 GnRH secretion
    100657948 (PIK3CA)
   04915 Estrogen signaling pathway
    100657948 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    100657948 (PIK3CA)
   04917 Prolactin signaling pathway
    100657948 (PIK3CA)
   04926 Relaxin signaling pathway
    100657948 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    100657948 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    100657948 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100657948 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100657948 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    100657948 (PIK3CA)
   04722 Neurotrophin signaling pathway
    100657948 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100657948 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    100657948 (PIK3CA)
   04380 Osteoclast differentiation
    100657948 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    100657948 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    100657948 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100657948 (PIK3CA)
   05206 MicroRNAs in cancer
    100657948 (PIK3CA)
   05205 Proteoglycans in cancer
    100657948 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    100657948 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    100657948 (PIK3CA)
   05203 Viral carcinogenesis
    100657948 (PIK3CA)
   05230 Central carbon metabolism in cancer
    100657948 (PIK3CA)
   05231 Choline metabolism in cancer
    100657948 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100657948 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100657948 (PIK3CA)
   05212 Pancreatic cancer
    100657948 (PIK3CA)
   05225 Hepatocellular carcinoma
    100657948 (PIK3CA)
   05226 Gastric cancer
    100657948 (PIK3CA)
   05214 Glioma
    100657948 (PIK3CA)
   05221 Acute myeloid leukemia
    100657948 (PIK3CA)
   05220 Chronic myeloid leukemia
    100657948 (PIK3CA)
   05218 Melanoma
    100657948 (PIK3CA)
   05211 Renal cell carcinoma
    100657948 (PIK3CA)
   05215 Prostate cancer
    100657948 (PIK3CA)
   05213 Endometrial cancer
    100657948 (PIK3CA)
   05224 Breast cancer
    100657948 (PIK3CA)
   05222 Small cell lung cancer
    100657948 (PIK3CA)
   05223 Non-small cell lung cancer
    100657948 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100657948 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    100657948 (PIK3CA)
   05161 Hepatitis B
    100657948 (PIK3CA)
   05160 Hepatitis C
    100657948 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    100657948 (PIK3CA)
   05164 Influenza A
    100657948 (PIK3CA)
   05162 Measles
    100657948 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    100657948 (PIK3CA)
   05163 Human cytomegalovirus infection
    100657948 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100657948 (PIK3CA)
   05169 Epstein-Barr virus infection
    100657948 (PIK3CA)
   05165 Human papillomavirus infection
    100657948 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100657948 (PIK3CA)
   05135 Yersinia infection
    100657948 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    100657948 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100657948 (PIK3CA)
   05142 Chagas disease
    100657948 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100657948 (PIK3CA)
   05017 Spinocerebellar ataxia
    100657948 (PIK3CA)
   05020 Prion disease
    100657948 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100657948 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    100657948 (PIK3CA)
   05415 Diabetic cardiomyopathy
    100657948 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100657948 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    100657948 (PIK3CA)
   04931 Insulin resistance
    100657948 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100657948 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100657948 (PIK3CA)
   01524 Platinum drug resistance
    100657948 (PIK3CA)
   01522 Endocrine resistance
    100657948 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:lav04131]
    100657948 (PIK3CA)
Enzymes [BR:lav01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     100657948 (PIK3CA)
Membrane trafficking [BR:lav04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100657948 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 100657948
NCBI-ProteinID: XP_003416277
UniProt: G3SRN1
LinkDB
Position
Unknown
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLYQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKISHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWSEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFNYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggagaactgtggggcatccacttgatgcccccaagaatc
ttagtagaatgtttactaccaaatggcatgatagtgactttagaatgcctccgtgaggct
acattaataactataaagcatgaactatttaaagaagcaagaaaataccctctgtatcaa
cttcttcaggatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaatcgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
atcggcatgccagtgtgtgaatttgacatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatctgagggatctgaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcgccagaactgccaaagcac
atatataacaaattagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgataagcagaaatatactctgaaaatcagccatgactgtgtgccagaacaggtg
attgccgaagcaatcaggaagaaaactcgaagtatgttgctgtcctccgagcaactaaaa
ctatgtgttttagaatatcagggcaagtatattttaaaagtgtgcggatgtgacgaatat
ttcctcgaaaagtatcctctgagtcaatataagtatataagaagctgtataatgctggga
aggatgcccaatttgatgctgatggctaaagaaagcctctactctcagctgccaatggac
tgttttacaatgccatcttactccaggcgcatttccacagctacaccctatatgaatgga
gaaacatctacaaaatccctttgggttatcaatagtgcactcagaataaaaattctctgt
gcaacctatgtgaatgtaaatattcgagatattgacaagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgacaatgtaaacactcaaagagtaccttgttccaat
cccaggtggagtgaatggctgaattatgacatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgctctgttaaaggccgaaagggtgctaaagaggaacattgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattggaagatttactgaaccctattggt
gttactggatcaaatccaaataaagaaactccatgcctggagttggagtttgactggttt
agcagtgttgtgaagtttccagatatgtcagtgattgaagagcatgccaactggtctgtg
tcccgagaagcaggattcaactattcccacgcaggactgagtaacagactagctagagac
aatgaattaagagaaaatgacaaagaacagctccgagcaatttgtacacgagatcctctg
tctgaaatcactgagcaagaaaaagattttctgtggagccacaggcactattgtgtaact
atccctgaaattctgcccaaattgctcctgtctgttaaatggaattctagagatgaagta
gcccagatgtattgcctggtcaaagactggcctccaatcaaacctgaacaagccatggag
cttctggactgtaattacccagatcctatggttcgaggctttgctgttcgatgcctggaa
aaatatttaacagatgacaagctttctcagtacctaattcagctagtacaggtcctaaaa
tatgaacaatatttggataacctgcttgtgaggtttttacttaagaaagctttgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagta
agtcagaggtttggcctgcttttggagtcatattgtcgtgcttgtgggatgtatttgaag
cacctgaatagacaagttgaggctatggaaaagctgattaatttaactgacatcctcaaa
caggagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatgagg
cgaccagatttcatggatgctctacagggctttctgtctcctctaaaccctgctcaccaa
ctaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactgtttcagaacaatgagatcatc
tttaaaaatggggatgatttgcggcaagatatgttaacacttcaaattattcgcattatg
gaaaatatctggcaaaatcaaggtcttgatcttcggatgttaccttatggttgtctgtca
attggtgactgtgtgggacttattgaggtggtgagaaattctcacactattatgcaaatt
cagtgcaaaggcggcctgaaaggcgctctgcagttcaacagccacacactacaccagtgg
ctcaaagacaaaaacaaaggagaaatatacgatgcagccattgacttgttcacacgttcc
tgtgctgggtattgtgtcgctaccttcattttgggaattggagatcgtcacaatagtaac
atcatggttaaagatgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaagaaatttggttataaacgagaacgtgtaccatttgttttgacacaagatttc
ttaatagtcattagtaaaggagcccaagaatgcacaaaaacaagagaatttgaaagattt
caggagatgtgttacaaggcttatctagctattcggcagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccggaactacaatcttttgatgatattgca
tacattcgaaagaccctagccttagataaaactgagcaagaggctttggagtatttcatg
aaacaaatgaatgatgcacaccatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcacgctttgaactga

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