KEGG   Loxodonta africana (African savanna elephant): 100675607
Entry
100675607         CDS       T04351                                 
Symbol
MAP2K3
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 3 isoform X1
  KO
K04432  mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]
Organism
lav  Loxodonta africana (African savanna elephant)
Pathway
lav04010  MAPK signaling pathway
lav04015  Rap1 signaling pathway
lav04218  Cellular senescence
lav04620  Toll-like receptor signaling pathway
lav04664  Fc epsilon RI signaling pathway
lav04668  TNF signaling pathway
lav04714  Thermogenesis
lav04750  Inflammatory mediator regulation of TRP channels
lav04912  GnRH signaling pathway
lav04935  Growth hormone synthesis, secretion and action
lav04936  Alcoholic liver disease
lav05014  Amyotrophic lateral sclerosis
lav05022  Pathways of neurodegeneration - multiple diseases
lav05132  Salmonella infection
lav05135  Yersinia infection
lav05145  Toxoplasmosis
lav05161  Hepatitis B
lav05169  Epstein-Barr virus infection
lav05170  Human immunodeficiency virus 1 infection
lav05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
lav05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:lav00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100675607 (MAP2K3)
   04015 Rap1 signaling pathway
    100675607 (MAP2K3)
   04668 TNF signaling pathway
    100675607 (MAP2K3)
 09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    100675607 (MAP2K3)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    100675607 (MAP2K3)
   04664 Fc epsilon RI signaling pathway
    100675607 (MAP2K3)
  09152 Endocrine system
   04912 GnRH signaling pathway
    100675607 (MAP2K3)
   04935 Growth hormone synthesis, secretion and action
    100675607 (MAP2K3)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100675607 (MAP2K3)
  09159 Environmental adaptation
   04714 Thermogenesis
    100675607 (MAP2K3)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100675607 (MAP2K3)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    100675607 (MAP2K3)
   05161 Hepatitis B
    100675607 (MAP2K3)
   05169 Epstein-Barr virus infection
    100675607 (MAP2K3)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100675607 (MAP2K3)
   05135 Yersinia infection
    100675607 (MAP2K3)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    100675607 (MAP2K3)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    100675607 (MAP2K3)
   05022 Pathways of neurodegeneration - multiple diseases
    100675607 (MAP2K3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100675607 (MAP2K3)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    100675607 (MAP2K3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:lav01001]
    100675607 (MAP2K3)
Enzymes [BR:lav01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     100675607 (MAP2K3)
Protein kinases [BR:lav01001]
 Serine/threonine kinases: STE group
  STE7 family
   100675607 (MAP2K3)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kinase-like ABC1 Haspin_kinase Pkinase_fungal Seadorna_VP7 Choline_kinase APH RIO1 DUF4344
Other DBs
NCBI-GeneID: 100675607
NCBI-ProteinID: XP_010598520
UniProt: G3U6S9
LinkDB
Position
Unknown
AA seq 347 aa
MESPASSQPPSAPQSKGKSRKKKDLRITCVSKPPPPNPTPPRNLDSRTFITIGDRNFEVE
ADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDC
FYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHL
HSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPEL
NQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVD
FTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS
NT seq 1044 nt   +upstreamnt  +downstreamnt
atggagtcgcccgcctcgagccagccccccagcgcgccccagtccaaaggaaaatccagg
aagaagaaggacttacggataacctgtgtgtccaagcctccaccacccaaccccacgccc
ccccggaaccttgattccaggaccttcatcaccataggagaccggaacttcgaggtggaa
gccgatgacctggtgaccatctcggagctgggccgtggagcctatggggtagtggagaag
gtgcgacatgcccagagtggtaccatcatggctgtgaagcggattcgagccaccgtgaac
tcacaggagcagaagaggctgctcatggacttggacatcaacatgcggacagttgactgc
ttctacactgtcaccttctacggggccctcttcagagagggtgatgtgtggatctgtatg
gagcttatggacacctctctggataaattctaccggaaggtgctggacaaaaacatgaca
attccagaggatattttgggggagattgctgtgtcgattgtgagggccctggagcacctg
cacagcaaactctccgtgatccacagagacgtgaagccctccaatgtgctcatcaacaag
gagggccatgtgaagatgtgcgactttgggattagtggctacttggtggactccgtggct
aagactatggacgccggctgcaagccctacatggcccctgagagaatcaacccggagctg
aaccagaagggctacaatgtcaagtccgatgtctggagcctcggcatcacaatgattgag
atggccatcctgcggtttccttatgagtcctgggggaccccgttccaacagctgaagcag
gtggtagaggagccgtccccccagctcccagctgaccggttctctcctgagtttgtggac
ttcactgcacagtgcctgaggaagaaccccgcggagcgcatgagctacctggagctgatg
gagcaccctttcttcaccttgcacaaaaccaagaagacagacattgctgccttcgtgaag
gagatcctgggggaggactcgtag

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