| Entry |
|
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| Symbol |
TOP2A
|
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| Name |
(RefSeq) DNA topoisomerase 2-alpha
|
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| KO |
|
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| Organism |
lav Loxodonta africana (African savanna elephant)
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| Pathway |
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| Brite |
KEGG Orthology (KO) [BR:lav00001]
09160 Human Diseases
09176 Drug resistance: antineoplastic
01524 Platinum drug resistance
100667411 (TOP2A)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03032 DNA replication proteins [BR:lav03032]
100667411 (TOP2A)
03036 Chromosome and associated proteins [BR:lav03036]
100667411 (TOP2A)
Enzymes [BR:lav01000]
5. Isomerases
5.6 Isomerases altering macromolecular conformation
5.6.2 Enzymes altering nucleic acid conformation
5.6.2.2 DNA topoisomerase (ATP-hydrolysing)
100667411 (TOP2A)
DNA replication proteins [BR:lav03032]
Eukaryotic type
DNA Topoisomerases
100667411 (TOP2A)
Chromosome and associated proteins [BR:lav03036]
Eukaryotic type
Chromosome condensation proteins
Other regulators of chromosome condensation
100667411 (TOP2A)
Centrosome formation proteins
Centriole proteins
100667411 (TOP2A)
|
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| SSDB |
|
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| Motif |
|
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| Other DBs |
|
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| LinkDB |
|
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| Position |
Unknown
|
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| AA seq |
1533 aa
MEVSPLQPVNENMQINKIKKNEDAKKRLSIERIYQKKTQLEHILLRPDTYIGSVELVTQQ
MWVYDEDIGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWN
NGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE
TASREYKKKFKQTWMDNMGKAGEMELKPFSGEDYTCITFQPDLSKFKMQSLDKDIVALMV
RRAYDIAGSTKDVKVFLNGNTLPVKGFRSYVDMYLKDKVDETGNPLKVIYEQVNHRWEVC
LTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHM
WIFVNALIENPTFDSQTKENMTLQVKSFGSTCQLSEKFIKAATGCGIVESILNWVKFKAQ
IQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTDCTLILTEGDSAKTLAVSGLGVVGRDK
YGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDEDSLKTLRYGKIMIMT
DQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEIAFYSLPEFEEWKS
STPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDD
RKEWLTHFMEDRRQRKLLGLPEDYLYGQATTYLTYNDFINKELILFSNSDNERSIPSMVD
GLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNN
LNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLLFPPKDDHTLKFLYDDNQRVEPEW
YIPIIPMVLINGAEGIGTGWSCKIPNFDVREVVNNIRRLMDGEEPLPMLPSYKNFKGTIE
ELASNQYVISGEVAILNSTTIEISELPIRTWTQTYKEQVLEPMLNGTEKTPPLITDYREY
HTDTTVKFVVKMTEEKLAEAERAGLHKVFKLHTSLTCNSMVLFDHVGCLKKYDTVLDILR
DFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQR
GYDSDPVKAWKEAQQKVPEEEENEDSDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEK
KDELCKLRNEKEQELETLKKKSPSDLWKEDLAAFIEELETVEAKEKQDEQVGFPGKGGKG
KGKKAQMAEVLPSPSGKRVIPRVTVEMKAEAEKKIKRKIKSENTEGSPQEDSVEPESLKQ
RLEKKQKREPGTKTKKQTTLPFKPVKKGKKKNPWSDSDSDISDNESNFDLPPRETEPRRA
AKSKFIIDLDSEEDFSDFDEKTQDEDFVPSDPSPPKAKTSPKHTNKELRPQKSAKSAVDL
DADDAKDNVPLPSSSPTADLPAETEITNPISKKGATVKKTAAKSQSSNSTAGTKKRAAPK
GTKKDSGLNSDLSPKKPGPAKSKNPRKRKPSTSDDSDSNFEKMISKAVTSKKSKGESNDF
QMDLDSAVAPRAKSVRAKKPIRYLEESDEDDLF |
|---|
| NT seq |
4602 nt +upstreamnt +downstreamnt
atggaggtgtcaccactgcagcctgtgaatgaaaatatgcaaatcaacaaaataaagaaa
aatgaagatgctaagaaaagactgtctatcgaaagaatctatcaaaagaaaacgcaattg
gaacatattttgctccgcccggacacctacattggttctgtggaattagtgacccagcaa
atgtgggtttacgatgaagatattggcattaactacagggaagtcacttttgttcctggt
ttatacaaaatctttgatgagattctagtcaatgctgcggacaacaagcaaagggaccca
aaaatgtcttgtatcagagtcacaattgacccggaaaacaatttaattagtatatggaat
aatggaaaaggtattcctgttgttgagcacaaggttgagaagatgtatgtcccagctctc
atttttggacagctcctaacttctagtaactatgatgatgatgaaaagaaagtaacaggt
ggtcgaaatggctatggagccaaattgtgtaatatattcagtaccaaattcactgtagaa
acagccagtagagaatacaagaaaaagttcaaacagacatggatggataacatggggaaa
gctggcgagatggaactcaagccctttagtggagaagattatacatgtatcaccttccag
cctgatttgtctaagtttaaaatgcaaagcttggacaaagatattgttgcactgatggtt
agaagagcttatgatattgctggatccactaaagatgtcaaagtctttcttaatggaaat
acactgccagtaaaaggattccgtagctatgtggacatgtatttgaaggataaggtagat
gaaactggcaacccactgaaagttatctatgaacaagtaaaccacaggtgggaagtgtgt
ttaacaatgagtgaaaaaggttttcagcaaattagcttcgtcaacagcattgctacttcc
aagggaggcagacatgttgattatgtagctgaccagatagtgactaaacttgttgatgtt
gtgaagaagaagaacaagggtggtgttgctgtaaaagcgcatcaggtgaaaaatcacatg
tggatttttgtgaatgccttaattgaaaacccaacctttgactctcaaacaaaggaaaac
atgactttacaggtcaagagctttggatcaacatgccaattaagtgaaaaattcatcaaa
gctgcaactggctgcggtattgtagaaagcatactaaactgggtgaagtttaaggcccaa
atccagttaaacaagaagtgttcagctgtaaaacataacagaattaagggaattcccaaa
cttgatgatgccaatgatgcagggggccgaaactccactgattgtactcttatcctgact
gagggagactcagctaaaactttggctgtttcaggccttggtgtggttgggagagacaag
tatggggtttttcctcttagaggaaaaatactcaatgttcgagaagcttctcataaacag
ataatggaaaatgccgaaattaacaatatcattaagattgtgggtcttcagtacaagaaa
agctatgacgatgaagattcattgaagactcttcgttatgggaagataatgattatgaca
gatcaggaccaagacggttcccatatcaaaggcttgctgattaattttatccatcacaac
tggccttctcttctaagacatcgttttctggaggaatttatcacccccattgtaaaggta
tctaaaaataagcaagaaatagcattctatagccttcctgaatttgaagaatggaaaagt
tctactccaaatcataaaaaatggaaagtcaagtattacaaaggtttgggcaccagcaca
tcaaaagaagctaaagaatactttgcagatatgaaaagacatcggattcaattcaaatat
tctggtcctgaagatgatgctgcaatcagcctggcctttagcaaaaaacagattgatgat
cgaaaggagtggttaactcatttcatggaggatagaagacaacggaagttgcttggcctt
ccagaggattacttgtatgggcaggctaccacatatctaacctacaatgacttcataaac
aaggaacttatcctgttctcaaattctgacaatgagagatctatcccatctatggtggat
ggtttgaaaccaggtcagagaaaggttttgtttacttgtttcaaacggaatgacaagcga
gaggtgaaggttgcccagttagctgggtcagtggctgagatgtcctcttatcatcatggt
gagatgtcactaatgatgaccattattaatttggctcagaattttgtgggcagcaataat
ctgaacctcttgcaacccattggtcagtttggtaccaggctgcatggtggcaaggattca
gctagtcctcgatacatcttcacaatgctcagccctttggctcggttgttatttccaccg
aaagatgatcacacattaaagttcttatatgatgacaaccaacgcgttgaacctgaatgg
tacattcctattatacccatggtcctgataaatggtgctgaaggaatcggtaccgggtgg
tcctgcaaaatccccaactttgatgttcgtgaagttgtgaataacatcaggcgactaatg
gatggagaagaacctttgccaatgcttccgagttacaagaacttcaagggtactattgaa
gaactggcttctaatcaatatgtgattagtggtgaagtagctattctcaattccacaacc
attgaaatctcagagcttcccatcagaacttggacccagacatataaagaacaggttcta
gagcccatgttgaatggcactgagaagacaccgcctctcataacagactacagggaatac
catacagataccactgtgaagtttgtcgtgaagatgactgaagaaaaactagcagaggca
gagagagctggattacacaaagtattcaagctccatactagtctcacatgcaactctatg
gtgctttttgaccatgttggctgtttaaagaaatatgacacagtgttggatattctaaga
gacttctttgaactcaggcttaaatattacggattacgaaaagaatggcttctaggaatg
cttggtgctgaatctgctaaactgaacaatcaagctcgctttattttagagaaaatcgat
ggcaaaataatcattgaaaataaacctaagaaagaattaattaaagttctgattcagagg
ggatatgattcggatcctgtgaaagcctggaaagaagcacagcaaaaggttccagaggaa
gaagaaaatgaagacagtgacaatgaaaaggaaactgaaaagagtgactctgtgacagat
tctggaccaactttcaattaccttcttgatatgcccctttggtatctaaccaaggagaag
aaagatgaactgtgcaaactaagaaatgaaaaagaacaagagctggaaacattaaagaaa
aagagtccatcagatttgtggaaagaagatttggctgcttttattgaagaactggagact
gttgaagccaaggaaaaacaagatgaacaagtaggatttcctgggaaaggggggaaagga
aaagggaaaaaagcacaaatggccgaagttttgccttctccatctggcaaaagagtcatt
ccccgagtaactgtagagatgaaagcagaggcagaaaagaaaattaaaaggaaaattaag
agtgaaaatactgaaggaagtcctcaagaggacagtgtggaaccagagagcctaaaacaa
agattagagaagaaacagaaaagagaaccaggtaccaagacaaagaaacaaactaccttg
ccatttaaaccagtcaaaaaaggaaagaagaaaaatccctggtctgattcagattcagat
attagtgataatgaaagtaactttgatctccctccacgagaaacagagccccggagagca
gcaaaatccaaattcataattgatttggattcagaggaagatttctcagattttgatgaa
aaaactcaagatgaagattttgtcccatcagatcctagtccacctaaagccaaaacttcc
ccaaagcacactaacaaagaactgaggccacagaaaagtgccaaatcagcagtggacctt
gatgctgatgatgctaaggacaatgtgccacttccttcaagctctcctactgctgattta
ccagccgaaactgaaattacgaacccaatttctaaaaaaggcgcgacagtgaagaagaca
gcagcaaaaagtcagtcttccaactccactgcaggcaccaaaaaaagggctgcaccaaaa
ggaaccaaaaaggactcaggcttgaattctgacctctctccaaaaaagcctggtcctgcc
aaatccaagaatccccgcaaaaggaagccatccacttctgatgattccgactctaatttt
gagaaaatgatttctaaagcggtgacaagcaagaaatccaagggagagagtaatgacttc
cagatggatttagactcagctgtggctcctcgggcaaagtctgtacgggctaagaaacct
ataagatacctggaagaatccgatgaagatgatctgttttaa |
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